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Results for "

molecular inhibitor

" in MedChemExpress (MCE) Product Catalog:

156

Inhibitors & Agonists

5

Screening Libraries

2

Fluorescent Dye

9

Biochemical Assay Reagents

15

Peptides

1

Inhibitory Antibodies

2

Natural
Products

1

Recombinant Proteins

5

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P5107
    Low molecular weight protamine

    LMWP

    		 VEGFR Cancer
    Low molecular weight protamine is a cell-penetrating peptide with vascular endothelial growth factor (VEGF) inhibitory activity. Low molecular weight protamine can inhibit tumor growth and is used in cancer research .
    Low molecular weight protamine
  • HY-111489B
    LMPTP inhibitor 1 dihydrochloride

    		Phosphatase Metabolic Disease
    LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
    LMPTP inhibitor 1 dihydrochloride
  • HY-P10238
    MYBMIM

    		Apoptosis Cancer
    MYBMIM is an inhibitor for assembly of the molecular MYB:CBP/P300 complex. MYBMIM inhibits growth of leukemia cells .
    MYBMIM
  • HY-136358
    LDN-211904

    		Ephrin Receptor Neurological Disease Cancer
    LDN-211904 is an inhibitor of EphB3 receptor tyrosine kinase. LDN-211904 enhances the inhibitory activity of EphB3 kinase by maintaining the 2-chloroaniline group and introducing a phenyl or small electron donor substituent to the 5 position of pyrazole and [1,5-a] pyridine. LDN-211904 can be used as a molecular probe to study the function and signaling pathways of EphB3 receptors, especially in the nervous system during neurodevelopment and adulthood .
    LDN-211904
  • HY-157090
    AChE/MAO-B-IN-6

    		Monoamine Oxidase Cholinesterase (ChE) Neurological Disease
    AChE/MAO-B-IN-6 (compound 3a) is a dual inhibitor of AChE and h-MAO-B with potential to inhibit Alzheimer's disease .
    AChE/MAO-B-IN-6
  • HY-149646
    HDAC6-IN-24

    		HDAC Cancer
    HDAC6-IN-24 (compound N1) is a inhibitor of HDAC6 .
    HDAC6-IN-24
  • HY-161066
    KRAS G13D-IN-1

    		Ras Cancer
    KRAS G13D-IN-1 (compound 41) is a selective and covalently reversible inhibitor of KRAS G13D (IC50: 0.41 nM). The selectivity for KRAS G13D is 29-fold against KRAS wild type. KRAS G13D-IN-1 is an inhibitor of the GDP state and targets the SWII binding pocket of KRAS G13D. KRAS G13D-IN-1 inhibits KRAS binding to GDP and turns on/off downstream signaling cascades .
    KRAS G13D-IN-1
  • HY-162339
    BChE-IN-30

    		Cholinesterase (ChE) Neurological Disease
    BChE-IN-30 (compound (R)-37a) is a BChE inhibitor (IC50: 5 nM) with anti-inflammatory activity and low toxicity. BChE-IN-30 can improve cognitive deficits induced by scopolamine and Aβ1-42 peptide and can be used in the study of late-stage AD .
    BChE-IN-30
  • HY-111489A
    LMPTP inhibitor 1 hydrochloride

    		Phosphatase Metabolic Disease
    LMPTP inhibitor 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
    LMPTP inhibitor 1 hydrochloride
  • HY-111489
    LMPTP inhibitor 1

    		Phosphatase Metabolic Disease
    LMPTP inhibitor 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
    LMPTP inhibitor 1
  • HY-156754
    3β-Hydroxy-lup-20(29)-en-16-one

    		Cholinesterase (ChE) Neurological Disease
    3β-Hydroxy-lup-20(29)-en-16-one (compound 9) is a dual inhibitor of AChE and BChE, with selectivity for BChE (IC50: 28.9 μM) .
    3β-Hydroxy-lup-20(29)-en-16-one
  • HY-157168
    TrkA-IN-6

    		Trk Receptor Neurological Disease
    TrkA-IN-6 (compound R48) is a hydrazone-like, selective inhibitor of tropomyosin kinase type A receptor kinase (TrkA). TrkA-IN-6 exhibited a higher cytotoxic effect on U87 GBM cells than Temozolomide (HY-17364), with an IC50 of 68.99 μM .
    TrkA-IN-6
  • HY-P10799
    SLAFVDVLN

    		Amyloid-β Neurological Disease Metabolic Disease
    SLAFVDVLN, a molecular peptide, is a BACE-1 inhibitor with a Ki value of 94 nM. SLAFVDVLN can reduce Aβ42 production .
    SLAFVDVLN
  • HY-151287
    KRAS inhibitor-20

    		Ras Cancer
    KRAS inhibitor-20 is a small molecular inhibitor of KRas G12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRas G12C with the IC50 value <10 nM .
    KRAS inhibitor-20
  • HY-153607
    HDAC-IN-55

    		Others Cancer
    HDAC-IN-55(8j) is a small molecular compound that can increase the expression of E-cadherin and inhibit the proliferation of cancer cells .
    HDAC-IN-55
  • HY-135253
    GR122222X

    		DNA/RNA Synthesis Others
    GR122222X is a DNA gyrase B protein inhibitor related to the cyclothiidine structure, which allows the crystallization of this protein fragment for molecular replacement studies.
    GR122222X
  • HY-123708
    SNAP 398299

    		Galectin Others
    SNAP 398299 is a compound mentioned in the study of Gal3 receptor inhibitors. Through molecular dynamics simulation and docking studies, it provides a structural basis and understanding of the binding site for the design of more effective inhibitors.
    SNAP 398299
  • HY-151211
    BTK-IN-16

    		Btk Inflammation/Immunology Cancer
    BTK-IN-16 is a dual inhibitor of BTK wild type and C481S mutant of Bruton’s tyrosine kinase (BTK) with IC50s of 5.1 and 4.1 μM. BTK-IN-16 can be used for the research of autoimmune diseases and chronic lymphocytic leukemia .
    BTK-IN-16
  • HY-156332
    TNKS-2-IN-2

    		PARP Cancer
    TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC50 of 22 nM .
    TNKS-2-IN-2
  • HY-162520
    DJ-1-IN-1

    		Others Cancer
    DJ-1-IN-1 (compound 797780-71-3) is a DJ-1 inhibitor. DJ-1-IN-1 exhibits antiproliferative activity in ACHN cells with an IC50 value of 12.18 μM and can inhibit the Wnt signaling pathway. DJ-1-IN-1 can be used in cancer research .
    DJ-1-IN-1
  • HY-168001
    TcNTPDase1-IN-1

    		NTPDase Infection Cancer
    TcNTPDase1-IN-1 (compound 16) is an inhibitor of nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1) from Trypanosoma cruzi in vitro. TcNTPDase1-IN-1 can be used in antibacterial, antitoxic and antitumor related research .
    TcNTPDase1-IN-1
  • HY-101238
    Agmatine sulfate

    		Imidazoline Receptor NO Synthase Endogenous Metabolite Neurological Disease Cancer
    Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.
    Agmatine sulfate
  • HY-D1005A14
    Poloxamer 217 (F77)

    PEG-PPG-PEG, 6600 (Averag)

    		 Biochemical Assay Reagents Others
    Poloxamer 217 F77 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 6600. Poloxamer 217 F77 inhibits proliferation of human lymphocyte cell IIBR1 .
    Poloxamer 217 (F77)
  • HY-122878
    HS-131

    		HSP Cancer
    HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers .
    HS-131
  • HY-D0039
    3-Cyanoumbelliferone

    		Fluorescent Dye Others
    3-Cyanoumbelliferone is a coumarin derivative, acting as molecular probe and fluorescent dye. 3-Cyanoumbelliferone is also a macrophage migration inhibitory factor (MIF) tautomerase inhibitor with a Ki of 2.9 μM .
    3-Cyanoumbelliferone
  • HY-162457
    Mn007

    		Others Infection
    Mn007 is a potent inhibitor of bovine pancreatic DNase I, with the IC50 of 45 μM, by forming molecular aggregation. Mn007 shows suppression of S. pyogenes growth in human whole blood .
    Mn007
  • HY-12836
    IFN alpha-IFNAR-IN-1

    		IFNAR Inflammation/Immunology
    IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).
    IFN alpha-IFNAR-IN-1
  • HY-157170
    CYP450-IN-1

    		Cytochrome P450 Cancer
    CYP450-IN-1 (compound 2e) is a potent inhibitor of CYP450 .
    CYP450-IN-1
  • HY-P5459
    Elafin(human)

    		Bacterial Elastase Infection
    Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus .
    Elafin(human)
  • HY-141520
    ART558
    15+ Cited Publications

    		 DNA/RNA Synthesis Cancer
    ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer .
    ART558
  • HY-19296
    BDCRB

    2-Bromo-5,6-dichloro-1-β-D-ribofuranosyl benzimidazole

    		 Others Infection
    BDCRB is a selective Human cytomegalovirus (HCMV) inhibitor through blocking the maturational cleavage of high-molecular-weight DNA. BDCRB shows a mean IC50 of 0.03 μM for viral yield at 72 h postinfection .
    BDCRB
  • HY-W243303O
    Poly(acrylic acid) (Mv 1250000) (viscous liquid)

    		Biochemical Assay Reagents Cancer
    Poly(acrylic acid) (Mv 1250000) (viscous liquid) is an anionic polymer with a molecular weight of 1,250,000. It can be used as a corrosion inhibitor and surface stabilizer, as well as a biomaterial or organic compound relevant to life sciences research .
    Poly(acrylic acid) (Mv 1250000) (viscous liquid)
  • HY-121042
    BSBM6

    		Others Others
    BSBM6 is a compound with the activity of inhibiting Aβ aggregation and regulating Aβ aggregation. BSBM6 can be demonstrated to inhibit Aβ aggregation through molecular dynamics simulation and related experiments, reducing soluble oligomers, and providing structural guidance for the design of new aggregation regulating ligands.
    BSBM6
  • HY-147416
    Vipoglanstat

    BI 1029539; GS-248; OX-MPI

    		 PGE synthase Infection Cancer
    Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 (mPGES-1). Vipoglanstat also has anti-inflammatory activity .
    Vipoglanstat
  • HY-18660B
    Ciraparantag acetate

    PER977 acetate

    		 Factor Xa Cardiovascular Disease
    Ciraparantag (PER977) acetate is a thrombin and factor Xa inhibitor. Ciraparantag acetate is a broad-spectrum reversal agent for anticoagulants, including low molecular weight heparins, unfractionated heparins, and some direct oral anticoagulants, but not VKAs .
    Ciraparantag acetate
  • HY-W011400
    TLR1
    3 Publications Verification

    		 MyD88 Inflammation/Immunology
    TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses .
    TLR1
  • HY-139144
    YM-08

    		Sirtuin HSP Neurological Disease Cancer
    YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2,with the IC50 of 19.9 μM. YM-08 also is inhibitor of Hsp70 .
    YM-08
  • HY-157015
    Antifungal agent 81

    		Fungal Infection
    Antifungal agent 81(G22)exhibitsexcellent in vitro antifungal activities against Valsa mali withIC50values of 0.48 mg/L. Antifungal agent 81also exhibits excellent in vivo protective againstV. maliat 40 mg/L .
    Antifungal agent 81
  • HY-162349
    PARP7/HDACs-IN-1

    		HDAC PARP Cancer
    PARP7/HDACs-IN-1 (compound 9l) is a dual-target inhibitor targeting PARP7/HDAC with anti-tumor activity. PARP7/HDACs-IN-1 inhibits different subtypes of PARPs and HDACs with IC50s of 83.3 nM (PARP1), 3.1 nM (PARP7), 35 nM (HDAC1), 30.3 nM (HDAC2), 35.4 nM (HDAC3), and 6.4 nM respectively. (HDAC6) . br/ .
    PARP7/HDACs-IN-1
  • HY-100415
    UKI-1

    WX-UK1; UKI-1C

    		 PAI-1 Ser/Thr Protease Cancer
    UKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 0.41 μM. UKI-1 is also a low molecular weight serine protease inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells .
    UKI-1
  • HY-122704A
    Surfen dihydrochloride
    1 Publications Verification

    Aminoquinuride dihydrochloride

    		 FGFR HSV VEGFR Infection
    Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection .
    Surfen dihydrochloride
  • HY-122704
    Surfen

    Aminoquinuride

    		 FGFR HSV VEGFR Infection
    Surfen is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection .
    Surfen
  • HY-137924
    JA2131

    		Poly(ADP-ribose) Glycohydrolase (PARG) Cancer
    JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death .
    JA2131
  • HY-169949
    TAK-756

    		MAP3K Inflammation/Immunology
    TAK-756 is a TAK1 inhibitor with good selectivity for IRAK1/4 and excellent intra-articular pharmacokinetic properties. TAK1 is a potential molecular target for osteoarthritis (OA) with complementary anti-catabolic and anti-inflammatory effects .
    TAK-756
  • HY-151591
    SPAA-52

    		Phosphatase Metabolic Disease
    SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research .
    SPAA-52
  • HY-110249
    CINPA1
    1 Publications Verification

    		 Constitutive Androstane Receptor Metabolic Disease
    CINPA1 is a potent and specific inhibitor of constitutive androstane receptor (CAR) that does not activate pregnane X receptor (PXR). CINPA1 reduces CAR-mediated transcription with an IC50 of ~70 nM. CINPA1 can be used as a molecular tool for understanding CAR function .
    CINPA1
  • HY-122311
    Orniplabin

    SMTP-7

    		 Reactive Oxygen Species Neurological Disease Inflammation/Immunology
    Orniplabin (SMTP-7) is a low-molecular-weight compound that enhances plasminogen–fibrin binding, urokinase-catalyzed activation of plasminogen, and urokinase and plasminogen-mediated fibrin degradation. Orniplabin shows potential thrombolytic and anti-inflammatory effects. Orniplabin inhibits ROS .
    Orniplabin
  • HY-W243303C
    Poly(acrylic acid) (Mv 4000000)

    		Biochemical Assay Reagents Others
    Poly(acrylic acid) (Mv 4000000) is a polyacrylic acid (and an anionic polymer) with a molecular weight of 4000000. Poly(acrylic acid) (Mv 4000000) can be used as a corrosion inhibitor and surface stabilizer. Poly(acrylic acid) (Mv 4000000) is a biomaterial or organic compound that can be used in life science research .
    Poly(acrylic acid) (Mv 4000000)
  • HY-162509
    YS07

    		VEGFR Cancer
    YS07 is a potent VEGFR-2 inhibitor. Molecular dynamics simulation study revealed sustained interactions of YS07 with key amino acids of VEGFR-2 at a run time of 100 ns. YS07 can be used for anticancer research .
    YS07
  • HY-W129233
    Dihydroartemisinin (mixture of α and β isomers)

    Dihydroartemisinin (α,β mixture)

    		 Parasite Autophagy Apoptosis Infection Cancer
    Dihydroartemisinin (mixture of α and β isomers) is an anti-malaria and anticancer agent, as well as an active metabolite of artemisinin and its derivatives. Dihydroartemisinin exerts anticancer effects through various molecular mechanisms, such as inhibiting proliferation, inducing apoptosis, inhibiting tumor metastasis and angiogenesis, promoting immune function, inducing autophagy and endoplasmic reticulum stress .
    Dihydroartemisinin (mixture of α and β isomers)

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