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Muscarinic acetylcholine receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mAChR (92) nAChR (8) Adrenergic Receptor (1) Amyloid-β (1) Apoptosis (1) Autophagy (1) Cholinesterase (ChE) (4) Endogenous Metabolite (2) GABA Receptor (1) Histamine Receptor (1) Imidazoline Receptor (1) Isotope-Labeled Compounds (7) Monoamine Oxidase (1) Opioid Receptor (1) Parasite (1) Phosphodiesterase (PDE) (2) Prolyl Endopeptidase (PREP) (1) Trace Amine-associated Receptor (TAAR) (1)
By Research Areas:	Cancer (24) Cardiovascular Disease (11) Infection (3) Inflammation/Immunology (10) Metabolic Disease (9) Neurological Disease (83)
Click Chemistry:	Alkynes (1)

108

Inhibitors & Agonists

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oxotremorine M iodide	mAChR	Neurological Disease
Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms .

DREADD agonist 21 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

DREADD agonist 21 dihydrochloride 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 dihydrochloride is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

Aceclidine Quinuclidin-3-yl acetate	mAChR	Cardiovascular Disease Neurological Disease
Aceclidine (Quinuclidin-3-yl acetate) is a modulator of M3 muscarinic acetylcholine receptor and a M1 receptor agonist (EC₅₀: 40 μM). Aceclidine is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia .

Benzetimide hydrochloride R4929	mAChR	Neurological Disease
Benzetimide hydrochloride is a muscarinic acetylcholine receptor antagonist.

Pilocarpine Hydrochloride Maximum Cited Publications 29 Publications Verification	mAChR	Neurological Disease Cancer
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

BAY-2413555	Others	Cardiovascular Disease
BAY-2413555 is an orally active muscarinic acetylcholine receptor M2 modulator that protects the heart and improve cardiac function. BAY-2413555 is promising for research of heart failure .

TAAR1 agonist 2	Trace Amine-associated Receptor (TAAR) Histamine Receptor mAChR	Neurological Disease
TAAR1 agonist 2 (compound 30) is a full agonist of trace amine-associated receptor 1 (TAAR1) (pEC₅₀=7.5). TAAR1 agonist 2 also exhibits agonist activity at H1 receptors and activates several members of the muscarinic acetylcholine receptor family, such as the M2 receptor (pEC₅₀=5). TAAR1 agonist 2 can be used in the study of neuropsychiatric diseases .

M1 ligand 1	mAChR	Others
M1 ligand 1 (compound 3b-b) is a muscarinic acetylcholine receptor M1 ligand. M1 ligand 1 is a N-desmethyl congener of arecoline derivative. M1 ligand 1 can be used as PET (positron emission tomography) radiotracer .

Aceclidine hydrochloride Quinuclidin-3-yl acetate hydrochloride	mAChR	Neurological Disease
Aceclidine (Quinuclidin-3-yl acetate) hydrochloride is a modulator of M3 muscarinic acetylcholine receptor and a M1 receptor agonist (EC₅₀: 40 μM). Aceclidine hydrochloride is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine hydrochloride has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia .

Pilocarpine Maximum Cited Publications 29 Publications Verification	mAChR	Neurological Disease Cancer
Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

Pilocarpine nitrate Maximum Cited Publications 29 Publications Verification	mAChR	Neurological Disease Cancer
Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

Methylbenactyzium Bromide	mAChR	Inflammation/Immunology
Methylbenactyzium Bromide is a **muscarinic acetylcholine receptor (mAChR**) inhibitor.

Elucaine	mAChR	Inflammation/Immunology
Elucaine is a **muscarinic acetylcholine receptor** antagonist with anti-ulcerative activity.

Irsogladine 2 Publications Verification Dicloguamine	mAChR Phosphodiesterase (PDE)	Inflammation/Immunology
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.

Irsogladine maleate Dicloguamine maleate; MN1695	mAChR Phosphodiesterase (PDE)	Inflammation/Immunology
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.

(±)-Muscarine chloride DL-Muscarin chloride	mAChR	Neurological Disease
(±)-Muscarine chloride is the racemate of Muscarine chloride. Muscarine is a prototype muscarinic acetylcholine receptor agonist .

Homatropine	mAChR	Neurological Disease
Homatropine is an orally active **muscarinic acetylcholine receptor** antagonist and can be used as an anticholinergic agent .

Tiotropium Bromide 1 Publications Verification BA679 BR	mAChR	Neurological Disease
Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

Pilocarpine Hydrochloride (Standard)	mAChR	Neurological Disease Cancer
Pilocarpine (Hydrochloride) (Standard) is the analytical standard of Pilocarpine (Hydrochloride). This product is intended for research and analytical applications. Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

Homatropine Bromide	mAChR	Neurological Disease
Homatropine Bromide is an orally active **muscarinic acetylcholine receptor** antagonist and can be used as an anticholinergic agent .

Scopolamine butylbromide 1 Publications Verification Hyoscine butylbromide; (-)-Scopolamine butylbromide; Butylscopolamine bromide	mAChR	Neurological Disease
Scopolamine butylbromide is a competitive antagonist of muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM.

Pilocarpine nitrate (Standard)	mAChR	Neurological Disease Cancer
Pilocarpine (nitrate) (Standard) is the analytical standard of Pilocarpine (nitrate). This product is intended for research and analytical applications. Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

Rapacuronium bromide Org 9487	mAChR	Neurological Disease
Rapacuronium bromide (Org 9487), a non-depolarizing neuromuscular blocker, is an allosteric modulator of muscarinic acetylcholine receptor (mAChR) .

VU0486846	mAChR	Neurological Disease
VU0486846 is an orally active and selective muscarinic acetylcholine receptor M1 positive allosteric modulator (PAM) .

Eucatropine	mAChR	Neurological Disease
Eucatropine is a potent muscarinic acetylcholine receptor (mAChR) inhibitor with an IC₅₀ value of 0.583 μM. Eucatropine is an anticholinergic agent .

VU6016235	Others	Cancer
VU6016235 is a highly selective, orally available and structurally unique tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.

VU 0238429 1 Publications Verification	mAChR	Others
VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC₅₀ of 1.16 μM.

Muscarine iodide (+)-Muscarine iodide	mAChR	Neurological Disease
Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype **muscarinic acetylcholine receptor** agonist .

Biperiden hydrochloride KL 373 hydrochloride	mAChR	Neurological Disease
Biperiden (KL 373) hydrochloride is a non-selective **muscarinic receptor** antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting *acetylcholine* and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders .

Biperiden KL 373	mAChR	Neurological Disease
Biperiden (KL 373) is a non-selective **muscarinic receptor** antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting *acetylcholine* and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders .

Heliosupine N-oxide	mAChR	Neurological Disease
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

VU6021625	mAChR	Neurological Disease
VU6021625 is a selective antagonist muscarinic acetylcholine receptors (mAChRs), with the IC₅₀ value of 0.44 nM, 57 nM for human M4 and rat M4, respectively .

Tiotropium Bromide (Standard) BA679 BR (Standard)	mAChR	Neurological Disease
Tiotropium (Bromide) (Standard) is the analytical standard of Tiotropium (Bromide). This product is intended for research and analytical applications. Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

Thiochrome	mAChR	Metabolic Disease
Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective *M4 muscarinic* receptor of acetylcholine (ACh)** affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors .

Otenzepad 1 Publications Verification AF-DX 116	mAChR	Neurological Disease Metabolic Disease
Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC₅₀ values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively .

Dimethyl-W84 dibromide	mAChR	Neurological Disease
Dimethyl-W84 (dibromide) modulates M2 muscarinic acetylcholine receptors. Dimethyl-W84 (dibromide) can be used in nervous system related research .

Iperoxo 1 Publications Verification	mAChR	Neurological Disease
Iperoxo is a potent superagonist of muscarinic acetylcholine receptor (mAChR). [ ³H]Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors . Iperoxo is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Biperiden (Standard)	mAChR	Neurological Disease
Biperiden (Standard) is the analytical standard of Biperiden. This product is intended for research and analytical applications. Biperiden (KL 373) is a non-selective **muscarinic receptor** antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting *acetylcholine* and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders .

Biperiden lactate KL 373 lactate	mAChR	Neurological Disease
Biperiden (KL 373) lactate is an orally active non-selective **muscarinic receptor** antagonist that competitively binds to M1 muscarinic receptors. Biperiden (KL 373) lactate inhibits *acetylcholine* and enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders .

Biperiden hydrochloride (Standard) KL 373 hydrochloride (Standard)	mAChR	Neurological Disease
Biperiden (hydrochloride) (Standard) is the analytical standard of Biperiden (hydrochloride). This product is intended for research and analytical applications. Biperiden (KL 373) hydrochloride is a non-selective **muscarinic receptor** antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting *acetylcholine* and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders .

Recombinant Proteins Recommended:

Muscarinic Acetylcholine Receptor

Species:	Human (3) Rat (1)
Tag:	His (2) Flag (3)
Source:	HEK293 (2) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72138

	CHRM1 Protein, Rat (His) Chrm1; Chrm-1Muscarinic acetylcholine receptor M1	Rat	E. coli
	CHRM1, the muscarinic acetylcholine receptor, mediates cellular responses, including adenylate cyclase inhibition, phosphoinositide breakdown, and potassium channel modulation through G protein actions.It engages with GPRASP2 and TMEM147, contributing to a complex network of signaling pathways and cellular processes regulated by the receptor.CHRM1 Protein, Rat (His) is the recombinant rat-derived CHRM1 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P703102

	M1R Protein, Human (HEK293, Flag) Muscarinic acetylcholine receptor M1; CHRM1; Homo sapiens; Human; G-protein coupled receptor; receptor; Transducer	Human	HEK293
	M1R Protein, Human (HEK293, Flag) is the recombinant human-derived M1R, expressed by HEK293 , with Flag labeled tag. ,

HY-P703104

	M2R Protein, Human (HEK293, Flag) Muscarinic acetylcholine receptor M2; CHRM2; Homo sapiens; Human; G-protein coupled receptor; receptor; Transducer	Human	HEK293
	M2R Protein, Human (HEK293, Flag) is the recombinant human-derived M2R, expressed by HEK293 , with Flag labeled tag. ,

HY-P703103

	M2R Protein, Human (Sf9, Flag, His) Muscarinic acetylcholine receptor M2; CHRM2; Homo sapiens; Human; G-protein coupled receptor; receptor; Transducer	Human	Sf9 insect cells
	M2R Protein, Human (Sf9, Flag, His) is the recombinant human-derived M2R, expressed by Sf9 insect cells , with His, Flag labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-B0394S

Atropine-d5
Atropine-d₅ is the deuterium labeled Atropine (sulfate monohydrate). Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect[1].

HY-B0321S

Tropicamide-d3
Tropicamide-d₃ is the deuterium labeled Tropicamide[1]. Tropicamide (Ro 1-7683) is a selective M4 muscarinic acetylcholine receptor antagonist. Tropicamide produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops[2][3].

HY-B0726S

Pilocarpine-d3 hydrochloride
Pilocarpine-d₃ (hydrochloride) is deuterium labeled Pilocarpine (Hydrochloride). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B0726S1

Pilocarpine-d5 hydrochloride
Pilocarpine-d₅ hydrochloride is deuterated labeled Pilocarpine hydrochloride (HY-B0726). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-32067AS

Aceclidine-d3 hydrochloride
Aceclidine-d₃ hydrochloride is a deuterated version of Aceclidine (HY-32067). Aceclidine is a modulator of the M3 muscarinic acetylcholine receptor.

HY-17360S

Tiotropium-d3 bromide
Tiotropium-d₃ (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-17360S1

Tiotropium-d6 bromide
Tiotropium-d₆ (bromide) is deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-107654S

Muscarine-d9 iodide
Muscarine-d₉ (iodide) is the deuterium labeled Muscarine iodide. Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist[1][2].

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81142

	Muscarinic Acetylcholine receptor M3 Antibody Muscarinic acetylcholine receptor M3; cholinergic receptor, Muscarinic 3; CHRM 3; CHRM3; HM 3; HM3; HM3; EGBRS; M3 Muscarinic receptor; Muscarinic 3; m3 Muscarinic acetylcholine receptor; ACM3_HUMAN; Muscarinic receptor M3; Muscarinic cholinergic m3 receptor; Muscarinic m3 receptor; acetylcholine receptor(M3).	WB	Human
	Muscarinic Acetylcholine receptor M3 Antibody is an unconjugated, approximately 66 kDa, rabbit-derived, anti-Muscarinic Acetylcholine receptor M3 monoclonal antibody. Muscarinic Acetylcholine receptor M3 Antibody can be used for: WB expriments in human background without labeling.

HY-P82865

	Muscarinic Acetylcholine Receptor M2 Antibody (YA2610) CHRM2; HM2; AChR; Acm2	WB, IHC-P, IP	Human, Mouse, Rat
	Muscarinic Acetylcholine Receptor M2 Antibody (YA2610) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2610), targeting Muscarinic Acetylcholine Receptor M2, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). Muscarinic Acetylcholine Receptor M2 Antibody (YA2610) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-134061

Arecaidine propargyl ester hydrobromide		Alkynes
Arecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors and has the activity of inhibiting tumor cell proliferation. The application of arecaidine propargyl ester hydrobromide has shown that it can reduce the number of ovarian cancer cells in vitro and induce apoptosis and the production of reactive oxygen species (ROS) at specific concentrations. Arecaidine propargyl ester hydrobromide can also arrest cells at the G2/M phase of the cell cycle and increase the percentage of abnormal mitosis. Arecaidine propargyl ester hydrobromide is more sensitizing to ovarian surface epithelial cells with higher M2 receptor levels than to cancer cells. Arecaidine propargyl ester hydrobromide exhibits the effect of lowering arterial blood pressure when interacting with the cardiovascular system in a natural physiological state, indicating its potential pharmacological application .

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