TXN2 - thioredoxin 2 Gene

Homo sapiens

Also known as TXN; MTRX; TRX2; MT-TRX; COXPD29

Gene ID: 25828 | Gene type: protein coding

About TXN2

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,467,046-36,481,640 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 39.7), kidney (RPKM 28.5) and 25 other tissues.

Summary

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced Apoptosis. [provided by RefSeq, Jul 2008]

TXN2 Products(1)

mRNA	Protein	Name
NM_012473.4	NP_036605.2	thioredoxin, mitochondrial precursor

TXN2 Protein Structure

Thioredoxin

0
100
166 a.a.

Protein Preferred Names

Protein Names

thioredoxin, mitochondrial

mitochondrial thioredoxin

TXN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TXN2	Q99757	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	TXN2	Q99757	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	TXN2	Q99757	ODAD1	Homo sapiens	Q96M63	Y2H Array	25416956
Intra	TXN2	Q99757	ODAD1	Homo sapiens	Q96M63	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	TXN2	Q99757	ZBTB14	Homo sapiens	O43829	Validated Y2H	25416956
Intra	TXN2	Q99757	ZBTB14	Homo sapiens	O43829	Y2H Array	25416956
Intra	TXN2	Q99757	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	MAGEA11	Homo sapiens	P43364-2	Validated Y2H	25416956
Intra	TXN2	Q99757	q6zn96_human	Homo sapiens	Q6ZN96	Y2H Array	32296183
Intra	TXN2	Q99757	q6zn96_human	Homo sapiens	Q6ZN96	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
Intra	TXN2	Q99757	BCAS2	Homo sapiens	O75934	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	BCAS2	Homo sapiens	O75934	Y2H Array	32296183
Intra	TXN2	Q99757	UQCC2	Homo sapiens	Q9BRT2	Validated Y2H	32296183
Intra	TXN2	Q99757	UQCC2	Homo sapiens	Q9BRT2	Y2H Array	32296183
Intra	TXN2	Q99757	UQCC2	Homo sapiens	Q9BRT2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	CHMP1A	Homo sapiens	Q9HD42	Validated Y2H	32296183
Intra	TXN2	Q99757	CHMP1A	Homo sapiens	Q9HD42	Y2H Array	32296183
Intra	TXN2	Q99757	CHMP1A	Homo sapiens	Q9HD42	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MAGEB2	Homo sapiens	O15479	Y2H Array	32296183
Intra	TXN2	Q99757	MAGEB2	Homo sapiens	O15479	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	RBM45	Homo sapiens	Q8IUH3-3	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	RBM45	Homo sapiens	Q8IUH3-3	Y2H Array	32296183
Intra	TXN2	Q99757	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	TXN2	Q99757	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	TXN2	Q99757	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	TXN2	Q99757	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	TXN2	Q99757	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	TXN2	Q99757	AP2B1	Homo sapiens	P63010-2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	AP2B1	Homo sapiens	P63010-2	Y2H Array	32296183
Intra	TXN2	Q99757	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	TXN2	Q99757	SCYL3	Homo sapiens	Q8IZE3-2	Y2H Array	32296183
Intra	TXN2	Q99757	SCYL3	Homo sapiens	Q8IZE3-2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	GUCD1	Homo sapiens	Q96NT3-2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	GUCD1	Homo sapiens	Q96NT3-2	Y2H Array	32296183
Intra	TXN2	Q99757	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Array	32296183
Intra	TXN2	Q99757	KAZN	Homo sapiens	Q674X7-2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	KAZN	Homo sapiens	Q674X7-2	Y2H Array	32296183
Intra	TXN2	Q99757	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	TXN2	Q99757	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	TXN2	Q99757	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Array	32296183
Intra	TXN2	Q99757	POMC	Homo sapiens	P01189	Y2H Array	32296183
Intra	TXN2	Q99757	POMC	Homo sapiens	P01189	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	CIB4	Homo sapiens	A0PJX0	Y2H Array	32296183
Intra	TXN2	Q99757	CIB4	Homo sapiens	A0PJX0	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MYL9	Homo sapiens	P24844-2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MYL9	Homo sapiens	P24844-2	Y2H Array	32296183
Intra	TXN2	Q99757	CSTPP1	Homo sapiens	Q9H6J7-2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	CSTPP1	Homo sapiens	Q9H6J7-2	Validated Y2H	32296183
Intra	TXN2	Q99757	CSTPP1	Homo sapiens	Q9H6J7-2	Y2H Array	32296183
Intra	TXN2	Q99757	SCYL3	Homo sapiens	Q8IZE3	Y2H Array	31515488
Intra	TXN2	Q99757	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	TXN2	Q99757	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	TXN2	Q99757	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	CDCA4	Homo sapiens	Q9BXL8	Validated Y2H	32296183
Intra	TXN2	Q99757	CDCA4	Homo sapiens	Q9BXL8	Y2H Array	32296183
Intra	TXN2	Q99757	CDCA4	Homo sapiens	Q9BXL8	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	RBM45	Homo sapiens	Q8IUH3	Y2H Array	25416956
Intra	TXN2	Q99757	RBM45	Homo sapiens	Q8IUH3	Validated Y2H	25416956
Intra	TXN2	Q99757	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	SSNA1	Homo sapiens	O43805	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	SSNA1	Homo sapiens	O43805	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	SSNA1	Homo sapiens	O43805	Y2H Array	25416956
Intra	TXN2	Q99757	SSNA1	Homo sapiens	O43805	Y2H Array	32296183
Intra	TXN2	Q99757	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	TXN2	Q99757	HAUS8	Homo sapiens	Q9BT25	Y2H Array	32296183
Intra	TXN2	Q99757	HAUS8	Homo sapiens	Q9BT25	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	HAUS8	Homo sapiens	Q9BT25	Validated Y2H	32296183
Intra	TXN2	Q99757	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	TXN2	Q99757	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	TXN2	Q99757	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	TXN2	Q99757	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	PSME3	Homo sapiens	P61289	Validated Y2H	25416956
Intra	TXN2	Q99757	STUB1	Homo sapiens	Q9UNE7	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	STUB1	Homo sapiens	Q9UNE7	Validated Y2H	25416956
Intra	TXN2	Q99757	SPTA1	Homo sapiens	P02549	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	SPTA1	Homo sapiens	P02549	Y2H Array	32296183
Intra	TXN2	Q99757	AP2B1	Homo sapiens	P63010	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	AP2B1	Homo sapiens	P63010	Validated Y2H	25416956
Intra	TXN2	Q99757	GPRASP2	Homo sapiens	Q96D09	Y2H	21988832
Intra	TXN2	Q99757	GPRASP2	Homo sapiens	Q96D09	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	GPRASP2	Homo sapiens	Q96D09	Y2H Array	32296183
Intra	TXN2	Q99757	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	TXN2	Q99757	PEX19	Homo sapiens	P40855	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	PEX19	Homo sapiens	P40855	Y2H Array	32296183
Intra	TXN2	Q99757	GTPBP2	Homo sapiens	Q9BX10	Validated Y2H	32296183
Intra	TXN2	Q99757	GTPBP2	Homo sapiens	Q9BX10	Y2H Array	32296183
Intra	TXN2	Q99757	GTPBP2	Homo sapiens	Q9BX10	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	SYCE1	Homo sapiens	Q8N0S2	Y2H Array	32296183
Intra	TXN2	Q99757	SAT1	Homo sapiens	P21673	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	SAT1	Homo sapiens	P21673	Y2H Array	32296183
Intra	TXN2	Q99757	ETHE1	Homo sapiens	O95571	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	ETHE1	Homo sapiens	O95571	Y2H Array	32296183
Intra	TXN2	Q99757	CGGBP1	Homo sapiens	Q9UFW8	Validated Y2H	32296183
Intra	TXN2	Q99757	CGGBP1	Homo sapiens	Q9UFW8	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	CGGBP1	Homo sapiens	Q9UFW8	Y2H Array	32296183
Intra	TXN2	Q99757	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	TXN2	Q99757	PPCDC	Homo sapiens	Q96CD2	Y2H Array	32296183
Intra	TXN2	Q99757	PPCDC	Homo sapiens	Q96CD2	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MAPRE3	Homo sapiens	Q9UPY8	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	25416956
Intra	TXN2	Q99757	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183
Intra	TXN2	Q99757	MAPRE3	Homo sapiens	Q9UPY8	Y2H Array	32296183
Intra	TXN2	Q99757	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	TXN2	Q99757	MAPRE2	Homo sapiens	Q15555	Validated Y2H	25416956
Intra	TXN2	Q99757	MAPRE2	Homo sapiens	Q15555	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MAPRE2	Homo sapiens	Q15555	Y2H Array	25416956
Intra	TXN2	Q99757	MAPRE2	Homo sapiens	Q15555	Y2H Array	32296183
Intra	TXN2	Q99757	TIFA	Homo sapiens	Q96CG3	Y2H Array	25416956
Intra	TXN2	Q99757	ABI3	Homo sapiens	Q9P2A4	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	TXN2	Q99757	ABI3	Homo sapiens	Q9P2A4	Y2H Array	32296183
Intra	TXN2	Q99757	TRIP6	Homo sapiens	Q15654	Validated Y2H	25416956
Intra	TXN2	Q99757	DDIT3	Homo sapiens	P35638	Y2H Array	32296183
Intra	TXN2	Q99757	DDIT3	Homo sapiens	P35638	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	TXN2	Q99757	MAGEA4	Homo sapiens	P43358	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MAGEA4	Homo sapiens	P43358	Y2H Array	32296183
Intra	TXN2	Q99757	RPIA	Homo sapiens	P49247	Y2H Array	25416956
Intra	TXN2	Q99757	RPIA	Homo sapiens	P49247	Y2H Array	32296183
Intra	TXN2	Q99757	RPIA	Homo sapiens	P49247	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	RPIA	Homo sapiens	P49247	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	STN1	Homo sapiens	Q9H668	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	STN1	Homo sapiens	Q9H668	Validated Y2H	32296183
Intra	TXN2	Q99757	STN1	Homo sapiens	Q9H668	Y2H Array	32296183
Intra	TXN2	Q99757	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	25416956
Intra	TXN2	Q99757	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	25416956
Intra	TXN2	Q99757	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	32296183
Intra	TXN2	Q99757	REEP6	Homo sapiens	Q96HR9	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	REEP6	Homo sapiens	Q96HR9	Validated Y2H	25416956
Intra	TXN2	Q99757	REEP6	Homo sapiens	Q96HR9	Y2H Array	25416956
Intra	TXN2	Q99757	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	TXN2	Q99757	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	CCDC197	Homo sapiens	Q8NCU1	Y2H Array	32296183
Intra	TXN2	Q99757	CCDC197	Homo sapiens	Q8NCU1	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	TRIM21	Homo sapiens	P19474	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	TRIM21	Homo sapiens	P19474	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	TRIM21	Homo sapiens	P19474	Y2H Array	32296183
Intra	TXN2	Q99757	TRIM21	Homo sapiens	P19474	Validated Y2H	25416956
Intra	TXN2	Q99757	TTC32	Homo sapiens	Q5I0X7	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	TTC32	Homo sapiens	Q5I0X7	Y2H Array	32296183
Intra	TXN2	Q99757	RABGEF1	Homo sapiens	Q9UJ41	Y2H Prey Pooling	25416956
Intra	TXN2	Q99757	TMOD4	Homo sapiens	Q9NZQ9	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	TMOD4	Homo sapiens	Q9NZQ9	Validated Y2H	32296183
Intra	TXN2	Q99757	TMOD4	Homo sapiens	Q9NZQ9	Y2H Array	32296183
Intra	TXN2	Q99757	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32296183
Intra	TXN2	Q99757	MRFAP1	Homo sapiens	Q9Y605	Y2H Prey Pooling	32296183
Intra	TXN2	Q99757	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TXN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71393	TXN2 Protein, Human (His)	Q99757 (T60-G166)	≥95%

TXN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82447	Thioredoxin 2 Antibody (YA2192)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 29

COXPD29

Combined Oxidative Phosphorylation Defect Type 29

Ocular Hypertension

Hypertension, Ocular	Intraocular Pressure Increase
Oh - [Ocular Hypertension]	Oht - [Ocular Hypertension]

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15288	TXN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TXN2	RGD	RGD:71040
Canis familiaris	TXN2	VGNC	VGNC:48009
Bos taurus	TXN2	VGNC	VGNC:36533
Felis catus	TXN2	VGNC	VGNC:66723
Mus musculus	TXN2	MGD	MGI:1929468
Others	TXN2	NCBI

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