Myc - myelocytomatosis oncogene Gene

Mus musculus

Also known as Myc2; Nird; Niard; bHLHe39

Gene ID: 17869 | Gene type: protein coding

About Myc

Chromosome 15: 61,857,240-61,862,223 forward strand.GRCm39:CM001008.3

This gene has 7 transcripts (splice variants), 217 orthologues, 4 paralogues and is associated with 81 phenotypes. Broad expression in ovary adult (RPKM 36.6), thymus adult (RPKM 28.3) and 22 other tissues.

Summary

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, Apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Myc Products(4)

mRNA	Protein	Name
NM_001177352.1	NP_001170823.1	myc proto-oncogene protein isoform b
NM_010849.4	NP_034979.3	myc proto-oncogene protein isoform a
NM_001177354.1	NP_001170825.1	myc proto-oncogene protein isoform b
NM_001177353.1	NP_001170824.1	myc proto-oncogene protein isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12970171	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18625840	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15511642	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9764821	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22328504	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell apoptotic process	IGI IGI: Inferred from genetic interaction	11604501	MGI
acts upstream of or within B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12970677	MGI
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	20212154	MGI
involved in NK T cell proliferation	IMP IMP: Inferred from mutant phenotype	19423665	MGI
acts upstream of or within Wnt signaling pathway	IDA IDA: Inferred from direct assay	19056892	MGI
acts upstream of acinar cell proliferation	IGI IGI: Inferred from genetic interaction	17596282	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	14517295	MGI
involved in branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	19161241	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	17596282	MGI
acts upstream of or within cellular response to interferon-alpha	IDA IDA: Inferred from direct assay	24795346	MGI
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	19179467	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	17523175	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	14517295	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	14517295	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	17523175	MGI
acts upstream of or within myotube differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
acts upstream of or within negative regulation of protein binding	IDA IDA: Inferred from direct assay	18045875	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12196193	MGI
acts upstream of or within pigmentation	IMP IMP: Inferred from mutant phenotype	17523175	MGI
acts upstream of or within positive regulation of B cell apoptotic process	IGI IGI: Inferred from genetic interaction	11604501	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20434984	MGI
acts upstream of or within positive regulation of acinar cell proliferation	IGI IGI: Inferred from genetic interaction	17596282	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14517295	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	14517295	MGI
acts upstream of or within positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	17382917	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12235125	MGI
involved in positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	19161241	MGI
involved in positive regulation of metanephric cap mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	19161241	MGI
involved in positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	9637678	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23277542	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9637678	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17382917	MGI
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	26691508	MGI
acts upstream of or within protein processing	IMP IMP: Inferred from mutant phenotype	12970677	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	31005419	MGI
acts upstream of or within regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	8521822	MGI
acts upstream of or within regulation of apoptotic process	IDA IDA: Inferred from direct assay	12235125	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23277542	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	11438662	MGI
involved in regulation of somatic stem cell population maintenance	IDA IDA: Inferred from direct assay	31005419	MGI
acts upstream of or within response to alkaloid	IMP IMP: Inferred from mutant phenotype	12970677	MGI
acts upstream of or within response to radiation	IDA IDA: Inferred from direct assay	14517295	MGI
acts upstream of or within response to radiation	IMP IMP: Inferred from mutant phenotype	14517295	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	17523175	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17382917	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Myc-Max complex	IPI IPI: Inferred from physical interaction	20434984	MGI
located in axon	IDA IDA: Inferred from direct assay	10482234	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	22723415	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	15735755	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11872843	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22328504	MGI
located in spindle	IDA IDA: Inferred from direct assay	15509711	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Myc Protein Structure

Myc_N

bHLHzip_c-Myc

0
100
200
300
400
439 a.a.

Protein Preferred Names

Protein Names

myc proto-oncogene protein

c-myc proto-oncogene

transcription factor p64

Myc Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Myc	P01108	Max	Mus musculus	P28574	Anti Tag CoIP	20946988
Intra	Myc	P01108	Max	Mus musculus	P28574	Pull Down	20946988
Intra	Myc	P01108	Max	Mus musculus	P28574	Anti Bait CoIP	20434984
Intra	Myc	P01108	Trim32	Mus musculus	Q8CH72	Anti Bait CoIP	19269368

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17381A	Idarubicin		/	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-111784	Inobrodib	Inhibitor	99.94%	Phase 2
HY-153356	MRT-2359	Inducer	99.98%	Phase 2
HY-13241	Ralimetinib dimesylate		99.91%	Phase 2
HY-100653	AZD5153	Inhibitor	99.20%	Phase 2
HY-109050	Alobresib	Inhibitor	98.04%	Phase 2
HY-13241A	Ralimetinib	Inhibitor	/	Phase 2
HY-16291	APTO-253		98.86%	Phase 1
HY-145898	WBC100	Inhibitor	≥95.0%	Phase 1
HY-136938	NEO2734	Inhibitor	99.63%	Phase 1
HY-112316	BAY1238097	Inhibitor	99.02%	Phase 1
HY-16291A	APTO-253 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (176)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12702	10058-F4	Inhibitor	99.77%	Unkown
HY-80013	THZ1	Inhibitor	99.84%	Unkown
HY-107738	Guggulsterone		99.83%	Unkown
HY-134582	dCBP-1	Inhibitor	99.44%	Unkown
HY-112929	DT-061	Activator	99.95%	Unkown
HY-19735	KJ Pyr 9	Inhibitor	99.62%	Unkown
HY-12863	Pelabresib	Inhibitor	99.95%	Unkown
HY-126477	NNK		99.98%	Unkown
HY-139330	MGH-CP1	Inducer	99.56%	Unkown
HY-139361	Sulfopin	Inhibitor	99.69%	Unkown
HY-124675	MYCMI-6		98.14%	Unkown
HY-N0330	Momordin Ic		99.78%	Unkown
HY-134761	EN4	Inhibitor	97.05%	Unkown
HY-123954	BTX-A51		98.58%	Unkown
HY-N2068	Didymin	Inducer	99.96%	Unkown
HY-100996	10074-G5	Inhibitor	98.11%	Unkown
HY-80013A	THZ1 Hydrochloride	Inhibitor	99.06%	Unkown
HY-145669	DIF-3		98.07%	Unkown
HY-114208A	BI-9321 trihydrochloride	Antagonist	98.40%	Unkown
HY-124447	BTYNB	Inhibitor	≥98.0%	Unkown
HY-100669	Mycro 3	Inhibitor	98.11%	Unkown
HY-129600	MYCi361	Inhibitor	99.74%	Unkown
HY-112296	T025		99.64%	Unkown
HY-P0312	c-Myc Peptide TFA		99.84%	Unkown
HY-129937A	GNE-987	Inhibitor	99.91%	Unkown
HY-N3005	Britannin		99.93%	Unkown
HY-N0704	Agrimol B		99.75%	Unkown
HY-122683	sAJM589	Inhibitor	99.47%	Unkown
HY-133121	WDR5-IN-1		≥98.0%	Unkown
HY-13250	Silvestrol aglycone		99.70%	Unkown
HY-112056	DIM-C-pPhCO2Me		99.47%	Unkown
HY-N2534	Karanjin		99.75%	Unkown
HY-120028	GNE-207	Inhibitor	99.94%	Unkown
HY-153713	MYC-RIBOTAC		98.05%	Unkown
HY-103038	ML327	Inhibitor	98.06%	Unkown
HY-162318	MYC degrader 1	Degrader	99.61%	Unkown
HY-12703	KSI-3716	Inhibitor	98.94%	Unkown
HY-149230	USP28-IN-4	Inhibitor	99.35%	Unkown
HY-19759	SRT 2183		98.06%	Unkown
HY-117203A	CDK12-IN-E9	Inhibitor	99.97%	Unkown
HY-N6747	Stauprimide	Inhibitor	99.45%	Unkown
HY-114189	GW284543	Inhibitor	99.94%	Unkown
HY-135691	hnRNPK-IN-1		≥97.0%	Unkown
HY-112440	HZX-02-059	Activator	99.40%	Unkown
HY-N8146	Bruceantinol	Inhibitor	98.89%	Unkown
HY-124811	IRES-C11	Inhibitor	98.01%	Unkown
HY-149209	LL-K8-22		99.76%	Unkown
HY-123955	Casein Kinase inhibitor A86		99.26%	Unkown
HY-148836	c-Myc inhibitor 6	Inhibitor	98.04%	Unkown
HY-153728	WM-586	Inhibitor	98.74%	Unkown
HY-162318A	MYC degrader 1 TFA	Degrader	99.36%	Unkown
HY-144878	VPC-70619	Inhibitor	99.93%	Unkown
HY-133131	PROTAC BRD4 Degrader-1	Inhibitor	99.12%	Unkown
HY-125236	BET-IN-19	Inhibitor	99.74%	Unkown
HY-111411	IZCZ-3	Inhibitor	99.74%	Unkown
HY-154847	WM-662	Inhibitor	99.48%	Unkown
HY-134333	ICCB280	Activator	99.43%	Unkown
HY-150259	MDEG-541	Degrader	98.05%	Unkown
HY-160409	TopBP1-IN-1	Inhibitor	98.35%	Unkown
HY-163828	PPA24		98.09%	Unkown
HY-112799	DK419	Inhibitor	99.88%	Unkown
HY-149873	Anticancer agent 126	Inhibitor	≥98.0%	Unkown
HY-N10790	RA-V		99.63%	Unkown
HY-119271	CMLD010509		99.11%	Unkown
HY-121418	Lusianthridin	Inhibitor	≥98.0%	Unkown
HY-149229	USP28-IN-3	Inhibitor	98.26%	Unkown
HY-111522	RK-9123016	Inhibitor	99.02%	Unkown
HY-112929B	(1S,2S,3R)-DT-061		99.77%	Unkown
HY-134975	NY2267	Inhibitor	98.53%	Unkown
HY-147651	β-catenin-IN-4	Inhibitor	99.84%	Unkown
HY-148446	eIF4A3-IN-12	Inhibitor	99.70%	Unkown
HY-148450	eIF4A3-IN-16	Inhibitor	98.37%	Unkown
HY-162470	DBPR728	Inhibitor	98.11%	Unkown
HY-112316A	(R)-BAY1238097		99.07%	Unkown
HY-101280	LB-60-OF61	Inhibitor	99.25%	Unkown
HY-124129	10074-A4	Inhibitor	98.03%	Unkown
HY-126979	Mycro2	Inhibitor	99.81%	Unkown
HY-147291	VPC-70063		99.92%	Unkown
HY-147973	IZTZ-1		/	Unkown
HY-148443	eIF4A3-IN-9	Inhibitor	99.71%	Unkown
HY-148444	eIF4A3-IN-10	Inhibitor	97.87%	Unkown
HY-148445	eIF4A3-IN-11	Inhibitor	99.24%	Unkown
HY-148447	eIF4A3-IN-13	Inhibitor	99.92%	Unkown
HY-148448	eIF4A3-IN-14	Inhibitor	99.81%	Unkown
HY-148449	eIF4A3-IN-15	Inhibitor	/	Unkown
HY-148451	eIF4A3-IN-17	Inhibitor	99.56%	Unkown
HY-148452	eIF4A3-IN-18	Inhibitor	99.58%	Unkown
HY-153996	CT1113	Inhibitor	/	Unkown
HY-RS08878	Myc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W011616	Cardionogen 1	Inhibitor	99.21%	Unkown
HY-RS08877	MYC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-101280A	LB-60-OF61 hydrochloride	Inhibitor	/	Unkown
HY-111537	rel-AZ5576	Inhibitor	/	Unkown
HY-104072	BRD4-IN-3	Inhibitor	/	Unkown
HY-114189A	GW284543 hydrochloride	Inhibitor	/	Unkown
HY-114208	BI-9321	Antagonist	/	Unkown
HY-115832	Ap44mSe		/	Unkown
HY-120750	A 62176 hydrochloride		/	Unkown
HY-121444	MYRA-A		/	Unkown
HY-121917	Ro 31-7837		/	Unkown
HY-125090	PHA-680626		/	Unkown
HY-125636	Mycro1	Inhibitor	/	Unkown
HY-125978	JY-3-094	Inhibitor	97.04%	Unkown
HY-128761	CBP/p300-IN-2	Inhibitor	/	Unkown
HY-129937	(S)-GNE-987	Inhibitor	/	Unkown
HY-131203	PROTAC BRD4 Degrader-6		/	Unkown
HY-136794	SB-284851-BT	Inhibitor	/	Unkown
HY-139885	c-Myc inhibitor 4	Inhibitor	/	Unkown
HY-141666	MYC-IN-2	Inhibitor	/	Unkown
HY-143235	BRD4 Inhibitor-15		/	Unkown
HY-143471	WNY0824		/	Unkown
HY-145843	c-Myc inhibitor 5	Inhibitor	/	Unkown
HY-146445	P300 bromodomain-IN-1	Inhibitor	/	Unkown
HY-147261	B026	Inhibitor	/	Unkown
HY-148837	PROTAC c-Myc degrader-1		/	Unkown
HY-148838	c-Myc inhibitor 8	Inhibitor	/	Unkown
HY-148839	c-Myc inhibitor 9	Inhibitor	/	Unkown
HY-149228	USP28-IN-2	Inhibitor	/	Unkown
HY-149495	CP-07	Degrader	/	Unkown
HY-149513	EP12		/	Unkown
HY-149735	BET-IN-20		/	Unkown
HY-150683	NC-III-49-1	Inhibitor	/	Unkown
HY-150684	GXH-II-052	Inhibitor	/	Unkown
HY-151471	Anticancer agent 84	Inhibitor	/	Unkown
HY-15163A	Zotiraciclib hydrochloride	Inhibitor	/	Unkown
HY-151884	FUBP1-IN-2	Inhibitor	/	Unkown
HY-152471	Eleven-Nineteen-Leukemia Protein IN-3	Inhibitor	/	Unkown
HY-154839	c-Myc inhibitor 10	Inhibitor	/	Unkown
HY-155153	CDK9-IN-24		/	Unkown
HY-155507	c-Myc inhibitor 11	Inhibitor	/	Unkown
HY-155508	c-Myc inhibitor 12	Inhibitor	/	Unkown
HY-156084	LL-K9-3		/	Unkown
HY-156673	m-Se3	Inhibitor	/	Unkown
HY-158062	LC-1-40		/	Unkown
HY-160549	c-Myc inhibitor 14	Inhibitor	/	Unkown
HY-160689	GW694590A	Inhibitor	/	Unkown
HY-161127	NT-B2R	Inhibitor	/	Unkown
HY-161826	Antitumor agent-174	Inhibitor	/	Unkown
HY-162294	c-Myc inhibitor 13	Inhibitor	/	Unkown
HY-162460	ERK1/2 inhibitor 10	Inhibitor	/	Unkown
HY-162469	6K465	Inhibitor	/	Unkown
HY-162686	MYC-IN-3	Inhibitor	98.66%	Unkown
HY-162796	TS-2		/	Unkown
HY-163108	ATAD2-IN-1		/	Unkown
HY-163679	PROTAC ERα Degrader-9		/	Unkown
HY-163774	WDR5-MYC-IN-1	Inhibitor	/	Unkown
HY-168439	HLB-0532259	Degrader	/	Unkown
HY-168483	FTO-IN-13		/	Unkown
HY-168684	E3 Ligase Ligand-linker Conjugate 136		/	Unkown
HY-168685	c-Myc ligand 1	Inhibitor	/	Unkown
HY-168886	Anticancer agent 263	Ligand	/	Unkown
HY-169348	β-catenin-IN-8	Inhibitor	/	Unkown
HY-169378	CSI86	Degrader	/	Unkown
HY-169921	c-Myc inhibitor 15	Inhibitor	/	Unkown
HY-170595	PROTAC LZK-IN-1		/	Unkown
HY-170820	XYD049		/	Unkown
HY-170841	HDAC3/BRD4-IN-1	Inhibitor	/	Unkown
HY-170900	SJ44236	Degrader	/	Unkown
HY-172113	H122		/	Unkown
HY-172368	PROTAC CARM1/IKZF3 degrader-1		/	Unkown
HY-172399	FTO-IN-14		/	Unkown
HY-173062	BRD4 Inhibitor-40	Inhibitor	/	Unkown
HY-173212	PLK1-IN-13		/	Unkown
HY-N11576	Secalonic acid D		/	Unkown
HY-P10418	VGN50	Inhibitor	/	Unkown
HY-RS08879	Myc Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119271A	(-)-CMLD010509		/	Unkown
HY-130369	NSC10010 hydrochloride		/	Unkown
HY-139118	NSC308848		/	Unkown
HY-145748	SYUIQ-5		/	Unkown
HY-149451	SYHA1815	Inhibitor	/	Unkown
HY-150109A	Purinostat	Inhibitor	/	Unkown
HY-168326	Antiproliferative agent-64	Inhibitor	/	Unkown
HY-169843	Cotylenin A	Inhibitor	/	Unkown
HY-N12563	γ-Sitosterol		/	Unkown
HY-W806047	BRD4 Inhibitor-37		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990850	Anti-c-myc Antibody (9E10)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myc	NCBI	NCBI:4609
Macaca fascicularis	Myc	NCBI	NCBI:102127966
Susscrofa domestica	Myc	NCBI
Leporidae	Myc	NCBI
Rattus norvegicus	Myc	NCBI	NCBI:24577

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