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Results for "

5-HT(3)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (139) Adrenergic Receptor (15) Apoptosis (7) Autophagy (8) Bacterial (3) Biochemical Assay Reagents (1) Cholinesterase (ChE) (1) Dopamine Receptor (10) Drug Metabolite (1) Endogenous Metabolite (3) Flavivirus (1) Histamine Receptor (6) Isotope-Labeled Compounds (16) mAChR (6) Mitophagy (5) Monoamine Oxidase (3) nAChR (14) SARS-CoV (2) Serotonin Transporter (6) Sodium Channel (1)
By Research Areas:	Cancer (33) Cardiovascular Disease (13) Endocrinology (5) Infection (3) Inflammation/Immunology (16) Metabolic Disease (7) Neurological Disease (127)

159

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: 5-HT Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148038

5-HT3 antagonist 5	5-HT Receptor	Neurological Disease
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT₃ receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on *5-HT₃* agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice .

HY-100938

m-CPBG hydrochloride 1-(3-Chlorophenyl)biguanide hydrochloride	5-HT Receptor	Neurological Disease
m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective *5-HT₃* agonist. m-CPBG hydrochloride can be used for the research of neurological disease .

HY-U00322

5-HT3 antagonist 3	5-HT Receptor	Neurological Disease
5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist. 5-HT3 antagonist 3 binds to 5-HT3 receptors in rat brain cortical membranes with K_i of 0.25 nM .

HY-U00408

5-HT3 antagonist 2	5-HT Receptor	Neurological Disease
5-HT3 antagonist 2 is a *5-HT3* receptor antagonist.

HY-131954

5-HT3 antagonist 4	5-HT Receptor	Neurological Disease
5-HT3 antagonist 4 is a **5-HT3 receptor (5HT3R)** antagonist. 5-HT3 antagonist 4 prevents diabetes-induced depressive phenotypes in mice .

HY-U00368

5-HT3 antagonist 1	5-HT Receptor	Neurological Disease
5-HT3 antagonist 1 is a potent and selective antagonist of *serotonin 3 (5-HT3) receptor*.

HY-U00413

5-HT3-In-1	5-HT Receptor	Cardiovascular Disease Neurological Disease
5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. It shows *5-HT3* inhibition activity.

HY-106807

Litoxetine SL 81.0385	5-HT Receptor	Neurological Disease
Litoxetine (SL 81.0385) is a selective 5-HT uptake inhibitor. Litoxetine is a 5-HT₃ receptor antagonist with a K_i of 85 nM for cerebral 5-HT₃ receptors. Litoxetine is an antidepressant and has antiemetic properties .

HY-19684

Pancopride LAS 30451	5-HT Receptor	Neurological Disease
Pancopride is a new potent and selective 5-HT₃ receptor antagonist.

HY-109543A

Indisetron dihydrochloride	5-HT Receptor	Neurological Disease
Indisetron dihydrochloride is a 5-HT3 receptor antagonist with anti-emetic activity.

HY-109543

Indisetron	5-HT Receptor
Indisetron is a 5-HT3 receptor antagonist with anti-emetic activity.

HY-105090

Lerisetron	5-HT Receptor	Cardiovascular Disease Neurological Disease
Lerisetron is a potent *5-HT₃* antagonists and possess high-affinity binding for the 5-HT₃ receptors with pK_i value of 9.2. Lerisetron has a potent ability to inhibit the 5-HT-evoked reflex bradycardia in urethane-anesthetized rats .

HY-100552

VUF10166	5-HT Receptor	Neurological Disease
VUF10166 is a potent and high-affinity 5-HT₃ receptor antagonist, with K_i values of 0.04 nM (5-HT₃A) and 22 nM (5-HT₃AB). VUF10166 inhibits 5-HT-induced responses at 5-HT₃A and 5-HT₃AB receptors at nanomolar concentrations. At 5-HT₃ receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC₅₀ of 5.2 μM .

HY-19110

RG-12915	5-HT Receptor	Cancer
RG-12915 is a selective *5-HT3* antagonist, with IC₅₀ value of 0.16 nM.

HY-103137

Zacopride hydrochloride	5-HT Receptor	Neurological Disease
Zacopride hydrochloride is a highly potent *5-HT₃* receptor antagonist with K_is of 0.38 and 373 nM for *5-HT₃* and 5-HT₄ receptor, respectively. Zacopride hydrochloride is also a moderate I_K1 channel agonist. Zacopride hydrochloride exerts significant antiarrhythmic and cardiac protective effects .

HY-111156

NW-1172 free base	Monoamine Oxidase	Neurological Disease
NW-1172 (free base) (compound 22b) is a 5-HT3 receptor antagonist with performance-enhancing activity in a delayed matching task in monkeys, with the (R) isomer producing more systematic improvements than the (S) isomer, a difference paralleled by the higher affinity of the (R) enantiomer for the 5-HT3 receptor.

HY-A0018

Palonosetron	5-HT Receptor	Cardiovascular Disease
Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

HY-101331

Phenylbiguanide N-Phenylbiguanide; PBG; 1-Phenylbiguanide	5-HT Receptor	Neurological Disease
Phenylbiguanide is a 5-HT₃ receptor selective agonist with an EC₅₀ of 3.0±0.1 μM.

HY-101062

3-AQC	5-HT Receptor	Neurological Disease
3-AQC, a piperazinylquinoxaline derivative, is a potent and competitive *5-HT₃* receptor antagonist .

HY-119806

TMPPAA	5-HT Receptor	Neurological Disease
TMPPAA is an allosteric agonist and positive allosteric modulator of the *5-HT3* receptor. TMPPAA enhances 5-HT-mediated 5-HT3AR signaling .

HY-U00028

T 82	5-HT Receptor Cholinesterase (ChE)	Neurological Disease
T 82 is a potent *5-HT3* antagonist and acetylcholinesterase (AChE) inhibitor, used for treatment of Alzheimer's Disease.

HY-105109

Cilansetron	5-HT Receptor	Neurological Disease
Cilansetron is a *5-HT3* receptor antagonist. Cilansetron can be used in studies of irritable bowel syndrome .

HY-105196

DAT-582	5-HT Receptor	Neurological Disease
DAT-582 is a *serotonin 3 (5-HT3) receptor* antagonist that has an antiemetic effect .

HY-105108

Cilansetron hydrochloride hydrate	5-HT Receptor	Neurological Disease
Cilansetron hydrochloride hydrate is a *5-HT3* receptor antagonist. Cilansetron hydrochloride hydrate can be used in studies of irritable bowel syndrome .

HY-70050CS

Alosetron D3 Hydrochloride GR-68755C d₃	5-HT Receptor	Neurological Disease
Alosetron-d₃ (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.

HY-116554

GYKI-46903	5-HT Receptor	Neurological Disease
GYKI-46903 is a non-competitive antagonist for 5-HT3 receptor, with the pIC₅₀ of 6.91 .

HY-B0071

Granisetron BRL 43694	5-HT Receptor	Neurological Disease
Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-B0071A

Granisetron Hydrochloride BRL 43694A	5-HT Receptor	Neurological Disease Cancer
Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

HY-B0750

Dolasetron MDL-73147	5-HT Receptor	Others
Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

HY-B1541

Bemesetron MDL 72222	5-HT Receptor	Neurological Disease
Bemesetron (MDL 72222) is a selective 5-HT₃ receptor antagonist with an IC₅₀ of 0.33 nM . Neuroprotective effect .

HY-44132A

Dehydro Palonosetron hydrochloride RS 42358-197 hydrochloride	5-HT Receptor	Cancer
Dehydro Palonosetron hydrochloride (RS 42358-197 hydrochloride) is a 5-HT3 receptor antagonist. Dehydro Palonosetron hydrochloride has an antiemetic effect .

HY-U00234

Zatosetron maleate LY 277359 maleate	5-HT Receptor	Neurological Disease
Zatosetron maleate is a potent and selective 5HT3 receptor antagonist.

HY-102064

SR 57227A 1 Publications Verification	5-HT Receptor	Neurological Disease
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC₅₀) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects .

HY-70050AS

Alosetron-d3 GR 68755-d₃; GR 68755X-d₃	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Alosetron-d₃ is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].

HY-101638

(±)-Fabesetron hydrochloride (±)-FK1052	5-HT Receptor	Neurological Disease
(±)-Fabesetron hydrochloride ((±)-FK1052) is the racemate of Fabesetron hydrochloride, which is a potent *5-HT3* and 5-HT4 receptor dual antagonist .

HY-B0750A

Dolasetron Mesylate MDL-73147EF	5-HT Receptor	Cancer
Dolasetron Mesylate (MDL-73147EF) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

HY-B0750B

Dolasetron Mesylate hydrate MDL-73147EF hydrate	5-HT Receptor	Others
Dolasetron Mesylate hydrate (MDL-73147EF hydrate) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

HY-70050A

Alosetron GR 68755; GR 68755X	5-HT Receptor	Neurological Disease Inflammation/Immunology
Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC₅₀ at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects .

HY-70050C

Alosetron Hydrochloride GR 68755C; GR 68755 Hydrochloride; GR 68755X Hydrochloride	5-HT Receptor	Neurological Disease
Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC₅₀ at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects .

HY-B0595

Ramosetron Hydrochloride YM060	5-HT Receptor	Neurological Disease Inflammation/Immunology Cancer
Ramosetron (YM060) Hydrochloride is an orally active 5-HT3 receptor antagonist used for studying nausea, vomiting, and inflammatory diseases .

HY-115724

FPPQ	5-HT Receptor	Neurological Disease
FPPQ is a dual-acting 5-HT₃ (K_i = 0.9 nM) and 5-HT₆ (K_i = 3 nM) receptor antagonist with antipsychotic and procognitive properties.

HY-105109B

(S)-Cilansetron	Others	Neurological Disease
(S)-Cilansetron is the S-isomer of Cilansetron. Cilansetron is a *5-HT3* receptor antagonist that can be used in research related to irritable bowel syndrome .

HY-100243

(+)-Norcisapride Ticalopride	5-HT Receptor	Neurological Disease
(+)-Norcisapride (Ticalopride) is a potent 5-HT4 agonist and a *5-HT3* antagonist. (+)-Norcisapride has activity in animals models of constipation .

HY-B0002

Ondansetron hydrochloride 5+ Cited Publications GR 38032 hydrochloride; SN 307 hydrochloride	5-HT Receptor	Neurological Disease
Ondansetron hydrochloride (GR 38032 hydrochloride; SN 307 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.

HY-19199

E-3620	5-HT Receptor	Neurological Disease Metabolic Disease
E-3620 is a potent *5-HT₃* receptor antagonist. E-3620 can be used for the research of dyskinesi and gastrointestinal motility .

HY-101638A

(±)-Fabesetron (±)-FK1052 free base	5-HT Receptor	Neurological Disease
(±)-Fabesetron ((±)-FK1052 free base) is the racemate of Fabesetron, which is a potent *5-HT3* and 5-HT4 receptor dual antagonist .

HY-A0021R

Palonosetron hydrochloride (Standard)	5-HT Receptor	Cardiovascular Disease Cancer
Palonosetron (hydrochloride) (Standard) is the analytical standard of Palonosetron (hydrochloride). This product is intended for research and analytical applications. Palonosetron hydrochloride is a 5-HT3 antagonist that inhibits chemotherapy-induced nausea and vomiting (CINV).

HY-103118

PU02	5-HT Receptor Apoptosis	Neurological Disease Cancer
PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT₃ receptor, with IC₅₀ values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT₃A and 5-HT₃AB receptors respectively .

HY-B0068

Azasetron hydrochloride 2 Publications Verification Y-25130 hydrochloride	5-HT Receptor	Neurological Disease
Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective *5-HT3* receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV) .

HY-19650

Pumosetrag Hydrochloride 1 Publications Verification MKC-733; DDP-733	5-HT Receptor	Metabolic Disease
Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available *5-HT3* partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

Cat. No.	Product Name	Target	Research Area

HY-P1441A

Mambalgin 1 TFA	Sodium Channel	Neurological Disease
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015169

5-Methoxytryptamine O-Methylserotonin	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	Drug Metabolite 5-HT Receptor Endogenous Metabolite
5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action .

HY-W015169A

5-Methoxytryptamine hydrochloride	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	5-HT Receptor Endogenous Metabolite
5-Methoxytryptamine hydrochloride, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine hydrochloride has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine hydrochloride is also a potent antioxidant and has radioprotective action .

HY-W001160

5-Hydroxyindole	Alkaloids Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite
5-Hydroxyindole, a hydroxylated indole, can be found in a vast array of pharmacologically active agents and natural products. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells .

HY-B2065

Scopolamine hydrochloride (-)-Scopolamine hydrochloride; Hyoscine hydrochloride	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR 5-HT Receptor
Scopolamine hydrochloride is a non-selective and high affinity (≤1 nM) muscarinic antagonist that is used for the prevention of post-operative nausea and vomiting. Scopolamine readily passes the blood brain barrier. Scopolamine also reversibly inhibits *5-HT3* receptor-responses with an IC₅₀ of 2.09 μM . Scopolamine induces Alzheimer's disease-like pathology through alteration of cholinergic system .

Cat. No.	Product Name	Chemical Structure

HY-70050CS

Alosetron D3 Hydrochloride
Alosetron-d₃ (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.

HY-B0002BS

Ondansetron-d5
Ondansetron-d₅ is the deuterium labeled Ondansetron. Ondansetron (GR 38032; SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.

HY-B0002S

Ondansetron-d3 hydrochloride
Ondansetron-d₃ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride. Ondansetron hydrochloride (GR 38032 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[1][2].

HY-B0352S

Mirtazapine D3
Mirtazapine-d₃ is a deuterium labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors[1].

HY-70050AS

Alosetron-d3
Alosetron-d₃ is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].

HY-A0021S

Palonosetron-d3 hydrochloride
Palonosetron-d₃ (hydrochloride) is the deuterium labeled Palonosetron hydrochloride. Palonosetron hydrochloride is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)[1][2].

HY-132348S

Granisetron-d3
Granisetron-d₃ is the deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy[1][2].

HY-B0750S1

Dolasetron-d5
Dolasetron-d₅ is deuterated labeled Dolasetron (HY-B0750). Dolasetron (MDL-73147) is a *5-HT3* receptor antagonist with potential for treatment of chemotherapy-induced nausea and vomiting.

HY-B0002BS1

Ondansetron-d3
Ondansetron-d₃ is the deuterium labeled Ondansetron[1]. Ondansetron(GR 38032;SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2].

HY-B0002S1

Ondansetron-d6 hydrochloride
Ondansetron-d₆ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride[1]. Ondansetron hydrochloride is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2][3][4][5][6][7].

HY-17382S

Metoclopramide-d3
Metoclopramide-d₃ is deuterium labeled Metoclopramide. Metoclopramide is a potent antagonist of 5-HT3 and dopamine D2 receptor, with IC50s of 308 nM and 483 nM, respectively. Metoclopramide can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis[1][2].

HY-B0352BS

(R)-Mirtazapine-d3
(R)-Mirtazapine-d₃ is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].

HY-14264S

Cyamemazine-d6
Cyamemazine-d₆ is the deuterium labeled Cyamemazine. Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity[1][2].

HY-B0352S2

Mirtazapine-d4
Mirtazapine-d₄ is deuterium labeled Mirtazapine. Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively[1][2].

HY-B0352S3

Mirtazapine-d4 hydrochloride
Mirtazapine-d₄ hydrochloride is deuterated labeled Mirtazapine (HY-B0352). Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT₂, *5-HT₃, histamine H1 receptor* and α2-adrenoceptor antagonist with pK_i values of 8.05, 8.1, 9.3 and 6.95, respectively .

HY-32329S

Setiptiline-d3

Setiptiline-d₃ is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].

HY-10564S

Sarpogrelate-d3 hydrochloride

Sarpogrelate-d₃ (hydrochloride) is the deuterium labeled Sarpogrelate hydrochloride. Sarpogrelate hydrochloride (MCI-9042) is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis[1][2][3].

HY-14541S

Olanzapine-d3
Olanzapine-d₃ is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].

HY-14541S2

Olanzapine-d8

Olanzapine-d8 is a deuterated labeled Olanzapine . Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic .

HY-15414AS

Vortioxetine-d8 hydrobromide
Vortioxetine-d₈ (Lu AA 21004-d₈) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-15414S

Vortioxetine-d8
Vortioxetine-d₈ (Lu AA 21004-d₈) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-15414S1

Vortioxetine-d6
Vortioxetine-d6 (Lu AA 21004-d6) is the deuterium labeled Vortioxetine (HY-B1490A). Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial agonist of 5-HT_1B (K_i: 15 nM, 33 nM) .

HY-B0991S

Amoxapine-d8
Amoxapine-d₈ is the deuterium labeled Amoxapine. Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT₂/5-HT₃ antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death .

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