Bdnf - brain-derived neurotrophic factor Gene

Rattus norvegicus

Gene ID: 24225 | Gene type: protein coding

About Bdnf

Summary

Enables neurotrophin TrkB receptor binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to norepinephrine stimulus; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of Glucocorticoid Receptor signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and synaptic vesicle. Used to study Alzheimer's disease; cystitis; eye disease (multiple); neuropathy (multiple); and status epilepticus. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; hypertensive encephalopathy; middle cerebral artery infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Bdnf Products(10)

mRNA	Protein	Name
NM_001270630.1	NP_001257559.1	brain-derived neurotrophic factor isoform 1
NM_001270631.1	NP_001257560.1	brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270632.1	NP_001257561.1	brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270633.1	NP_001257562.1	brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270634.1	NP_001257563.1	brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270635.1	NP_001257564.1	brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270636.1	NP_001257565.1	brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270637.1	NP_001257566.1	brain-derived neurotrophic factor isoform 3 preproprotein
NM_001270638.1	NP_001257567.1	brain-derived neurotrophic factor isoform 3 preproprotein
NM_012513.4	NP_036645.2	brain-derived neurotrophic factor isoform 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neurotrophin TRKB receptor binding	IDA IDA: Inferred from direct assay	1889806	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	23583595	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	21958434	RGD
involved in cellular response to norepinephrine stimulus	IEP IEP: Inferred from expression pattern	16292510	RGD
involved in cellular response to potassium ion	IEP IEP: Inferred from expression pattern	25424568	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	21958434	RGD
involved in chronic inflammatory response	IEP IEP: Inferred from expression pattern	20223282	RGD
involved in cognition	IEP IEP: Inferred from expression pattern	20852970	RGD
involved in conditioned place preference	IMP IMP: Inferred from mutant phenotype	23583595	RGD
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17192436	RGD
involved in learning	IMP IMP: Inferred from mutant phenotype	22056599	RGD
involved in mitochondrial electron transport, NADH to ubiquinone	IMP IMP: Inferred from mutant phenotype	15341590	RGD
involved in negative regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	16723531	RGD
involved in negative regulation of striated muscle tissue development	IMP IMP: Inferred from mutant phenotype	16723531	RGD
involved in nervous system development	IDA IDA: Inferred from direct assay	12427830	RGD
involved in neuron projection extension	IDA IDA: Inferred from direct assay	8469387	RGD
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23878391	RGD
involved in positive regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	24873730	RGD
acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway	IDA IDA: Inferred from direct assay	23878391	RGD
involved in positive regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	14699417	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11050383	RGD
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	23878391	RGD
involved in regeneration	IDA IDA: Inferred from direct assay	24388817	RGD
involved in regulation of axon extension	IMP IMP: Inferred from mutant phenotype	14697662	RGD
involved in regulation of long-term neuronal synaptic plasticity	IDA IDA: Inferred from direct assay	12201640	RGD
involved in regulation of short-term neuronal synaptic plasticity	IDA IDA: Inferred from direct assay	12201640	RGD
involved in response to L-glutamate	IEP IEP: Inferred from expression pattern	12654519	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	15199375	RGD
involved in response to anesthetic	IEP IEP: Inferred from expression pattern	16738805	RGD
involved in response to auditory stimulus	IEP IEP: Inferred from expression pattern	21034795	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	11007900	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	18322102	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	12770552	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	20018181	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	15821016	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	14699417	RGD
involved in response to light intensity	IEP IEP: Inferred from expression pattern	21076359	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	17640634	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	30550948	RGD
involved in response to nerve growth factor	IEP IEP: Inferred from expression pattern	10366647	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	20655333	RGD
involved in response to potassium ion	IEP IEP: Inferred from expression pattern	11007900	RGD
involved in response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	18830614	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	21188516	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	12049586	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	11050383	RGD
located in dendrite	IDA IDA: Inferred from direct assay	8726105	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	10779676	RGD
located in mitochondrial crista	IDA IDA: Inferred from direct assay	16626872	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8726105	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	16626872	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	20739562	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	17192436	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	16626872	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

brain-derived neurotrophic factor

brain derived neurothrophic factor

Related Agents

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B1618	Corticosterone	Agonist	99.76%	Phase 3
HY-114384B	NV-5138 hydrochloride	Activator	≥98.0%	Phase 2
HY-139897	CX 717	Agonist	99.86%	Phase 2
HY-13999	NSI-189		99.57%	Phase 2
HY-110255	AZD 2066		99.8%	Phase 2
HY-110255A	AZD 2066 hydrate		≥99.0%	Phase 2
HY-120251A	Leteprinim potassium	Inhibitor	≥99.0%	Phase 2
HY-13999A1	NSI-189 phosphate	Activator	99.75%	Phase 2

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W013372	7,8-Dihydroxyflavone		99.90%	Unkown
HY-106224B	Orexin A (human, rat, mouse) (acetate)	Agonist	99.93%	Unkown
HY-P1178	Cyclotraxin B	Inhibitor	98.11%	Unkown
HY-100115	TA-02	Inhibitor	99.85%	Unkown
HY-14569	CDPPB		99.32%	Unkown
HY-N2055	Kaempferol 3-O-sophoroside		99.84%	Unkown
HY-110166	PD 90780		≥99.0%	Unkown
HY-N7981	Pratensein	Inhibitor	99.92%	Unkown
HY-N2038	3,5,6,7,8,3',4'-Heptemthoxyflavone	Inhibitor	99.86%	Unkown
HY-N6076	Tenuifoliside A	Inhibitor	98.07%	Unkown
HY-153383	PDCD4-IN-1		99.65%	Unkown
HY-RS16220	Bdnf Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-124591	TC-2153	Inhibitor	98.73%	Unkown
HY-132993	Hcyb1	Inhibitor	98.20%	Unkown
HY-N3298	Meranzin	Modulator	≥98.0%	Unkown
HY-W044525	Phyllodulcin	Inhibitor	98.15%	Unkown
HY-111527	PPZ2		99.70%	Unkown
HY-121793	Roemerine	Inhibitor	99.61%	Unkown
HY-122742	HBT1		99.83%	Unkown
HY-102091	(2R,4R)-APDC	Agonist	/	Unkown
HY-102091A	(2R,4R)-APDC hydrate	Agonist	≥98.0%	Unkown
HY-160921	Capeserod	Agonist	98.66%	Unkown
HY-169964	TSPO/Carbonic Anhydrase Modulator 1	Modulator	/	Unkown
HY-120251	Leteprinim	Inhibitor	/	Unkown
HY-120306	HHL-6	Inhibitor	/	Unkown
HY-121012	(rac)-AG-205		/	Unkown
HY-123222	CGP 56999	Antagonist	/	Unkown
HY-123439	FTY720-C2		/	Unkown
HY-138967	BRF110		/	Unkown
HY-139806	SRA880 free base	Inhibitor	/	Unkown
HY-146523	TRK-IN-17	Inhibitor	/	Unkown
HY-146524	TRK-IN-18	Inhibitor	/	Unkown
HY-157792	Antidepressant agent 6	Antagonist	/	Unkown
HY-173025	Nurr1 agonist 12	Agonist	/	Unkown
HY-N11872	Suffruticosol A	Activator	/	Unkown
HY-N4161	Euparin	Inhibitor	≥99.0%	Unkown
HY-P1178A	Cyclotraxin B TFA	Inhibitor	/	Unkown
HY-RS01460	BDNF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-110255B	AZD-2066 hydrochloride		/	Unkown
HY-124503	Longanlactone	Activator	/	Unkown
HY-164461	AZD6918	Inhibitor	/	Unkown
HY-167836	BNN-20	Activator	/	Unkown
HY-N1414A	3′,6-Disinapoylsucrose	Inhibitor	/	Unkown
HY-W101298S	(Leu-13C6,15N)-Ile-OH TFA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bdnf	NCBI	NCBI:627
Canis familiaris	Bdnf	NCBI	NCBI:403461
Mus musculus	Bdnf	NCBI	NCBI:12064

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