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Results for "

cardiomyopathy

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Adrenergic Receptor (7) Akt (3) AMPK (1) Angiotensin Receptor (1) Antibiotic (3) AP-1 (3) Apoptosis (11) Autophagy (5) Bacterial (6) Caspase (3) CaSR (2) Cathepsin (1) Cytochrome P450 (1) DNA/RNA Synthesis (3) Endogenous Metabolite (2) Ferroptosis (1) G Protein-coupled Receptor Kinase (GRK) (1) HBV (3) HDAC (2) HIV (3) JAK (1) JNK (4) Keap1-Nrf2 (2) Myosin (5) Necroptosis (1) Neprilysin (1) NF-κB (3) p38 MAPK (2) Parasite (3) PDHK (1) PI3K (3) Potassium Channel (2) Prostaglandin Receptor (2) PTEN (1) Pyroptosis (1) Reactive Oxygen Species (6) Topoisomerase (3) Transthyretin (TTR) (2)
By Research Areas:	Cancer (17) Cardiovascular Disease (29) Endocrinology (9) Infection (8) Inflammation/Immunology (14) Metabolic Disease (12) Neurological Disease (12)
Oligonucleotides:	Antisense Oligonucleotides (2)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139465

Aficamten CK-274; CK-3773274	Myosin	Cardiovascular Disease
Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC₅₀ of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM) .

HY-121744

PS10 2 Publications Verification	PDHK	Inflammation/Immunology
PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC₅₀ of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (K_d= 239 nM) than for Hsp90 (K_d= 47 μM) . PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy .PDK: pyruvate dehydrogenase kinase

HY-152190

JB002	Myosin	Cardiovascular Disease
JB002 is a myosin II inhibitor, with an IC₅₀ of ≤10 μM. JB002 can be used for the research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .

HY-145564A

Emprumapimod hydrochloride PF-07265803 hydrochloride	p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Emprumapimod (PF-07265803) hydrochloride is an orally active and selective inhibitor of p38α MAPK. Emprumapimod hydrochloride can be used for the research of dilated cardiomyopathy and acute inflammatory pain .

HY-106577

Cibenzoline Cifenline; Ro 22-7796	Potassium Channel	Cardiovascular Disease
Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic agent. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy .

HY-145564

Emprumapimod PF-07265803	p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Emprumapimod (PF-07265803) is a potent, orally active and selective inhibitor of p38α MAPK directly inhibits LPS-induced IL-6 production from RPMI-8226 cell (IC₅₀=100 pM). Emprumapimod can be used for the research of dilated cardiomyopathy and acute inflammatory pain .

HY-105218A

Ifetroban sodium 1 Publications Verification BMS-180291 sodium	Prostaglandin Receptor	Cardiovascular Disease Endocrinology Cancer
Ifetroban (BMS-180291) sodium is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban sodium shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban sodium can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research .

HY-150040

CCG-273463	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease Cancer
CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC₅₀ value of 8.6 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer .

HY-125863B

Glucose 6-phosphate dehydrogenase (yeast, recombinant) G6PD (yeast, recombinant)	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
Glucose 6-phosphate dehydrogenase (yeast, recombinant) is the rate-limiting enzyme of the pentose phosphate pathway and a major source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, and cytochrome P450 systems. Glucose 6-phosphate dehydrogenase helps cells resist oxidative stress and regulates metabolic rates. It holds potential for research in fields such as diabetes, endothelial dysfunction, cancer, and cardiomyopathy .

HY-105218

Ifetroban BMS-180291	Prostaglandin Receptor	Cardiovascular Disease Endocrinology Cancer
Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research .

HY-106577R

Cibenzoline (Standard)	Potassium Channel	Cardiovascular Disease
Cibenzoline (Standard) is the analytical standard of Cibenzoline. This product is intended for research and analytical applications. Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic agent. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy .

HY-169052

Cyy-272	JNK Apoptosis	Cardiovascular Disease Inflammation/Immunology
Cyy-272 is an orally active JNK inhibitor with IC₅₀ values of 1.25 μM for JNK1, 1.07 μM for JNK2, and 1.24 μM for JNK3. Cyy-272 exerts anti-inflammatory effects by inhibiting JNK phosphorylation, thereby alleviating acute lung injury (ALI) induced by lipopolysaccharide (LPS, HY-D1056). Additionally, Cyy-272 significantly reduces inflammation in cardiomyocytes and cardiac tissue induced by high lipid concentrations, further mitigating cardiac hypertrophy, fibrosis, and apoptosis. Cyy-272 can be used in the study of obese cardiomyopathy .

HY-B0573A

(S)-(-)-Propranolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology
(S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log K_d values of -8.16, -9.08, and -6.93 for β₁, β₂, and β₃, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-103320A

Calhex 231 hydrochloride 5 Publications Verification	CaSR	Metabolic Disease
Calhex 231 hydrochloride is a potent negative allosteric modulator that blocks (IC₅₀ = 0.39 μM) increases in [ ³H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca ²⁺-sensing receptor. Calhex 231 hydrochloride can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .

HY-152206

JB062	Myosin	Neurological Disease
JB062 is a nonmuscle myosin inhibitor with IC₅₀ values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .

HY-103320

Calhex 231	CaSR	Metabolic Disease
Calhex 231 is a potent negative allosteric modulator that blocks (IC₅₀ = 0.39 μM) increases in [ ³H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca ²⁺-sensing receptor. Calhex 231 can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .

HY-103320B

(1R,2R)-Calhex 231 hydrochloride	Others	Metabolic Disease
(1R,2R)-Calhex 231 hydrochloride is the isomer of Calhex 231 hydrochloride (HY-103320A), and can be used as an experimental control. Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca ²⁺-induced accumulation of [ ³H]inositol phosphate with an IC₅₀ of 0.39 μM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment .

HY-B0573BS

Propranolol-d7	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology
Propranolol-d₇ is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

HY-B0573S

Propranolol-d7 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology
Propranolol-d₇ (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

HY-B0573S1

Propranolol-d7 (ring-d7)	Adrenergic Receptor	Neurological Disease Endocrinology
Propranolol-d₇ (ring-d₇) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

HY-160845

HDAC6-IN-39	HDAC	Cardiovascular Disease
HDAC6-IN-39 (Compound I-132) is an inhibitor for HDAC6 with IC₅₀ of 0.0096 μM .

HY-160846

HDAC6-IN-40	HDAC	Cardiovascular Disease
HDAC6-IN-40 (Compound I-6) is an inhibitor for HDAC6 with IC₅₀ of 0.029 μM .

HY-113907

SDZ-285604 VNF	Cytochrome P450 Parasite	Infection
SDZ-285604 (VNF) is a T. cruzi CYP51 inhibitor and can be used for study of Trypanosoma cruzi infection .

HY-110067

VO-OHPic	PTEN Apoptosis Autophagy	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC₅₀ of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy .

HY-115704

Butyryl-L-carnitine chloride	Others	Others
Butyryl-L-carnitine chloride is an acylcarnitine that can be isolated from Plasma/Serum .

HY-117772

FSC231	Others	Metabolic Disease Inflammation/Immunology
FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects .

HY-18204A

Sacubitril/Valsartan 5+ Cited Publications LCZ696	Angiotensin Receptor Neprilysin Apoptosis	Cardiovascular Disease Endocrinology Cancer
Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure . Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis .

HY-P2780A

Cathepsin B, Human Liver	Apoptosis Cathepsin Pyroptosis Ferroptosis Autophagy Necroptosis	Inflammation/Immunology Cancer
Cathepsin B, Human Liver is a cysteine protease in liver and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death). Cathepsin B (CTSB) have been implicated in various ECM-related disorders, such as dilated cardiomyopathy, lung fibrosis, proteinuric renal disorders, cancer, and osteoporosis .

HY-14858

Derenofylline SLV 320	Adenosine Receptor	Cardiovascular Disease
Derenofylline (SLV 320) is a potent, selective and orally active adenosine A₁ receptor antagonist, with K_i values of 1 nM, 200 nM and 398 nM for human A₁, A₃ and A_2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats .

HY-119678

Fortunellin	AMPK Keap1-Nrf2	Cardiovascular Disease Metabolic Disease
Fortunellin, is a flavonoid, that can be isolated from the fruits of Fortunella margarita (kumquat). Fortunellin exhibits little toxicity to mice and suppresses inflammation and ROS generation in H9C2 cells induced by LPS. Fortunellin protects against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway. Fortunellin can be used for diabetic cardiomyopathy research .

HY-N6653

Lentinan 3 Publications Verification	JAK Keap1-Nrf2 Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering ^[1][4].

HY-B0573

Propranolol hydrochloride 20+ Cited Publications	Adrenergic Receptor Bacterial	Neurological Disease Endocrinology Cancer
Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573B

Propranolol 20+ Cited Publications	Adrenergic Receptor Bacterial	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-125863

Glucose-6-phosphate dehydrogenase, Microorganism G6PD	Endogenous Metabolite	Metabolic Disease Cancer
Glucose-6-phosphate dehydrogenase, Microorganism (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase, Microorganism is a primary source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 systems, and others. Glucose-6-phosphate dehydrogenase, Microorganism is applicable in research related to diabetes, endothelial dysfunction, cancer, and cardiomyopathy .

HY-148542

EpoY SD-142	Others	Cardiovascular Disease Cancer
EpoY (SD-142) acts as an irreversible inhibitor of the brain's primary tubulin tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and the small vasohibin binding protein (SVBP). By inhibiting TCP with an IC₅₀ value of approximately 500 nM, EpoY effectively decreases levels of detyrosinated alpha-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition leads to significant differentiation defects and has been linked to underlying issues associated with cancer and cardiomyopathies.

HY-161608

Myosin modulator 1	Myosin	Cardiovascular Disease
Myosin modulator 1 (Compound B141) is a modulator for myosin, that inhibits ATPase in rabbits psoas, porcine atria and in porcine ventricle, with IC₂₅s of 0.42, 0.13 and 3.09 μM, respectively. Myosin modulator 1 regulates systolic cardiac performance in Sprague Dawley rats .

HY-161609

Myosin modulator 2	Myosin	Cardiovascular Disease
Myosin modulator 2 (Compound B172) is a modulator for myosin, that inhibits ATPase in rabbits psoas, porcine atria and in porcine ventricle, with IC₂₅s of 2.013, 2.94 and 20.93 μM, respectively. Myosin modulator 2 regulates systolic cardiac performance in Sprague Dawley rats .

HY-B0573R

Propranolol hydrochloride (Standard)	Adrenergic Receptor Bacterial	Neurological Disease Endocrinology Cancer
Propranolol (hydrochloride) (Standard) is the analytical standard of Propranolol (hydrochloride). This product is intended for research and analytical applications. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-116364

AZT triphosphate 3'-Azido-3'-deoxythymidine-5'-triphosphate	HIV DNA/RNA Synthesis HBV Reactive Oxygen Species Apoptosis	Infection
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate also inhibits the DNA polymerase of HBV. AZT triphosphate activates the mitochondria-mediated apoptosis pathway .

HY-116364A

AZT triphosphate TEA 3'-Azido-3'-deoxythymidine-5'-triphosphate TEA	HIV DNA/RNA Synthesis HBV Reactive Oxygen Species Apoptosis	Infection
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) TEA is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TEA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TEA also inhibits the DNA polymerase of HBV. AZT triphosphate TEA activates the mitochondria-mediated apoptosis pathway .

HY-116364B

AZT triphosphate tetraammonium 3'-Azido-3'-deoxythymidine-5'-triphosphate tetraammonium	HIV DNA/RNA Synthesis HBV Reactive Oxygen Species Apoptosis	Infection
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV. AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway .

HY-N7627

Regaloside C	Others	Cardiovascular Disease Inflammation/Immunology
Regaloside C is a glycerol glucoside isolated from the bulbs of Lilium genus with anti-inflammatory activities. Regaloside C has cardiomyocyte protective activity by protecting the mitochondria in H₂O₂-induced heart H9C2 cells .

HY-N0716A

Berberine hemisulfate Maximum Cited Publications 43 Publications Verification Natural Yellow 18 hemisulfate	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .

HY-N0716

Berberine Natural Yellow 18	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-N0716B

Berberine sulfate Maximum Cited Publications 43 Publications Verification Natural Yellow 18 sulfate	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

HY-148089

Eplontersen	Transthyretin (TTR)	Neurological Disease
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-148089A

Eplontersen sodium	Transthyretin (TTR)	Neurological Disease
Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

Cat. No.	Product Name	Target	Research Area

HY-P10023

Evuzamitide	Peptides	Cancer
Evuzamitide is a diagnostic imaging agent. Evuzamitide as a pan-amyloid radiotracer binding to amyloid deposits from multiple amyloidogenic proteins. Evuzamitide can be used for the research of early diagnosis of amyloid cardiomyopathy (CMP) and monitoring .

HY-P10554

Myhc-α(334–352)	Peptides	Cardiovascular Disease Others Inflammation/Immunology
Myhc-α(334–352) is a sequence fragment of amino acid residues 334 to 352 of cardiac myosin heavy chain α. Myhc-α(334–352) is an immunodominant epitope that can induce autoimmune reactions in A/J mice, leading to the occurrence of myocarditis. Myhc-α(334–352) can be used to study the autoimmune pathways of myocarditis and dilated cardiomyopathy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119678

Fortunellin	Structural Classification Flavonoids Flavones Source classification Rutaceae Citrus japonica Thunb. Plants	AMPK Keap1-Nrf2
Fortunellin, is a flavonoid, that can be isolated from the fruits of Fortunella margarita (kumquat). Fortunellin exhibits little toxicity to mice and suppresses inflammation and ROS generation in H9C2 cells induced by LPS. Fortunellin protects against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway. Fortunellin can be used for diabetic cardiomyopathy research .

HY-N6653

Lentinan 3 Publications Verification	Structural Classification Polysaccharides Agaricaceae Classification of Application Fields Source classification Lentinus edodes (Berk. ) Sing Plants Disease Research Fields Saccharides Cancer	JAK Keap1-Nrf2 Apoptosis
Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering ^[1][4].

HY-B0573

Propranolol hydrochloride 20+ Cited Publications	Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Endocrinology	Adrenergic Receptor Bacterial
Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-B0573B

Propranolol 20+ Cited Publications	Cardiovascular Disease Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Adrenergic Receptor Bacterial
Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-125863

Glucose-6-phosphate dehydrogenase, Microorganism G6PD	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Glucose-6-phosphate dehydrogenase, Microorganism (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase, Microorganism is a primary source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 systems, and others. Glucose-6-phosphate dehydrogenase, Microorganism is applicable in research related to diabetes, endothelial dysfunction, cancer, and cardiomyopathy .

HY-N7627

Regaloside C	Cardiovascular Disease Classification of Application Fields Simple Phenylpropanols Gramineae Source classification Secale cereale Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields	Others
Regaloside C is a glycerol glucoside isolated from the bulbs of Lilium genus with anti-inflammatory activities. Regaloside C has cardiomyocyte protective activity by protecting the mitochondria in H₂O₂-induced heart H9C2 cells .

HY-N0716A

Berberine hemisulfate Maximum Cited Publications 43 Publications Verification Natural Yellow 18 hemisulfate	Infection Structural Classification Alkaloids Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .

HY-N0716B

Berberine sulfate Maximum Cited Publications 43 Publications Verification Natural Yellow 18 sulfate	Alkaloids Structural Classification Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

HY-B0573R

Propranolol hydrochloride (Standard)	Alkaloids Other Alkaloids Source classification Endogenous metabolite	Adrenergic Receptor Bacterial
Propranolol (hydrochloride) (Standard) is the analytical standard of Propranolol (hydrochloride). This product is intended for research and analytical applications. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K_i values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ ³H]-DHA binding to rat brain membrane preparation with an IC₅₀ of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .

HY-N0716

Berberine Natural Yellow 18	Structural Classification Classification of Application Fields Anti-aging Ranunculaceae Source classification Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Alkaloids Coptis chinensis Franch. Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Cancer	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

Cat. No.	Compare	Product Name	Species	Source

HY-P71698

	TTN Protein, Human (His) MPRM; cardiomyopathy dilated 1G CMD1G; CMH 9; CMH9; CMPD 4; CMPD4; Connectin; HMERF; LGMD2J; MU RMS 40.14; MYLK5; TMD; TTN	Human	E. coli
	The TTN protein is critical for vertebrate striated muscle assembly, establishing microfilament connections that are critical for sarcomeric force balance. TTN coordinates cross-link size and extensibility, shaping sarcomere extensibility and muscle function. TTN Protein, Human (His) is the recombinant human-derived TTN protein, expressed by E. coli , with N-His labeled tag. The total length of TTN Protein, Human (His) is 207 a.a., with molecular weight of ~26.5 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-B0573BS

Propranolol-d7

Propranolol-d₇ is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

HY-B0573S

Propranolol-d7 hydrochloride

Propranolol-d₇ (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

HY-B0573S1

Propranolol-d7 (ring-d7)

Propranolol-d₇ (ring-d₇) is the deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

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HY-P81144

	Cardiac Troponin I/TNNC1 Antibody troponin I type 3 (cardiac); Cardiac troponin I; Troponin I, cardiac muscle; cardiomyopathy, familial hypertrophic, 7, included; CMD1FF; CMD2A; CMH7; cTnI; Familial hypertrophic cardiomyopathy 7; MGC116817; RCM1; Tn1; Tni; TNN I3; TNNC 1; TNNC-1; TNNC1; TNNI3; Troponin I cardiac; Troponin I cardiac muscle; Troponin I cardiac muscle isoform; Troponin I type 3 cardiac; troponin I, cardiac 3; TroponinI; Troponin I; TNNI3_HUMAN.	WB, IHC-P, ICC/IF, IP	Human
	Cardiac Troponin I/TNNC1 Antibody is an unconjugated, approximately 23 kDa, rabbit-derived, anti-Cardiac Troponin I/TNNC1 monoclonal antibody. Cardiac Troponin I/TNNC1 Antibody can be used for:WB,IHC-P,ICC/IF,IP expriments in human background without labeling.

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Cat. No.	Product Name		Classification

HY-148089A

Eplontersen sodium		Antisense Oligonucleotides
Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-148089

Eplontersen		Antisense Oligonucleotides
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

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