2. Gene
  3. KLRC1 - killer cell lectin like receptor C1 Gene

KLRC1 - killer cell lectin like receptor C1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NKG2; NKG2A; CD159A

Gene ID: 3821 | Gene type: protein coding

About KLRC1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,442,264-10,454,685 (from NCBI)

This gene has 7 transcripts (splice variants), 676 orthologues and 23 paralogues. Broad expression in spleen (RPKM 1.5), endometrium (RPKM 1.3) and 21 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]

KLRC1 Products(5)

mRNA Protein Name
NM_001304448.1 NP_001291377.1 NKG2-A/NKG2-B type II integral membrane protein isoform C
NM_002259.5 NP_002250.2 NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A
NM_007328.4 NP_015567.2 NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-B
NM_213657.3 NP_998822.2 NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-B
NM_213658.3 NP_998823.2 NKG2-A/NKG2-B type II integral membrane protein isoform NKG2-A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables HLA-E specific inhibitory MHC class Ib receptor activity IDA
IDA: Inferred from direct assay
9486650 GOA
enables MHC class I protein complex binding IPI
IPI: Inferred from physical interaction
18448674 GOA
enables inhibitory MHC class Ib receptor activity IDA
IDA: Inferred from direct assay
37264229 GOA
NOT enables protein antigen binding IDA
IDA: Inferred from direct assay
18448674 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9485206 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CD8-positive, gamma-delta intraepithelial T cell differentiation IDA
IDA: Inferred from direct assay
18064301 GOA
involved in natural killer cell inhibitory signaling pathway IDA
IDA: Inferred from direct assay
9485206 GOA
involved in negative regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9485206 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9485206 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
9485206 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
18448674 GOA
part of receptor complex IPI
IPI: Inferred from physical interaction
18448674 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLRC1 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (137 - 230)

  • 0
  • 100
  • 200
  • 233 a.a.
Protein Preferred Names Protein Names

NKG2-A/NKG2-B type II integral membrane protein

C-lectin type II protein

KLRC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KLRC1 P26715 CD151 Homo sapiens P48509
Validated Y2H
32296183
Intra
KLRC1 P26715 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
Intra
KLRC1 P26715 TMEM182 Homo sapiens Q6ZP80
Validated Y2H
32296183
Intra
KLRC1 P26715 LSMEM2 Homo sapiens Q8N112
Validated Y2H
32296183
Intra
KLRC1 P26715 CYB561A3 Homo sapiens Q8NBI2
Validated Y2H
32296183
Intra
KLRC1 P26715 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
KLRC1 P26715 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
KLRC1 P26715 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
KLRC1 P26715 ERMP1 Homo sapiens Q7Z2K6
Validated Y2H
32296183
Intra
KLRC1 P26715 TMPPE Homo sapiens Q6ZT21
Validated Y2H
32296183
Intra
KLRC1 P26715 CLEC2D Homo sapiens Q9UHP7-3
Complementation
32296183
Intra
KLRC1 P26715 CLEC2D Homo sapiens Q9UHP7-3
Validated Y2H
32296183
Intra
KLRC1 P26715 CLEC7A Homo sapiens Q9BXN2-6
Validated Y2H
32296183
Intra
KLRC1 P26715 CTXN3 Homo sapiens Q4LDR2
Validated Y2H
32296183
Intra
KLRC1 P26715 MS4A13 Homo sapiens Q5J8X5
Validated Y2H
32296183
Intra
KLRC1 P26715 PLP1 Homo sapiens P60201-2
Validated Y2H
32296183
Intra
KLRC1 P26715 TSPO2 Homo sapiens Q5TGU0
Validated Y2H
32296183
Intra
KLRC1 P26715 BRICD5 Homo sapiens Q6PL45-2
Validated Y2H
32296183
Intra
KLRC1 P26715 GPR61 Homo sapiens Q9BZJ8
Validated Y2H
32296183
Intra
KLRC1 P26715 GJB4 Homo sapiens Q9NTQ9
Validated Y2H
32296183
Intra
KLRC1 P26715 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra
KLRC1 P26715 PMP22 Homo sapiens Q01453
Validated Y2H
25416956
Intra
KLRC1 P26715 PMP22 Homo sapiens Q01453
Validated Y2H
32296183
Intra
KLRC1 P26715 PMP22 Homo sapiens Q01453
Y2H Array
25416956
Intra
KLRC1 P26715 PMP22 Homo sapiens Q01453
Y2H Prey Pooling
25416956
Intra
KLRC1 P26715 ITM2B Homo sapiens Q9Y287
Y2H Array
32814053
Intra
KLRC1 P26715 ITM2B Homo sapiens Q9Y287
Validated Y2H
32814053
Intra
KLRC1 P26715 ITM2B Homo sapiens Q9Y287
Y2H Pooling
32814053
Intra
KLRC1 P26715 DLST Homo sapiens P36957
Validated Y2H
32814053
Intra
KLRC1 P26715 DLST Homo sapiens P36957
Y2H Array
32814053
Intra
KLRC1 P26715 DLST Homo sapiens P36957
Y2H Pooling
32814053
Intra
KLRC1 P26715 ATP6V0B Homo sapiens Q99437
Validated Y2H
32296183
Intra
KLRC1 P26715 GJB2 Homo sapiens P29033
Validated Y2H
32296183
Intra
KLRC1 P26715 EMP3 Homo sapiens P54852
Validated Y2H
32296183
Intra
KLRC1 P26715 EMP3 Homo sapiens P54852
Complementation
32296183
Intra
KLRC1 P26715 NKG7 Homo sapiens Q16617
Validated Y2H
32296183
Intra
KLRC1 P26715 TMEM54 Homo sapiens Q969K7
Validated Y2H
32296183
Intra
KLRC1 P26715 MAL Homo sapiens P21145
Validated Y2H
25416956
Intra
KLRC1 P26715 MAL Homo sapiens P21145
Y2H Array
25416956
Intra
KLRC1 P26715 MAL Homo sapiens P21145
Y2H Prey Pooling
25416956
Intra
KLRC1 P26715 EMP1 Homo sapiens P54849
Validated Y2H
32296183
Intra
KLRC1 P26715 UNC93B1 Homo sapiens Q9H1C4
Validated Y2H
32296183
Intra
KLRC1 P26715 CD82 Homo sapiens P27701
Validated Y2H
32296183
Intra
KLRC1 P26715 ATP6V0C Homo sapiens P27449
Validated Y2H
32296183
Intra
KLRC1 P26715 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra
KLRC1 P26715 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra
KLRC1 P26715 KLRG1 Homo sapiens Q96E93
Validated Y2H
32296183
Intra
KLRC1 P26715 KLRD1 Homo sapiens Q13241
BN-PAGE
32575403
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLRC1 Proteins

Cat. No. Product Name Accession Purity
HY-P70551 NKG2A Protein, Human (HEK293, His) P26715-1 (R100-L233) ≥95%
HY-P70713 NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P74691 NKG2A Protein, Human (Biotinylated, HEK293, His) P26715-1 (P94-L233) ≥95%
HY-P77803 NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77804 NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77805 NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P77806 NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) P26715 (R100-L233)&Q13241 (S34-I179) ≥95%
HY-P78182 NKG2A Protein, Human (Biotinylated, HEK293, His-Avi) P26715-1 (R100-L233) ≥95%
HY-P78497 NKG2A Protein, Human (HEK293, Fc) P26715-1 (R100-L233) ≥95%
HY-P78499 NKG2A Protein, Human (HEK293, His-Avi) P26715-1 (R100-L233) ≥95%

Related Diseases

Diseases Alias
Nk Cell Deficiency
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
Bronchiectasis 1
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07391 KLRC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KLRC1 MGD MGI:1336161
Rattus norvegicus KLRC1 RGD RGD:2976
Macaca fascicularis KLRC1 NCBI
Macaca mulatta KLRC1 NCBI NCBI:574146
Others KLRC1 NCBI