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Results for "

PRMTs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (1) Apoptosis (12) Bcl-2 Family (1) BCL6 (1) CDK (1) DNA/RNA Synthesis (1) E3 Ligase Ligand-Linker Conjugates (1) EGFR (1) Fluorescent Dye (1) HDAC (2) Histone Methyltransferase (138) HSP (1) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (1) NF-κB (1) Parasite (2) Phosphodiesterase (PDE) (2) PKA (1) Potassium Channel (1) PROTACs (3) SARS-CoV (1) Small Interfering RNA (siRNA) (20) WDR5 (1)
By Research Areas:	Cancer (135) Infection (3) Inflammation/Immunology (5) Metabolic Disease (3)
Oligonucleotides:	Aptamers (1) Rat Pre-designed siRNA Sets (6) Mouse Pre-designed siRNA Sets (6) Human Pre-designed siRNA Sets (8) siRNAs (20)

162

Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162003A

DCPT1061 hydrochloride	Histone Methyltransferase	Cancer
DCPT1061 hydrochloride has a strong inhibitory effect on *PRMT1, PRMT6, and PRMT8* in vitro, The epigenetic enzymes such as *PRMT3, PRMT4* and *PRMT5* had little inhibitory effect. DCPT1061 hydrochloride has antitumor effects .

HY-18962

AMI-1 5+ Cited Publications	Histone Methyltransferase	Cancer
AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC₅₀s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-18962A

AMI-1 free acid 5+ Cited Publications	Histone Methyltransferase	Cancer
AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC₅₀s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-111030

PRMT1-IN-2	Histone Methyltransferase	Cancer
PRMT1-IN-2 (RM65) is a potent *PRMT1* inhibitor with an IC₅₀ of 55.4 μM. PRMT1-IN-2 shows histone hypomethylation in HepG2 cells .

HY-155154

PRMT4-IN-2	Histone Methyltransferase	Cancer
PRMT4-IN-2 (compound 55) is a pan-inhibitor of protein arginine methyltransferase (PRMT) with IC₅₀s of 92 nM (PRMT4), 436 nM (PRMT6), 460 nM (PRMT1), 823 nM ( PRMT8), 1.386 μM (PRMT3) .

HY-155154A

PRMT4-IN-3	Histone Methyltransferase	Cancer
PRMT4-IN-3 (compound 56) is a potent inhibitor of class I protein arginine methyltransferase (PRMT), targeting PRMT4 (IC₅₀: 37 nM) and PRMT4 (IC₅₀: 253 nM) .

HY-159732

PRMT3-IN-4	Histone Methyltransferase	Cancer
PRMT3-IN-4 (intermediate 15) is a protein arginine methyltransferase 3 (PRMT3) inhibitor. PRMT3-IN-4 is an active control for HY-19715. PRMT3-IN-4 can be used to synthesize PROTACs targeting PRMT3. PRMT3-IN-4 can be used in leukemia-related research .

HY-171132

PRMT3-IN-5	Histone Methyltransferase
PRMT3-IN-5 (Compound 14) is an allosteric *PRMT3* inhibitor (IC₅₀: 291 nM). PRMT3-IN-5 can be used for investigating PRMT3's biological functions and disease associations .

HY-163593

PRMT5-IN-44	Histone Methyltransferase	Cancer
PRMT5-IN-44 (compound 12) is a *PRMT5* inhibitor. PRMT5-IN-44 can be used in cancer research .

HY-163592

PRMT5-IN-43	Histone Methyltransferase	Cancer
PRMT5-IN-43 (compound 4A) is a *PRMT5* inhibitor. PRMT5-IN-43 can be used in cancer research .

HY-163587

PRMT5-IN-39-d3	Histone Methyltransferase	Cancer
PRMT5-IN-39-d3 is the deuterated form of PRMT5-IN-39. PRMT5-IN-39-d3 is an orally active *PRMT5* inhibitor and can be used for study of cancer .

HY-163591

PRMT5-IN-36-d3	Histone Methyltransferase	Cancer
PRMT5-IN-36-d3 is the deuterated derivative of PRMT5-IN-36. PRMT5-IN-36-d3 (compound 4) is an orally active PRMT5 inhibitor for cancer research .

HY-168842

PRMT5-IN-47	Histone Methyltransferase	Cancer
PRMT5-IN-47 (compound 20) is a potent, selectively and orally active, MTA cooperative *PRMT5* inhibitor with an IC₅₀ value of 15 nM. PRMT5-IN-47 shows antiproliferative activity. PRMT5-IN-47 shows anticancer activity .

HY-148674

PRMT5-IN-25	Histone Methyltransferase	Cancer
PRMT5-IN-25 (compound 503) is a potent *PRMT5* inhibitor with an K_i value of 0.06 nM. PRMT5-IN-25 shows antiproliferative .

HY-115758

PRMT1-IN-1	Histone Methyltransferase	Cancer
PRMT1-IN-1 is a PRMT1 inhibitor.

HY-162003

DCPT1061	Histone Methyltransferase	Cancer
DCPT1061 potently inhibits PRMT1, PRMT6 and PRMT8 in vitro with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. DCPT1061 has antitumor effect .

HY-160029

PRMT5-IN-32	Histone Methyltransferase	Cancer
PRMT5-IN-32 is an inhibitor of *PRMT5. PRMT5-IN-32 inhibits HCT116 cell proliferation with an IC ₅₀* of 0.13 μM .

HY-Q36691

PRMT5-IN-30	Histone Methyltransferase	Cancer
PRMT5-IN-30 (compound 17) is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC₅₀ of 0.33 μM and a K_d of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation .

HY-146810

PRMT4-IN-1	Histone Methyltransferase	Cancer
PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC₅₀=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability .

HY-155050

PRMT5-IN-31	Apoptosis Histone Methyltransferase	Cancer
PRMT5-IN-31 (Compound 3m) is a selective *PRMT5* inhibitor (IC₅₀: 0.31 μM). PRMT5-IN-31 up-regulates hnRNP E1 protein level. PRMT5-IN-31 occupies the substrate site of PRMT5 and forms essential interactions with amino acid residues. PRMT5-IN-31 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. PRMT5-IN-31 has high metabolic stability on human liver microsomes (T_1/2: 132.4 min) .

HY-153422

PRMT5-IN-29	Histone Methyltransferase	Cancer
PRMT5-IN-29 is a potent and orally active *PRMT5* Inhibitor with an IC₅₀ of 1.5 μΜ. PRMT5-IN-29 has the potential for advanced cancers research .

HY-162230

PRMT5-IN-33	Apoptosis Histone Methyltransferase	Cancer
PRMT5-IN-33 (compound A8) is a selective, SAM-competitve *PRMT5* inhibitors with IC₅₀ of 10.9 nM. PRMT5-IN-33 induces apoptosis and inhibits proliferation of cells Z-138 and MOLM-13. PRMT5-IN-33 exhibits an antitumor activity .

HY-19615A

MS023 trihydrochloride	Histone Methyltransferase	Cancer
MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-19615B

MS023 dihydrochloride 10+ Cited Publications	Histone Methyltransferase	Cancer
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-19615

MS023 10+ Cited Publications	Histone Methyltransferase	Cancer
MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-147185

PRMT7-IN-1	Histone Methyltransferase	Cancer
PRMT7-IN-1 (Compound 14) is a *PRMT7* inhibitor with an IC₅₀ of 2.1 μM. PRMT7-IN-1 shows anticancer activity against different cancer cells .

HY-160865

PRMT5-IN-35	Histone Methyltransferase	Cancer
PRMT5-IN-35 (Compound 87) is a potent, selective and orally active *PRMT5* inhibitor with an IC₅₀ value of 1 nM . PRMT5-IN-35 can be used in cancer research .

HY-170603

PRMT5-targeted fluorescent ligand-1	Fluorescent Dye Histone Methyltransferase Apoptosis	Cancer
PRMT5-targeted fluorescent ligand-1 (Compound 7) is a *PRMT5*-targeted fluorescent ligand, that inhibits *PRMT5* with an IC₅₀ of 29.39 nM. PRMT5-targeted fluorescent ligand-1 exhibits cell imaging activity, that exhibits good fluorescence signal in MCF-7 with an IC₅₀ of 29 nM. PRMT5-targeted fluorescent ligand-1 induces apoptosis. PRMT5-targeted fluorescent ligand-1 exhibits a maximal excitation wavelength of 438 nm and a maximal emission wavelength of 550 nm .

HY-141874

PRMT5-IN-12	Histone Methyltransferase	Cancer
PRMT5-IN-12 shows remarkable inhibitory activity on *PRMT5*.

HY-152236

PRMT6-IN-3	Histone Methyltransferase Apoptosis	Cancer
PRMT6-IN-3 (compound 25) is a selective *PRMT6* inhibitor with an IC₅₀ value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity .

HY-163590

PRMT5-IN-41	Histone Methyltransferase Potassium Channel	Cancer
PRMT5-IN-41 (compound 130) is a potent and orally active *PRMT5* inhibitor. PRMT5-IN-41 inhibits hERG ion channel with IC₅₀ value of 1.36 µM .

HY-144189

PRMT5-IN-18	Histone Methyltransferase	Cancer
PRMT5-IN-18 (Compound 002) is a potent *PRMT5* inhibitor that can be used for the research of a disease mediated by PRMT5， such as cancer .

HY-158143

PRMT5-IN-34	Histone Methyltransferase	Cancer
PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT) .

HY-139823

PRMT5-IN-10	Histone Methyltransferase	Others
PRMT5-IN-10 has promising structure-dependent inhibition of the protein methyltransferase *PRMT5:MEP50* complex.

HY-153057

PRMT5-IN-46	Histone Methyltransferase	Metabolic Disease Cancer
PRMT5-IN-46 (compound 278) inhibits *PRMT5* with IC₅₀ of 1-10 μM. *PRMT5* is a methyltransferase which is associated with specific genetic alterations. PRMT5-IN-46 can be used for research of proliferative diseases, metabolic disorders, and blood diseases .

HY-136809

PRMT6-IN-2	Histone Methyltransferase	Cancer
PRMT6-IN-2 (compound 2) is a dual inhibitor of protein arginine methyltransferase PRMT6 and CARM1 with an IC50 of 30 nM. PRMT6 is abnormally expressed in many cancer cells, and PRMT6-IN-2-based derivatives have potential anticancer activity.

HY-142211

PRMT5-IN-15	Histone Methyltransferase	Cancer
PRMT5-IN-15 is a *PRMT5* inhibitor with an IC₅₀ value of 0.84 nM.

HY-163589

PRMT5-IN-40	Histone Methyltransferase	Others
PRMT5-IN-40 (compound 104) is a potent inhibitor of *PRMT5* .

HY-163799

PRMT5-MTA-IN-1	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor for protein arginine methyltransferase *PRMT5-MTA. PRMT5-MTA-IN-1 inhibits the proliferation of colorectal cancer cell HCT116 wildtype and MTAP del mutant, with an IC₅₀* of 16 nM and 2.47 μM. PRMT5-MTA-IN-1 exhibits good liver microsomal stability and film permeability. PRMT5-MTA-IN-1 exhibits good pharmacokinetic characteristics in CD-1 mice .

HY-149005

PRMT5-IN-19	Histone Methyltransferase	Cancer
PRMT5-IN-19 (Compound 41) is an selective orally active non-nucleoside *PRMT5* inhibitor with IC₅₀ values of 23.9 nM (radioactive biochemical assay) and 47 nM (AlphaLISA assay). PRMT5-IN-19 can occupy the SAM-binding pocket in PRMT5 and block methyltransferase activity, which displays good selectivity over other PRMTs and PKMTs. PRMT5-IN-19 inhibits cell proliferation by inducing cell apoptosis, and can be used for cancer-related research .

HY-139611

Navlimetostat 3 Publications Verification MRTX-1719	Histone Methyltransferase	Cancer
Navlimetostat is a potent, orally active, selective *PRMT5•MTA* complex inhibitor, with IC₅₀ of 3.6 and 20.5 nM for *PRMT5•MTA* and *PRMT5. Navlimetostat binds to the PRMT5•MTA* complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study .

HY-141875

PRMT5-IN-13	Histone Methyltransferase	Cancer
PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5).

HY-134883

PRMT5-IN-4	Histone Methyltransferase	Others
PRMT5-IN-4 (compound AAA-1) is a *PRMT5* inhibitor .

HY-169708

PRMT5-IN-49	Histone Methyltransferase	Cancer
PRMT5-IN-49 (Compound 4b16) is an inhibitor of *PRMT5* .

HY-150081

PRMT5-IN-21	Histone Methyltransferase	Cancer
PRMT5-IN-21 (compound 1) is a potent cyclonucleoside *PRMT5* inhibitor .

HY-139823A

PRMT5-IN-11	Histone Methyltransferase	Others
PRMT5-IN-11 is a promising structure-dependent inhibition of the protein methyltransferase *PRMT5:MEP50* complex in the (sub)micromolar range.

HY-151576

PRMT5:MEP50 PPI	Histone Methyltransferase	Cancer
PRMT5:MEP50 PPI is a novel PRMT5:MEP50 protein-protein interaction (PRMT5:MEP50 PPI) inhibitor, shows anti-tumor activity and anti-proliferative activity of lung and prostate cancer cells .

HY-172197

MRK-990	Histone Methyltransferase	Cancer
MRK-990 is the inhibitor for *PRMT* that inhibits *PRMT5* and *PRMT9* with IC₅₀ of 30 nM and 10 nM .

HY-168142

YD1130	Histone Methyltransferase	Cancer
YD1130 is a *PRMT4* inhibitor (0.5 nM, 75% inhibition rate), and its inhibitory potency against other PRMTs is not significant (PRMT5 IC₅₀> 1 μM, PRMT1/3/6/7/8 IC₅₀ > 10 μM). .

HY-163434

PRMT5/EGFR-IN-1	EGFR Histone Methyltransferase	Cancer
PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual *PRMT5/EGFR* inhibitor, with IC₅₀s of 15.47 and 19.31 μM, respectively. PRMT5/EGFR-IN-1 exhibits antiproliferative activity against A549, MCF7, HeLa, and MDA-MB-231 cell lines. PRMT5/EGFR-IN-1 has favorable in vivo PK and PD properties. PRMT5/EGFR-IN-1 can significantly inhibit the growth of MCF7 orthotopic xenograft tumors .

Cat. No.	Product Name	Target	Research Area

HY-P3822

PRMT5-IN-23	Histone Methyltransferase	Cancer
PRMT5-IN-23 (compound 50) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) with anti-tumor activity. *PRMT5* is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

Cat. No.	Product Name	Chemical Structure

HY-163587

PRMT5-IN-39-d3
PRMT5-IN-39-d3 is the deuterated form of PRMT5-IN-39. PRMT5-IN-39-d3 is an orally active *PRMT5* inhibitor and can be used for study of cancer .

HY-163591

PRMT5-IN-36-d3
PRMT5-IN-36-d3 is the deuterated derivative of PRMT5-IN-36. PRMT5-IN-36-d3 (compound 4) is an orally active PRMT5 inhibitor for cancer research .

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