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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA cleavage

" in MedChemExpress (MCE) Product Catalog:

52

Inhibitors & Agonists

5

Peptides

8

Natural
Products

2

Isotope-Labeled Compounds

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19024
    Merbarone

    NSC 336628

    		 Topoisomerase Cancer
    Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent .
    Merbarone
  • HY-108882
    DNase I, Bovine pancreas
    Maximum Cited Publications
    11 Publications Verification

    DNAse

    		 Others Inflammation/Immunology Cancer
    DNase I (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer .
    DNase I, Bovine pancreas
  • HY-100951
    Beaucage reagent
    1 Publications Verification

    		 DNA/RNA Synthesis Cancer
    Beaucage reagent is found to be potent in causing DNA cleavage .
    Beaucage reagent
  • HY-N5048
    Galloylpaeoniflorin

    6'-O-Galloyl paeoniflorin

    		 NF-κB Others
    Galloylpaeoniflorin is a NF-κB inhibitor . And Galloylpaeoniflorin is a inhibitor of DNA cleavage .
    Galloylpaeoniflorin
  • HY-18350
    Indimitecan

    LMP776

    		 Topoisomerase Cancer
    Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities .
    Indimitecan
  • HY-148649
    Demethyl bleomycin A2

    		Antibiotic Others
    Demethyl bleomycin A2 is a Bleomycin (HY-108345) congener. The DNA cleavage of demethyl bleomycin A2 is insensitive to the presence of 5-Methylcytidine (HY-113135) .
    Demethyl bleomycin A2
  • HY-113642
    CP-67804

    		Topoisomerase Cancer
    CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent .
    CP-67804
  • HY-N12129
    6,6′-Dihydroxythiobinupharidine

    		Cathepsin Others
    6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively .
    6,6′-Dihydroxythiobinupharidine
  • HY-120185
    Saintopin

    UCT-1003

    		 Topoisomerase Infection Cancer
    Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage .
    Saintopin
  • HY-18350A
    Indimitecan hydrochloride

    LMP776 hydrochloride

    		 Topoisomerase Cancer
    Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities .
    Indimitecan hydrochloride
  • HY-13618
    Edotecarin

    J 107088; PF 804950

    		 Topoisomerase Cancer
    Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM.
    Edotecarin
  • HY-171029
    C902

    		Amino Acid Derivatives Others
    C902 is a cysteine residue in the RAG1 protein, that binds to Zn 2+ ion and contributes to the DNA cleavage .
    C902
  • HY-N0499A
    Cyanidin

    		Others Inflammation/Immunology
    Cyanidin, an antioxidant, has protective effect on DNA cleavage, free radical scavenging activity and significant inhibition of XO activity .
    Cyanidin
  • HY-113915
    Kuguaglycoside C

    		Apoptosis Neurological Disease Cancer
    Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF) .
    Kuguaglycoside C
  • HY-126490
    Phleomycin
    1 Publications Verification

    		 Bacterial Antibiotic DNA/RNA Synthesis Infection Cancer
    Phleomycin is an anticancer glycopeptide antibiotic found in Streptomyces verticillus, which cause DNA cleavage. Phleomycin binds and intercalates DNA to damage the integrity of the double helix, which is similar to Bleomycin (HY-17565A) .
    Phleomycin
  • HY-164062
    LZCap AG(3'Acm) Cas9 mRNA

    		CRISPR/Cas9 Others
    The Cas9 protein, guided by sgRNA, induces DNA double-strand breaks (DSBs) at specific genomic locations, activating the cell's endogenous DNA repair mechanisms, non-homologous end joining (NHEJ), or homology-directed repair (HDR), for repairing the targeted DSBs, enabling genome DNA target recognition and cleavage. LZCap AG(3'Acm) Cas9 mRNA can be used together with purified sgRNA for CRISPR/Cas genome editing, where the expressed Cas9 protein acts in conjunction with sgRNA to perform cleavage.
    LZCap AG(3'Acm) Cas9 mRNA
  • HY-118581
    Coralyne chloride
    1 Publications Verification

    		 Topoisomerase Cancer
    Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes .
    Coralyne chloride
  • HY-120173
    Ro 47-3359

    		Topoisomerase Others
    Ro 47-3359 is a pyrimido[1,6-a]benzimidazole compound with the activity of enhancing eukaryotic topoisomerase II-mediated DNA cleavage and being toxic to Kc cells.
    Ro 47-3359
  • HY-141867
    Z-FF-FMK

    Z-Phe-Phe-FMK

    		 Cathepsin Neurological Disease
    Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .
    Z-FF-FMK
  • HY-123786
    NSC745887

    		Apoptosis Caspase Cancer
    NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances γH2AX expression and causes DNA fragmentation leading to DNA damage .
    NSC745887
  • HY-W097867
    8-Methoxyciprofloxacin

    8-Methoxy-cipro

    		 Bacterial Infection
    8-Methoxyciprofloxacin (8-Methoxy-cipro) induces DNA cleavage mediated by wild-type gyrase and Quinolone-resistant mutants. 8-Methoxyciprofloxacin can be used for research of drug resistance .
    8-Methoxyciprofloxacin
  • HY-19296
    BDCRB

    2-Bromo-5,6-dichloro-1-β-D-ribofuranosyl benzimidazole

    		 CMV Infection
    BDCRB is a selective Human cytomegalovirus (HCMV) inhibitor through blocking the maturational cleavage of high-molecular-weight DNA. BDCRB shows a mean IC50 of 0.03 μM for viral yield at 72 h postinfection .
    BDCRB
  • HY-108882C
    DNase I (filtered)

    		DNA/RNA Synthesis Others
    DNase I (filtered) (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer . Filtered through a 0.22 μM filter, not tested for pyrogenicity.
    DNase I (filtered)
  • HY-113091
    Alpha-Tocotrienol

    		Apoptosis Neurological Disease
    Alpha-Tocotrienol is a vitamin E analog with anti-apoptotic neuroprotective action and antioxidant properties. Alpha-Tocotrienol prevents oxidative stress-independent apoptotic cell death, DNA cleavage, and nuclear morphological changes .
    Alpha-Tocotrienol
  • HY-108882A
    Recombinant DNase I (RNase-free)
    Maximum Cited Publications
    11 Publications Verification

    		 Endonuclease Others
    Recombinant DNase I (RNase-free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I is essential for limiting inflammatory responses and maintaining homeostasis .
    Recombinant DNase I (RNase-free)
  • HY-N6865
    Groenlandicine
    2 Publications Verification

    		 Topoisomerase Metabolic Disease Cancer
    Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR) . Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage .
    Groenlandicine
  • HY-136251
    BRD0539

    		CRISPR/Cas9 Infection
    BRD0539 is a cell-permeable and non-toxic inhibitor of CRISPR-Cas9. BRD0539 inhibits Streptococcus pyogenes Cas9 (SpCas9) (apparent IC50=22 μM) in an in vitro DNA cleavage assay .
    BRD0539
  • HY-155693
    Topoisomerase II inhibitor 16

    		Topoisomerase Parasite Infection
    Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research .
    Topoisomerase II inhibitor 16
  • HY-13945
    NVP 231
    3 Publications Verification

    		 Apoptosis Cancer
    NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC50=12 nM) that competitively inhibits binding of ceramide to CerK . NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage .
    NVP 231
  • HY-108882B
    DNase I RNase & Protease free

    		DNA/RNA Synthesis Others
    DNase I (RNase & Protease free) (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer . Molecular biology grade, chromatographically purified to remove RNases and proteases. Supplied as a solution containing 50% glycerol and 1 mM Calcium chloride.
    DNase I RNase & Protease free
  • HY-W130236
    Methylene Violet 3RAX

    		Cholinesterase (ChE) Cancer
    Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy) .
    Methylene Violet 3RAX
  • HY-108882D
    Recombinant DNase I Protease & RNase free, animal free

    		DNA/RNA Synthesis Others
    Recombinant DNase I (Protease & RNase free, animal free) (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer . This product is recombinant bovine pancreatic DNase I, purified by chromatography, free of animal-derived components, RNase and protease, and contains glycine as a stabilizer.
    Recombinant DNase I Protease & RNase free, animal free
  • HY-146437
    Topoisomerase I inhibitor 6

    		Topoisomerase Cancer
    Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases .
    Topoisomerase I inhibitor 6
  • HY-113056AS
    N1-Acetylspermidine-d6 hydrochloride

    		Endogenous Metabolite Cancer
    N1-Acetylspermidine-d6 (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA[1][2][3].
    N1-Acetylspermidine-d6 hydrochloride
  • HY-50936S
    Trabectedin-d3

    Ecteinascidin 743-d3; ET-743-d3

    		 Isotope-Labeled Compounds Reactive Oxygen Species Apoptosis Inflammation/Immunology Cancer
    Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .
    Trabectedin-d3
  • HY-113056A
    N1-Acetylspermidine hydrochloride

    		Endogenous Metabolite Cancer
    N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA .
    N1-Acetylspermidine hydrochloride
  • HY-P3473
    Evybactin

    		Bacterial DNA/RNA Synthesis Infection
    Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity .
    Evybactin
  • HY-103293
    Lys-Bradykinin

    Kallidin (380-389) (human, porcine, bovine)

    		 Bradykinin Receptor Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Lys-Bradykinin, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin involves in vascular regulation, inflammation and pain sensation .
    Lys-Bradykinin
  • HY-159162A
    7-(2-Aminoethyl)camptothecin TFA

    7CPT TFA

    		 Drug Derivative Others
    7-(2-Aminoethyl)camptothecin TFA (7CPT TFA) is the TFA salt form of Camptothecin (HY-16560) derivative 7-(2-Aminoethyl)camptothecin (HY-159162). 7-(2-Aminoethyl)camptothecin TFA can be used for synthesis of conjugate with triple helix-forming oligonucleotides (TFOs) and camptothecin (CPT). The TFO-CPT conjugate is used for DNA cleavage .
    7-(2-Aminoethyl)camptothecin TFA
  • HY-155070
    SRE-II

    		DNA/RNA Synthesis Apoptosis Cancer
    SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer .
    SRE-II
  • HY-147959
    Antibacterial agent 114

    		Bacterial Infection
    Antibacterial agent 114 (compound 1) is a potent antibacterial agent. Antibacterial agent 114 shows antibacterial activity against P.aeruginosa, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, S.mutans, and S.aureus microorganisms, with MIC values of 625, 625, 625, 625, 625, 1250 and 1250 μM, respectively .
    Antibacterial agent 114
  • HY-147958
    Antibacterial agent 113

    		Bacterial Infection
    Antibacterial agent 113 (compound 3) is a potent antibacterial agent. Antibacterial agent 113 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values all of 156.25 μM .
    Antibacterial agent 113
  • HY-147957
    Antibacterial agent 112

    		Bacterial Infection
    Antibacterial agent 112 (compound 2) is a potent antibacterial agent. Antibacterial agent 112 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values of 625, 625, 1250, 1250, 1250, 1250 and 1250 μM, respectively .
    Antibacterial agent 112
  • HY-107545
    Dynole 34-2
    1 Publications Verification

    		 Dynamin Apoptosis Cancer
    Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME) .
    Dynole 34-2
  • HY-147291
    VPC-70063

    		c-Myc PARP Apoptosis Cancer
    VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer .
    VPC-70063
  • HY-103293B
    Lys-Bradykinin tetraacetate

    Kallidin (380-389) (human, porcine, bovine) tetraacetate

    		 Bradykinin Receptor Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation .
    Lys-Bradykinin tetraacetate
  • HY-171184
    EAPB0503

    		Bcr-Abl Apoptosis PARP Cancer
    EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC50=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein .
    EAPB0503
  • HY-103293A
    Lys-Bradykinin TFA

    Kallidin (380-389) (human, porcine, bovine) TFA

    		 Bradykinin Receptor Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Lys-Bradykinin TFA is the TFA salt form of Lys-Bradykinin (HY-103293). Lys-Bradykinin TFA is a ligand for kallidin and bradykinin receptor, which can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin TFA serves as a vasodilator, which widens blood vessels and increases blood flow. Lys-Bradykinin TFA stimulates net Na+ influx, and contributes to DNA synthesis. Lys-Bradykinin TFA involves in vascular regulation, inflammation and pain sensation .
    Lys-Bradykinin TFA
  • HY-W010706
    N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine

    5'-O-DMT-N4-Bz-dC

    		 Nucleoside Antimetabolite/Analog Others
    N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (5'-O-DMT-N4-Bz-dC) can be used for synthesis oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is an useful tool for probing enzyme-catalyzed cleavage processes in DNA .
    N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
  • HY-116692
    Apoptosis inducer 34

    		Apoptosis Caspase Mitochondrial Metabolism PARP DNA/RNA Synthesis
    Apoptosis inducer 34 (Compound 4) is a small molecule compound that induces apoptosis by directly activating the intrinsic apoptotic pathway. Apoptosis inducer 34 promotes Apaf-1 oligomerization to form mature apoptosomes, thereby activating caspase-9 and caspase-3. It significantly activates the apoptotic pathway in Jurkat cells by enhancing the cytochrome c-dependent apoptotic signaling pathway, inducing PARP cleavage and chromosomal DNA fragmentation. Furthermore, Apoptosis inducer 34 exhibits low toxicity to normal cells, demonstrating potential for selective targeting of cancer cells. Apoptosis inducer 34 is a promising candidate for studying cancer related to apoptotic pathways .
    Apoptosis inducer 34

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