Search Result

Results for "

actin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arp2/3 Complex (20) Akt (2) Antibiotic (2) Apoptosis (4) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (1) Carbonic Anhydrase (1) Cathepsin (1) CDK (1) Disulfidptosis (2) DNA Methyltransferase (1) Dynamin (1) EGFR (1) Endogenous Metabolite (5) Epigenetic Reader Domain (2) FAK (1) Fluorescent Dye (7) Fungal (5) GLUT (3) HBV (2) Histone Methyltransferase (1) HIV (1) HIV Integrase (1) HIV Protease (1) HSP (1) Integrin (1) Isotope-Labeled Compounds (2) LIM Kinase (LIMK) (2) Liposome (1) mAChR (1) Microtubule/Tubulin (1) MMP (1) Myosin (6) NF-κB (3) P2Y Receptor (1) PAK (1) Parasite (1) PI3K (1) PKA (1) PPAR (1) Prostaglandin Receptor (2) PROTACs (1) RANKL/RANK (1) Ras (4) ROCK (7) Src (1) Topoisomerase (1) YAP (1) β-catenin (1)
By Research Areas:	Cancer (41) Cardiovascular Disease (2) Endocrinology (1) Infection (13) Inflammation/Immunology (14) Metabolic Disease (6) Neurological Disease (8)
Click Chemistry:	Azide (1)
Oligonucleotides:	Phospholipids (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cytochalasin D Maximum Cited Publications 49 Publications Verification Zygosporin A; NSC 209835	Arp2/3 Complex Antibiotic YAP	Infection Cancer
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

Swinholide A	Fungal	Infection
Swinholide A is the *actin*-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

SMIFH2 2 Publications Verification	Arp2/3 Complex	Cancer
SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton .

Fequesetide	Arp2/3 Complex	Inflammation/Immunology
Fequesetide, a peptide segment, is the active site within the protein thymosin β₄ responsible for actin binding, cell migration and wound healing .

Latrunculin B	Fungal	Infection
Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity .

6,7-Epoxy-latrunculin A 6,7-Epoxy-LAT-A	Arp2/3 Complex	Others
6,7-Epoxy-latrunculin A can be isolated from the Red Sea sponge Negombata magnifica and is initially identified as an inhibitor of actin polymerization by its morphological effects .

610CP	Fluorescent Dye	Others
610CP is a new type of actin labeling dye. It dissolves in organic solvents. In DMSO the 610CP excitation/emission wavelength is between 609 and 634 nm. 610CP is a fluorescent dye that penetrates living cells. Upon cell entry, 610CP binds to Bromo-des-methyl-Jasplakinolide Therefore, 610CP dye can be used to stain actin fluorescence images with low background and high resolution.

Jasplakinolide	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

TR-100	Arp2/3 Complex	Metabolic Disease Cancer
TR-100 is a small molecule inhibitor of tumor-associated troponin (Tpm). TR-100 affects the interaction of Tpm3.1 with actin filaments by binding to the C-terminal of Tpm3.1, thereby affecting the stability and function of the actin filaments. This mechanism of action allows TR-100 to specifically affect actin filaments in cancer cells without compromising heart muscle function. TR-100 can be used to study the role of Tpm3.1 in cancer cell proliferation and survival and the effects of Tpm3.1 on insulin-stimulated glucose uptake and insulin secretion .

19-O-Acetylchaetoglobosin A	Arp2/3 Complex	Cancer
19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .

ROCK2-IN-9	ROCK	Cancer
ROCK2-IN-9 (compound 7u) is a selective ROCK2 inhibitor (IC₅₀=36.8 nM) with anticancer activity. ROCK2-IN-9 inhibits cancer cell migration and invasion by regulating multiple cellular activities of the actin cytoskeleton. ROCK2-IN-9 can be used in breast cancer research .

EG-011	Arp2/3 Complex	Cancer
EG-011 is the first-in-class and potent Wiskott-Aldrich syndrome protein (WASP) activator. EG-011 activates the auto-inhibited form of WASP with strong actin polymerization. EG-011 has selective anti-tumor activity in lymphomas .

AuM1Phe	Topoisomerase	Cancer
AuM1Phe, an N-Heterocyclic carbene (NHC) metal complexe, blocks the human topoisomerase I activity and actin polymerization reaction. AuM1Phe affects the growth of MDA-MB-231 breast cancer cells, with an IC₅₀ value of 1.2 μM .

Latrunculin A 5+ Cited Publications LAT-A	Arp2/3 Complex	Cancer
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a *G-actin* polymerization** inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

DCVJ 9-(2,2-Dicyanovinyl)julolidine	Fluorescent Dye	Others
DCVJ (9-(2,2-Dicyanovinyl)julolidine), a molecular rotor and unique fluorescent dye, binds to tubulin and actin, and increases its fluorescence intensity drastically upon polymerization. DCVJ also binds to phospholipid bilayers and increases its fluorescence intensity. DCVJ can detect the kinetic process of degranulation of mast cells (Absorption/emission=489/505 nm) .

Aminopurvalanol A 1 Publications Verification	CDK Apoptosis	Cancer
Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization .

BTS 2 Publications Verification N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine	Myosin	Others
BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC₅₀s of ~5 μM for actin- and Ca ²⁺-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers .

Pfn1-IN-1	Others	Cancer
Pfn1-IN-1 (compound C1) is a Pfn1 inhibitor that inhibits the angiogenic capacity of endothelial cells (EC). Pfn1 is a regulator of the actin cytoskeleton, inducing actin polymerization and essential cellular activities. Pfn1-IN-1 inhibits Pfn1-Actin interaction and Actin polymerization.

Bis-T-23 AG1717	Dynamin HIV Integrase	Infection Metabolic Disease Inflammation/Immunology
Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD) .

Cytochalasin B 25+ Cited Publications Phomin	Arp2/3 Complex	Cancer
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of *actin* filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

CCG-222740	Ras ROCK	Cancer
CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor . CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis .

Cytochalasin E	Autophagy	Cancer
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .

Latrunculin M	Fluorescent Dye	Others
Latrunculin M is a highly selective actin-macrolide conjugate that can be isolated from marine products. Latrunculin M can be converted from Latrunculin B, which can effectively induce actin depolymerization and is a good probe for detecting the actin skeleton.

Phallacidin	Arp2/3 Complex	Others
Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin .

Phalloidin 10+ Cited Publications	Fluorescent Dye	Others
Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome .

Benproperine phosphate	Arp2/3 Complex	Inflammation/Immunology Cancer
Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis .

LIMK-IN-3	LIM Kinase (LIMK)	Neurological Disease
LIMK-IN-3 (Compound 33) is a LIMK2 inhibitor (IC₅₀: 1.2 nM). LIMK-IN-3 can be used for glaucoma research .

NGX-267 AF-267B	mAChR	Others
NGX-267 is a selective agonist of the actin M1 receptor, which has high selectivity among the five actin receptor subtypes, especially for the M1 receptor rather than the M3 receptor. NGX-267 also has significant differences in affinity for dopamine D2 and 5-HT2B receptors .

CK-869 1 Publications Verification	Arp2/3 Complex	Cancer
CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC₅₀ of 7 μM.

Phorbol-12,13-didecanoate	Others	Cancer
Phorbol-12,13-didecanoate is an anti-viral TPA compound and a tumor promoter. It can cause changes in actin-containing structures ^{[1] ^.}

Neopetromin	Others	Others
Neopetromin is a tripeptide with a rare heteroaromatic C-N cross-link between side chains of tryptophan and tyrosine. Neopetromin causes vacuole fragmentation in an actin-independent manner .

Pfn1-IN-2	Others	Cancer
Pfn1-IN-2 is an inhibitor of Profilin1 (Pfn1) and has the activity to interfere with the interaction between Pfn1 and actin. Pfn1-IN-2 can significantly reduce the overall level of intracellular filamentous (F) actin. Pfn1-IN-2 also slows down the migration and proliferation of endothelial cells (EC). Pfn1-IN-2 can inhibit the angiogenic ability of endothelial cells both in vivo and in vitro .

N-Acetyl-S-geranylgeranyl-L-cysteine AGGC	DNA Methyltransferase Integrin	Cancer
N-Acetyl-S-geranylgeranyl-L-cysteine is a Methyltransferase inhibitor. N-Acetyl-S-geranylgeranyl-L-cysteine inhibits beta 2 integrin-induced actin polymerization with an IC₅₀ of 45nM .

2,3-Bis(3-indolylmethyl)indole	RANKL/RANK	Others
2,3-Bis(3-indolylmethyl)indole significantly suppresses RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner.

BIPM	ROCK	Cancer
BIPM is a potent ROCK2 inhibitor. BIPM leads to significant changes in neurite length, cell migration and actin stress fibers. BIPM plays an important role in anti-cancer metastasis .

3-Methyl-L-histidine-d3 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Others
3-Methyl-L-histidine-d₃ hydrochloride is the deuterium labeled 3-Methyl-L-histidine hydrochloride. 3-Methyl-L-histidine hydrochloride can be found in actin and myosin and is a derivative of histidine .

LHVS	Cathepsin Parasite	Infection Neurological Disease
LHVS is a potent, non-selective, irreversible, cell-permeable cysteine protease and cathepsin inhibitor. LHVS decreases actin ring formation. LHVS inhibits T. gondii invasion with an IC₅₀ of 10 μM .

N-(7-Nitrobenzofurazan-4-yl)phallacidin	Fluorescent Dye	Others
N-(7-Nitrobenzofurazan-4-yl)phallacidin is a fluorochrome. N-(7-Nitrobenzofurazan-4-yl)phallacidin can be used visualizing probe for actin .

TAT-PAK18 inhibitory peptide	PAK	Cancer
TAT-PAK18 inhibitory peptide is a membrane-permeable PAK inhibitory peptide. TAT-PAK18 inhibitory peptide reduces F-actin clusters and occludes the effect of Shank3 knockdown .

3-Methyl-D-histidine-d3 hydrochloride	Endogenous Metabolite	Others
3-Methyl-D-histidine-d₃ hydrochloride is the deuterium labeled 3-Methyl-D-histidine hydrochloride. 3-Methyl-D-histidine hydrochloride can be found in actin and myosin and is a derivative of histidine .

Narciclasine 10+ Cited Publications Lycoricidinol	ROCK	Cancer
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

YH-306	FAK Src PI3K MMP Apoptosis	Cancer
YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization .

Chaetoglobosin A	Apoptosis	Infection Cancer
Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration .

3-(4-Pyridyl)indole Rockout; 3-(4-Pyridinyl)-1H-indole; Rho Kinase Inhibitor III, Rockout	ROCK	Inflammation/Immunology
3-(4-Pyridyl)indole (Rockout) is a Rho-kinase (ROCK) inhibitor, with an IC₅₀ of 25 μM. 3-(4-Pyridyl)indole can inhibit blebbing and cause dissolution of actin stress fibers in a wound healing assay .

Lifeact peptide	Bacterial	Infection
Lifeact peptide is a fusion structure of BP100 bound to actin. BP100 (KKLFKKILKYL-amide) is an antimicrobial peptide against plant pathogens that acts as a fast and effective cell penetrant to transport fluorescent test cargo into the cytoplasm of plant cell walls .

Myelin basic protein (human)	Arp2/3 Complex Microtubule/Tubulin	Neurological Disease
Myelin basic protein human, the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. Myelin basic protein human mediates interactions with actin and tubulin and effect of post-translational modifications .

Cat. No.	Product Name

HY-L060

Cytoskeleton Compound Library

1,467 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1,467 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-D0098

Fluorescein-5-maleimide

3 Publications Verification

N-(5-Fluoresceinyl)maleimide

Fluorescent Dyes/Probes

Fluorescein-5-maleimide (N-(5-Fluoresceinyl)maleimide) is a fluorescent dye. Fluorescein-5-maleimide can be used to detect the redox state of thiols in eukaryotic cells. Fluorescein-5-maleimide can label peptides and is used to detect negatively charged nanoparticles. Fluorescein-5-maleimide can also label actin to explore its interaction with cardiac myosin-binding protein C (cMyBP-C), which helps in developing small molecule modulators for heart failure. Fluorescein-5-maleimide can screen mutant proteins that contain cysteine residues. The excitation wavelength of Fluorescein-5-maleimide is 494 nm, and the emission wavelength is 519 nm .

HY-D1346

610CP	Fluorescent Dyes/Probes
610CP is a new type of actin labeling dye. It dissolves in organic solvents. In DMSO the 610CP excitation/emission wavelength is between 609 and 634 nm. 610CP is a fluorescent dye that penetrates living cells. Upon cell entry, 610CP binds to Bromo-des-methyl-Jasplakinolide Therefore, 610CP dye can be used to stain actin fluorescence images with low background and high resolution.

HY-D1525

N-(7-Nitrobenzofurazan-4-yl)phallacidin	Fluorescent Dyes/Probes
N-(7-Nitrobenzofurazan-4-yl)phallacidin is a fluorochrome. N-(7-Nitrobenzofurazan-4-yl)phallacidin can be used visualizing probe for actin .

Cat. No.	Product Name	Type

HY-NP136

Myelin basic protein (human)	Native Proteins
Myelin basic protein human, the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. Myelin basic protein human mediates interactions with actin and tubulin and effect of post-translational modifications .

HY-157699

1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium

Drug Delivery

1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium is a membrane-bound signaling molecule with intracellular activity in regulating membrane trafficking and signal transduction. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can be used in the preparation of liposomes to enhance the efficiency of compound delivery. 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium can also act as a coordinator of the actin cytoskeleton and participate in the regulation of cell morphology and motility.

Cat. No.	Product Name	Target	Research Area

HY-P2463

Fequesetide	Arp2/3 Complex	Inflammation/Immunology
Fequesetide, a peptide segment, is the active site within the protein thymosin β₄ responsible for actin binding, cell migration and wound healing .

HY-P2031

Phallacidin	Arp2/3 Complex	Others
Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin .

HY-P0028

Phalloidin Maximum Cited Publications 13 Publications Verification	Fluorescent Dye	Others
Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome .

HY-P1045

187-1, N-WASP inhibitor 1 Publications Verification	Arp2/3 Complex	Others
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein .

HY-P0027

Jasplakinolide	Arp2/3 Complex Fungal	Infection Cancer
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K_d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity .

HY-P10106

TAT-PAK18 inhibitory peptide	PAK	Cancer
TAT-PAK18 inhibitory peptide is a membrane-permeable PAK inhibitory peptide. TAT-PAK18 inhibitory peptide reduces F-actin clusters and occludes the effect of Shank3 knockdown .

HY-P10651

Lifeact peptide	Bacterial	Infection
Lifeact peptide is a fusion structure of BP100 bound to actin. BP100 (KKLFKKILKYL-amide) is an antimicrobial peptide against plant pathogens that acts as a fast and effective cell penetrant to transport fluorescent test cargo into the cytoplasm of plant cell walls .

HY-P3828

Biotin-myelin basic protein (94-102)	Fluorescent Dye	Neurological Disease
Biotin-myelin basic protein (94-102) is a peptide fragemt. Myelin basic protein is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin, it plays an important role in the process of myelination of nerves in the nervous system. Myelin basic protein also acts as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin .

HY-P5350

FN-A208 fusion peptide	Peptides	Others
FN-A208 is a biological active peptide. (This peptide is a fusion of A208, derived from murine laminin a1, and the active site of fibronectin (GRGDS), with a glycine spacer. This peptide forms amyloid-like fibrils and promotes formation of actin stress fibers that mediate fibroblast cell attachment, offering it potential as a bioadhesive for tissue regeneration and engineering. FN-A208 interacts with IKVAV receptors and integrins. Its activity is disrupted by the presence of EDTA.)

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

HY-P1045A

187-1, N-WASP inhibitor TFA	Arp2/3 Complex	Others
187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein .

Cat. No.	Product Name

HY-K0901

AMCA Phalloidin
MCE AMCA Phalloidin is Phalloidin conjugated to the fluorescent dye AMCA. Phalloidin binds F-actins with high selectivity while AMCA provides stable and bright blue fluorescence.

HY-K0902

Fluorescein Phalloidin 2 Publications Verification
MCE Fluorescein Phalloidin is Phalloidin conjugated to the fluorescent dye Fluorescein. Phalloidin binds F-actins with high selectivity while Fluorescein provides stable and bright green fluorescence.

HY-K0903

Rhodamine Phalloidin 3 Publications Verification
MCE Rhodamine Phalloidin is Phalloidin conjugated to the fluorescent dye Tetramethylrhodamine. Phalloidin binds F-actins with high selectivity while Rhodamine provides stable and bright orange fluorescence.

Species:	Human (10)
Tag:	His (7) SUMO (1) Tag Free (3) Strep (2) GST (2)
Source:	Sf9 insect cells (4) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P76733

	ARP3/ACTR3 Protein, Human (sf9, His-GST) actin-related protein 3; actin-like protein 3	Human	Sf9 insect cells
	ARP3/ACTR3 Proteinas, an ATPase preferentially stimulated by single-stranded DNA, crucially participates in homologous recombination repair (HRR). Independent of its ATPase function, it exhibits DNA-binding activity. SWSAP1 forms a functional complex with ZSWIM7, contributing to HRR and mutual protein stabilization. It also interacts with key players in HRR, including RAD51, RAD51B, RAD51C, RAD51D, and XRCC3, emphasizing its role in facilitating DNA repair through homologous recombination mechanisms. ARP3/ACTR3 Protein, Human (sf9, His-GST) is the recombinant human-derived ARP3/ACTR3 protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. The total length of ARP3/ACTR3 Protein, Human (sf9, His-GST) is 417 a.a., with molecular weight of ~75.1 KDa.

HY-P7453

	ACTB Protein, Human (His) rHuACTB, His; actin cytoplasmic 1; ACTB	Human	E. coli
	ACTB Protein, Human (His) is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Phe375) of Human ACTB fused with a His tag at the C-terminus.

HY-P72116

	CAPZA2 Protein, Human (His-SUMO) CAPPA2 ; Capping protein actin filament; muscle Z line; alpha 2 ; CapZ alpha 2; CapZ alpha-2; CAPZ; CAPZA2; CAZA2_HUMAN; F actin capping protein alpha 2 subunit; F actin capping protein subunit alpha 2; F-actin-capping protein subunit alpha-2	Human	E. coli
	The CAPZA2 protein is a member of the F-actin capping protein family and binds to the barbed ends of actin filaments, preventing subunit exchange without severing the filaments. CAPZA2 Protein, Human (His-SUMO) is the recombinant human-derived CAPZA2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CAPZA2 Protein, Human (His-SUMO) is 285 a.a., with molecular weight of ~48.8 kDa.

HY-P75601

	CAPG Protein, Human Macrophage-capping protein; actin regulatory protein CAP-G; CAPG; AFCP; MCP	Human	E. coli
	Macrophage-capping protein (CAPG), a ubiquitous actin-binding protein, belongs to the gelsolin/villin superfamily and is associated with cell motility. CAPG is a Ca²⁺-sensitive protein and plays a role in macrophage function and is involved in the process of metastasis by promoting the invasiveness of tumor cells. CAPG Protein, Human is the recombinant human-derived CAPG protein, expressed by E. coli , with tag free. The total length of CAPG Protein, Human is 348 a.a..

HY-P76470

	KLHL2 Protein, Human (His) Kelch-like protein 2; actin-binding protein Mayven; KLHL2	Human	E. coli
	KLHL2 is a substrate-specific linker in the BCR E3 ubiquitin ligase complex that directs ubiquitination and proteasomal degradation of targets such as NPTXR, WNK1, WNK3, and WNK4. KLHL2 is critical for cellular homeostasis and catalyzes NPTXR ubiquitination, emphasizing its role in targeted protein turnover. KLHL2 Protein, Human (His) is the recombinant human-derived KLHL2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of KLHL2 Protein, Human (His) is 306 a.a., with molecular weight of ~63 KDa.

HY-P701570

	IPP Protein, Human (Sf9) IPP; actin-binding protein IPP; Intracisternal A particle-promoted polypeptide; IPP; Kelch-like protein 27	Human	Sf9 insect cells
	IPP may organize the actin cytoskeleton, affecting the structural arrangement and dynamics of the cell's cytoskeletal network. It contributes to the organization of actin filaments, which is critical for cell morphology, movement and signaling. IPP Protein, Human (Sf9) is the recombinant human-derived IPP protein, expressed by Sf9 insect cells , with tag free. The total length of IPP Protein, Human (Sf9) is 583 a.a., .

HY-P701571

	IPP Protein, Human (Sf9, His, StrepⅡ) IPP; actin-binding protein IPP; Intracisternal A particle-promoted polypeptide; IPP; Kelch-like protein 27	Human	Sf9 insect cells
	IPP may organize the actin cytoskeleton, affecting the structural arrangement and dynamics of the cell's cytoskeletal network. It contributes to the organization of actin filaments, which is critical for cell morphology, movement and signaling. IPP Protein, Human (Sf9, His, Strep) is the recombinant human-derived IPP protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of IPP Protein, Human (Sf9, His, Strep) is 583 a.a., .

HY-P703323

	MYO3A Protein, Human (Active, Sf9, His, GST, Strep) Myosin-IIIa; MYO3A; Homo sapiens; Human; actin-binding; Kinase; Motor protein; Myosin; Serine/threonine-protein kinase; Transferase; 2.7.11.1	Human	Sf9 insect cells
	MYO3A Protein, Human (Active, Sf9, His, GST, Strep) is the recombinant human-derived MYO3A, expressed by Sf9 insect cells , with Strep, His, GST labeled tag. ,

HY-P701528

	HLTF Protein, Human HLTF; Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human is the recombinant human-derived HLTF protein, expressed by E. coli , with tag free. The total length of HLTF Protein, Human is 117 a.a., .

HY-P701529

	HLTF Protein, Human (His) HLTF; Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human (His) is the recombinant human-derived HLTF protein, expressed by E. coli , with N-6*His labeled tag. The total length of HLTF Protein, Human (His) is 117 a.a., .

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82980

	Actin Related Protein 2 Antibody (YA2725) ACTR2; ARP2; ARP2/3 COMPLEX	WB, ICC/IF	Human, Mouse, Rat
	Actin Related Protein 2 Antibody (YA2725) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2725), targeting Actin Related Protein 2, with a predicted molecular weight of 45 kDa (observed band size: 45 kDa). Actin Related Protein 2 Antibody (YA2725) can be used for WB, ICC/IF experiment in human, mouse, rat background.

HY-P81254

	*Beta Actin* (Fruit Fly) Antibody** ACT1_DROME; Dro-actin; actin 5C; Act5C; Fruit Fly actin; β-actin; β actin	WB	Fruit Fly
	Beta Actin (Fruit Fly) Antibody is a biotin-conjugated non-conjugated IgG antibody, targeting Beta Actin (Fruit Fly), with a predicted molecular weight of 42 kDa. Beta Actin (Fruit Fly) Antibody can be used for WB experiment in fruit fly background.

HY-P80438

	*Beta Actin* Antibody** 2 Publications Verification	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Beta Actin Antibody is a non-conjugated and Mouse origined monoclonal antibody about 42 kDa, targeting to Beta Actin. It can be used for WB,ICC,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80484

	*alpha smooth muscle Actin* Antibody** 1 Publications Verification alpha sarcomeric actin; alpha smooth muscle actin; actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; actin, aortic smooth muscle; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; Alpha-actin 2; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-Smooth Muscle actin; α Smooth Muscle actin	WB, IHC-P, FC, IP	Human, Mouse
	alpha smooth muscle Actin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 42 kDa, targeting to alpha smooth muscle Actin. It can be used for WB,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse.

HY-P81258

	*alpha Skeletal Muscle Actin* Antibody (YA930)** ACTA1; ACTA; actin; alpha skeletal muscle; Alpha-actin-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	alpha Skeletal Muscle Actin Antibody (YA930) is a mouse-derived non-conjugated IgG antibody (Clone NO.: YA930), targeting alpha Skeletal Muscle Actin, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). alpha Skeletal Muscle Actin Antibody (YA930) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82010

	Actin Related Protein 3 Antibody (YA1755) ACTR3; ARP3; actin-related protein 3; actin-like protein 3	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Actin Related Protein 3 Antibody (YA1755) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1755), targeting Actin Related Protein 3, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). Actin Related Protein 3 Antibody (YA1755) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P82731

	Actin Regulatory Protein CAPG Antibody (YA2476) AFCP; Capg; gCap39; HEL S 66; mbh1; MCP	WB	Human, Mouse, Rat
	Actin Regulatory Protein CAPG Antibody (YA2476) is a biotin-conjugated non-conjugated IgG antibody, targeting Actin Regulatory Protein CAPG, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). Actin Regulatory Protein CAPG Antibody (YA2476) can be used for WB experiment in human, mouse, rat background.

HY-P80261

	*Pan-Actin* Antibody**	WB, IHC-P	Human, Mouse, Rat
	Pan-Actin Antibody is a non-conjugated and Mouse origined monoclonal antibody about 42kDa, targeting to Pan-Actin. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P83739

	*alpha smooth muscle Actin* Antibody(YA3468)** alpha sarcomeric actin; alpha smooth muscle actin; actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; actin alpha 2 smooth muscle aorta; actin aortic smooth muscle; actin, aortic smooth muscle; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; Alpha-actin 2; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-Smooth Muscle actin; α Smooth Muscle actin	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	alpha smooth muscle Actin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 42 kDa, targeting to alpha smooth muscle Actin. It can be used for WB, IF-Cell, IF-Tissue, IHC-P, FC, mIHC assays with tag free, in the background of Human, Mouse,Rat.

HY-P81258A

	*alpha Skeletal Muscle Actin* Antibody (YA931)** ACTA1; ACTA; actin; alpha skeletal muscle; Alpha-actin-1	IHC-P	Human
	alpha Skeletal Muscle Actin Antibody (YA931) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA931), targeting alpha Skeletal Muscle Actin. alpha Skeletal Muscle Actin Antibody (YA931) can be used for IHC-P experiment in human background.

HY-P80993

	*Beta Actin* Antibody HRP Conjugated**	WB	Human, Mouse, Rat, Zebrafish, Monkey, Hamster, Plant
	Beta Actin Antibody HRP Conjugated is a rabbit-derived HRP-conjugated antibody targeting beta-Actin with a molecular weight of approximately 42 KDa. Beta Actin Antibody HRP Conjugated can be used for WB experiments in human, mouse, rat, zebrafish, monkey, hamster, plant backgrounds.

HY-P81035

	*Plant Actin* Antibody (YA881)**	WB	Oryza sativa L, Brassica napus
	Plant Actin Antibody (YA881) is an unconjugated, approximately 42 kDa, mouse-derived, anti-Plant Actin (YA881) monoclonal antibody. Plant Actin Antibody (YA881) can be used for: WB expriments in Oryza sativa L, Brassica napus background without labeling.

HY-P80667

	Fascin Antibody 55 kDa actin bundling protein; actin bundling protein; FAN1; Fascin 1; Fascin; Singed (Drosophila) like (sea urchin fascin homolog like); Fascin homolog 1; Fascin	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat, Monkey
	Fascin Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 55 kDa, targeting to Fascin. It can be used for WB,IHC-F,IHC-P,ICC/IF,FC,IP assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P82939

	ACTL6A Antibody (YA2684) ACTL6A; BAF53; BAF53A; INO80K; actin-like protein 6A; 53 kDa BRG1-associated factor A; actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K	WB, ICC/IF, IP	Human
	ACTL6A Antibody (YA2684) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2684), targeting ACTL6A, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). ACTL6A Antibody (YA2684) can be used for WB, ICC/IF, IP experiment in human background.

HY-P82497

	GCDFP 15 Antibody (YA2242) BRST2; GCDGP15; gp17; GPIP4; PIP; Prolactin induced protein; SABP; Secretory actin binding protein	WB, ICC/IF, IP	Human
	GCDFP 15 Antibody (YA2242) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2242), targeting GCDFP 15, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). GCDFP 15 Antibody (YA2242) can be used for WB, ICC/IF, IP experiment in human background.

HY-P82158

	Sarcomeric alpha Actinin Antibody (YA1903) actin binding protein; actinin alpha 2; ACTN2; Alpha actinin 2; CMD1AA	WB, IHC-P, IP	Human, Mouse, Rat
	Sarcomeric alpha Actinin Antibody (YA1903) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1903), targeting Sarcomeric alpha Actinin, with a predicted molecular weight of 104 kDa (observed band size: 104 kDa). Sarcomeric alpha Actinin Antibody (YA1903) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

HY-P82252

	ACTN3 Antibody (YA1997) ACTN3; Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	ACTN3 Antibody (YA1997) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1997), targeting ACTN3, with a predicted molecular weight of 103 kDa (observed band size: 103 kDa). ACTN3 Antibody (YA1997) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P81344

	LSP1 Antibody (YA1089) Lymphocyte-specific protein 1; Protein pp52; 52 kDa phosphoprotein; Lymphocyte-specific antigen WP34; 47 kDa actin-binding protein	IHC-P	Human
	LSP1 Antibody (YA1089) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1089), targeting LSP1. LSP1 Antibody (YA1089) can be used for IHC-P experiment in human background.

HY-P81461

	TAGLN/Transgelin Antibody (YA1206) TAGLN; Transgelin; SM22; WS3-10; 22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha (SM22-alpha)	IHC-P	Human
	TAGLN/Transgelin Antibody (YA1206) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1206), targeting TAGLN/Transgelin. TAGLN/Transgelin Antibody (YA1206) can be used for IHC-P experiment in human background.

HY-P83496

	SMARCA2 Antibody (YA3241) SMARCA2; BAF190B; BRM; SNF2A; SNF2L2; Probable global transcription activator SNF2L2; ATP-dependent helicase SMARCA2; BRG1-associated factor 190B; BAF190B; Protein brahma homolog; hBRM; SNF2-alpha; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2	WB, IHC-F, IHC-P, ICC/IF	Human
	SMARCA2 Antibody (YA3241) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3241), targeting SMARCA2, with a predicted molecular weight of 181 kDa (observed band size: 190 kDa). SMARCA2 Antibody (YA3241) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.