Mutated EGFR-IN-1 (Synonyms: Osimertinib analog)

Cat. No.: HY-78869 Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

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Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.

For research use only. We do not sell to patients.

Mutated EGFR-IN-1 Chemical Structure

CAS No. : 1421372-66-8

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 32	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
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5 g		Get quote

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Purity & Documentation
References
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Description

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. IC50 value: Target: Mutated EGFR inhibitor More information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer.

IC₅₀ & Target^[1]

EGFR^L858R

EGFR^{Exon 19 deletion/T790M}

EGFR^T790M

Molecular Weight

445.56

Formula

C₂₅H₃₁N₇O

CAS No.

1421372-66-8

Appearance

Solid

SMILES

NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 75 mg/mL (168.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2444 mL	11.2218 mL	22.4437 mL
5 mM	0.4489 mL	2.2444 mL	4.4887 mL
10 mM	0.2244 mL	1.1222 mL	2.2444 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (254 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Patent WO 2013014448 A1. 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer .

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2444 mL	11.2218 mL	22.4437 mL	56.1092 mL
	5 mM	0.4489 mL	2.2444 mL	4.4887 mL	11.2218 mL
	10 mM	0.2244 mL	1.1222 mL	2.2444 mL	5.6109 mL
	15 mM	0.1496 mL	0.7481 mL	1.4962 mL	3.7406 mL
	20 mM	0.1122 mL	0.5611 mL	1.1222 mL	2.8055 mL
	25 mM	0.0898 mL	0.4489 mL	0.8977 mL	2.2444 mL
	30 mM	0.0748 mL	0.3741 mL	0.7481 mL	1.8703 mL
	40 mM	0.0561 mL	0.2805 mL	0.5611 mL	1.4027 mL
	50 mM	0.0449 mL	0.2244 mL	0.4489 mL	1.1222 mL
	60 mM	0.0374 mL	0.1870 mL	0.3741 mL	0.9352 mL
	80 mM	0.0281 mL	0.1403 mL	0.2805 mL	0.7014 mL
	100 mM	0.0224 mL	0.1122 mL	0.2244 mL	0.5611 mL

Mutated EGFR-IN-1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mutated EGFR-IN-11421372-66-8OsimertinibEGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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