2. Anti-infection
  3. Dengue virus Flavivirus Virus Protease
  4. Mosnodenvir

Mosnodenvir  (Synonyms: JNJ-1802)

Cat. No.: HY-153810 Purity: 99.31%
SDS COA Handling Instructions

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Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates.

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Mosnodenvir Chemical Structure

Mosnodenvir Chemical Structure

CAS No. : 2890688-86-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 577 In-stock
Solution
10 mM * 1 mL in DMSO USD 577 In-stock
Solid
5 mg USD 450 In-stock
10 mg USD 690 In-stock
25 mg USD 1290 In-stock
50 mg USD 1950 In-stock
100 mg USD 2950 In-stock
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

Mosnodenvir Related Antibodies

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Description

Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates[1][2].
IC50 & Target

DENV[1].
In Vitro

Mosnodenvir exhibits antiviral activity and limited cytotoxicity in Vero, C6/36, Huh-7, and THP-1/DC-SIGN cells infected with DENV[2].
Mosnodenvir (0.00256 nM-8 nM, 24 h) has inhibitory effects on infection of two DENV 2 strains (DENV-2/16681 and DENV-2/RL) in Vero cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mosnodenvir Related Antibodies

Real Time qPCR[3].

Cell Line: Vero cells (African green monkey kidney cells)
Concentration: 0.00256 nM-8 nM
Incubation Time: 24 h
Result: Inhibited virus replication, with a nearly 100% inhibitory effect at concentrations of 1.6 nM or higher.
In Vivo

Mosnodenvir (0.2-60 mg/kg; first administration 1 hour before DENV attack; b.i.d; 3 days; p.o.) can block the NS3-NS4B interaction in viral replication complexes and has potent antiviral effects against four types of DENV infections in mice[2].
Mosnodenvir (0.01, 0.18, 3 mg/kg; once daily; 11 days; p.o.) has antiviral efficacy in a non-human primate rhesus monkey model infected with DENV[2].
Mosnodenvir has good pharmacokinetic characteristics in mice, with a terminal half-life of 6.2 hours and oral bioavailability of 46% and 59% at 1 and 3 mg/kg, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AG129 mouse model infected with dengue virus (DENV)[2].
Dosage: 0.2-60 mg/kg
Administration: Oral gavage (p.o.); first administration 1 hour before DENV attack; b.i.d; 3 days
Result: Reduced the level of viral RNA and increased the survival rate of mice.
Animal Model: DENV-2/16681 rhesus macaque model[2].
Dosage: 0.01, 0.18, 3 mg/kg
Administration: Oral gavage (p.o.); once daily; 11 days
Result: Inhibited virus replication without causing DENV IgG and IgM seroconversion.
Molecular Weight

582.98

Formula

C26H22ClF3N2O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(C1=CC(OC)=CC(N[C@@H](C2=C(C=C(C=C2)Cl)OC)C(C(C3=C4)=CNC3=CC=C4OC(F)(F)F)=O)=C1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (171.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7153 mL 8.5766 mL 17.1532 mL
5 mM 0.3431 mL 1.7153 mL 3.4306 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.29 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.29 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.94%

SDS (252 KB)

COA (255 KB) HNMR (294 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7153 mL 8.5766 mL 17.1532 mL 42.8831 mL
5 mM 0.3431 mL 1.7153 mL 3.4306 mL 8.5766 mL
10 mM 0.1715 mL 0.8577 mL 1.7153 mL 4.2883 mL
15 mM 0.1144 mL 0.5718 mL 1.1435 mL 2.8589 mL
20 mM 0.0858 mL 0.4288 mL 0.8577 mL 2.1442 mL
25 mM 0.0686 mL 0.3431 mL 0.6861 mL 1.7153 mL
30 mM 0.0572 mL 0.2859 mL 0.5718 mL 1.4294 mL
40 mM 0.0429 mL 0.2144 mL 0.4288 mL 1.0721 mL
50 mM 0.0343 mL 0.1715 mL 0.3431 mL 0.8577 mL
60 mM 0.0286 mL 0.1429 mL 0.2859 mL 0.7147 mL
80 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.5360 mL
100 mM 0.0172 mL 0.0858 mL 0.1715 mL 0.4288 mL
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Mosnodenvir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mosnodenvir2890688-86-3JNJ-1802JNJ1802JNJ 1802Dengue virusFlavivirusVirus ProteaseDENVantiviralVero cellrhesus macaqueInhibitorinhibitorinhibit

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