2. Gene
  3. Tg - thyroglobulin Gene

Tg - thyroglobulin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tgn; cog

Gene ID: 21819 | Gene type: protein coding

About Tg

Summary

Enables identical protein binding activity. Involved in thyroid hormone generation. Acts upstream of or within iodide transport; regulation of myelination; and thyroid hormone metabolic process. Located in extracellular space. Is expressed in thyroid gland; thyroid gland follicle; thyroid gland left lobe colloid-filled follicles; thyroid gland lobe; and thyroid gland right lobe colloid-filled follicles. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; goiter; and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin). [provided by Alliance of Genome Resources, Apr 2022]

Tg Products(1)

mRNA Protein Name
NM_009375.2 NP_033401.2 thyroglobulin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IDA
IDA: Inferred from direct assay
19276074 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within iodide transport IMP
IMP: Inferred from mutant phenotype
3803305 MGI
acts upstream of or within regulation of myelination IMP
IMP: Inferred from mutant phenotype
1508304 MGI
involved in thyroid hormone generation IDA
IDA: Inferred from direct assay
12782676 MGI
acts upstream of or within thyroid hormone metabolic process IMP
IMP: Inferred from mutant phenotype
3803305 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
12782676 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thyroglobulin

congenital goiter

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10409 Fedratinib 99.87% Yes
HY-10409A Fedratinib hydrochloride hydrate 99.92% Yes
HY-B0747 Eicosapentaenoic acid ethyl ester ≥98.0% Yes
HY-111023 Nemonoxacin malate Inhibitor 99.43% Unkown
HY-165090 1,3-Distearoyl-2-lauroyl glycerol / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99538 Ublituximab Inhibitor 98.42% Unkown
Clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-165051 1,3-Dibutyryl-2-oleoyl glycerol / Phase 4
HY-165037 1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol / Phase 3
HY-19359 Vilagletistat Inhibitor 99.97% Phase 2
HY-10111 TG100-115 Inhibitor 99.41% Phase 2
HY-19867A Burixafor hydrobromide Antagonist ≥98.0% Phase 2
HY-10186 TG 100801 Inhibitor 98.61% Phase 2
HY-15163 Zotiraciclib Inhibitor / Phase 2
HY-145522 13-Dimyristoyl-2-Eicosapentaenoyl Glycerol / Phase 2
HY-10187 TG 100801 Hydrochloride Inhibitor / Phase 2
HY-14783 Apricoxib Inhibitor / Phase 2
HY-P2962 Transglutaminase, Streptoverticillium mobaraense / Phase 1
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99833 Cosibelimab Inhibitor 99.90% Phase 3
HY-P99512 Zampilimab Inhibitor 98.81% Phase 2
HY-P990694 Zeripatamig Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (155)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112540B Acetoacetic acid sodium ≥98.0% Unkown
HY-15338 TG003 Inhibitor 99.57% Unkown
HY-112540A Acetoacetic acid lithium ≥98.0% Unkown
HY-15166 (E/Z)-Zotiraciclib Inhibitor 99.96% Unkown
HY-153523 Hi 76-0079 Inhibitor 99.90% Unkown
HY-N2118 Bilobetin Activator 99.39% Unkown
HY-123290 KCC009 Inhibitor 98.06% Unkown
HY-10410 TG101209 99.22% Unkown
HY-110381 JNJ-DGAT2-A Inhibitor 98.26% Unkown
HY-117678 TG-2-IN-1 Inhibitor ≥98.0% Unkown
HY-16978 TG6-10-1 Antagonist 99.92% Unkown
HY-18971 TG4-155 Antagonist 99.91% Unkown
HY-139362 Enpp-1-IN-2 Inhibitor 99.16% Unkown
HY-156010 PPARγ-IN-2 Inhibitor 99.57% Unkown
HY-14956 Nemonoxacin Inhibitor 99.80% Unkown
HY-P1123 MEDICA16 ≥98.0% Unkown
HY-15166A (E/Z)-Zotiraciclib hydrochloride Inhibitor 99.90% Unkown
HY-10185 TG 100572 Hydrochloride Inhibitor 98.96% Unkown
HY-B1434 7-Aminocephalosporanic acid Inhibitor ≥98.0% Unkown
HY-15166B (E/Z)-Zotiraciclib citrate Inhibitor 98.06% Unkown
HY-158774 TG2-179-1 Inducer ≥99.0% Unkown
HY-13514 TG 100713 Inhibitor 99.49% Unkown
HY-145933 BJJF078 Inhibitor 99.34% Unkown
HY-160939 ASK1-IN-6 Inhibitor 98.13% Unkown
HY-164049 TG8-260 Antagonist 98.25% Unkown
HY-N0368S Linalool-d3 95.17% Unkown
HY-160132 TG-2-IN-4 Inhibitor 99.62% Unkown
HY-137438 Edralbrutinib Inhibitor 99.75% Unkown
HY-114994 MS437 Activator ≥98.0% Unkown
HY-155102 PROTAC TG2 degrader-2 Degrader 99.15% Unkown
HY-172089 TG101209 analog 1 Inducer 98.27% Unkown
HY-N2078 Yamogenin Antagonist 98.80% Unkown
HY-122631 TG693 Inhibitor 99.95% Unkown
HY-128595 MT-4 Inhibitor 98.85% Unkown
HY-146913S 15:0-18:1-15:0 TG-d5 / Unkown
HY-146914S 16:0-18:0-16:0 TG-d5 99.90% Unkown
HY-14956S Nemonoxacin-d3 Inhibitor 99.77% Unkown
HY-163164S 18:1-17:1-18:1 TG-d5 / Unkown
HY-23199 H2-003 Inhibitor 99.53% Unkown
HY-P1822 BDC2.5 mimotope 1040-31 Agonist 98.00% Unkown
HY-W015600 2-Acetamidophenol 99.48% Unkown
HY-10184 TG 100572 Inhibitor / Unkown
HY-122709 hTG2 inhibitor VA4 Inhibitor 99.66% Unkown
HY-163163S 18:1-21:2-18:1 TG-d5 / Unkown
HY-102073 TG53 Inhibitor / Unkown
HY-111298 TG 41 Modulator / Unkown
HY-116845 TG3-95-1 / Unkown
HY-118243 KMS88009 Inhibitor / Unkown
HY-125958 AA9 Inhibitor / Unkown
HY-129126 NC9 Inhibitor / Unkown
HY-146398 AMPK activator 6 Activator / Unkown
HY-146737S Tripentadecanoin-d5 / Unkown
HY-146799S 15:0-18:1-15:0 TG-d7 / Unkown
HY-146912S 14:0-16:1-14:0 TG-d5 / Unkown
HY-146915S 17:0-17:1-17:0 TG-d5 / Unkown
HY-146916S 19:0-12:0-19:0 TG-d5 ≥99.0% Unkown
HY-146917S 20:0-20:1-20:0 TG-d5 99.90% Unkown
HY-149257 HAT-SIL-TG-1&AT Inhibitor / Unkown
HY-14956S1 Nemonoxacin-d3-1 Inhibitor / Unkown
HY-14956S2 Nemonoxacin-d4 Inhibitor / Unkown
HY-151997S 1,2-Dioleoyl-3-lauroyl-rac-glycerol-13C3 / Unkown
HY-15338A (E/Z)-TG003 Inhibitor / Unkown
HY-155643 PROTAC TG2 degrader-1 Inhibitor / Unkown
HY-157254 AA10 Inhibitor / Unkown
HY-157975 LM11 Inhibitor / Unkown
HY-158614 1-Palmitoyl-2-12-PAHSA-3-oleoyl-sn-glycerol / Unkown
HY-160984 Rotraxate / Unkown
HY-161939 7030B-C5 Inhibitor / Unkown
HY-161985 PPARγ-IN-3 Inhibitor / Unkown
HY-162141 MD102 / Unkown
HY-163165S 16:0-19:2-16:0 TG-d5 / Unkown
HY-163345 5-HT7R antagonist 2 Antagonist / Unkown
HY-165038 1,2-Didecanoyl-3-stearoyl-rac-glycerol / Unkown
HY-165039 1,3-Dioleoyl-2-octanoyl glycerol / Unkown
HY-165046 1,2,3-Trilinoelaidoyl glycerol Inhibitor / Unkown
HY-165049 1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol Substrate / Unkown
HY-165050 1,3-Dilinoleoyl-2-stearoyl glycerol / Unkown
HY-165053 1,3-Distearoyl-2-palmitoyl glycerol / Unkown
HY-165054 1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol / Unkown
HY-165089 1,2-Dioleoyl-3-lauroyl-rac-glycerol / Unkown
HY-165091 1,2-Dioctanoyl-3-decanoyl-rac-glycerol / Unkown
HY-165094 1-Myristoyl-2-linoleoyl-3-palmitoyl-rac-glycerol / Unkown
HY-165106 1,2-Dibutyryl-3-palmitoyl-rac-glycerol / Unkown
HY-165108 1,2-Dilinoleoyl-3-α-linolenoyl-rac-glycerol / Unkown
HY-165109 1,3-Dioleoyl-2-lauroyl glycerol / Unkown
HY-165110 1-Stearoyl-2-palmitoyl-3-oleoyl-rac-glycerol / Unkown
HY-165111 1,2-Dioleoyl-3-myristoyl-rac-glycerol / Unkown
HY-165112 1,2-Dioleoyl-3-α-linolenoyl-rac-glycerol / Unkown
HY-165113 1,2-Distearoyl-3-arachidoyl-rac-glycerol / Unkown
HY-18301 JAK-IN-35 Inhibitor / Unkown
HY-18970 TG6-129 Antagonist / Unkown
HY-D1545 Violamine R / Unkown
HY-E70436 Human keratinocyte transglutaminase / Unkown
HY-E70437 Guinea pig liver transglutaminase / Unkown
HY-E70439 Human epidermal transglutaminase / Unkown
HY-E70453 Human prostate transglutaminase / Unkown
HY-E70454 Human neuronal transglutaminase / Unkown
HY-N0368R Linalool (Standard) / Unkown
HY-N11286 Tridocosahexaenoylglycerol / Unkown
HY-N11551 Salvifaricin / Unkown
HY-N12249 7-Deoxy-trans-dihydronarciclasine Inhibitor / Unkown
HY-N7907 Myricetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside / Unkown
HY-N8214 Isorhamnetin 3-O-β-D-glucose-7-O-β-D-gentiobioside / Unkown
HY-P10677 HB-3-20 Degrader / Unkown
HY-P1822A BDC2.5 mimotope 1040-31 TFA Inhibitor / Unkown
HY-RS14432 TG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-10409S Fedratinib-d9 / Unkown
HY-112540 Acetoacetic acid / Unkown
HY-115705 1,2,3-Tri-10(Z)-heptadecenoyl glycerol / Unkown
HY-117110 Arginylproline / Unkown
HY-122989 Aristolactam BIII Inhibitor / Unkown
HY-125830 ITIC / Unkown
HY-142971 1-Myristoyl-2-Linoleoyl-3-Oleoyl-rac-glycerol / Unkown
HY-142974 1,2-Dioleoyl-3-Docosohexaenoyl-rac-glycerol / Unkown
HY-158749 1-Oleoyl-2-lauroyl-3-palmitoyl-rac-glycerol / Unkown
HY-158763 MPI8 Inhibitor / Unkown
HY-158945 1,3-Dipalmitoleoyl-2-11(Z)-octadecenoyl glycerol / Unkown
HY-158946 1,2-Dielaidoyl-3-linoleoyl-rac-glycerol / Unkown
HY-158948 1-Palmitoyl-2-11(Z)-octadecenoyl-3-butyroyl-rac-glycerol / Unkown
HY-158949 1-Palmitoyl-2-11(Z)-octadecenoyl-3-oleoyl-rac-glycerol / Unkown
HY-158957 1,3-Diheptadecanoyl-2-oleoyl glycerol / Unkown
HY-158959 1,3-Diarachidonoyl-2-oleoyl glycerol / Unkown
HY-158960 1,2-Dioleoyl-3-arachidonoyl-rac-glycerol / Unkown
HY-158961 1,3-Dielaidoyl-2-oleoyl glycerol / Unkown
HY-158964 1-Palmitoyl-2-oleoyl-3-linolenoyl-rac-glycerol / Unkown
HY-16266 JNJ-DGAT1-A Inhibitor / Unkown
HY-163166S 18:1-19:2-18:1 TG-d5 / Unkown
HY-165036 1,2-Dieicosapentaenoyl-3-palmitoyl-rac-glycerol / Unkown
HY-165041 1,3-Dioleoyl-2-stearoyl glycerol / Unkown
HY-165042 1,2-Dipalmitoyl-3-decanoyl-rac-glycerol / Unkown
HY-165047 1-Palmitoyl-2-linoleoyl-3-stearoyl-rac-glycerol / Unkown
HY-165048 1,3-Distearoyl-2-linoleoyl glycerol / Unkown
HY-165052 1,3-Didocosahexaenoyl-2-palmitoyl glycerol / Unkown
HY-165055 1-Oleoyl-2-palmitoyl-3-linoleoyl-rac-glycerol / Unkown
HY-165056 1,2-Dipalmitoyl-3-linoleoyl-rac-glycerol / Unkown
HY-165092 1-Arachidoyl-2-palmitoyl-3-oleoyl-rac-glycerol / Unkown
HY-165093 1-Arachidoyl-2-oleoyl-3-palmitoyl-rac-glycerol / Unkown
HY-165095 1,2-Dipalmitoleoyl-3-palmitoyl-rac-glycerol / Unkown
HY-165105 1,3-Dioleoyl-2-decanoyl glycerol / Unkown
HY-165107 1,2-Dioctanoyl-3-stearoyl-rac-glycerol / Unkown
HY-165115 1,2-Dipalmitoyl-3-pentadecanoyl-rac-glycerol / Unkown
HY-169473 1,2,3-Tri-13(E)-docosenoyl glycerol / Unkown
HY-170465 1,2-Distearoyl-3-butyryl-glycerol / Unkown
HY-170469 1,2-Dioleoyl-3-caprin / Unkown
HY-171217 TG-100435 Inhibitor / Unkown
HY-173148 TKB272 Inhibitor / Unkown
HY-18112 AZ-4217 Inhibitor / Unkown
HY-N8353 Stachybotramide / Unkown
HY-W010667 (Z)-2-(Oleoyloxy)propane-1,3-diyl dipalmitate / Unkown
HY-W643167 1,2,3-Tritridecanoylglycerol / Unkown
HY-W674124 Tripentadecanoin / Unkown
HY-W704600 1,3-Distearoyl-2-oleoyl glycerol / Unkown
HY-W710440 1,2-Distearoyl-3-palmitoyl-rac-glycerol / Unkown
HY-W710512 Propane-1,2,3-triyl tritricosanoate-d5 / Unkown
HY-W923355 1,2,3-Trieicosapentaenoyl glycerol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tg NCBI NCBI:7038
Canis familiaris Tg NCBI NCBI:482047
Macaca fascicularis Tg NCBI NCBI:102121703
Susscrofa domestica Tg NCBI
Rattus norvegicus Tg NCBI NCBI:24826
Macaca mulatta Tg NCBI NCBI:701756