LSM3 - LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Homo sapiens

Also known as SMX4; USS2; YLR438C

Gene ID: 27258 | Gene type: protein coding

About LSM3

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:14,178,817-14,201,122 (from NCBI)

This gene has 1 transcript (splice variant) and 205 orthologues. Ubiquitous expression in kidney (RPKM 53.9), fat (RPKM 40.8) and 25 other tissues.

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM3 Products(1)

mRNA	Protein	Name
NM_014463.3	NP_055278.1	U6 snRNA-associated Sm-like protein LSm3

LSM3 Protein Structure

LSM

0
102 a.a.

Protein Preferred Names

Protein Names

U6 snRNA-associated Sm-like protein LSm3

LSM3 U6 small nuclear RNA and mRNA degradation associated

Recombinant LSM3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75915	LSM3 Protein, Human (His)	P62310 /NP_055278.1(M1-G102)	≥95%

Related Diseases

Diseases

Alias

Coffin-Siris Syndrome 3

CSS3	Mrd15
Mental Retardation, Autosomal Dominant 15	Autosomal Dominant Mental Retardation 15
Coffin-Siris Syndrome, Type 3

Spondylolysis

Acquired Spondylolysis

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07858	LSM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LSM3	RGD	RGD:1305971
Bos taurus	LSM3	VGNC	VGNC:31055
Canis familiaris	LSM3	VGNC	VGNC:42843
Mus musculus	LSM3	MGD	MGI:1914928
Others	LSM3	NCBI

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