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Results for "

Arrestin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arrestin (30) 5-HT Receptor (9) Adenosine Receptor (3) Adrenergic Receptor (6) Angiotensin Receptor (2) Apelin Receptor (APJ) (9) Apoptosis (1) Cannabinoid Receptor (6) CCR (2) Chemerin Receptor (1) CXCR (13) Dopamine Receptor (13) Endogenous Metabolite (1) ERK (2) Fluorescent Dye (1) Free Fatty Acid Receptor (3) G Protein-coupled Receptor Kinase (GRK) (1) GHSR (2) GLP Receptor (1) GPR35 (6) GPR55 (3) Histamine Receptor (2) HIV (2) Hydroxycarboxylic Acid Receptor (HCAR) (1) Insulin Receptor (1) Interleukin Related (1) Ligands for Target Protein for PROTAC (1) LXR (1) mAChR (1) Mas-related G-protein-coupled Receptor (MRGPR) (2) Melatonin Receptor (1) Neuropeptide Y Receptor (1) Neurotensin Receptor (3) Opioid Receptor (8) Orphan Receptor (1) Oxytocin Receptor (1) P2Y Receptor (2) PKC (1) Prostaglandin Receptor (1) Protease Activated Receptor (PAR) (1) PTHR (2) Reference Standards (2) RXFP Receptor (1) Small Interfering RNA (siRNA) (1) Succinate Receptor 1 (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (19) Endocrinology (10) Infection (2) Inflammation/Immunology (26) Metabolic Disease (13) Neurological Disease (40)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) siRNAs (1)

108

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

UNC9994 1 Publications Verification	Dopamine Receptor 5-HT Receptor Histamine Receptor Arrestin	Neurological Disease
UNC9994, an analog of Aripiprazole, is a functionally selective *β-arrestin-biased dopamine D2 receptor* (D2R) agonist with EC₅₀ <10 nM for β-arrestin-2 recruitment to D2 receptors. UNC9994 is simultaneously partial agonists of β-arrestin-2 translocation and antagonists of G_i-regulated cAMP production. Antipsychotic Activity .

UNC9994 hydrochloride 1 Publications Verification	Dopamine Receptor 5-HT Receptor Arrestin	Neurological Disease
UNC9994 hydrochloride is a functionally selective, *β-arrestin–biased* dopamine D₂ receptor (D₂R) agonist that selectively activates β-arrestin recruitment and signaling. UNC9994 hydrochloride shows a binding affinity with a K_i of 79 nM for D₂R. UNC9994 hydrochloride is also an antagonist of G_i-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9994 hydrochloride shows antipsychotic-like activity .

Barbadin Maximum Cited Publications 11 Publications Verification	Apoptosis Arrestin	Others
Barbadin is a novel and selective *β-arrestin/β2-adaptin* interaction inhibitor, has IC₅₀ values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis .

UNC9995	Dopamine Receptor	Inflammation/Immunology
UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing *β-arrestin2-NLRP3* interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the *Drd2/β-arrestin2* signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions .

CCX-777	Arrestin	Cancer
CCX-777 is a partial agonist of *β-arrestin-2* recruitment to ACKR3 (atypical chemokine receptor 3) .

FGH31	Dopamine Receptor Arrestin G Protein-coupled Receptor Kinase (GRK)	Neurological Disease
FGH31 (Compound 24) is a potent, selective, GRK2 dependency dopamine D4 agonist, with the K_i of 1.6 nM. FGH31 partial activates β- arrestin .

CMKLR1 antagonist 3	Chemerin Receptor	Metabolic Disease Inflammation/Immunology
CMKLR1 antagonist 3 (Compound VU0514009) is a competitive chemokine-like receptor 1 (CMKLR1) antagonist (EC₅₀=2 nM). CMKLR1 antagonist 3 prevents chemerin-9-induced arrestin recruitment and receptor internalization, significantly reducing Ca ²⁺ flux response in HEK293 cells. CMKLR1 antagonist 3 is promising for research of inflammatory diseases and metabolic syndrome .

UNC9975	Dopamine Receptor	Neurological Disease
UNC9975 is a D₂R agonist that displays signaling bias via β-arrestin–ergic signaling and a simultaneously antagonist of Gi-regulated cAMP production and partial agonist for D₂R/β-arrestin-2 interactions. UNC9975 can be utilized in antipsychotic research .

Sag Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sag Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sag gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

UNC0006	Dopamine Receptor	Neurological Disease
UNC0006 is a β-arrestin-biased dopamine D2 ligand. UNC0006 can be used in the study of antipsychotic .

IHCH-7086	5-HT Receptor	Neurological Disease
IHCH-7086 is a β-arrestin-biased 5-HT_2A serotonin receptor agonist (K_i: 12.59 nM). IHCH-7086 recruits β-arrestin through activation of 5-HT2A receptors, thereby removing hallucinogenic activity. IHCH-7086 improves depression-like behavior in mice without hallucinogenic effects .

Noncatechol agonist-1	Dopamine Receptor	Neurological Disease
Noncatechol agonist-1 (19) is a Noncatechol agonist with full efficacy at both D1R-G protein and D1R-β-arrestin2 pathways, with pEC₅₀ values of 8.41 for D1R-mediated cAMP production and 7.7 for β-arrestin2 recruitment, respectively .

D1R antagonist 1	Dopamine Receptor	Neurological Disease
D1R antagonist 1 (compound 12a) is a D1R antagonist, involved in G-protein- and β-arrestin-based signaling .

(Rac)-Tavapadon (Rac)-PF-06649751; (Rac)-CVL-751	Dopamine Receptor Arrestin	Neurological Disease
(Rac)-Tavapadon ((Rac)-PF-06649751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the *β-arrestin2* recruitment assay (GS-cAMP, EC₅₀=0.8 nM; β-arrestin2, EC₅₀=68 nM). (Rac)-Tavapadon has antiparkinsonian activity .

TRV-120027 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027, a *β-arrestin-1*-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling . TRV120027?induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the?acute decompensated heart failure (ADHF) treatment .

TRV-120027 TFA 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027 TFA, a *β-arrestin-1*-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling . TRV120027?TFA induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the?acute decompensated heart failure (ADHF) treatment .

M4 mAChR Modulator-1	mAChR	Neurological Disease
M4 mAChR Modulator-1 (compound 23i) is a M4 mAChR positive allosteric modulator (PAM). M4 mAChR Modulator-1 exhibits significantly greater cooperativity with ACh in β-arrestin recruitment over G protein activation. M4 mAChR Modulator-1 displays weak PAM effect in G protein-mediated responses, but strong PAM effect in β-arrestin recruitment .

CID 2745687	GPR35	Cardiovascular Disease Inflammation/Immunology
CID 2745687 acts as a specific, reversible and competitive GPR35 antagonist with a K_i of 12.8 nM .

NCGC00135472	Arrestin	Inflammation/Immunology
NCGC00135472 is a potent agonist of resolvin D1 receptor (DRV1), with the EC₅₀ of 0.37 nM and 0.05 μM for β-arrestin and cAMP activities, respectively .

ML192	GPR55 PKC ERK Arrestin	Metabolic Disease
ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the *β-arrestin* trafficking, ERK1/2 phosphorylation and PKCβII translocation .

GPR35 agonist 2	GPR35 Arrestin	Metabolic Disease Inflammation/Immunology
GPR35 agonist 2 (compound 11) is a potent agonist of GPR35, with EC₅₀s of 26 and 3.2 nM in the *β-arrestin* and Ca ²⁺ release assay, respectively .

PSB-22034	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
PSB-22034 (compound 30d) is a selective agonist of MRGPRX4 with EC₅₀s of 11.2 nM and 30.0 nM in Ca ²⁺ and β-arrestin experiments, respectively .

tBPC	Neuropeptide Y Receptor	Metabolic Disease
tBPC is a selective positive allosteric modulator for human Y4 receptor (Y4R), which enhances the activation of Y4R in G protein signaling and arrestin3 recruitment .

AAA	Orphan Receptor	Cardiovascular Disease
AAA is a potent blocker of 20-Hydroxyeicosatetraenoic acid (20-HETE) receptor that binds directly to GPR75 and prevents the increases in intracellular Ca2+, IP-1 and β-arrestin .

cis-Epoxysuccinic acid 2 Publications Verification	Succinate Receptor 1	Cardiovascular Disease
cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC₅₀ value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system .

VIP36	Cannabinoid Receptor	Neurological Disease
VIP36 is an agonist of cannabinoid receptor type 1 (CB1) and has analgesic activity. VIP36 exerts its analgesic activity by reducing the recruitment of arrestin proteins and can be used for research in the field of chronic pain .

LIH383	CXCR	Neurological Disease Inflammation/Immunology
LIH383 is an agonist of ACKR3 (CXCR7) (EC₅₀=0.61 nM). LIH383 efficiently induces the recruitment of β-arrestin to ACKR3 but does not trigger typical G protein signaling .

GPR55 agonist 4	GPR55	Cancer
GPR55 agonist 4 (Compound 28) is a GPR55 agonist (EC₅₀: 131 nM, and 1.41 nM for hGPR55 and rGPR55). GPR55 agonist 4 induces β-arrestin recruitment to human GPR55 .

CYT-1010 hydrochloride	Opioid Receptor	Neurological Disease
CYT-1010 hydrochloride is a mu-opioid receptor agonist extracted from patent WO2013173730A2, with EC₅₀s of 13.1 nM and 0.0053 nM on beta-arrestin recruitment and inhibition of cAMP production, respectively .

VUF11207 TFA	CXCR	Endocrinology
VUF11207 (Compound 29) TFA is a CXCR7 agonist (pK_i of 8.1) that induces recruitment of *β-arrestin2* (pEC₅₀ of 8.8) and subsequent internalization (pEC₅₀ of 7.9) of CXCR7 .

CYT-1010	Opioid Receptor	Neurological Disease
CYT-1010 is a mu-opioid receptor agonist extracted from patent WO2013173730A2, with EC₅₀s of 13.1 nM and 0.0053 nM on beta-arrestin recruitment and inhibition of cAMP production, respectively .

ELA-11(human)	Apelin Receptor (APJ) Arrestin	Inflammation/Immunology
ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pK_i of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates *β-arrestin* recruitment .

5-OxoETE methyl ester	Hydroxycarboxylic Acid Receptor (HCAR)	Inflammation/Immunology Cancer
5-OxoETE methyl ester is the agonist for oxoeicosanoid receptor 1 (OXER1). 5-OxoETE methyl ester binds to OXER1, and activates downstream signaling pathways *β-arrestin* recruitment with an EC₅₀** of 1.54 µM .

7-Fluorotryptamine hydrochloride	Arrestin	Inflammation/Immunology Cancer
7-Fluorotryptamine hydrochloride is a potent agonist of GPRC5A. 7-Fluorotryptamine hydrochloride induces GPRC5A-mediated β-arrestin recruitment. 7-Fluorotryptamine hydrochloride can be used for research of immune and cancer signaling .

MRS5663	Adenosine Receptor	Cardiovascular Disease
MRS5663 (Compound 3a) is an A3AR agonist, with an EC₅₀ of 5.62 nM for β-arrestin2 recruitment assay. MRS5663 has a cytoprotective effect on skeletal muscle ischemia-reperfusion injury/claudication model .

LIH383 TFA	CXCR	Neurological Disease Inflammation/Immunology
LIH383 TFA is an agonist of ACKR3 (CXCR7) (EC₅₀=0.61 nM). LIH383 TFA efficiently induces the recruitment of β-arrestin to ACKR3 but does not trigger typical G protein signaling .

GPR120 Agonist 4	Free Fatty Acid Receptor	Metabolic Disease
GPR120 Agonist 4 (example 1) is a GPR120 agonist，with the EC₅₀ values of 1 μM and 0.35 μM for *β-arrestin* A and Calcium A**. GPR120 Agonist 4 can be used for the research of type II diabetes mellitus .

ML339 1 Publications Verification	CXCR Apelin Receptor (APJ) Arrestin	Cancer
ML339 is a selective CXCR6 antagonist with an IC₅₀ of 140 nM. ML339 antagonizes *β-arrestin* recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC₅₀ of 0.3 μM and 1.4 μM, respectively. ML339 shows weaker activity against the recruitment of *β-arrestin* in mouse CXCR6 receptors, with an IC₅₀ of 18 μM. ML339 has no inhibitory effect on CXCR5，CXCR4，CXCR6 and apelin receptor (APJ), with IC₅₀ >79 μM. ML339 has the potential to promote the development of prostate cancer research .

VUF11207 2 Publications Verification	CXCR	Endocrinology
VUF11207 (Compound 29) is a CXCR7 agonist and a high-potency CXCR7 (pK_i of 8.1) ligand that induces recruitment of *β-arrestin2* (pEC₅₀ of 8.8) and subsequent internalization (pEC₅₀ of 7.9) of CXCR7 .

GPR55 agonist 3	GPR55	Cancer
GPR55 agonist 3 (Compound 26) is a GPR55 agonist (EC₅₀: 0.239 nM, and 1.76 nM for hGPR55 and rGPR55). GPR55 agonist 3 induces β-arrestin recruitment to human GPR55 (EC₅₀: 6.2 nM) .

(Val3,Pro8)-Oxytocin	Oxytocin Receptor	Endocrinology
(Val3,Pro8)-Oxytocin is the Gq-dependent pathway agonist. (Val3,Pro8)-Oxytocin is also a weaker agonist for the *β-arrestin* engagement and endocytosis toward the oxytocin receptor (OXTR) .

APJ receptor agonist 6	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with K_i of 1.3 μM. APJ receptor agonist 6 has EC₅₀ values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and *β-arrestin*, respectively .

CB1R Allosteric modulator 3	Cannabinoid Receptor Arrestin	Neurological Disease
CB1R Allosteric modulator 3 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and *β-Arrestin* with EC₅₀ values of 0.018 μM and 1.241 μM, respectively .

UNC10099984A	Dopamine Receptor	Neurological Disease
UNC10099984A (Compound 6) is a functionally selective ligand for the dopamine D₂ receptor, with a K_i value of 4.6 nM and an EC₅₀ value of 6.2 nM for *β-arrestin. UNC10099984A can be used for research into central nervous system disorders related to the D₂ receptor* .

ML221 5+ Cited Publications	Arrestin Apelin Receptor (APJ)	Neurological Disease
ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC₅₀s of 0.70 μM in the cAMP assay, and 1.75 μM in the *β-arrestin* assay, and EC₈₀ of 10 nM in both assays.

ELA-21 (human)	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
ELA-21 (human) is an apelin receptor agonist with a pK_i of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates *β-arrestin* recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways .

Cat. No.	Product Name	Target	Research Area

HY-P2141

TRV-120027 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027, a *β-arrestin-1*-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling . TRV120027?induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the?acute decompensated heart failure (ADHF) treatment .

HY-P2141A

TRV-120027 TFA 3 Publications Verification	Angiotensin Receptor Arrestin	Cardiovascular Disease
TRV120027 TFA, a *β-arrestin-1*-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling . TRV120027?TFA induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the?acute decompensated heart failure (ADHF) treatment .

HY-P2197

ELA-11(human)	Apelin Receptor (APJ) Arrestin	Inflammation/Immunology
ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pK_i of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates *β-arrestin* recruitment .

HY-P10333A

LIH383 TFA	CXCR	Neurological Disease Inflammation/Immunology
LIH383 TFA is an agonist of ACKR3 (CXCR7) (EC₅₀=0.61 nM). LIH383 TFA efficiently induces the recruitment of β-arrestin to ACKR3 but does not trigger typical G protein signaling .

HY-P2249

ELA-21 (human)	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
ELA-21 (human) is an apelin receptor agonist with a pK_i of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates *β-arrestin* recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways .

HY-108742

Abaloparatide 1 Publications Verification BA 058; BIM 44058	PTHR Arrestin	Metabolic Disease Cancer
Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and *β-arrestin* recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis .

HY-P1102

TC14012 3 Publications Verification	CXCR HIV	Infection Cancer
TC14012, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity .

HY-P10333

LIH383	CXCR	Neurological Disease Inflammation/Immunology
LIH383 is an agonist of ACKR3 (CXCR7) (EC₅₀=0.61 nM). LIH383 efficiently induces the recruitment of β-arrestin to ACKR3 but does not trigger typical G protein signaling .

HY-P5017

(Val3,Pro8)-Oxytocin	Oxytocin Receptor	Endocrinology
(Val3,Pro8)-Oxytocin is the Gq-dependent pathway agonist. (Val3,Pro8)-Oxytocin is also a weaker agonist for the *β-arrestin* engagement and endocytosis toward the oxytocin receptor (OXTR) .

HY-138951

AY77	Protease Activated Receptor (PAR)	Inflammation/Immunology Cancer
AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC₅₀ of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca ²⁺ release .

HY-P2197A

ELA-11(human) TFA	Apelin Receptor (APJ)	Inflammation/Immunology
ELA-11(human) TFA is a high affinity apelin receptor agonist (K_i=14 nM). ELA-11(human) TFA is a bioactive fragment of ELA-32. ELA-11(human) TFA inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.

HY-108742A

Abaloparatide TFA 1 Publications Verification BA 058 TFA; BIM 44058 TFA	Arrestin PTHR	Metabolic Disease Endocrinology Cancer
Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and *β-arrestin* recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis .

HY-P1102A

TC14012 TFA	CXCR HIV	Infection Cancer
TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC₅₀ of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist with an EC₅₀ of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has anti-HIV activity and anti-cancer activity .

HY-P2106

Elabela(19-32) 4 Publications Verification	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the G_αi1 and *β-arrestin-2* signaling pathways with EC₅₀s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .

HY-P2106A

Elabela(19-32) TFA 4 Publications Verification	Apelin Receptor (APJ) Arrestin	Cardiovascular Disease
Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the G_αi1 and *β-arrestin-2* signaling pathways with EC₅₀s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .

HY-P1682

Balixafortide POL6326	CXCR Arrestin	Cancer
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide blocks *β-arrestin* recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

HY-P1682A

Balixafortide TFA 1 Publications Verification POL6326 TFA	CXCR Arrestin	Cancer
Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC₅₀ < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks *β-arrestin* recruitment and calcium flux with IC₅₀s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .

Species:	Human (2)
Tag:	His (2)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71781

	SAG Protein, Human (P.pastoris, His) 48kDa protein; Arrestin 1; Arrestin; ARRS_HUMAN; S antigen; S Arrestin; S-AG; S-Arrestin; SAG	Human	P. pastoris
	SAG proteins play a crucial role in phototransduction, regulating signal transduction by binding to light-activated and phosphorylated rhodopsin (RHO). It terminates RHO signaling by competitively interacting with G proteins at the same binding site on RHO. SAG Protein, Human (P.pastoris, His) is the recombinant human-derived SAG protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P7606

	*ARRB1/Beta-Arrestin* 1 Protein, Human (His)** rHuARRB1/beta-Arrestin 1, His; ARRB1, β-Arrestin 1	Human	E. coli
	ARRB1/Beta-Arrestin 1 Protein, Human (His) expresses in E. coli with a His tag. ARRB1/beta-Arrestin 1, found in the hypothalamus (ARH) and in N-38 neurons, is a scaffolding protein organizing downstream signaling molecules and as an adaptor protein aiding in ER internalization after its activation.

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HY-P85419

	Arrestin-β-2 Antibody (YA5111) ARRB2; ARB2; ARR2; Beta-Arrestin-2; Arrestin beta-2	WB, ICC/IF	Human, Mouse, Rat, Pig
	Arrestin-β-2 Antibody (YA5111) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Arrestin-β-2. It can be applicated for WB, ICC/IF assays, in the background of human, mouse, rat, pig.

HY-P80569

	*beta Arrestin* 1 Antibody (YA822)** ARB1; ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-Arrestin-1.	WB	Human
	beta Arrestin 1 Antibody (YA822) is a non-conjugated and Mouse origined monoclonal antibody about 47 kDa, targeting to beta Arrestin 1 (6A1). It can be used for WB assays with tag free, in the background of Human.

HY-P85544

	*β-Arrestin* 1 Antibody (YA5236)** ARB 1; ARB 1; ARB1; ARB1; ARR 1; ARR 1; ARR1; ARR1; ARRB 1; ARRB1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-Arrestin-1.	WB	Mouse, Rat, Human
	β-Arrestin 1 Antibody (YA5236) is a mouse-derived and non-conjugated monoclonal antibody, targeting to β-Arrestin 1. It can be applicated for WB assays, in the background of mouse, rat, human.

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HY-155480

PSB-22034		Alkynes
PSB-22034 (compound 30d) is a selective agonist of MRGPRX4 with EC₅₀s of 11.2 nM and 30.0 nM in Ca ²⁺ and β-arrestin experiments, respectively .

Cat. No.	Product Name		Classification

HY-RS16512

Sag Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sag Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sag gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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