1. Gene
  2. PPP1CC - protein phosphatase 1 catalytic subunit gamma Gene

PPP1CC - protein phosphatase 1 catalytic subunit gamma Gene

Homo sapiens

Also known as PP1C; PP-1G; PPP1G

Gene ID: 5501 | Gene type: protein coding

About PPP1CC

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,708,376-110,742,891 (from NCBI)

This gene has 11 transcripts (splice variants), 231 orthologues and 12 paralogues. Ubiquitous expression in duodenum (RPKM 77.6), small intestine (RPKM 62.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the protein Phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine Phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PPP1CC Products(2)

mRNA Protein Name
NM_001244974.2 NP_001231903.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2
NM_002710.4 NP_002701.1 serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

PPP1CC Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (59 - 250)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase PP1-gamma catalytic subunit

protein phosphatase 1, catalytic subunit, gamma isozyme

PPP1CC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPP1CC P36873 KNL1 Homo sapiens Q8NG31
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q13625-3
Y2H Prey Pooling
25416956
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q13625-3
Validated Y2H
25416956
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q13625-3
Y2H Array
25416956
Intra
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
Anti Tag CoIP
24366813
Intra
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
Y2H Fragment Pooling
23414517
Intra
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
BioID
28330616
Intra
PPP1CC P36873 PPP1R7 Homo sapiens Q15435
Pull Down
28330616
Intra
PPP1CC P36873 PPP1R2B Homo sapiens Q6NXS1
Validated Y2H
32296183
Intra
PPP1CC P36873 PPP1R11 Homo sapiens O60927
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 PPP1R11 Homo sapiens O60927
Anti Tag CoIP
24366813
Intra
PPP1CC P36873 PPP1R11 Homo sapiens O60927
BioID
28330616
Intra
PPP1CC P36873 PPP1R11 Homo sapiens O60927
Pull Down
28330616
Intra
PPP1CC P36873 PPP1R2 Homo sapiens P41236
BioID
28330616
Intra
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Pull Down
28330616
Intra
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
24366813
Intra
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
12761178
Intra
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 PPP1R2 Homo sapiens P41236
Anti Tag CoIP
26496610
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
32296183
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
PPP1CC P36873 TPRN Homo sapiens Q4KMQ1-2
Validated Y2H
32296183
Intra
PPP1CC P36873 TPRN Homo sapiens Q4KMQ1-2
Y2H Array
32296183
Intra
PPP1CC P36873 TPRN Homo sapiens Q4KMQ1-2
Y2H Prey Pooling
32296183
Intra
PPP1CC P36873 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra
PPP1CC P36873 NRAC Homo sapiens Q8N912
Validated Y2H
32296183
Intra
PPP1CC P36873 PPP1R8 Homo sapiens Q12972-2
Y2H Prey Pooling
32296183
Intra
PPP1CC P36873 PPP1R8 Homo sapiens Q12972-2
Validated Y2H
32296183
Intra
PPP1CC P36873 PPP1R8 Homo sapiens Q12972-2
Y2H Array
32296183
Intra
PPP1CC P36873 URI1 Homo sapiens O94763-1
Anti Bait CoIP
27505673
Intra
PPP1CC P36873 AATK Homo sapiens Q6ZMQ8
Ub Reconstruction
28065597
Intra
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Anti Tag CoIP
24366813
Intra
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Ub Reconstruction
28065597
Intra
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
BioID
28330616
Intra
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Pull Down
28330616
Intra
PPP1CC P36873 LMTK2 Homo sapiens Q8IWU2
Anti Tag CoIP
26496610
Intra
PPP1CC P36873 PPP1R3C Homo sapiens Q9UQK1
Y2H Prey Pooling
32296183
Intra
PPP1CC P36873 PPP1R3C Homo sapiens Q9UQK1
Validated Y2H
32296183
Intra
PPP1CC P36873 PPP1R3C Homo sapiens Q9UQK1
Y2H Array
32296183
Intra
PPP1CC P36873 PPP1R15B Homo sapiens Q5SWA1
BioID
28330616
Intra
PPP1CC P36873 PPP1R15B Homo sapiens Q5SWA1
Pull Down
28330616
Intra
PPP1CC P36873 PPP1R15B Homo sapiens Q5SWA1
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 ZFYVE9 Homo sapiens O95405
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 ZFYVE9 Homo sapiens O95405
Validated Y2H
25416956
Intra
PPP1CC P36873 ZFYVE9 Homo sapiens O95405
Y2H Prey Pooling
25416956
Intra
PPP1CC P36873 ZFYVE9 Homo sapiens O95405
Anti Tag CoIP
24366813
Intra
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Pull Down
28330616
Intra
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Anti Bait CoIP
25785436
Intra
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
24366813
Intra
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
Anti Tag CoIP
26496610
Intra
PPP1CC P36873 PPP1R9B Homo sapiens Q96SB3
BioID
28330616
Intra
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Bait CoIP
27505673
Intra
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Tag CoIP
26496610
Intra
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Bait CoIP
21397856
Intra
PPP1CC P36873 URI1 Homo sapiens O94763
Pull Down
28330616
Intra
PPP1CC P36873 URI1 Homo sapiens O94763
Anti Tag CoIP
24366813
Intra
PPP1CC P36873 URI1 Homo sapiens O94763
BioID
28330616
Intra
PPP1CC P36873 RRP1B Homo sapiens Q14684
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 RRP1B Homo sapiens Q14684
Anti Tag CoIP
24366813
Intra
PPP1CC P36873 RRP1B Homo sapiens Q14684
IF
20926688
Intra
PPP1CC P36873 RRP1B Homo sapiens Q14684
BioID
28330616
Intra
PPP1CC P36873 RRP1B Homo sapiens Q14684
Pull Down
28330616
Intra
PPP1CC P36873 RRP1B Homo sapiens Q14684
Far-WB
20926688
Intra
PPP1CC P36873 PPP1R3B Homo sapiens Q86XI6
Validated Y2H
32296183
Intra
PPP1CC P36873 PPP1R3B Homo sapiens Q86XI6
Y2H Array
32296183
Intra
PPP1CC P36873 PPP1R3B Homo sapiens Q86XI6
Y2H Prey Pooling
32296183
Intra
PPP1CC P36873 CSRNP1 Homo sapiens Q96S65
Y2H Prey Pooling
25416956
Intra
PPP1CC P36873 CSRNP1 Homo sapiens Q96S65
Validated Y2H
25416956
Intra
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Y2H Prey Pooling
32296183
Intra
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Validated Y2H
32296183
Intra
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Y2H Array
32296183
Intra
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 CSRNP2 Homo sapiens Q9H175
Y2H Array
29892012
Intra
PPP1CC P36873 OGT Homo sapiens O15294
Anti Bait CoIP
27505673
Intra
PPP1CC P36873 PPP1R16A Homo sapiens Q96I34
Validated Y2H
32296183
Intra
PPP1CC P36873 CD2BP2 Homo sapiens O95400
Validated Y2H
25416956
Intra
PPP1CC P36873 CD2BP2 Homo sapiens O95400
Y2H Array
25416956
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Anti Tag CoIP
33961781
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Peptide Array
18448430
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Anti Tag CoIP
24366813
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
BioID
28330616
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Pull Down
28330616
Intra
PPP1CC P36873 TP53BP2 Homo sapiens Q13625
Y2H
21988832
Intra
PPP1CC P36873 ESR1 Homo sapiens P03372
Antibody Array
17274640
Cross
PPP1CC P36873 Clock Mus musculus O08785
Anti Tag CoIP
23555304
Intra
PPP1CC P36873 ZNF629 Homo sapiens Q9UEG4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPP1CC Proteins

Cat. No. Product Name Accession Purity
HY-P71228 PPP1CC Protein, Human (His) P36873-1 (M1-K323) ≥95%

Related Diseases

Diseases Alias
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus PPP1CC MGD MGI:104872
Rattus norvegicus PPP1CC RGD RGD:3377
Bos taurus PPP1CC VGNC VGNC:53916
Canis familiaris PPP1CC VGNC VGNC:52957
Felis catus PPP1CC VGNC VGNC:80466
Others PPP1CC NCBI