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Results for "

anticonvulsant activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Adenosine Kinase (1) Adrenergic Receptor (3) Akt (2) Antibiotic (1) Apoptosis (7) Bacterial (2) Biochemical Assay Reagents (2) Calcium Channel (5) Cannabinoid Receptor (1) Carbonic Anhydrase (1) Drug Derivative (8) Drug Intermediate (2) Drug Metabolite (3) EAAT (1) Endogenous Metabolite (8) Fungal (1) GABA Receptor (34) GSK-3 (1) HCN Channel (4) HSV (1) iGluR (15) Imidazoline Receptor (3) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (4) JAK (2) Keap1-Nrf2 (2) Liposome (1) mGluR (3) Monoamine Oxidase (6) nAChR (3) NO Synthase (1) Nucleoside Antimetabolite/Analog (59) Opioid Receptor (4) Parasite (3) PI3K (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (3) Reactive Oxygen Species (4) Sodium Channel (8) VEGFR (2) β-catenin (2)
By Research Areas:	Cancer (42) Cardiovascular Disease (7) Endocrinology (4) Infection (6) Inflammation/Immunology (11) Neurological Disease (103)
Click Chemistry:	Azide (5) Alkynes (2)
Oligonucleotides:	Nucleosides and their Analogs (51) Nucleoside Phosphoramidites (5)

175

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100797

(RS)-CPP (±)-CPP	iGluR	Neurological Disease
(RS)-CPP ((±)-CPP) is a potent and selective NMDA antagonist. (RS)-CPP inhibits central neuron responses, and has anticonvulsant activity .

HY-154436

Anticonvulsant agent 2	GABA Receptor	Neurological Disease
Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity .

HY-B1185

Beclamide N-Benzyl-3-chloropropionamide	Drug Derivative	Neurological Disease
Beclamide is an active molecule with anticonvulsant activity, used as an anticonvulsant drug.

HY-22183

Anticonvulsant agent 3	Drug Derivative	Neurological Disease
Anticonvulsant agent 3 is a 2-amino derivative with *anticonvulsant* activity ^{[1] ^.}

HY-114871

SL651498	GABA Receptor	Neurological Disease
SL651498 is a full agonist of α2 and α3 GABAA receptors, and a partial agonist of α1 and α5 GABAA receptors. SL651498 shows anxiolytic and anticonvulsant activities .

HY-14336

SB 271046	5-HT Receptor	Neurological Disease
SB 271046 is a potent, selective and orally active 5-HT6 receptor antagonist with a pK_i of 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity .

HY-W845607

Milacemide	Monoamine Oxidase	Neurological Disease
Milacemide, a glycinamide derivative, is an orally active MAO-B inhibitor with anticonvulsant activity. Milacemide reduces the levels of dihydroxyphenylacetic acid and homovanilic acid, but increases the levels of dopamine and serotonin in the caudate nucleus. Milacemide is promising for research of Alzheimer's disease .

HY-130205

Milacemide hydrochloride CP 1552 S	Monoamine Oxidase	Neurological Disease
Milacemide hydrochloride (CP 1552 S), a glycinamide derivative, is an orally active MAO-B inhibitor with anticonvulsant activity. Milacemide hydrochloride reduces the levels of dihydroxyphenylacetic acid and homovanilic acid, but increases the levels of dopamine and serotonin in the caudate nucleus. Milacemide hydrochloride is promising for research of Alzheimer's disease .

HY-170930

Anticonvulsant agent 9	GABA Receptor Sodium Channel	Neurological Disease
Anticonvulsant agent 9 (compound 4f) is an α1β2γ2 GABAA receptors activator. Anticonvulsant agent 9 activatesα1β2γ2 GABAA receptors with an EC₅₀ of 1.24 μM. Anticonvulsant agent 9 inhibits the inactivation of Nav1.2 channels. Anticonvulsant agent 9 exhibits significant anticonvulsant activities .

HY-116826

Buramate	Others	Neurological Disease
Buramate exhibits neuroprotective and anticonvulsant activities.

HY-162757

Anticonvulsant agent 5	GABA Receptor Sodium Channel	Neurological Disease
Anticonvulsant agent 5 (Compound 5c) exhibits high affinity for GABA_A receptors and NaV_1.3 receptors. Anticonvulsant agent 5 shows anticonvulsant efficacy in mice psychomotor epilepsy test with an ED₅₀ of 107 mg/kg. Anticonvulsant agent 5 exhibits neuroprotective activity against Kainic acid (HY-N2309) with an IC₅₀ of 113 μM. Anticonvulsant agent 5 is blood-brain barrier (BBB) penetrable .

HY-170801

Anticonvulsant agent 7	Others	Neurological Disease
Anticonvulsant agent 7 (Compound 19) is an orally active broad-spectrum anticonvulsant that demonstrates excellent anticonvulsive activity in both the MES (maximal electroshock seizure) and 6 Hz epilepsy modelsmouse .

HY-W090292

Olivetolic acid	Drug Intermediate	Neurological Disease
Olivetolic acid is a biosynthetic precursor of cannabinol acid (CBGA). Olivetolic acid has anticonvulsant activity .

HY-119461

Capuride	Drug Derivative	Neurological Disease
Capuride is an orally active sedative agent. Capuride has anticonvulsant activity .

HY-B1229

Isovaleramide 3-Methylbutanamide	GABA Receptor	Neurological Disease
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant that modulates central nervous system activity. Isovaleramide has anticonvulsant, anxiolytic, sedative, and sleep aid activities. Isovaleramide is promising for research of ethylene glycol (EG) poisoning-induced acute kidney injury and epilepsy .

HY-106670

Dulozafone F1933	Others	Neurological Disease
Dulozafone (F1933) shows anticonvulsant activity and can be used for epilepsy research .

HY-121393

Imidazenil	GABA Receptor	Neurological Disease
Imidazenil is a partial positive allosteric modulator of GABA_A receptors with anxiolytic, antipanic and anticonvulsant activities.

HY-W294348

Prenderol 2,2-Diethyl-1,3-propanediol	Drug Derivative	Neurological Disease
Prenderol is a potent central-nervous-system depressant. Prenderol has anticonvulsant activity .

HY-118490

T-2000 DMMDPB	GABA Receptor	Neurological Disease
T-2000 (DMMDPB) is an orally active GABA receptor agonist with anticonvulsant activities .

HY-106747

Ralitoline	Sodium Channel	Neurological Disease
Ralitoline is a sodium channel blocker with IC₅₀ of 2 μM. Ralitoline has anticonvulsant activity .

HY-100379

Valrocemide TV1901	Sodium Channel Fungal	Neurological Disease
Valrocemide (TV1901) is a promising antiepileptic agent candidate that shows a broad spectrum of anticonvulsant activity.

HY-170717

3-Methylnordiazepam RO-5-2751	Drug Derivative	Neurological Disease
3-Methylnordiazepam (RO-5-2751) is a benzodiazepine and shows anticonvulsant activity in mice .

HY-133486

GABAA receptor agent 1	GABA Receptor	Neurological Disease
GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity .

HY-W010383

3-Diethylamino-1-propanol	Others	Neurological Disease
3-Diethylamino-1-propanol is an tertiary amine compound with anticonvulsant activity .

HY-106716

SR 41378	Drug Derivative	Neurological Disease
SR 41378 is an orally active aminopyrazine derivative. SR 41378 has anticonvulsant, antianxiety and hypnotic activities .

HY-15068

NBQX 10+ Cited Publications FG9202	iGluR	Neurological Disease
NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity .

HY-167936

cis-AY 9944	Liposome	Neurological Disease
cis-AY 9944 is a cholesterol synthesis inhibitor, exhibiting anticonvulsant activity that influences the dynamics of spike and wave discharges in EEG recordings.

HY-141795

Posovolone Co 134444	Others	Neurological Disease
Posovolone (Co 134444) is an orally active, neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects .

HY-N9502

Linalool oxide	Others	Neurological Disease
Linalool oxide is a secondary metabolite in elongating wheat plants with antinociceptive and anticonvulsant effects. Linalool oxide shows anxiolytic activity .

HY-133160

Valproic acid hydroxamate VPA-HA	Drug Derivative	Neurological Disease
Valproic acid hydroxamate (VPA-HA) has shown anticonvulsant activity in a mouse neural tube defect model, without any teratogenic effects .

HY-113457

11-Oxo etiocholanolone 11-Ketoetiocholanolone	Endogenous Metabolite	Neurological Disease Endocrinology
11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a metabolite of Etiocholanolone. Etiocholanolone is the excreted metabolite of testosterone and has anticonvulsant activity .

HY-15068A

NBQX disodium 10+ Cited Publications FG9202 disodium	iGluR	Neurological Disease
NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity .

HY-101240

Propranolol glycol	Endogenous Metabolite	Neurological Disease
Propranolol glycol is a metabolite of propranolol (HY-B0573B). Propranolol glycol shows instantaneous anticonvulsant activity .

HY-136591

Demoxepam	Drug Metabolite	Neurological Disease Cancer
Demoxepam is a major metabolite of Chlordiazepoxide. Demoxepam exhibits cytotoxicity activity against cancer cell lines. Demoxepam has anticonvulsant and anxiolytic effects .

HY-100963

U-54494A	Opioid Receptor	Neurological Disease
U-54494A is a benzamide derivative related to κ-opioid receptor agonists, U-54494A has an *anticonvulsant* activity .

HY-171253

Clotizolam	Platelet-activating Factor Receptor (PAFR)	Neurological Disease
Clotizolam is a thienobenzodiazepine derivative that has antagonistic activity against platelet-activating factor (PAF). Clotizolam possesses sedative, anxiolytic, anticonvulsant,and muscle relaxant effects .

HY-19259

GP3269	Adenosine Kinase	Neurological Disease
GP3269 is a potent, selective, and orally active inhibitor of human adenosine kinase (AK) with an IC₅₀ of 11 nM. GP3269 exhibits anticonvulsant activity in rats .

HY-101387A

ACPT-II	mGluR	Neurological Disease
ACPT-II is an antagonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects .

HY-120240

AND-302	Others	Others
AND-302 is a small molecule anticonvulsant with activity in preventing glutamate- or hydrogen peroxide-induced cell death and decreased neuronal viability in in vitro hippocampal cultures.

HY-12503

CFM-2 1 Publications Verification	iGluR	Neurological Disease Cancer
CFM-2 is a potent and selective non-competitive AMPAR antagonist . CFM-2 possesses anticonvulsant activity in various models of seizures .

HY-19082

Y-23684	GABA Receptor	Neurological Disease
Y-23684 is a partial agonist of benzodiazepine receptor (BZR) with anticonvulsant and anxiolytic activities. Y-23684 can be used in the research of treatment of anxiety disorders .

HY-101387

rel-ACPT-I	mGluR	Neurological Disease
rel-ACPT-I is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects .

HY-129408

SGE-516	GABA Receptor	Neurological Disease
SGE-516 is a neuroactive steroid that is a potent positive allosteric modulator of synaptic and extra-synaptic GABAA receptors. SGE-516 has anticonvulsant activity .

HY-120769

Pimprinine	Monoamine Oxidase	Neurological Disease Inflammation/Immunology
Pimprinine is a potent monoamine oxidase inhibitor, could be isolated from fermented broths. Pimprinine has antioxidative activity and anticonvulsant activity. Pimprinine inhibits tremorine-induced tremors and analgesia in mice .

HY-168363

Ciclotizolam WE-973	GABA Receptor	Neurological Disease
Ciclotizolam (WE-973) is a thienotriazolodiazepine with anticonvulsant and anti-aggressive activities. Ciclotizolam binds to benzodiazepine receptors in the central nervous system. Ciclotizolam decreases total sleep time in cats .

HY-125508

CCD-3693	GABA Receptor	Neurological Disease
CCD-3693 is an orally active GABA receptor agonist. CCD-3693 has anxiolytic, anticonvulsant and sedative hypnotic activities and can be used in research related to neurological diseases .

HY-152732

6-Methyluridine	Nucleoside Antimetabolite/Analog	Others
6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-152755

4’-Cyanouridine	Nucleoside Antimetabolite/Analog	Others
4’-Cyanouridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-114880

AB-FUBINACA 3-fluorobenzyl isomer	Cannabinoid Receptor	Neurological Disease
AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid that belongs to the indole derivatives and has a high affinity for the central CB1 receptors (K_i= 0.9 nM), exhibiting anticonvulsant activity .

HY-W020098

2'-C-methyluridine	Nucleoside Antimetabolite/Analog	Cancer
2'-C-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

Cat. No.	Product Name	Type

HY-W010365

Rhodanine	Enzyme Substrates
Rhodanine, which can be used for anticonvulsant, antibacterial, antiviral, and antidiabetic activities, is used to determine tanninase in tannic acid-degrading fungal cultures. Rhodanine is a biomaterial or organic compound that can be used as a research-related biomaterial or organic compound in life sciences .

HY-Y1267D

Magnesium sulfate, for cell culture	Buffer Reagents
Magnesium sulfate, suitable for cell culture, bioreagent. Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor. Magnesium sulfate has anti-inflammatory and an anticonvulsant activity. Magnesium sulfate is a tocolytic agent. Magnesium sulfate can be used for severe pre-eclampsis/eclampsia research .

Cat. No.	Product Name	Target	Research Area

HY-P1285

Conantokin R Con-R	iGluR	Neurological Disease
Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC₅₀ of 93 nM. Conantokin R binds Zn ²⁺ and Mg ²⁺ with K_ds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1229

Isovaleramide 3-Methylbutanamide	Structural Classification Natural Products other families Source classification Plants	GABA Receptor
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant that modulates central nervous system activity. Isovaleramide has anticonvulsant, anxiolytic, sedative, and sleep aid activities. Isovaleramide is promising for research of ethylene glycol (EG) poisoning-induced acute kidney injury and epilepsy .

HY-N9502

Linalool oxide	Natural Products Neurological Disease Classification of Application Fields Source classification Brazilian taheebo Myrtaceae Plants Disease Research Fields	Others
Linalool oxide is a secondary metabolite in elongating wheat plants with antinociceptive and anticonvulsant effects. Linalool oxide shows anxiolytic activity .

HY-113457

11-Oxo etiocholanolone 11-Ketoetiocholanolone	Source classification Endogenous metabolite Steroids	Endogenous Metabolite
11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a metabolite of Etiocholanolone. Etiocholanolone is the excreted metabolite of testosterone and has anticonvulsant activity .

HY-113320

Etiocholanolone 5β-Androsterone	Structural Classification Microorganisms Source classification Endogenous metabolite Steroids	GABA Receptor Endogenous Metabolite
Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity . Etiocholanolone is a less potent?neurosteroid positive allosteric modulator?(PAM) of the GABA_A?receptor than its?enantiomer form .

HY-114489A

Haemanthamine	Infection Alkaloids Classification of Application Fields Neurological Disease Source classification Plants Sprekelia formosissima (L.) Herb. Isoquinoline Alkaloids Disease Research Fields Amaryllidaceae	Apoptosis Influenza Virus Parasite
Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities .

HY-N0219

Bicuculline Maximum Cited Publications 26 Publications Verification (+)-Bicuculline; d-Bicuculline	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	GABA Receptor
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-N0527

Pentagalloylglucose 10+ Cited Publications Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose	Infection Structural Classification other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

HY-D0803

Thymoquinone 5+ Cited Publications	Quinones Structural Classification Classification of Application Fields Nigella sativa L. Ranunculaceae Benzene Quinones Plants Inflammation/Immunology Disease Research Fields	Apoptosis VEGFR PI3K Akt
Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .

HY-114489B

Haemanthamine hydrochloride	Infection Alkaloids Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Sprekelia formosissima (L.) Herb. Isoquinoline Alkaloids Disease Research Fields Amaryllidaceae	Apoptosis Influenza Virus Parasite
Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities .

HY-N0219R

Bicuculline (Standard)	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	GABA Receptor
Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-N6778

Paxilline 5+ Cited Publications	Alkaloids Structural Classification Microorganisms other families Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Indole Alkaloids	Potassium Channel Calcium Channel Reactive Oxygen Species
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

HY-N0527R

Pentagalloylglucose (Standard)	Structural Classification other families Source classification Phenols Polyphenols Plants	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species
Pentagalloylglucose (Standard) is the analytical standard of Pentagalloylglucose. This product is intended for research and analytical applications. Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

HY-D0803R

Thymoquinone (Standard)	Quinones Structural Classification Nigella sativa L. Ranunculaceae Benzene Quinones Plants	Apoptosis VEGFR PI3K Akt
Thymoquinone (Standard) is the analytical standard of Thymoquinone. This product is intended for research and analytical applications. Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .

HY-101392

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-101392A

Harmane hydrochloride	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Rauwolfia canescens	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name	Chemical Structure

HY-113320S

Etiocholanolone-d5
Etiocholanolone-d₅ is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2].

HY-B0688S

Dapsone-d8

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

HY-113457S

11-Oxo etiocholanolone-d5
11-Oxo etiocholanolone-d₅ is the deuterium labeled 11-Oxo etiocholanolone. 11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a metabolite of Etiocholanolone. Etiocholanolone is the excreted metabolite of testosterone and has anticonvulsant activity[1][2][3].

HY-113320S1

Etiocholanolone-d2
Etiocholanolone-d₂ is the deuterium labeled Etiocholanolone. Etiocholanolone (5β-Androsterone) is the excreted metabolite of testosterone and has anticonvulsant activity[1]. Etiocholanolone is a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor than its enantiomer form[2][3].

HY-B0162S

Ivabradine-d6

Ivabradine-d₆ is the deuterium labeled Ivabradine[1]. Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[2][3][4][5].

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name		Classification

HY-152476

3’-β-C-Ethynyluridine		Alkynes
3’-β-C-Ethynyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-β-C-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154736

N3-(Butyn-3-yl)uridine		Alkynes
N3-(Butyn-3-yl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . N3-(Butyn-3-yl)uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-77650

4'-C-Azidouridine 4'-Azidouridine		Azide
4'-C-azidouridine (4'-Azidouridine) is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4'-C-Azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152985

3’-Azido-3’-deoxy-4-deoxyuridine		Azide
6-Chloro-N1-(trimethylsilylethoxymethyl)pseudouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-Azido-3’-deoxy-4-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154590

2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine		Azide
2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152782

4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine		Azide
4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154357

4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine		Azide
4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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