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Results for "

AP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (21) Adrenergic Receptor (1) Akt (2) AMPK (1) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (1) Apoptosis (12) Autophagy (2) Bacterial (2) Bcl-2 Family (3) Caspase (2) COX (3) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (2) Drug Metabolite (3) EGFR (1) Endogenous Metabolite (2) ERK (3) Estrogen Receptor/ERR (1) Fluorescent Dye (1) Fungal (2) Glucocorticoid Receptor (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) HSV (1) Insecticide (3) Interleukin Related (6) Isotope-Labeled Compounds (1) JNK (4) Keap1-Nrf2 (2) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (1) MEK (2) mGluR (1) MMP (3) mTOR (1) Necroptosis (3) NF-κB (13) NO Synthase (2) p38 MAPK (3) PARP (1) PKA (1) PPAR (2) PROTACs (2) RAR/RXR (1) Ras (2) Reactive Oxygen Species (3) Small Interfering RNA (siRNA) (13) Sodium Channel (1) STAT (1) TGF-β Receptor (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) Vasopressin Receptor (2) VEGFR (2)
By Research Areas:	Cancer (31) Cardiovascular Disease (6) Endocrinology (1) Infection (5) Inflammation/Immunology (26) Metabolic Disease (4) Neurological Disease (3)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (13) siRNAs (13)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: AP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133987

AP-1/NF-κB activation inhibitor 1 1 Publications Verification	NF-κB	Inflammation/Immunology
AP-1/NF-κB activation inhibitor 1 is a potent *AP-1* and NF-κB mediated transcriptional activation inhibitor (IC₅₀=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells ^[1].

HY-169481

*AP-1*	PROTACs Anaplastic lymphoma kinase (ALK)	Cancer
AP-1 is a PROTAC targeting anaplastic lymphoma kinase (ALK). AP-1 is composed of PROTAC target protein ligand CS-1243648 (HY-169482) (red part), E3 ligase ligand Pomalidomide (HY-10984) (blue part) and PROTAC Linker 2-(Tert-Butoxy)-2-oxoacetic acid (HY-W687662) (black part) ^[1].

HY-P10513

AcrAP1 AP1-Z1	Bacterial Fungal Apoptosis	Infection Cancer
AcrAP1 (AP1-Z1) is an antimicrobial peptide found in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP1 has antimicrobial activity and can inhibit the growth of Gram-positive and Gram-negative bacteria as well as yeast. AcrAP1 exerts antitumor activity by promoting apoptosis of cancer cells and inhibiting angiogenesis. AcrAP1 can be used in cancer therapy research ^[1].

HY-RS00777

AP1G1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP1G1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP1G1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP1G1 Human Pre-designed siRNA Set A AP1G1 Human Pre-designed siRNA Set A

HY-RS00781

AP1S1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP1S1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP1S1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP1S1 Human Pre-designed siRNA Set A AP1S1 Human Pre-designed siRNA Set A

HY-RS00779

AP1M1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP1M1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP1M1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP1M1 Human Pre-designed siRNA Set A AP1M1 Human Pre-designed siRNA Set A

HY-RS00780

AP1M2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP1M2 Human Pre-designed siRNA Set A contains three designed siRNAs for AP1M2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP1M2 Human Pre-designed siRNA Set A AP1M2 Human Pre-designed siRNA Set A

HY-RS00776

AP1B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP1B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP1B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP1B1 Human Pre-designed siRNA Set A AP1B1 Human Pre-designed siRNA Set A

HY-RS00778

AP1G2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP1G2 Human Pre-designed siRNA Set A contains three designed siRNAs for AP1G2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP1G2 Human Pre-designed siRNA Set A AP1G2 Human Pre-designed siRNA Set A

HY-RS00783

AP1S3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP1S3 Human Pre-designed siRNA Set A contains three designed siRNAs for AP1S3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP1S3 Human Pre-designed siRNA Set A AP1S3 Human Pre-designed siRNA Set A

HY-RS00782

AP1S2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP1S2 Human Pre-designed siRNA Set A contains three designed siRNAs for AP1S2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP1S2 Human Pre-designed siRNA Set A AP1S2 Human Pre-designed siRNA Set A

HY-15870

SR 11302 5+ Cited Publications	AP-1	Inflammation/Immunology Cancer
SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) ^[1].

HY-W008628S

Bisphenol AP-d5	Isotope-Labeled Compounds	Others
Bisphenol AP-d₅ is the deuterium labeled Bisphenol AP[1].

HY-15870A

(6E)-SR 11302	AP-1	Inflammation/Immunology Cancer
(6E)-SR 11302 is a E-isomer of SR 11302. SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE) ^[1].

HY-161389

SP-alkyne	Interleukin Related	Inflammation/Immunology
SP-alkyne (compound 8) suppresses IL-2 production and AP-1 and NFAT reporters ^[1].

HY-119418

Desketoraloxifene	Estrogen Receptor/ERR	Cancer
Desketoraloxifene is an estrogen receptors alpha (ERα) activator at an AP-1 site. Desketoraloxifene can be used for the research of osteoporosis and breast cancer ^[1].

HY-161390

SPC-alkyne	Interleukin Related	Inflammation/Immunology Cancer
SPC-alkyne (compound 9) is an alkynyl derivative. SPC-alkyne suppresses IL-2 production and AP-1 and NFAT reporters ^[1].

HY-N10926

(+)-Glaucarubinone	AP-1	Cancer
(+)-Glaucarubinone is a potent **AP-1 (activator protein-1) inhibitor with an EC₅₀** value of 0.13 µM. (+)-Glaucarubinone shows noncytotoxic ^[1].

HY-10072

SPC 839	NF-κB AP-1	Inflammation/Immunology
SPC 839 (compound 10) is an orally active inhibitor of *AP-1* and NF-kB mediated transcriptional activation with IC₅₀ of 0.008 μM ^[1].

HY-N4182

Licochalcone E 1 Publications Verification	Akt p38 MAPK Autophagy	Inflammation/Immunology
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation ^[1].

HY-N2907

Atranorin	Ras Endogenous Metabolite	Cancer
Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity ^[1] .

HY-122808

(-)-Camphoric acid	mGluR	Metabolic Disease
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression. Camphoric acid also significantly induced the activation of NF-κB and AP-1 ^[1].

HY-P1185

Antagonist G	Vasopressin Receptor Apoptosis	Cardiovascular Disease Cancer
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy ^[1] .

HY-P1185A

Antagonist G TFA	Vasopressin Receptor Apoptosis	Cancer
Antagonist G TFA is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy ^[1] .

HY-N1513

Ganoderic acid H	AP-1 NF-κB	Cancer
Ganoderic acid H is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderic acid H suppresses growth and invasive behavior of breast cancer cells through the inhibition of transcription factors AP-1 and NF-kappaB signaling ^[1].

HY-N10913

Chloranthalactone B	AP-1 p38 MAPK NO Synthase TNF Receptor COX Interleukin Related	Inflammation/Immunology
Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the *AP-1* and p38 MAPK pathways ^[1].

HY-N2907R

Atranorin (Standard)	Ras Endogenous Metabolite	Cancer
Atranorin (Standard) is the analytical standard of Atranorin. This product is intended for research and analytical applications. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity ^[1] .

HY-169751

Dihydro-N-caffeoyltyramine	Fungal AP-1	Infection Inflammation/Immunology Cancer
Dihydro-N-caffeoyltyramine is a new phenolic amide that can be isolated from the root bark of wolfberry and has strong antioxidant activity and antifungal effects. Dihydro-N-caffeoyltyramine downregulates the expression of cyclooxygenase-2 by inhibiting the activity of C/EBP and AP-1 transcription factors ^[1].

HY-155395

DDAN-MT	Fluorescent Dye	Infection
DDAN-MT is an enzymatic activated near-infrared fluorescent probe. DDAN-MT can be used for rapid, highly selective, and real-time monitoring of endogenous MtMET-AP1 activity in M. tuberculosis ^[1].

HY-12031B

(2Z,3Z)-U0126	MEK	Inflammation/Immunology
(2Z,3Z)-U0126 is a selective inhibitor of MEK1 and MEK2, demonstrating potent antiinflammatory effects by noncompetitively inhibiting AP-1 transcriptional activity with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. (2Z,3Z)-U0126 also inhibits anchorage-independent growth of Ki-ras-transformed rat fibroblasts by blocking both the extracellular signal-regulated kinase and mammalian target of rapamycin pathways. Additionally, (2Z,3Z)-U0126 can undergo isomerization and cyclization, resulting in various products that show reduced affinity for MEK and diminished AP-1 inhibition compared to the parent compound.

HY-169482

ALK protein ligand-1	Ligands for Target Protein for PROTAC Anaplastic lymphoma kinase (ALK)	Cancer
ALK protein ligand-1 (Compound A1), a ligand for the anaplastic lymphoma kinase (ALK) protein, is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) that exhibits inhibitory effects on ALK. ALK protein ligand-1 can be used in the synthesis of AP-1 (HY-169481) ^[1].

HY-129239

Farudodstat 2 Publications Verification ASLAN003	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Apoptosis	Cancer
Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC₅₀ of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice ^[1] .

HY-N0510

Aristolochic acid A 5+ Cited Publications Aristolochic acid I; TR 1736	NF-κB	Cancer
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines ^[1].

HY-100233A

IQ-1S	JNK	Inflammation/Immunology Cancer
IQ-1S is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC₅₀ of 1.8 μM. IQ-1 has binding affinity (K_d values) in the nanomolar range for all three JNKs with K_ds of 87 nM, 360 nM, and 390 nM for JNK3, JNK2, and *JNK1*, respectively.

HY-100233

IQ-1S free acid 1 Publications Verification	JNK	Inflammation/Immunology Cancer
IQ-1S free acid is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC₅₀ of 2.3±0.41 μM. IQ-1S free acid has binding affinity (K_d values) in the nanomolar range for all three JNKs with K_ds of 100 nM, 240 nM, and 360 nM for JNK3, *JNK1, and JNK2*, respectively.

HY-151876

Glucocorticoid receptor modulator 1	Glucocorticoid Receptor NF-κB AP-1	Inflammation/Immunology
Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC₅₀ value of 9 nM and 130 nM for NF-κB and *AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1*β, TNF-α, also can relieve dermatitis in mice ^[1].

HY-N0510R

Aristolochic acid A (Standard)	NF-κB	Cancer
Aristolochic acid A (Standard) is the analytical standard of Aristolochic acid A. This product is intended for research and analytical applications. Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines ^[1].

HY-110177

SP-100030 1 Publications Verification	NF-κB	Inflammation/Immunology
SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC₅₀s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA) ^[1] .

HY-W010983

SC-236 1 Publications Verification	COX PPAR Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
SC-236 is an orally active COX-2 specific inhibitor (IC₅₀ = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model ^[1] .

HY-121607

INI-43	AP-1 Apoptosis	Cancer
INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G₂-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway ^[1] .

HY-12270

T-5224 Maximum Cited Publications 73 Publications Verification	AP-1 MMP	Others
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription ^[1] .

HY-15131

PNRI-299	Interleukin Related	Inflammation/Immunology
PNRI-299 is a selective *AP-1* transcription inhibitor with an IC₅₀ of 20 uM. PNRI-299 is a selective *APE/Ref-1* inhibitor. PNRI-299 has no effect on NF-κB transcription or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model ^[1] .

HY-19357

E3330 3 Publications Verification APX-3330	DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species	Cardiovascular Disease Neurological Disease Cancer
E3330 (APX-3330) is a direct, orally active and selective inhibitor of **Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α** in pancreatic cancer. E3330 shows anticancer activities ^[1] .

HY-151883

APE1-IN-2	Apoptosis MDM-2/p53	Cancer
APE1-IN-2 (compound AP1) is a Pt(IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals ^[1].

HY-N6969A

Dicentrine hydrochloride	Adrenergic Receptor	Cancer
Dicentrine hydrochloride is a drug with anti-inflammatory and anti-cancer activity. Dicentrine hydrochloride exerts its effects by enhancing TNF-α-induced apoptosis in A549 lung adenocarcinoma cells. Dicentrine hydrochloride increases caspase-8, -9, -3 and poly(ADP-ribose) polymerase (PARP) activities. Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells. Dicentrine hydrochloride significantly inhibited the TNF-α-activated TAK1, p38, JNK and Akt signaling pathways, and reduced the transcriptional activities of NF-κB and AP-1 ^[1].

HY-B1984

p,p'-DDD 4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane	Drug Metabolite Apoptosis Necroptosis Insecticide	Others
p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats ^[1] .

HY-101259

BMS-195614 BMS 614	RAR/RXR Bcl-2 Family NF-κB PPAR VEGFR Interleukin Related	Cardiovascular Disease Inflammation/Immunology Endocrinology
BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a K_i of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, *AP-1* and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis ^[1] .

HY-113443

12(S)-HPETE	AP-1	Metabolic Disease
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension ^[1] .

HY-B1984R

p,p'-DDD (Standard) 4,4'-DDD (Standard); p,p'-Dichlorodiphenyl dichloroethane (Standard)	Drug Metabolite Apoptosis Necroptosis Insecticide	Others
p,p'-DDD (Standard) is the analytical standard of p,p'-DDD. This product is intended for research and analytical applications. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats.

HY-107574

TC-E 5003	Histone Methyltransferase AP-1 NF-κB PKA	Metabolic Disease Inflammation/Immunology Cancer
TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 1.5 µM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-κB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers ^[1] .

Cat. No.	Product Name

HY-L090

Transcription Factor-Targeted Library

1,715 compounds

Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential.

MCE offers a unique collection of 1,715 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

Cat. No.	Product Name	Type

HY-W016412

Coenzyme Q0

2 Publications Verification

CoQ0

Enzyme Substrates

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P1185

Antagonist G	Vasopressin Receptor Apoptosis	Cardiovascular Disease Cancer
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy ^[1] .

HY-P2036A

FSL-1 TFA 3 Publications Verification	Toll-like Receptor (TLR) MMP HSV Antibiotic	Infection
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection ^[1]. FSL-1 TFA induces MMP-9 production through TLR2 and *NF-κB/AP-1* signaling pathways in monocytic THP-1 cells .

HY-P10513

AcrAP1 AP1-Z1	Bacterial Fungal Apoptosis	Infection Cancer
AcrAP1 (AP1-Z1) is an antimicrobial peptide found in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP1 has antimicrobial activity and can inhibit the growth of Gram-positive and Gram-negative bacteria as well as yeast. AcrAP1 exerts antitumor activity by promoting apoptosis of cancer cells and inhibiting angiogenesis. AcrAP1 can be used in cancer therapy research ^[1].

HY-P1185A

Antagonist G TFA	Vasopressin Receptor Apoptosis	Cancer
Antagonist G TFA is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10926

(+)-Glaucarubinone	Structural Classification Simaroubaceae Source classification Coumarins Phenylpropanoids Plants Nothospondias staudtii Engl.	AP-1
(+)-Glaucarubinone is a potent **AP-1 (activator protein-1) inhibitor with an EC₅₀** value of 0.13 µM. (+)-Glaucarubinone shows noncytotoxic ^[1].

HY-N4182

Licochalcone E 1 Publications Verification	Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Plants Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Akt p38 MAPK Autophagy
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation ^[1].

HY-N2907

Atranorin	Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Cancer	Ras Endogenous Metabolite
Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity ^[1] .

HY-122808

(-)-Camphoric acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Cinnamomum glanduliferum (Wall.) Nees Metabolic Disease Plants Lauraceae Disease Research Fields	mGluR
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression. Camphoric acid also significantly induced the activation of NF-κB and AP-1 ^[1].

HY-N1513

Ganoderic acid H	Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	AP-1 NF-κB
Ganoderic acid H is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderic acid H suppresses growth and invasive behavior of breast cancer cells through the inhibition of transcription factors AP-1 and NF-kappaB signaling ^[1].

HY-N0510

Aristolochic acid A 5+ Cited Publications Aristolochic acid I; TR 1736	Alkaloids Structural Classification other families Aristolochia debilis Sieb. et Zucc. Classification of Application Fields Other Alkaloids Source classification Plants Aristolochiaceae Disease Research Fields Cancer	NF-κB
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines ^[1].

HY-N10913

Chloranthalactone B	Structural Classification Terpenoids Sesquiterpenes Source classification Sarcandra glabra (Thunb.) Nakai Chloranthaceae Plants	AP-1 p38 MAPK NO Synthase TNF Receptor COX Interleukin Related
Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the *AP-1* and p38 MAPK pathways ^[1].

HY-N2907R

Atranorin (Standard)	Structural Classification other families Source classification Phenols Polyphenols Plants Endogenous metabolite	Ras Endogenous Metabolite
Atranorin (Standard) is the analytical standard of Atranorin. This product is intended for research and analytical applications. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity ^[1] .

HY-N0510R

Aristolochic acid A (Standard)	Alkaloids Structural Classification other families Aristolochia debilis Sieb. et Zucc. Other Alkaloids Source classification Plants Aristolochiaceae	NF-κB
Aristolochic acid A (Standard) is the analytical standard of Aristolochic acid A. This product is intended for research and analytical applications. Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines ^[1].

HY-N6969A

Dicentrine hydrochloride	Structural Classification Alkaloids Other Alkaloids Source classification Stephania epigaea Lo Plants Menispermaceae	Adrenergic Receptor
Dicentrine hydrochloride is a drug with anti-inflammatory and anti-cancer activity. Dicentrine hydrochloride exerts its effects by enhancing TNF-α-induced apoptosis in A549 lung adenocarcinoma cells. Dicentrine hydrochloride increases caspase-8, -9, -3 and poly(ADP-ribose) polymerase (PARP) activities. Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells. Dicentrine hydrochloride significantly inhibited the TNF-α-activated TAK1, p38, JNK and Akt signaling pathways, and reduced the transcriptional activities of NF-κB and AP-1 ^[1].

HY-113443

12(S)-HPETE	Microorganisms Source classification	AP-1
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension ^[1] .

HY-13755A

(R)-Sulforaphane L-SulforAPhane	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species NF-κB
(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and *AP-1*. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses ^[1] .

HY-N3261

Methyllinderone	Structural Classification Flavonoids Source classification Lindera erythrocarpa Makino Plants Lauraceae Other Flavonoids	AP-1 ERK STAT
Methyllinderone is an inhibitor of *AP-1/STAT/ERK*. Methyllinderone has anti-inflammatory effect. Methyllinderone reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Methyllinderone can be used in study breast cancer metastasis ^[1].

HY-N6868

Dimethyl lithospermate B dmLSB	Cardiovascular Disease Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields	Sodium Channel
Dimethyl lithospermate B (dmLSB) is a selective Na ⁺ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP) .

HY-N4226

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid	Structural Classification Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	AP-1
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function ^[1].

HY-N1190

DL-Syringaresinol (±)-Syringaresinol	Structural Classification Source classification Lignans Phenylpropanoids Plants Lauraceae Lindera akoensis Hay.	p38 MAPK AP-1 Bacterial
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing *MAPK/AP-1* signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv ^[1] .

HY-N1326

Santamarine Santamarin; Balchanin	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Magnoliaceae Plants Inflammation/Immunology Disease Research Fields Magnolia grandiflora L.	Keap1-Nrf2
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities ^[1] .

Cat. No.	Compare	Product Name	Species	Source

HY-P702589

	JUN Protein, Human (His, Myc) Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	Human	E. coli

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Cat. No.	Product Name	Chemical Structure

HY-W008628S

Bisphenol AP-d5
Bisphenol AP-d₅ is the deuterium labeled Bisphenol AP[1].

HY-B1984S

p,p'-DDD-d8

p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80800

	Phospho-c-Jun (Ser243) Antibody Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser243) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 36 kDa, targeting to Phospho-c-Jun (Ser243). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80801

	Phospho-c-Jun (Ser63) Antibody Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser63) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-c-Jun (Ser63). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80802

	Phospho-c-Jun (Ser73) Antibody Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser73) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 36 kDa, targeting to Phospho-c-Jun (Ser73). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P83248

	gamma Adaptin Antibody (YA2993) ADTG; AP1G1; CLAPG1	WB, IHC-P	Human, Mouse, Rat
	gamma Adaptin Antibody (YA2993) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2993), targeting gamma Adaptin, with a predicted molecular weight of 91 kDa (observed band size: 100 kDa). gamma Adaptin Antibody (YA2993) can be used for WB, IHC-P experiment in human, mouse, rat background.

HY-P80649

	eIF1A Antibody EIF1A; EIF4C; eIF-1A; eIF-4C; EIF1AP1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	eIF1A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 16 kDa, targeting to eIF1A. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82861

	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) JUN; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39; JUND; Transcription factor jun-D	WB, IP	Human, Mouse, Rat
	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2606), targeting Phospho-Jun/JunD (Ser73/Ser100), with a predicted molecular weight of 36 kDa (observed band size: 38,42,48 kDa). Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) can be used for WB, IP experiment in human, mouse, rat background.

HY-P83342

	Phospho-JunD (Ser255) Antibody (YA3087) Activator protein 1; AP 1; Jun D; jun D proto oncogene; Jund; JunD FL isoform; Transcription factor jun D	WB, IP	Human, Mouse, Rat
	Phospho-JunD (Ser255) Antibody (YA3087) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3087), targeting Phospho-JunD (Ser255), with a predicted molecular weight of 35 kDa (observed band size: 38,42 kDa). Phospho-JunD (Ser255) Antibody (YA3087) can be used for WB, IP experiment in human, mouse, rat background.