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Results for "

anti-proliferation activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Acetyl-CoA Carboxylase (1) ADC Cytotoxin (1) AMPK (1) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (2) Apoptosis (32) Aurora Kinase (1) Autophagy (5) Bacterial (2) Bcl-2 Family (5) Carbonic Anhydrase (1) COX (2) Cytochrome P450 (3) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (2) Dopamine Receptor (6) Drug Isomer (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (1) Epigenetic Reader Domain (2) ERK (2) Estrogen Receptor/ERR (2) FAK (1) Ferroptosis (1) FLT3 (1) Fungal (2) Glutaminase (1) HDAC (2) Histone Demethylase (6) Histone Methyltransferase (4) HMG-CoA Reductase (HMGCR) (1) Influenza Virus (1) Integrin (1) Isocitrate Dehydrogenase (IDH) (1) JNK (1) MDM-2/p53 (2) MEK (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitophagy (1) mTOR (1) NEDD8-activating Enzyme (1) Oxidative Phosphorylation (1) p38 MAPK (1) PARP (2) Peptide-Drug Conjugates (PDCs) (1) PROTACs (6) Proton Pump (1) PSMA (1) RAR/RXR (2) Ras (3) Reactive Oxygen Species (2) RET (1) Sirtuin (2) STAT (2) TAM Receptor (2) Topoisomerase (2) Wee1 (2) YAP (1) β-catenin (2)
By Research Areas:	Cancer (79) Cardiovascular Disease (7) Infection (2) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (7)

By Targets:

5-HT Receptor (3)

Acetyl-CoA Carboxylase (1)

ADC Cytotoxin (1)

AMPK (1)

Anaplastic lymphoma kinase (ALK) (2)

Antibiotic (2)

Apoptosis (32)

Aurora Kinase (1)

Autophagy (5)

Bacterial (2)

Bcl-2 Family (5)

Carbonic Anhydrase (1)

COX (2)

Cytochrome P450 (3)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (2)

Dopamine Receptor (6)

Drug Isomer (1)

E1/E2/E3 Enzyme (1)

Endogenous Metabolite (1)

Epigenetic Reader Domain (2)

ERK (2)

Estrogen Receptor/ERR (2)

FAK (1)

Ferroptosis (1)

FLT3 (1)

Fungal (2)

Glutaminase (1)

HDAC (2)

Histone Demethylase (6)

Histone Methyltransferase (4)

HMG-CoA Reductase (HMGCR) (1)

Influenza Virus (1)

Integrin (1)

Isocitrate Dehydrogenase (IDH) (1)

JNK (1)

MDM-2/p53 (2)

MEK (1)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (1)

Mitophagy (1)

mTOR (1)

NEDD8-activating Enzyme (1)

Oxidative Phosphorylation (1)

p38 MAPK (1)

PARP (2)

Peptide-Drug Conjugates (PDCs) (1)

PROTACs (6)

Proton Pump (1)

PSMA (1)

RAR/RXR (2)

Ras (3)

Reactive Oxygen Species (2)

RET (1)

Sirtuin (2)

STAT (2)

TAM Receptor (2)

Topoisomerase (2)

Wee1 (2)

YAP (1)

β-catenin (2)

By Research Areas:

Cancer (79)

Cardiovascular Disease (7)

Infection (2)

Inflammation/Immunology (4)

Metabolic Disease (4)

Neurological Disease (7)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0839

Quillaic acid 1 Publications Verification Quillaja sapogenin	Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Quillaic acid (Quillaja sapogenin)It is an anti-gastric cancer and anti-proliferation agent that can promote apoptosis of cancer cells. (apoptosis). Quillaic acidAlso has analgesic and local anti-inflammatory activity .

HY-N11438

3'-Hydroxymirificin	Estrogen Receptor/ERR	Cancer
3'-Hydroxymirificin (compound 3) is a naural compound that can be isolated from Pueraria lobata roots. 3'-Hydroxymirificin (compound 3) possesses estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-149726

EZH2-IN-17	Histone Methyltransferase	Cancer
EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC₅₀ value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively) .

HY-N6885

Puerarin-4'-O-β-D-glucopyranoside	Others	Cancer
Puerarin-4'-O-β-D-glucopyranoside (compound 8) is a isoflavone from Pueraria lobata root (PLR). Puerarin-4'-O-β-D-glucopyranoside has estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells .

HY-N4272

Protodeltonin	Others	Cancer
Protodeltonin is a steroidal saponin from Dioscorea zingiberensis Wright, with anti-proliferation activity .

HY-158230

SN-398	Topoisomerase	Cancer
SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC₅₀=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells .

HY-163456

Chx-HT	Apoptosis	Cancer
Chx-HT has an anti-proliferation activity and promotes apoptosis on ovarian cancer cells .

HY-149970

ER degrader 5	Estrogen Receptor/ERR	Cancer
ER degrader 5 is a potent estrogen receptor (ER) degrader. ER degrader 5 shows anti-proliferation activity. ER degrader 5 can be used for the research of breast cancer .

HY-N12534

Monaspin B	Apoptosis	Cancer
Monaspin B is a natural product produced by the co-culture of Monascus purpureus and Aspergillus oryzae. Monaspin B exerts anti-proliferation activity by inducing apoptosis of HL-60 cells, IC₅₀ 160 nM. Monaspin B has antitumor activity .

HY-144624

PROTAC Axl Degrader 1	PROTACs TAM Receptor	Cancer
PROTAC Axl Degrader 1 is a potent and selective PROTAC Axl degrader with an IC₅₀ of 0.92 μM. PROTAC Axl Degrader 1 shows anti-proliferation activity, anti-migration activity in vitro. PROTAC Axl Degrader 1 induces mehuosis .

HY-144627

PROTAC Axl Degrader 2	PROTACs TAM Receptor	Cancer
PROTAC Axl Degrader 2 is a potent and selective PROTAC Axl degrader with an IC₅₀ of 1.61 μM. PROTAC Axl Degrader 2 shows anti-proliferation activity, anti-migration activity in vitro. PROTAC Axl Degrader 2 induces mehuosis .

HY-149061

Anticancer agent 99	Apoptosis	Cancer
Anticancer agent 99 (compound 2p) has good anticancer activity against HepG2 cells, with an IC₅₀ value of 35.9 μM. Anticancer agent 99 can induce apoptosis and has anti-proliferation effect .

HY-150401

Exatecan-amide-cyclopropanol	ADC Cytotoxin Topoisomerase	Cancer
Exatecan-amide-cyclopropanol (compound 1) is a anticancer agent. Exatecan-amide-cyclopropanol shows anti-proliferation activity against SK-BR-3 and U87 cells, with IC₅₀ values of 0.12 and 0.23 nM, respectively .

HY-B1360

Chlorquinaldol 5 Publications Verification Chloquinan	Antibiotic Bacterial Fungal β-catenin Apoptosis	Infection Cancer
Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells .

HY-170762

Mcl-1 inhibitor 21	Apoptosis Bcl-2 Family	Cancer
Mcl-1 inhibitor 21 (Example 1-36) is a Mcl-1 inhibitor with an IC₅₀ of 328 nM. Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research .

HY-170762A

(+)-Mcl-1 inhibitor 21	Apoptosis Bcl-2 Family	Cancer
(+)-Mcl-1 inhibitor 21 (Example 1-37) is a Mcl-1 inhibitor with an IC₅₀ of 172 nM. (+)-Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research .

HY-170762B

(-)-Mcl-1 inhibitor 21	Apoptosis Bcl-2 Family	Cancer
(-)-Mcl-1 inhibitor 21 (Example 1-38) is a Mcl-1 inhibitor with an IC₅₀ of 7.51 μM. (-)-Mcl-1 inhibitor 21 exhibits proapototic and anti-proliferation activities against SUDHL5 and SUDHL10 cell lines and can be utilized in cancer research .

HY-117376

(all-E)-UAB30 UAB30	RAR/RXR	Cancer
(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC₅₀ of 34.7, 5.1, and 22.4 μM respectively .

HY-155526

FY-21	Histone Demethylase	Cancer
FY-21 is a selective inhibitor of LSD1 (IC₅₀=340 nM), with anti-proliferation and anti-colony formation activities. FY-21 enhances p53 expression, down-regulates HOXA9 and MEIS1 expression. FY-21 also induces leukemia cell differentiation to exhibts antitumor activity .

HY-162837

AURKA against 1	Aurora Kinase	Cancer
AURKA against 1 is an inhibitor of AURKA (IC₅₀ less than 0.5 nM), targeting endogenous lysine (K162) acetylation, and has anti-proliferation activity against tumor cells. AURKA against 1 induces K162 acetylation, and the kinase activity of AURKA is reversibly restored in HCT116 cells transfected with SIRT3 .

HY-B1360R

Chlorquinaldol (Standard)	Antibiotic Bacterial Fungal β-catenin Apoptosis	Infection Cancer
Chlorquinaldol (Standard) is the analytical standard of Chlorquinaldol. This product is intended for research and analytical applications. Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells .

HY-127103

FB23-2 15+ Cited Publications	Apoptosis	Cancer
FB23-2 is a potent and selective inhibitor of mRNA N ⁶-methyladenosine (m ⁶A) demethylase FTO, with an IC₅₀ of 2.6 μM. FB23-2 has anti-proliferation activity. FB23-2 can be used for the research of acute myeloid leukemia (AML) .

HY-N3940

Gelsevirine	Others	Neurological Disease Cancer
Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC₅₀ values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively .

HY-161268

NAE-IN-1	Apoptosis NEDD8-activating Enzyme Reactive Oxygen Species	Cancer
NAE-IN-1 (compound X-10) is a potent NAE1 inhibitor. NAE-IN-1 induces apoptosis and cell cycle arrest at the G2/M phase. NAE-IN-1 increases ROS levels and prevents cell migration. NAE-IN-1 shows anti-proliferation activity .

HY-170592

dALK-3	Anaplastic lymphoma kinase (ALK)	Cancer
dALK-3 is an anaplastic lymphoma kinase (ALK) degrader. dALK-3 can effectively induce EML4-ALK degradation with a DC₅₀ of 0.182 μM. dALK-3 has good anti-proliferation activity against H3122 cells and can be used in the study of cancer .

HY-170763

Mcl-1 inhibitor 22	Apoptosis Bcl-2 Family	Cancer
Mcl-1 inhibitor 22 (Example 36) is a myeloid cell leukemia-1 (MCL-1) inhibitor which inhibits the antiapoptotoic activity of MCL-1 by inhibiting its interaction with proapototic proteins. Mcl-1 inhibitor 22 exhibits anti-proliferation activities against various cancer cell lines and can be utilized in cancer research .

HY-170763A

(+)-Mcl-1 inhibitor 22	Apoptosis Bcl-2 Family	Cancer
(+)-Mcl-1 inhibitor 22 (Example 37) is a myeloid cell leukemia-1 (MCL-1) inhibitor which inhibits the antiapoptotoic activity of MCL-1 by inhibiting its interaction with proapototic proteins. (+)-Mcl-1 inhibitor 22 exhibits anti-proliferation activities against various cancer cell lines and can be utilized in cancer research .

HY-110329

ML179	Others	Cancer
ML179 (SR-1309) is a inverse LRH1/NR5A2 (Liver receptor homologue-1) agonist with IC₅₀ of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer .

HY-144131

RET-IN-11	Apoptosis RET	Cancer
RET-IN-11 is a potent and selective RET inhibitor with IC₅₀s of 6.20 nM, 18.68 nM for RET and RET ^V804M, respectively. RET-IN-11 shows anti-proliferation and migration activity in CCDC6-RET-driven LC-2/ad cells. RET-IN-11 induces cell apoptosis .

HY-14507

YK-4-279 5+ Cited Publications	DNA/RNA Synthesis Apoptosis	Cancer
YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer .

HY-147722

hCAIX-IN-8	Carbonic Anhydrase	Cancer
hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC₅₀s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential .

HY-142946

KRAS G12C inhibitor 44	Ras	Cancer
KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC₅₀s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo .

HY-146208

BRD4 Inhibitor-20	Epigenetic Reader Domain	Cancer
BRD4 Inhibitor-20 is a potent orally active bromodomain protein 4 (BRD4) inhibitor. BRD4 Inhibitor-20 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC₅₀ values of 19 nM and 28 nM, respectively. BRD4 Inhibitor-20 also has anti-proliferation activities in cancer cell lines. BRD4 Inhibitor-20 can be used for the research of kinds of cancer, such as colon cancer .

HY-155728

Sirt1/2-IN-3	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-3 (compound PS9) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respsectivley. Sirt1/2-IN-3 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-3 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines .

HY-155727

Sirt1/2-IN-2	Sirtuin Apoptosis	Cancer
Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC₅₀s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines .

HY-114323

PROTAC FLT-3 degrader 1	PROTACs FLT3 Apoptosis STAT MEK ERK	Cancer
PROTAC FLT-3 degrader 1 is an effective and selective FLT-3 PROTAC degrader with an IC₅₀ of 0.6 nM. PROTAC FLT-3 degrader 1 inhibits both FLT-3 and FLT-3 ITD mutants. PROTAC FLT-3 degrader 1 has the activity of anti-proliferation and induction of apoptosis, which can be used in the study of tumor. (Pink: FLT3 ligand (HY-168702); Black: Linker (HY-124380); Blue: VHL ligand (HY-125845)) .

HY-144099

Keap1-Nrf2-IN-4	E1/E2/E3 Enzyme Apoptosis	Cancer
Keap1-Nrf2-IN-4 is a potent neddylation inhibitor. Keap1-Nrf2-IN-4 exhibits potent anti-proliferation activity against MGC-803 cells (IC₅₀=2.55 µM). Keap1-Nrf2-IN-4 blocks the migration ability and induces apoptosis of gastric cancer cells. Keap1-Nrf2-IN-4 inhibits tumor growth without obvious toxicity .

HY-153359

M3913	Others	Cancer
M3913 is an antitumor compound. M3913 has antiproliferation activity against cancer cells .

HY-143234

mIDH1-IN-1	Isocitrate Dehydrogenase (IDH)	Cancer
mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC₅₀ of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC₅₀ of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC₅₀ of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research .

HY-154809

(R)-M3913	Drug Isomer	Others Cancer
(compound C-155) is a enantiomer of M3913. M3913 (HY-153359) is an antitumor compound. M3913 has antiproliferation activity against cancer cells .

HY-113840

Sumarotene Ro 14-9706	Others	Metabolic Disease Inflammation/Immunology
Sumarotene (Ro 14-9706), an arotinoid methyl sulfone, is a potent dermatologic agent for the repair of photodamage, antikeratinization, and antiproliferation. Sumarotene exhibits in rats a prolactin-suppressive activity which affects lactation .

HY-146095

p53 Activator 2	MDM-2/p53 DNA/RNA Synthesis Apoptosis	Cancer
p53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC₅₀ of 1.73 µM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models .

HY-110021

Fenoldopam hydrochloride SKF 82526 hydrochloride	Dopamine Receptor Histone Demethylase Apoptosis	Cardiovascular Disease Cancer
Fenoldopam (SKF 82526) hydrochloride is a D₁ receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis .

HY-N0189

Aloe emodin 2 Publications Verification Rhabarberone; 3-Hydroxymethylchrysazine	mTOR Influenza Virus Apoptosis Autophagy	Cancer
Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis . Aloe emodin also exhibits antiviral activity that against influenza A virus .

HY-170311

YAP/TEAD-IN-1	YAP	Cancer
YAP/TEAD-IN-1 (compound 4) is a potent YAP and TEAD inhibitor. YAP/TEAD-IN-1 shows antioxidant activity. YAP/TEAD-IN-1 shows antiproliferation activity for tumor cells. YAP/TEAD-IN-1 shows little cytotoxic activity for human normal cells .

HY-N2434

[10]-Shogaol 2 Publications Verification	COX	Cancer
[10]-Shogaol is an antioxidant from Zingiber officinale for human skin cell growth and a migration enhancer. [10]-Shogaol inhibits COX-2 with an IC₅₀ of 7.5 μM and has antiproliferation activity .

HY-12708

Chlorpromazine Maximum Cited Publications 66 Publications Verification	Dopamine Receptor Cytochrome P450 Autophagy 5-HT Receptor	Cardiovascular Disease Neurological Disease Cancer
Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis .

HY-B0407A

Chlorpromazine hydrochloride Maximum Cited Publications 66 Publications Verification	Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor	Cardiovascular Disease Neurological Disease Cancer
Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .

HY-169946

WEE1/PKMYT1-IN-1	Wee1	Cancer
WEE1/PKMYT1-IN-1 (compound 75) is a potent and orally active WEE1 and PKMYT1 inhibitor. WEE1/PKMYT1-IN-1 shows antiproliferation activity .

HY-17502

Simvastatin 55+ Cited Publications MK 733	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis Ferroptosis	Cardiovascular Disease Cancer
Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a K_i of 0.2 nM.

Cat. No.	Product Name	Target	Research Area

HY-P10783

BGC0222	Peptide-Drug Conjugates (PDCs) Integrin	Cancer
BGC0222 is a novel prodrug of Irinotecan (HY-16562). BGC0222, as a PEG-cRGD-conjugated Irinotecan (HY-16562) derivative, could slowly and steadily release Irinotecan (HY-16562). BGC0222 binds to α_Vβ₃ with IC₅₀ values of 4.25 μM (α_Vβ₃) and 58.7 μM (α_Vβ₅). BGC0222 possesses the property of inducing neovascularization. BGC0222 exhibits good antiproliferation activity in many tumors .

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