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ferroptosis inducers

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ferroptosis (118) Amyloid-β (1) Antibiotic (2) Apoptosis (34) Autophagy (17) Bacterial (8) Carbonic Anhydrase (1) Caspase (1) Cholinesterase (ChE) (1) COX (1) Dihydroorotate Dehydrogenase (2) Disulfidptosis (4) DNA Alkylator/Crosslinker (1) Endogenous Metabolite (9) FLT3 (4) Fluorescent Dye (3) Fungal (7) G-quadruplex (1) Glutathione Peroxidase (18) GPR68 (1) HDAC (2) Histamine Receptor (1) Histone Acetyltransferase (1) HIV (5) IKK (1) Influenza Virus (3) Isotope-Labeled Compounds (1) JNK (3) Keap1-Nrf2 (2) Ligands for E3 Ligase (1) Lipoxygenase (1) MDM-2/p53 (2) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) Mitophagy (1) Monoamine Oxidase (1) MyD88 (2) Necroptosis (1) NF-κB (2) p62 (1) Parasite (1) PROTACs (5) Pyroptosis (2) Raf (5) Reactive Oxygen Species (24) Sodium Channel (2) STAT (1) STING (1) Tau Protein (1) Telomerase (1) Toll-like Receptor (TLR) (2) VDAC (1) VEGFR (4)
By Research Areas:	Cancer (96) Cardiovascular Disease (5) Infection (11) Inflammation/Immunology (18) Metabolic Disease (12) Neurological Disease (20)
Click Chemistry:	Alkynes (6)
Oligonucleotides:	Antioxidants (1)

123

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Ferroptosis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0070

Solasonine 2 Publications Verification	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
Solasonine is a *ferroptosis* inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-145595A

*(1R,3R)-Ferroptosis* inducer-1**	Ferroptosis	Others
(1R,3R)-Ferroptosis inducer-1 is an isomer of Ferroptosis inducer-1 (HY-145595). (1R,3R)-Ferroptosis inducer-1 (compound BX-3a) is a Ferroptosis inducer with antitumor potential .

HY-155852

Lepadin H	Ferroptosis	Others
Lepadin H is a marine alkaloid and *ferroptosis* inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-163889

Ferroptosis/apoptosis inducer-1	Apoptosis Ferroptosis	Cancer
Ferroptosis/apoptosis inducer-1 (compound 4d) is a dual inducer of apoptosis and *ferroptosis. Ferroptosis/apoptosis inducer-1 induces* apoptosis and *ferroptosis* by reducing mitochondrial membrane potential and downregulating GPX4. Ferroptosis/apoptosis inducer-1 can significantly inhibit the proliferation and metastasis of triple-negative breast cancer (TNBC) both in vitro and in vivo, playing an important role in cancer research .

HY-162311

Anticancer agent 194	Ferroptosis Autophagy Reactive Oxygen Species	Cancer
Anticancer agent 194 (compound 10p) is a *ferroptosis* and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS .

HY-161928

GPX4 activator 1	Glutathione Peroxidase Ferroptosis	Cancer
GPX4 activator 1 (Compound A9) is a allosteric activator of GPX4 (K_d = 5.86 μM, EC₅₀ = 19.19 μM). GPX4 activator 1 can selectively act on ferroptosis and prevent the accumulation of intracellular lipid peroxides caused by ferroptosis inducers .

HY-N0070R

Solasonine (Standard)	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species	Cancer
Solasonine (Standard) is the analytical standard of Solasonine. This product is intended for research and analytical applications. Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-156286

GPX4-IN-7	Ferroptosis	Cancer
GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC₅₀ value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis .

HY-169146

Ferroptosis inducer-5	Ferroptosis	Cancer
Ferroptosis inducer-5 (compund 20a) is a ferroptosis inducer .

HY-161948

Ferroptosis inducer-4	Ferroptosis	Cancer
Ferroptosis inducer-4 (Compound 5) is a ferroptosis (Ferroptosis) inducer with a structure featuring terminal double bonds introduced at the sn-2 position of phospholipids. Ferroptosis inducer-4 exhibits significant cytotoxicity towards HT-1080 cells, with an IC₅₀ of 18 μM. This cytotoxic mechanism involves the generation of lipid peroxides and oxidative damage to the cell membrane triggered by the terminal double bonds. Ferroptosis inducer-4 can be used for research on ferroptosis regulation .

HY-161760

Ferroptosis inducer-3	Raf Ferroptosis	Cancer
Ferroptosis inducer-3 (compound JB3) is an oral bioactive inhibitor of RAF1, with the IC₅₀ of 226.9 nM. Ferroptosis inducer-3 can induce *ferroptosis* and plays an important role in cancer research .

HY-168097

Ferroptosis inducer-6	Ferroptosis Reactive Oxygen Species	Cancer
Ferroptosis inducer 6 (6d) is a *ferroptosis* inducer with high potency for type I/-II photodynamic therapy by inducing ROS generation, oxidative stress and mitochondrial damage. Ferroptosis inducer 6 has anti-tumor activity .

HY-161601

Ferroptosis inducer-2	Ferroptosis Reactive Oxygen Species	Cancer
Ferroptosis inducer-2 (Compound 24) is an inducer for heme oxygenase-1 (HO-1). Ferroptosis inducer-2 exhibits anticancer activity against triple-negative breast cancer (TNBC) cells through induction of *ferroptosis* .

HY-145595

Ferroptosis inducer-1	Ferroptosis	Cancer
Ferroptosis inducer-1 (compound BX-3a) is a *Ferroptosis* inducer with antitumor potential . Ferroptosis inducer-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163074

Ferroptosis-IN-6	Ferroptosis	Cancer
Ferroptosis-IN-6 (compound 13) is a potent inhibitor of *Ferroptosis* with EC₅₀ of 25.5 nM. Ferroptosis-IN-6 significantly inhibits RSL3-induced cell death in cells and in vivo .

HY-149670

Ferroptosis-IN-3	Ferroptosis	Inflammation/Immunology
Ferroptosis-IN-3 (Compound 25) is a *ferroptosis* inhibitor. Ferroptosis-IN-3 inhibits RSL3-induced ferroptosis (EC₅₀: 8.6?nM in HT-1080?cells). Ferroptosis-IN-3 scavenges DPPH and ABTS radicals (EC₅₀: 3.94?and 6.3 μM respectively). Ferroptosis-IN-3 decreases lipid peroxidation .

HY-103087

FIN56 10+ Cited Publications	Ferroptosis	Others
FIN56 is a specific inducer of *ferroptosis. FIN56 induces* ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .

HY-112063

CIL56 2 Publications Verification	Ferroptosis	Cancer
CIL56 is a potent and selective *ferroptosis* inducer. Ferroptosis is an iron-dependent form of regulated cell death (RCD).

HY-159567

Ferroptosis-IN-11	Ferroptosis	Cardiovascular Disease Neurological Disease
Ferroptosis-IN-11 (compound 43) is a *ferroptosis* inhibitor. Ferroptosis-IN-11 can inhibit Erastin (HY-15763) induced ferroptosis in HT-1080 human fibroblasts (EC₅₀=36 nM). Ferroptosis-IN-11 can be used in the study of cardiovascular disease and neurodegeneration .

HY-149719

Ferroptosis-IN-4	Ferroptosis	Metabolic Disease
Ferroptosis-IN-4 (compound 6k) is a *ferroptosis* inhibitor with EC₅₀ value of 20 μM. Ferroptosis-IN-4 has no obvious cytotoxicity. Ferroptosis-IN-4 has a protective effect in glycerol-induced RM-AKI mice with alleviating kidney dysfunction .

HY-169927

Ferroptosis-IN-16	Ferroptosis	Inflammation/Immunology
Ferroptosis-IN-16 (Compound 13l) is a specific inhibitor for *ferroptosis* with an EC₅₀ of 0.7 nM and 0.9 nM in ES-2 cell and LX-2 cell. Ferroptosis-IN-16 ameliorates Acetaminophen (HY-66005)-induced acute liver injury in mouse model, and exhibits good metabolic stability in mouse liver microsomes .

HY-136057

iFSP1 15+ Cited Publications	Ferroptosis	Cancer
iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces *ferroptosis* in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) .

HY-139369

QD394	Reactive Oxygen Species	Cancer
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis .

HY-169059

Ferroptosis-IN-12	Ferroptosis	Inflammation/Immunology
Ferroptosis-IN-12 (Cpd-A1) is a *ferroptosis* inhibitor. Ferroptosis-IN-12 exhibits effective *ferroptosis* inhibition in Erastin (HY-15763)-treated mouse tubular epithelial cells (mTECs) and improves kidney function, alleviates renal tubular damage, and reduces inflammation in a dose-dependent manner in acute kidney injury (AKI) mouse models induced by ischemia/reperfusion (I/R) or cecal ligation and puncture (CLP). Ferroptosis-IN-12 demonstrates good plasma stability and high distribution in kidney tissues in pharmacokinetic studies in mice. Ferroptosis-IN-12 holds promise for research in the field of acute kidney injury (AKI) .

HY-141649

Anticancer agent 251	Apoptosis Autophagy Ferroptosis	Cancer
Anticancer agent 251 (compound 7j) can induce cell death of bladder cancer cell T24 by inducing apoptosis, autophagy or ferroptosis .

HY-149422

NIR-FP	Fluorescent Dye	Neurological Disease
NIR-FP is a near-infrared fluorescent probe with high sensitivity and selectivity for superoxide anion O ^2-. O ^2- is the main precursor of ROS, and ferroptosis-mediated epilepsy models can be dynamically tracked by detecting O ^2-. Ferroptosis-mediated epilepsy models include: kainic acid (HY-N2309)-induced chronic epilepsy model, Pentylenetetrazole-induced acute epilepsy model, and pilocarpine (HY-B0726A)-induced epilepsy model .

HY-162449

GIC-20	Apoptosis Ferroptosis	Cancer
GIC-20 is a dual inducer for apoptosis and *ferroptosis*. GIC-20 exhibits antitumor efficacy against fibrosarcoma .

HY-162065

N6F11	Ferroptosis	Cancer
N6F11 is a selective *ferroptosis* inducer, and can selectively induce *ferroptosis* by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. N6F11 initiates HMGB1-dependent antitumor immunity mediated by CD8 ⁺ T cells .

HY-27787

α-Eleostearic acid cis-Eleostearic acid	Apoptosis Ferroptosis	Metabolic Disease Cancer
α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a *ferroptosis* inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity .

HY-151879

Tubulin inhibitor 30	Microtubule/Tubulin Ferroptosis	Cancer
Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC₅₀ of 0.52 μM. Tubulin inhibitor 30 can induce *ferroptosis* .

HY-135837

Fluorescein-diisobutyrate-6-amide	Ferroptosis	Cancer
Fluorescein-diisobutyrate-6-amide is a potent *ferroptosis* inducer. Fluorescein-diisobutyrate-6-amide has the potential for the research of cancer .

HY-17394

Cisplatin 485+ Cited Publications cis-Platinum; CDDP; cis-Diaminodichloroplatinum	DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase	Cancer
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates *ferroptosis* and induces autophagy .

HY-139087

Erastin2	Ferroptosis	Metabolic Disease
Erastin2, an Erastin (HY-15763) analog, is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter

HY-100887

Piperazine Erastin 5+ Cited Publications	Ferroptosis	Cancer
Piperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferroptosis. Piperazine erastin can be used in cancer research .

HY-162944

NA-Ir	Ferroptosis Mitochondrial Metabolism STING Autophagy	Cancer
NA-Ir is a *Ferroptosis* inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and *Ferroptosis*. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H₂S levels .

HY-162310

Anticancer agent 193	Ferroptosis Reactive Oxygen Species Autophagy	Cancer
Anticancer agent 193 (compound D3-3) is an inducer of ferritinophagy, eventually triggering *ferroptosis. Anticancer agent 193 induces* the production of lipid ROS, and significantly promoted colorectal cancer cells to release the ferrous ion in an autophagy-dependent manner .

HY-139001

JKE-1716	Glutathione Peroxidase Ferroptosis	Others
JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing *ferroptosis* selectively through covalent GPX4 inhibition .

HY-100579

Ferrostatin-1 Maximum Cited Publications 762 Publications Verification Fer-1	Ferroptosis Fungal	Cancer
Ferrostatin-1 (Fer-1), a potent and selective *ferroptosis* inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC₅₀=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .

HY-158336

E/Z-FETPY	Ferroptosis	Cancer
E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces *ferroptosis* in low-differentiated cell lines, such as A2780 cells .

HY-161947

TOFA-Plasmalogen	Ferroptosis	Others
TOFA-Plasmalogen (compound 1) is a glyceraldehyde derivative with *ferroptosis*-inducing activity. TOFA-Plasmalogen causes cytotoxicity by promoting lipid peroxidation on cell membranes (IC₅₀=32.87 μM) .

HY-14655

Sulfasalazine 35+ Cited Publications NSC 667219	NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 *ferroptosis* inducer .

HY-169287

TriPEX-ClO4	Apoptosis Ferroptosis	Neurological Disease Cancer
TriPEX-ClO4 is a cationic fluorescent anticancer agent capable of BBB penetration. TriPEX-ClO4 can induces apoptosis and *ferroptosis* and can be used for study of cancer and brain diseases .

HY-Y0278

Chloranil Tetrachloro-p-benzoquinone; TCBQ	Toll-like Receptor (TLR) MyD88 Apoptosis Ferroptosis JNK Fungal Reactive Oxygen Species	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Chloranil (Tetrachloro-p-benzoquinone), an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces *ferroptosis* and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells .

HY-162718

GPX4-IN-12	Ferroptosis	Cancer
GPX4-IN-12 (compound I22) is a non-covalent GPX4 inhibitor. GPX4-IN-12 induces *ferroptosis* and inhibits cell growth of HT1080 cells .

HY-162716

GPX4-IN-10	Ferroptosis	Cancer
GPX4-IN-10 (compound I20) is a non-covalent GPX4 inhibitor. GPX4-IN-10 induces *ferroptosis* and inhibits cell growth of HT1080 cells .

HY-139008

RC363	Others	Others
RC363 is a novel probucol analog with the activity to protect mouse hippocampal cells and primary cortical neurons from glutamate-induced oxidative cell death (ferroptosis) and increase glutathione peroxidase (GPx) 1 levels and activity.

HY-139012

RC574	Others	Others
RC574 is a novel probucol analog with the activity to protect mouse hippocampal cells and primary cortical neurons from glutamate-induced oxidative cell death (ferroptosis) and increase glutathione peroxidase (GPx) 1 levels and activity.

HY-B1645

Ammonium iron(III) citrate 25+ Cited Publications Ammonium ferric citrate; FAC	Ferroptosis	Cancer
Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause *ferroptosis* . Ammonium iron(III) citrate can enhance protein production .

HY-154954

Ogremorphin OGM; GPR68-IN-1	GPR68 Ferroptosis	Inflammation/Immunology Cancer
Ogremorphin (OGM) is a G protein coupled sensor GPR68 inhibitor with anti-inflammatory and anti-tumor activities. Ogremorphin can inhibit the migration of human melanoma cells and induce *ferroptosis* in glioblastoma cells .

HY-Y0278R

Chloranil (Standard) Tetrachloro-p-benzoquinone (Standard); TCBQ (Standard)	Toll-like Receptor (TLR) MyD88 Apoptosis Ferroptosis JNK Reactive Oxygen Species Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Chloranil (Standard) is the analytical standard of Chloranil. This product is intended for research and analytical applications. Chloranil, an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces *ferroptosis* and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells .

Cat. No.	Product Name

HY-L051

Ferroptosis Compound Library

1,053 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 1,053 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

HY-L133

Cuproptosis Compound Library

233 compounds

Copper is an important co-factor of all biological enzymes, but if the concentration exceeds the threshold of maintaining the homeostasis mechanism, copper will lead to cytotoxicity. This death mechanism has been named "Cuproptosis".

The mechanism of cuproptosis distinct from all other known mechanisms of regulated cell death, including apoptosis, pyroptosis, necroptosis, and ferroptosis.

Copper combine with the lipoylated components of the tricarboxylic acid cycle (TCA), leading to lipoylated protein aggregation and subsequent loss of iron-sulfur cluster proteins, ultimately resulting in protein toxicity stress and cell death. Studies have shown that the necessary factors for cuproptosis include the presence of glutathione, mitochondrial metabolism of galactose and pyruvate, and glutamine metabolism.

Targeted regulation of cuproptosis is a potential choice to treat cancer, rheumatoid arthritis, and other diseases. For example, up-regulation of LIPT1 may inhibit the occurrence and development of tumors by destroying TCA in mitochondria and then inducing cuproptosis.

MCE supplies a unique collection of 233 cuproptosis-related compounds, all of which act on the targets or signaling pathways related to cuproptosis and may have in inhibitory or activated effect on cuproptosis. MCE Cuproptosis Library is a useful tool for drug research related to cancer, rheumatoid arthritis, and other diseases.

Cat. No.	Product Name	Type

HY-163286

BODIQPy-TPA	Dyes
BODIQPy-TPA is a lipophilic probes, which induces *ferroptosis* in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

HY-D2438

CDDP-PEG-Cy3

Fluorescent Dyes/Probes

CDDP-PEG-Cy3 is a CDDP-PEG conjugate labeled with Cy3 (HY-D0822). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Cisplatin (CDDP) (HY-17394) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0070

Solasonine 2 Publications Verification	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Solanum nigrum Linn. Solanaceae Plants Disease Research Fields Cancer	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine is a *ferroptosis* inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-B1645

Ammonium iron(III) citrate 25+ Cited Publications Ammonium ferric citrate; FAC	Ketones, Aldehydes, Acids Source classification Rutaceae Plants Disease Research Fields Citrus reticulata Blanco Cancer	Ferroptosis
Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause *ferroptosis* . Ammonium iron(III) citrate can enhance protein production .

HY-N0115

Gastrodin 5+ Cited Publications Gastrodine	Structural Classification Natural Products Gastrodia elata Bl. Neurological Disease Classification of Application Fields Anti-aging Orchidaceae Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Apoptosis Ferroptosis
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin inhibits ethanol-induced hepatocellular apoptosis. Gastrodin inhibits H₂O₂-induced *ferroptosis* through its antioxidative effect. Gastrodin can be used for study of dizziness, epilepsy, stroke and dementia .

HY-120912

Gingerenone A	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Keap1-Nrf2 Glutathione Peroxidase Ferroptosis
Gingerenone A is an Nrf2-Gpx4 activator that can induce *Ferroptosis* in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice .

HY-N1487

Oleanonic acid 1 Publications Verification 3-Oxooleanolic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	HIV Autophagy Ferroptosis Amyloid-β
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, *ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced* by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats .

HY-W015273A

trans-3-Indoleacrylic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Ferroptosis
Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced *ferroptosis* via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis

HY-66005

Acetaminophen 40+ Cited Publications Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Histone Acetyltransferase Endogenous Metabolite Bacterial Parasite Ferroptosis
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent. . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces *ferroptosis* and leads to acute liver injury in mice model .

HY-155852

Lepadin H	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis
Lepadin H is a marine alkaloid and *ferroptosis* inducer. Lepadin H exhibits significant cytotoxicity, promotes p53 expression, increases ROS production and lipid peroxidation, decreases SLC7A11 and GPX4 levels, and upregulates ACSL4 expression. Lepadin H induces ferroptosis through the p53-SLC7A11-GPX4 pathway .

HY-N0070R

Solasonine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Solanum nigrum Linn. Solanaceae Plants	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
Solasonine (Standard) is the analytical standard of Solasonine. This product is intended for research and analytical applications. Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research .

HY-155851

Lepadin E	Structural Classification Alkaloids Animals Source classification Marine natural products Other marine organisms Quinoline Alkaloids	Ferroptosis MDM-2/p53 Glutathione Peroxidase
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-N0415

Trigonelline chloride 4 Publications Verification Trigonelline hydrochloride	Infection Alkaloids Structural Classification Classification of Application Fields Labiatae Source classification Pyridine Alkaloids Metabolic Disease Lactuca perennis Plants Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0414

Trigonelline 4 Publications Verification Trigenolline	Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Alkaloids Microorganisms other families Leguminosae Trigonella foenum-graecum Linn. Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-B0215

Acetylcysteine Maximum Cited Publications 406 Publications Verification N-Acetylcysteine; N-Acetyl-L-cysteine; NAC	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced *ferroptosis* by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-B0215R

Acetylcysteine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis
Acetylcysteine (Standard) is the analytical standard of Acetylcysteine. This product is intended for research and analytical applications. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor . Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases . Acetylcysteine induces cell apoptosis . Acetylcysteine also has anti-influenza virus activities . In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-N0414R

Trigonelline (Standard)	Alkaloids Structural Classification Microorganisms other families Leguminosae Source classification Pyridine Alkaloids Plants Endogenous metabolite Trigonella foenum-graecum Linn.	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N0415R

Trigonelline chloride (Standard)	Alkaloids Structural Classification Labiatae Source classification Pyridine Alkaloids Lactuca perennis Plants	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N6871

Abietic acid	Infection Structural Classification Colophony Classification of Application Fields Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	Bacterial IKK Ferroptosis
Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and *ferroptosis*. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .

Cat. No.	Product Name	Chemical Structure

HY-B0215S1

Acetylcysteine-15N

Acetylcysteine- ¹⁵N (N-Acetylcysteine- ¹⁵N) is the ¹⁵N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

Cat. No.	Product Name		Classification

HY-145595

Ferroptosis inducer-1		Alkynes
Ferroptosis inducer-1 (compound BX-3a) is a *Ferroptosis* inducer with antitumor potential . Ferroptosis inducer-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-169146

Ferroptosis inducer-5		Alkynes
Ferroptosis inducer-5 (compund 20a) is a ferroptosis inducer .

HY-151212

BCP-T.A		Alkynes
BCP-T.A, a tunable heterocyclic electrophile, is a potent *ferroptosis* inducer by binding to GPX4 . BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-168093

Cetzole		Alkynes
Cetzole (Compound 1) is a *ferroptosis* inducer that induces cell death through ROS accumulation. The CC₅₀ values of Cetzole for NCI-H522, NCI-H522 GFP-SCL7A11 #8, NCI-H522 RV-GFP, HT-1080, NARF2, and MDA-MB-231 are 2.56, 10.31, 2.71, 3.07, 14.9, and 6.28 μM, respectively. Cetzole holds potential for research in the field of cancer .

HY-159119

hDHODH-IN-15		Alkynes
hDHODH-IN-15 (Compound H19) is an inhibitor for human dihydroguanylate dehydrogenase (hDHODH) with an IC₅₀ of 0.21 µM. hDHODH-IN-15 exhibits cytotoxicity in cancer cells NCI-H226, HCT-116, and MDA-MB-231, with IC₅₀ of 0.95-2.81 µM. hDHODH-IN-15 induces *ferroptosis* in HCT-116, and exhibits antitumor efficacy .

HY-151872

HDAC-IN-48		Alkynes
HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI₅₀~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces *ferroptosis* and inhibits HDAC proteins . HDAC-IN-48 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-B1066

Butylhydroxyanisole 5 Publications Verification Butylated hydroxyanisole; BHA; E320		Antioxidants
Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a *ferroptosis* inducer .

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