2. Gene
  3. Dhodh - dihydroorotate dehydrogenase (quinone) Gene

Dhodh - dihydroorotate dehydrogenase (quinone) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 65156 | Gene type: protein coding

About Dhodh

Primary_assembly 19: 37,558,177-37,591,654 reverse strand.mRatBN7.2:CM026992.1

This gene has 5 transcripts (splice variants), 173 orthologues, 1 paralogue and is associated with 12 phenotypes. Biased expression in Adrenal (RPKM 46.5), Thymus (RPKM 4.8) and 9 other tissues.

Summary

Enables FMN binding activity; Dihydroorotate Dehydrogenase activity; and ubiquinone binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; lactation; and response to L-arginine. Located in mitochondrial inner membrane and neuronal cell body. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (Dihydroorotate Dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Apr 2022]

Dhodh Products(1)

mRNA Protein Name
NM_001008553.2 NP_001008553.1 dihydroorotate dehydrogenase (quinone), mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables FMN binding IDA
IDA: Inferred from direct assay
9693067 RGD
enables dihydroorotate dehydrogenase activity IDA
IDA: Inferred from direct assay
1313236 RGD
enables quinone binding IPI
IPI: Inferred from physical interaction
15044733 RGD
enables ubiquinone binding IDA
IDA: Inferred from direct assay
9179295 RGD
Biological Process GO Annotation Evidence Reference Source
involved in 'de novo' pyrimidine nucleobase biosynthetic process IDA
IDA: Inferred from direct assay
1476792 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
1476792 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
1476792 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15182735 RGD
involved in regulation of mitochondrial fission IMP
IMP: Inferred from mutant phenotype
16120318 RGD
involved in response to L-arginine IEP
IEP: Inferred from expression pattern
6167833 RGD
involved in response to caffeine IEP
IEP: Inferred from expression pattern
6149265 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
9879809 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
6331524 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
9123312 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
10727948 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20544541 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dhodh Protein Structure

DHOD_2_like

DHOD_2_like: cd04738 (42 - 372)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

dihydroorotate dehydrogenase (quinone), mitochondrial

DHOdehase

dihydroorotate dehydrogenase, mitochondrial

dihydroorotate oxidase

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0083 Leflunomide Inhibitor 99.82% Yes
HY-N0157 Orotic acid Chemical 98.14% Unkown
HY-110159 (E/Z)-Teriflunomide Inhibitor ≥95.0% Yes
HY-N0157A Orotic acid zinc Chemical 99.84% Unkown
HY-N0157R Orotic acid (Standard) Chemical / Unkown
Clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-124593 PTC299 Inhibitor 99.89% Phase 3
HY-108325 Brequinar Inhibitor 99.75% Phase 2
HY-14908 Vidofludimus 99.11% Phase 2
HY-129239 Farudodstat 99.68% Phase 2
HY-104029 Olorofim Inhibitor 99.57% Phase 2
HY-112645 BAY-2402234 Inhibitor 99.88% Phase 1
Pre-clinical Phase
Bioactive Molecules (54)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N6961 Lapachol Inhibitor 99.06% Unkown
HY-15510 Tenovin-6 98.33% Unkown
HY-139189 DHODH-IN-16 Inhibitor 99.88% Unkown
HY-13423 Tenovin-1 99.88% Unkown
HY-137463 AG-636 Inhibitor 98.25% Unkown
HY-100688 ML390 Inhibitor 99.72% Unkown
HY-128068 DHODH-IN-17 Inhibitor 99.91% Unkown
HY-15510B Tenovin-6 Hydrochloride 98.88% Unkown
HY-135282 DHODH-IN-1 Inhibitor 98.65% Unkown
HY-132170 DSM502 Inhibitor 99.74% Unkown
HY-101813 Laflunimus Inhibitor 99.76% Unkown
HY-N0157S1 Orotic acid-13C,15N2 monohydrate 99.93% Unkown
HY-153112 DHODH-IN-23 Inhibitor 99.82% Unkown
HY-132171A DSM705 hydrochloride Inhibitor 99.56% Unkown
HY-132174 CHIKV-IN-2 Inhibitor 99.21% Unkown
HY-128787 hDHODH-IN-4 Inhibitor 99.68% Unkown
HY-135675 DHODH-IN-11 Inhibitor 99.69% Unkown
HY-N7961 (E/Z)-Ginkgolic acid C17:2 Inhibitor 95.02% Unkown
HY-120924 BRD9185 Inhibitor / Unkown
HY-132171 DSM705 Inhibitor / Unkown
HY-14908A Vidofludimus hemicalcium / Unkown
HY-135618 DHODH-IN-3 Inhibitor / Unkown
HY-135619 DHODH-IN-4 Inhibitor / Unkown
HY-135664 hDHODH-IN-5 Inhibitor / Unkown
HY-135666 DHODH-IN-8 Inhibitor / Unkown
HY-135667 hDHODH-IN-7 Inhibitor / Unkown
HY-135676 DHODH-IN-12 Inhibitor / Unkown
HY-135677 DHODH-IN-13 Inhibitor / Unkown
HY-135678 DHODH-IN-14 Inhibitor / Unkown
HY-135679 DHODH-IN-15 Inhibitor / Unkown
HY-139825 Indoluidin E Inhibitor / Unkown
HY-139889 DHODH-IN-18 Inhibitor / Unkown
HY-142834 RORγt/DHODH-IN-2 Inhibitor / Unkown
HY-142843 RORγt/DHODH-IN-1 Inhibitor / Unkown
HY-142847 RORγt/DHODH-IN-3 Inhibitor / Unkown
HY-144169 DHODH-IN-19 Inhibitor / Unkown
HY-144371 DHODH-IN-20 Inhibitor / Unkown
HY-146317 P1788 Inhibitor / Unkown
HY-148395 UCK2 Inhibitor-2 Inhibitor / Unkown
HY-148396 UCK2 Inhibitor-3 / Unkown
HY-149030 DHODH-IN-21 Inhibitor / Unkown
HY-149031 DHODH-IN-22 Inhibitor / Unkown
HY-149877 hDHODH-IN-12 Inhibitor / Unkown
HY-158023 DHODH-IN-26 / Unkown
HY-163158 DHODH-IN-24 Inhibitor / Unkown
HY-163328 DHODH-IN-25 Inhibitor / Unkown
HY-B0083S Leflunomide-d4 Inhibitor / Unkown
HY-RS03734 DHODH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03735 Dhodh Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03736 Dhodh Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-108325S Brequinar-d3 Inhibitor / Unkown
HY-120462 Genz-669178 Inhibitor / Unkown
HY-169220S RORγ/DHODH-IN-1 Inhibitor / Unkown
HY-169222S RORγ/DHODH-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhodh NCBI NCBI:1723