Bdnf - brain derived neurotrophic factor Gene

Mus musculus

Gene ID: 12064 | Gene type: protein coding

About Bdnf

Summary

The protein encoded by this gene is a member of the nerve growth factor family. It is involved in the growth, differentiation and survival of specific types of developing neurons both in the central nervous system (CNS) and the peripheral nervous system. It is also involved in regulating synaptic plasticity in the CNS. Expression of a similar gene in human is reduced in both Alzheimer's and Huntington disease patients. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Bdnf Products(12)

mRNA	Protein	Name
NM_001048139.1	NP_001041604.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001048141.1	NP_001041606.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001048142.1	NP_001041607.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285416.1	NP_001272345.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285417.1	NP_001272346.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285418.1	NP_001272347.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285419.1	NP_001272348.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285420.1	NP_001272349.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285421.1	NP_001272350.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001285422.1	NP_001272351.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_001316310.1	NP_001303239.1	brain-derived neurotrophic factor isoform 2 preproprotein
NM_007540.4	NP_031566.4	brain-derived neurotrophic factor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11684666	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon extension	IDA IDA: Inferred from direct assay	24035762	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15014133	MGI
acts upstream of or within axon target recognition	IMP IMP: Inferred from mutant phenotype	15464571	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	15249684	MGI
acts upstream of or within cellular response to acid chemical	IDA IDA: Inferred from direct assay	25542970	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	23785138	MGI
acts upstream of or within dendrite development	IMP IMP: Inferred from mutant phenotype	12890780	MGI
acts upstream of or within dendrite extension	IDA IDA: Inferred from direct assay	24035762	MGI
acts upstream of or within fear response	IMP IMP: Inferred from mutant phenotype	15249684	MGI
acts upstream of or within feeding behavior	IMP IMP: Inferred from mutant phenotype	12796784	MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway	IDA IDA: Inferred from direct assay	16754670	MGI
acts upstream of or within glutamate secretion	IPI IPI: Inferred from physical interaction	16819522	MGI
acts upstream of or within inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	24201284	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	7605630	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	15249684	MGI
acts upstream of or within mechanoreceptor differentiation	IGI IGI: Inferred from genetic interaction	15376326	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12904469	MGI
involved in negative regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	26708520	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IDA IDA: Inferred from direct assay	12798291	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	8861722	MGI
acts upstream of or within negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	24378336	MGI
acts upstream of or within negative regulation of synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	16754670	MGI
acts upstream of or within nerve development	IMP IMP: Inferred from mutant phenotype	7605630	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	8861722	MGI
acts upstream of or within neuron recognition	IMP IMP: Inferred from mutant phenotype	15844198	MGI
acts upstream of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23878391	MGI
NOT acts upstream of or within positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	24573299	MGI
acts upstream of or within positive regulation of collateral sprouting	IDA IDA: Inferred from direct assay	24573299	MGI
acts upstream of or within positive regulation of collateral sprouting	IMP IMP: Inferred from mutant phenotype	24573299	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	12798291	MGI
involved in positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	26708520	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23878391	MGI
acts upstream of or within regulation of collateral sprouting	IGI IGI: Inferred from genetic interaction	24573299	MGI
acts upstream of or within regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	16516892	MGI
acts upstream of or within regulation of retinal cell programmed cell death	IDA IDA: Inferred from direct assay	11747369	MGI
acts upstream of or within regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	16819522	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	15249684	MGI
acts upstream of or within taste bud development	IMP IMP: Inferred from mutant phenotype	24378336	MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission	EXP EXP: Inferred from Experiment	19448629	MGI
involved in trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA IDA: Inferred from direct assay	19448629	MGI
acts upstream of or within ureteric bud development	IDA IDA: Inferred from direct assay	16018995	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	19448629	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	22209827	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	14715936	MGI
located in dendrite	IDA IDA: Inferred from direct assay	19448629	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	19448629	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19448629	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	22412021	MGI
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	22412021	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22209827	MGI
located in secretory granule	IDA IDA: Inferred from direct assay	24573299	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

brain-derived neurotrophic factor

Recombinant Bdnf Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74383	BDNF Protein, Mouse (R129A, R130A, HEK293, His, Solution)	P21237-1 (A19-R249, R129A, R130A)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B1618	Corticosterone	Agonist	99.76%	Phase 3
HY-114384B	NV-5138 hydrochloride	Activator	≥98.0%	Phase 2
HY-139897	CX 717	Agonist	99.79%	Phase 2
HY-120251A	Leteprinim potassium	Inhibitor	≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W013372	7,8-Dihydroxyflavone		99.90%	Unkown
HY-106224B	Orexin A (human, rat, mouse) (acetate)	Agonist	99.93%	Unkown
HY-P1178	Cyclotraxin B	Inhibitor	98.11%	Unkown
HY-100115	TA-02	Inhibitor	99.85%	Unkown
HY-N2055	Kaempferol 3-O-sophoroside		99.84%	Unkown
HY-N2038	3,5,6,7,8,3',4'-Heptemthoxyflavone	Inhibitor	99.85%	Unkown
HY-N7981	Pratensein	Inhibitor	99.92%	Unkown
HY-110166	PD 90780	Antagonist	≥99.0%	Unkown
HY-N6076	Tenuifoliside A	Inhibitor	98.07%	Unkown
HY-RS16220	Bdnf Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-132993	Hcyb1	Inhibitor	98.20%	Unkown
HY-153383	PDCD4-IN-1		99.65%	Unkown
HY-N3298	Meranzin	Modulator	≥98.0%	Unkown
HY-122742	HBT1		99.83%	Unkown
HY-124591	TC-2153	Inhibitor	98.73%	Unkown
HY-W044525	Phyllodulcin	Inhibitor	98.15%	Unkown
HY-102091	(2R,4R)-APDC	Agonist	/	Unkown
HY-102091A	(2R,4R)-APDC hydrate	Agonist	≥98.0%	Unkown
HY-160921	Capeserod	Agonist	98.66%	Unkown
HY-120251	Leteprinim	Inhibitor	/	Unkown
HY-120306	HHL-6		/	Unkown
HY-121012	(rac)-AG-205		/	Unkown
HY-123222	CGP 56999	Antagonist	/	Unkown
HY-123439	FTY720-C2		/	Unkown
HY-146523	TRK-IN-17	Inhibitor	/	Unkown
HY-146524	TRK-IN-18	Inhibitor	/	Unkown
HY-157792	Antidepressant agent 6	Antagonist	/	Unkown
HY-N11872	Suffruticosol A	Activator	/	Unkown
HY-N4161	Euparin	Inhibitor	≥99.0%	Unkown
HY-P1178A	Cyclotraxin B TFA	Inhibitor	/	Unkown
HY-RS01460	BDNF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-111527	PPZ2		/	Unkown
HY-124503	Longanlactone	Activator	/	Unkown
HY-139806	SRA880 free base		/	Unkown
HY-164461	AZD6918	Inhibitor	/	Unkown
HY-167836	BNN-20	Activator	/	Unkown
HY-W101298S	(Leu-13C6,15N)-Ile-OH TFA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bdnf	NCBI	NCBI:627
Canis familiaris	Bdnf	NCBI	NCBI:403461
Rattus norvegicus	Bdnf	NCBI	NCBI:24225

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