Kit - KIT proto-oncogene receptor tyrosine kinase Gene

Rattus norvegicus

Gene ID: 64030 | Gene type: protein coding

About Kit

Primary_assembly 14: 32,548,877-32,624,652 reverse strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 206 orthologues, 54 paralogues and is associated with 72 phenotypes. Biased expression in Lung (RPKM 35.8), Brain (RPKM 125.4) and 9 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including gamete generation; positive regulation of gastro-intestinal system smooth muscle contraction; and protein phosphorylation. Located in acrosomal vesicle; cytoplasmic side of plasma membrane; and external side of plasma membrane. Used to study aplastic anemia and male infertility. Biomarker of acute pancreatitis and gastroschisis. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell Cancer (multiple); piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Kit Products(1)

mRNA	Protein	Name
NM_022264.2	NP_071600.1	mast/stem cell growth factor receptor Kit precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7536501	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12821048	RGD
involved in germ cell migration	IMP IMP: Inferred from mutant phenotype	9283007	RGD
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7536501	RGD
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	15302600	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	9283007	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	7536501	RGD
involved in positive regulation of colon smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	17322067	RGD
involved in positive regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11112797	RGD
involved in positive regulation of pseudopodium assembly	IMP IMP: Inferred from mutant phenotype	9283007	RGD
involved in positive regulation of pyloric antrum smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	9832052	RGD
involved in positive regulation of small intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	7542218	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7536501	RGD
involved in regulation of bile acid metabolic process	IMP IMP: Inferred from mutant phenotype	7542218	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	24462979	RGD
involved in somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	15302600	RGD
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	12932303	RGD
involved in tongue development	IEP IEP: Inferred from expression pattern	10908606	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	11112797	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	9123725	RGD
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	11383883	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7536501	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kit Protein Structure

Ig_3

IgI_4_SCFR

PKc_like

0
200
400
600
800
978 a.a.

Protein Preferred Names

Protein Names

mast/stem cell growth factor receptor Kit

Kit oncogene	c-kit receptor tyrosine kinase
protein kinase	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Recombinant Kit Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74337	CD117/c-kit Protein, Rat (HEK293, His)	Q63116 (Q26-T522)	≥95%
HY-P74338	CD117/c-kit Protein, Rat (HEK293, Fc)	Q63116 (M1-T522)	≥95%

Related Agents

Approval

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10201	Sorafenib		99.92%	Yes
HY-10981	Lenvatinib	Inhibitor	99.75%	Yes
HY-16749	Pexidartinib		99.64%	Yes
HY-10331	Regorafenib		99.93%	Yes
HY-15463	Imatinib		99.95%	Yes
HY-13016	Cabozantinib		99.96%	Yes
HY-10230	Midostaurin		99.91%	Yes
HY-10208	Pazopanib		99.91%	Yes
HY-50946	Imatinib Mesylate		99.98%	Yes
HY-10201A	Sorafenib Tosylate		99.91%	Yes
HY-101561	Avapritinib	Inhibitor	99.94%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.86%	Yes
HY-112306	Ripretinib		98.90%	Yes
HY-16749A	Pexidartinib hydrochloride		99.86%	Yes
HY-10209	Masitinib		99.98%	Yes
HY-12009	Pazopanib Hydrochloride		99.99%	Yes
HY-10331A	Regorafenib monohydrate		99.96%	Yes
HY-12044	Cabozantinib S-malate		99.90%	Yes
HY-13308	Regorafenib Hydrochloride		99.58%	Yes
HY-13904	Flumatinib	Inhibitor	99.94%	Unkown
HY-10209A	Masitinib mesylate		99.83%	Yes
HY-10330	Toceranib	Inhibitor	96.86%	Unkown
HY-10330A	Toceranib phosphate	Inhibitor	98.54%	Unkown
HY-15240	c-Kit-IN-1	Inhibitor	98.83%	Unkown
HY-10201R	Sorafenib (Standard)		99.71%	Unkown
HY-10331B	Regorafenib mesylate		/	Unkown
HY-13016A	Cabozantinib hydrochloride		/	Unkown
HY-50946R	Imatinib Mesylate (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (34)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13905	Flumatinib mesylate	Inhibitor	99.87%	Phase 4
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-10205	Cediranib		99.58%	Phase 3
HY-145557	Bezuclastinib	Inhibitor	98.81%	Phase 3
HY-10228	Motesanib	Inhibitor	99.96%	Phase 3
HY-136256	Vimseltinib	Inhibitor	99.08%	Phase 3
HY-13049	Cediranib maleate		99.95%	Phase 3
HY-108713	Famitinib		98.43%	Phase 3
HY-124526	Chiauranib	Inhibitor	99.28%	Phase 3
HY-152839	Elenestinib	Inhibitor	98.82%	Phase 3
HY-10229	Motesanib Diphosphate	Inhibitor	99.64%	Phase 3
HY-10207	Dovitinib lactate	Inhibitor	99.75%	Phase 3
HY-16961A	Sitravatinib malate	Inhibitor	/	Phase 3
HY-B0062	Dovitinib lactate hydrate	Inhibitor	/	Phase 3
HY-108713A	Famitinib malate		/	Phase 3
HY-152839A	Elenestinib phosphate	Inhibitor	/	Phase 3
HY-110272	Vatalanib succinate	Inhibitor	/	Phase 3
HY-13024	Rebastinib		99.91%	Phase 2
HY-10206	Amuvatinib		99.47%	Phase 2
HY-109086	Edicotinib	Inhibitor	98.78%	Phase 2
HY-10501	SU14813	Inhibitor	99.63%	Phase 2
HY-10527	Telatinib	Inhibitor	99.60%	Phase 2
HY-10202	Tandutinib		99.48%	Phase 2
HY-109190	Seralutinib	Inhibitor	99.94%	Phase 2
HY-10202A	Tandutinib hydrochloride		99.78%	Phase 2
HY-10527C	Telatinib mesylate	Inhibitor	99.74%	Phase 2
HY-10206A	Amuvatinib hydrochloride	Inhibitor	/	Phase 2
HY-10204	OSI-930		98.57%	Phase 1
HY-12010	BMS-599626 Hydrochloride	Inhibitor	99.68%	Phase 1
HY-B1684	Mebrofenin		99.88%	Phase 1
HY-10251	BMS-599626	Inhibitor	/	Phase 1
HY-116116	Tafetinib	Inhibitor	/	Phase 1
HY-13645	Henatinib	Inhibitor	/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99462	Barzolvolimab	Inhibitor	99.83%	Phase 2

Pre-clinical Phase

Bioactive Molecules (69)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10514	BX795		99.84%	Unkown
HY-10873	N-Desethyl Sunitinib		99.90%	Unkown
HY-131339	SP-96	Inhibitor	99.42%	Unkown
HY-101443	ISCK03	Inhibitor	99.50%	Unkown
HY-132166	M4205	Inhibitor	99.47%	Unkown
HY-13894	Tyrphostin AG1296		99.69%	Unkown
HY-112802	AZD3229	Inhibitor	99.69%	Unkown
HY-G0017	N-Desmethyl imatinib		99.16%	Unkown
HY-13838	PLX647	Inhibitor	99.79%	Unkown
HY-10408	Ki20227	Inhibitor	99.17%	Unkown
HY-10501A	SU14813 maleate	Inhibitor	99.04%	Unkown
HY-I0678	Regorafénib N-oxyde (M2)		99.32%	Unkown
HY-101219	VEGFR-IN-1	Inhibitor	98.42%	Unkown
HY-112452	SU11652		99.06%	Unkown
HY-160765	WNTinib		99.95%	Unkown
HY-103274	PD180970		99.27%	Unkown
HY-15813	FIIN-1	Inhibitor	99.11%	Unkown
HY-112616	NAMPT inhibitor-linker 2	Inhibitor	/	Unkown
HY-18302	c-Kit-IN-5-1	Inhibitor	98.16%	Unkown
HY-18179	AZD2932	Inhibitor	99.04%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.34%	Unkown
HY-133980A	O-Demethyl Lenvatinib hydrochloride		95.54%	Unkown
HY-13493	AC710	Inhibitor	98.56%	Unkown
HY-W143698	PDGFRα kinase inhibitor 2	Inhibitor	98.95%	Unkown
HY-112615	NAMPT inhibitor-linker 1		98.08%	Unkown
HY-110293	CHMFL-FLT3-122		98.47%	Unkown
HY-136201	Sodium Glucoheptonate		≥98.0%	Unkown
HY-138813	N-Desethyl Sunitinib hydrochloride		99.77%	Unkown
HY-112802A	AZD3229 Tosylate	Inhibitor	99.80%	Unkown
HY-123450	S116836		99.65%	Unkown
HY-133980	O-Demethyl Lenvatinib		/	Unkown
HY-15198	KG5	Inhibitor	99.79%	Unkown
HY-156619	Labuxtinib	Inhibitor	99.76%	Unkown
HY-15814	HG-7-85-01		99.94%	Unkown
HY-18317	JNJ-38158471	Inhibitor	97.02%	Unkown
HY-101034	CHMFL-ABL/KIT-155		/	Unkown
HY-128589	CHMFL-KIT-033	Inhibitor	/	Unkown
HY-128602	c-Kit-IN-2	Inhibitor	/	Unkown
HY-10638	AP23464		/	Unkown
HY-109086A	Edicotinib hydrochloride	Inhibitor	/	Unkown
HY-110071	APcK110	Inhibitor	/	Unkown
HY-111947	c-Fms-IN-6	Inhibitor	/	Unkown
HY-117873	KBP-7018	Inhibitor	/	Unkown
HY-117873A	KBP-7018 hydrochloride	Inhibitor	/	Unkown
HY-121708	KI-328		/	Unkown
HY-121874	EP009	Inhibitor	/	Unkown
HY-131275	Imatinib Impurity E		96.05%	Unkown
HY-13838A	PLX647 dihydrochloride	Inhibitor	/	Unkown
HY-139996	Pomalidomide-C5-Dovitinib		/	Unkown
HY-143894	FLT3-IN-11	Inhibitor	/	Unkown
HY-143895	FLT3-IN-12	Inhibitor	/	Unkown
HY-147864	c-Fms-IN-12		/	Unkown
HY-149019	Antitumor agent-70		/	Unkown
HY-149415	Multi-kinase-IN-5	Inhibitor	/	Unkown
HY-150026	Multi-kinase-IN-2		/	Unkown
HY-156470	Multi-kinase-IN-6		/	Unkown
HY-160689	GW694590A	Inhibitor	/	Unkown
HY-168579	c-Kit-IN-6	Inhibitor	/	Unkown
HY-168580	c-Kit-IN-7	Inhibitor	/	Unkown
HY-168581	c-Kit-IN-8	Inhibitor	/	Unkown
HY-18949	JI6	Inhibitor	/	Unkown
HY-G0017A	N-Desmethyl imatinib mesylate		/	Unkown
HY-RS07319	KIT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07320	Kit Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07321	Kit Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-10202B	Tandutinib sulfate		/	Unkown
HY-112350	AGL 2043	Inhibitor	/	Unkown
HY-13493A	AC710 Mesylate	Inhibitor	/	Unkown
HY-18187	Ki 23057	Inducer	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990002	Anti-Mouse CD117/c-Kit Antibody (2B8)	Inhibitor	≥95.0%	Unkown
HY-P990020	Eglatoprutug	Inhibitor	/	Unkown
HY-P990754	Opelkibart	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kit	NCBI	NCBI:3815
Canis familiaris	Kit	NCBI	NCBI:403811
Mus musculus	Kit	NCBI	NCBI:16590
Macaca mulatta	Kit	NCBI	NCBI:696759

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