1. Gene
  2. PPP1CC - protein phosphatase 1 catalytic subunit gamma Gene

PPP1CC - protein phosphatase 1 catalytic subunit gamma Gene

Homo sapiens

Also known as PP1C; PP-1G; PPP1G

Gene ID: 5501 | Gene type: protein coding

About PPP1CC

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,708,376-110,742,891 (from NCBI)

This gene has 11 transcripts (splice variants), 231 orthologues and 12 paralogues. Ubiquitous expression in duodenum (RPKM 77.6), small intestine (RPKM 62.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the protein Phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine Phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PPP1CC Products(2)

mRNA Protein Name
NM_001244974.2 NP_001231903.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2
NM_002710.4 NP_002701.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

PPP1CC Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (59 - 250)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase PP1-gamma catalytic subunit

protein phosphatase 1, catalytic subunit, gamma isozyme

Recombinant PPP1CC Proteins

Cat. No. Product Name Accession Purity
HY-P71228 PPP1CC Protein, Human (His) P36873-1 (M1-K323) ≥95%

Related Diseases

Diseases Alias
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus PPP1CC MGD MGI:104872
Rattus norvegicus PPP1CC RGD RGD:3377
Bos taurus PPP1CC VGNC VGNC:53916
Canis familiaris PPP1CC VGNC VGNC:52957
Felis catus PPP1CC VGNC VGNC:80466
Others PPP1CC NCBI