Search Result

Results for "

neuroprotective and antioxidant effects

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (5) AMPK (1) Amyloid-β (2) Apoptosis (19) Aryl Hydrocarbon Receptor (1) Autophagy (5) Bacterial (13) Biochemical Assay Reagents (1) Calcineurin (1) Calcium Channel (3) Caspase (4) Cholinesterase (ChE) (7) DNA/RNA Synthesis (5) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (7) ERK (1) Fluorescent Dye (1) Glutathione Peroxidase (1) HBV (3) Histamine Receptor (2) HIV (3) HSV (2) Influenza Virus (2) Interleukin Related (3) Isotope-Labeled Compounds (2) JNK (2) Keap1-Nrf2 (4) MAPKAPK2 (MK2) (3) MARK (1) MDM-2/p53 (1) MEK (1) mGluR (1) Mitochondrial Metabolism (1) MMP (7) Monoamine Oxidase (1) Neurokinin Receptor (1) NF-κB (5) NO Synthase (3) p38 MAPK (6) Parasite (1) PARP (1) PI3K (4) Platelet-activating Factor Receptor (PAFR) (2) Potassium Channel (2) PPAR (6) Reactive Oxygen Species (10) ROS Kinase (3) SARS-CoV (3) Ser/Thr Protease (1) SOD (2) Sodium Channel (1) TNF Receptor (1) Toll-like Receptor (TLR) (3) Tyrosinase (2)
By Research Areas:	Cancer (28) Cardiovascular Disease (16) Infection (14) Inflammation/Immunology (50) Metabolic Disease (15) Neurological Disease (65)

By Targets:

Akt (5)

AMPK (1)

Amyloid-β (2)

Apoptosis (19)

Aryl Hydrocarbon Receptor (1)

Autophagy (5)

Bacterial (13)

Biochemical Assay Reagents (1)

Calcineurin (1)

Calcium Channel (3)

Caspase (4)

Cholinesterase (ChE) (7)

DNA/RNA Synthesis (5)

Drug Isomer (1)

Drug Metabolite (1)

Endogenous Metabolite (7)

ERK (1)

Fluorescent Dye (1)

Glutathione Peroxidase (1)

HBV (3)

Histamine Receptor (2)

HIV (3)

HSV (2)

Influenza Virus (2)

Interleukin Related (3)

Isotope-Labeled Compounds (2)

JNK (2)

Keap1-Nrf2 (4)

MAPKAPK2 (MK2) (3)

MARK (1)

MDM-2/p53 (1)

MEK (1)

mGluR (1)

Mitochondrial Metabolism (1)

MMP (7)

Monoamine Oxidase (1)

Neurokinin Receptor (1)

NF-κB (5)

NO Synthase (3)

p38 MAPK (6)

Parasite (1)

PARP (1)

PI3K (4)

Platelet-activating Factor Receptor (PAFR) (2)

Potassium Channel (2)

PPAR (6)

Reactive Oxygen Species (10)

ROS Kinase (3)

SARS-CoV (3)

Ser/Thr Protease (1)

SOD (2)

Sodium Channel (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (3)

Tyrosinase (2)

By Research Areas:

Cancer (28)

Cardiovascular Disease (16)

Infection (14)

Inflammation/Immunology (50)

Metabolic Disease (15)

Neurological Disease (65)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Fat Mass and Obesity-associated Protein (FTO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0037

Albiflorin 4 Publications Verification	Reactive Oxygen Species	Inflammation/Immunology
Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

HY-N0748

Oxypaeoniflorin 3 Publications Verification	Others	Neurological Disease Inflammation/Immunology
Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects .

HY-159062

Goji Extract	Biochemical Assay Reagents NO Synthase	Neurological Disease
Goji Extract is a natural product with anti-aging, antioxidant, and neuroprotective effects. The antioxidant effect of Goji Extract has a positive impact on erectile dysfunction and can be used in research to improve erectile function .

HY-107567B

Carcinine dihydrochloride β-Alanylhistamine dihydrochloride	Histamine Receptor	Neurological Disease
Carcinine (β-Alanylhistamine) dihydrochloride is a selective histamine H3 antagonist with antioxidant activity and neuroprotective effects on the retina of oxidatively stressed mice .

HY-N0820

Catalpol 5+ Cited Publications Catalpinoside	HBV	Infection Neurological Disease Inflammation/Immunology Cancer
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-163883

BChE-IN-34	Cholinesterase (ChE)	Neurological Disease
BChE-IN-34 is a potent and selective butyrylcholinesterase (BChE) inhibitor with an IIC₅₀ of 25 nM. BChE-IN-34 shows excellent selectivity against BChE over acetylcholinesterase. BChE-IN-34 has neuroprotective and antioxidant effects .

HY-N14021

Petasites japonicus extract	DNA/RNA Synthesis	Neurological Disease Inflammation/Immunology Cancer
Petasites japonicus extract is the extract from Petasites japonicus with antioxidant, anti-inflammatory, anti-obesity, neuroprotective and anti-cancer effects. Petasites japonicus extract promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells .

HY-162164

Neuroprotective agent 3	Others	Neurological Disease
Neuroprotective agent 3 (Compound 21a) is an antioxidant that exhibits neuroprotective effects. Neuroprotective agent 3 significantly increases neuronal viability and induces neuroprotection, as well as improves neurological deficit scores in an in vivo model of transient cerebral ischemia .

HY-107567

Carcinine β-Alanylhistamine	Histamine Receptor	Neurological Disease
Alistin (Carcinine; β-Alanylhistamine) is a selective histamine H3 antagonist with antioxidant activity and neuroprotective effects on the retina of oxidatively stressed mice .

HY-N12669

Curcumin monoglucoside	Bacterial Reactive Oxygen Species Apoptosis JNK Caspase	Neurological Disease
Curcumin monoglucoside is a flavonoid derivative possessing antioxidant, anti-apoptotic, neuroprotective effects, and antibacterial activity. Curcumin monoglucoside can be used in research on Parkinson's disease.

HY-168501

Neuroprotective agent 6	Others	Inflammation/Immunology
Neuroprotective Agent 6 (Compound Y12) is a neuroprotective agent with antioxidant activity. Neuroprotective Agent 6 demonstrates superior neuroprotective effects in both cellular models induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and animal models induced by transient middle cerebral artery occlusion (tMCAO). Additionally, Neuroprotective Agent 6 exhibits significant metal chelating activity towards Cu ²⁺ .

HY-105008

Secoisolariciresinol diglucoside 5 Publications Verification (S,S)-SDG; (S,S)-LGM2605	Others	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects .

HY-N0037R

Albiflorin (Standard)	Reactive Oxygen Species	Inflammation/Immunology
Albiflorin (Standard) is the analytical standard of Albiflorin. This product is intended for research and analytical applications. Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

HY-N2195

Nootkatone 3 Publications Verification (+)-Nootkatone	Interleukin Related TNF Receptor	Neurological Disease
Nootkatone, a neuroprotective agent from Vitis vinifera, has antioxidant and anti-inflammatory effects . Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease .

HY-N4191

Isorosmanol	Cholinesterase (ChE)	Neurological Disease
Isorosmanol is an abietane-type diterpene isolated from Rosmarinus officinalis L. aerial parts, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits AChE activity and melanin synthesis .

HY-N0013

Vitexin 5+ Cited Publications	Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-101445B

(S)-Trolox	Drug Isomer	Neurological Disease
(S)-Trolox is an analogue of vitamin E, in which the phytyl chain is replaced with a carboxyl group. (S)-Trolox is frequently used as a model compound for studies of structural features, as well as a standard for evaluation of antioxidant activity. (S)-Trolox has potent and specific neuroprotective and antioxidant effects .

HY-N7044

Vitexin arginine	Others	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Vitexin arginine is a c-glycosylated flavone, and is found in various medicinal plants species such as Ficus deltoid and Spirodela polyrhiza. Vitexin arginine has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-163772

Fraxinellone analog 1	Keap1-Nrf2	Neurological Disease
Fraxinellone analog 1 (compound 2) is a potent and rapid activator of the Nrf2 mediated antioxidant defense system, which protects against glutamate-mediated excitotoxicity and induces the expression of antioxidant genes Gpx4, Sod1, and Nqo1. Fraxinellone analog 1 has neuroprotective effects and regulatory effects against oxidative stress and inflammation, and can be used in the study of neurodegenerative diseases .

HY-N5086

Picroside IV	HBV	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0820R

Catalpol (Standard)	HBV	Infection Neurological Disease Inflammation/Immunology Cancer
Catalpol (Standard) is the analytical standard of Catalpol. This product is intended for research and analytical applications. Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0748R

Oxypaeoniflorin (Standard)	Others	Neurological Disease Inflammation/Immunology
Oxypaeoniflorin (Standard) is the analytical standard of Oxypaeoniflorin. This product is intended for research and analytical applications. Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects .

HY-Y1314

Dimethyl sulfone 1 Publications Verification	Bacterial	Metabolic Disease
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-134616

Ulinastatin 2 Publications Verification Uristatin	Ser/Thr Protease Apoptosis	Neurological Disease Inflammation/Immunology
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects .

HY-N10131

Biatractylolide (+)-Biatractylolide	Apoptosis	Neurological Disease Cancer
Biatractylolide is a compound isolated from the ethyl acetate extract of Atractylodes macrocephala. Biatractylolide has antitumor and antioxidant activities. Biatractylolide improves cell viability, inhibits the apoptosis of cells induced by glutamate, and reduces the activity of LDH. Biatractylolide has neuroprotective effects .

HY-N14039

Pinus pinaster bark extract	Toll-like Receptor (TLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases toll-like receptor (TLR) activity, inducing production of IL-10 .

HY-N2388

Auraptene	MMP PPAR Bacterial	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Auraptene is an orally active geranyloxycoumarin that can be isolated from plants in the Brassicaceae family, antibacterial, anti-pathogen, antioxidant, anti-tumor, and neuroprotective effects. Auraptene plays an important role in the treatment of various chronic diseases such as hypertension and cystic fibrosis ^[1][2].

HY-N0006

Demethoxycurcumin 3 Publications Verification Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase	Infection Neurological Disease Inflammation/Immunology Cancer
Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-N0013R

Vitexin (Standard)	Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N10431

Stigmane B	Keap1-Nrf2	Neurological Disease
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-117727A

Leriglitazone hydrochloride MIN-102 hydrochloride; Hydroxypioglitazone hydrochloride	PPAR	Neurological Disease Metabolic Disease Inflammation/Immunology
Leriglitazone (MIN-102; Hydroxypioglitazone) hydrochloride is an orally active and a BBB-penatrable PPARγ agonist with an EC₅₀ of 9 μM. Leriglitazone hydrochloride, as a regulator of mitochondrial function, has neuroprotective, anti-inflammatory and antioxidant effects. Leriglitazone hydrochloride can be used in the study of neuroinflammatory and neurodegenerative diseases .

HY-170798

Monoamine Oxidase B inhibitor 6	Monoamine Oxidase SOD Glutathione Peroxidase	Neurological Disease
Monoamine Oxidase B inhibitor 6 (Compound BT5) is a BBB-penatrable, highly selective, reversible and competitive MAO-B inhibitor, with an IC₅₀ of 0.11 μM. Monoamine Oxidase B inhibitor 6 has antioxidant and neuroprotective effects and can be used in the research of neurodegenerative diseases .

HY-117727

Leriglitazone MIN-102; Hydroxypioglitazone	PPAR	Neurological Disease Metabolic Disease Inflammation/Immunology
Leriglitazone (MIN-102; Hydroxypioglitazone) is an orally active and a BBB-penatrable PPARγ agonist with an EC₅₀ of 9 μM. Leriglitazone, as a regulator of mitochondrial function, has neuroprotective, anti-inflammatory and antioxidant effects. Leriglitazone can be used in the study of neuroinflammatory and neurodegenerative diseases .

HY-N0408

Picroside II 1 Publications Verification	NF-κB Reactive Oxygen Species Apoptosis Influenza Virus	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Picroside II is an antioxidant with oral activity that can reduce the production of ROS and protect the blood-brain barrier (BBB) after CI/R injury, offering neuroprotective effects. Picroside II has antioxidant, immune-regulating, antiviral properties, and inhibits apoptosis. Picroside II alleviates the inflammatory response in sepsis by suppressing the activation of the NLRP3 inflammasome and NF-κB pathways .

HY-N0188

Esculin 4 Publications Verification	p38 MAPK	Inflammation/Immunology Cancer
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-Y1314R

Dimethyl sulfone (Standard)	Drug Metabolite Endogenous Metabolite	Metabolic Disease
Dimethyl sulfone (Standard) is the analytical standard of Dimethyl sulfone. This product is intended for research and analytical applications. Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-N0664

Aucubin 5+ Cited Publications	Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

HY-76201

Dexrazoxane hydrochloride Maximum Cited Publications 12 Publications Verification ICRF-187 hydrochloride; ADR-529 hydrochloride; NSC-169780 hydrochloride	Others	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a heart protectant that can help preserve ovarian function and fertility. Dexrazoxane hydrochloride has antioxidant and anti-inflammatory properties, can cross the blood-brain barrier, improves motor function disorders, and offers neuroprotective effects, making it useful in the study of neurodegenerative diseases .

HY-N2393

Kukoamine B	Apoptosis MMP MAPKAPK2 (MK2) p38 MAPK PI3K Akt Reactive Oxygen Species DNA/RNA Synthesis	Neurological Disease Metabolic Disease Inflammation/Immunology
Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with K_d values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis .

HY-N2393A

Kukoamine B mesylate	Apoptosis MMP MARK PI3K Akt ROS Kinase DNA/RNA Synthesis	Neurological Disease Metabolic Disease Inflammation/Immunology
Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with K_d values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis. .

HY-N2393S

Kukoamine B-d5 dihydrochloride	MMP Apoptosis MAPKAPK2 (MK2) p38 MAPK PI3K Akt ROS Kinase DNA/RNA Synthesis	Neurological Disease Metabolic Disease Inflammation/Immunology
Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with K_d values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis. .

HY-N2388R

Auraptene (Standard)	MMP PPAR Bacterial	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Auraptene (Standard) is the analytical standard of Auraptene. This product is intended for research and analytical applications. Auraptene is an orally active geranyloxycoumarin that can be isolated from plants in the Brassicaceae family, antibacterial, anti-pathogen, antioxidant, anti-tumor, and neuroprotective effects. Auraptene plays an important role in the treatment of various chronic diseases such as hypertension and cystic fibrosis .

HY-122267

Clovamide trans-Clovamide	Reactive Oxygen Species Bacterial Influenza Virus Apoptosis	Neurological Disease Inflammation/Immunology
Clovamide (trans-Clovamide), a natural phenolic compound, is a potent antioxidant. Clovamide is an excellent ROS and oxygen radical scavenger. Clovamide also has anti-inflammatory and neuroprotective effects . Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, *Trypanosoma evansi, and Heliobacter pylori* .

HY-N0573

Umbelliferone 2 Publications Verification 7-Hydroxycoumarin; Hydrangin; NSC 19790	Apoptosis Fluorescent Dye	Neurological Disease Inflammation/Immunology Cancer
Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-N0006R

Demethoxycurcumin (Standard)	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase	Infection Neurological Disease Inflammation/Immunology Cancer
Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-N0272

Eleutheroside E 2 Publications Verification	Apoptosis NF-κB	Neurological Disease Inflammation/Immunology
Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects .

HY-103558

LY379268 1 Publications Verification	mGluR	Neurological Disease
LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC₅₀ values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects .

HY-N0188R

Esculin (Standard)	p38 MAPK	Inflammation/Immunology Cancer
Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-W012531

2-Hydroxycinnamic acid	HIV SARS-CoV Endogenous Metabolite Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against *Staphylococcus aureus* and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC₅₀ of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity .

HY-170658

AChE-IN-80	Autophagy Amyloid-β Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
AChE-IN-80 (Compound 1) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-80 can inhibit inflammation and the production of reactive oxygen species (ROS) in vitro- cultured neurons and microglia, trigger autophagy responses, and block the propagation of β-amyloid (Aβ) fibrils. AChE-IN-80 possesses antioxidant activity and neuroprotective effects and can be used in the study of Alzheimer's disease .

Cat. No.	Product Name	Type

HY-159062

Goji Extract	Carbohydrates
Goji Extract is a natural product with anti-aging, antioxidant, and neuroprotective effects. The antioxidant effect of Goji Extract has a positive impact on erectile dysfunction and can be used in research to improve erectile function .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0037

Albiflorin 4 Publications Verification	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Classification of Application Fields Terpenoids Source classification Plants Paeoniaceae Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

HY-N0748

Oxypaeoniflorin 3 Publications Verification	Structural Classification Other Monoterpenes Monophenols Paeonia lactiflora Pall. Terpenoids Source classification Phenols Plants Paeoniaceae	Others
Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects .

HY-N0820

Catalpol Maximum Cited Publications 10 Publications Verification Catalpinoside	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Infection Iridoids Terpenoids Scrophulariaceae Inflammation/Immunology Disease Research Fields Cancer	HBV
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-105008

Secoisolariciresinol diglucoside 5 Publications Verification (S,S)-SDG; (S,S)-LGM2605	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Source classification Lignans Plants Microorganisms Linum usitatissimum Linn. Linaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields	Others
Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects .

HY-N2195

Nootkatone 3 Publications Verification (+)-Nootkatone	Structural Classification Terpenoids Sesquiterpenes Source classification Vitis vinifera cv. Zalema Plants Vitaceae	Interleukin Related TNF Receptor
Nootkatone, a neuroprotective agent from Vitis vinifera, has antioxidant and anti-inflammatory effects . Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease .

HY-N4191

Isorosmanol	Structural Classification Neurological Disease Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Terpenoids Labiatae Source classification Phenols Polyphenols Diterpenoids Plants Disease Research Fields	Cholinesterase (ChE)
Isorosmanol is an abietane-type diterpene isolated from Rosmarinus officinalis L. aerial parts, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits AChE activity and melanin synthesis .

HY-N0013

Vitexin 5+ Cited Publications	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Flavones Anti-aging Source classification Metabolic Disease Plants Flavonoids Leguminosae Phenols Polyphenols Trigonella foenum-graecum Linn. Disease Research Fields Cancer	Autophagy
Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N14021

Petasites japonicus extract	Structural Classification Natural Products Source classification Plants Compositae Piptadenia Benth.	DNA/RNA Synthesis
Petasites japonicus extract is the extract from Petasites japonicus with antioxidant, anti-inflammatory, anti-obesity, neuroprotective and anti-cancer effects. Petasites japonicus extract promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells .

HY-N12669

Curcumin monoglucoside	Apocynaceae Structural Classification Source classification Plants Saccharides Monosaccharides Catharanthus roseus (L.) G. Don	Bacterial Reactive Oxygen Species Apoptosis JNK Caspase
Curcumin monoglucoside is a flavonoid derivative possessing antioxidant, anti-apoptotic, neuroprotective effects, and antibacterial activity. Curcumin monoglucoside can be used in research on Parkinson's disease.

HY-N0037R

Albiflorin (Standard)	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae	Reactive Oxygen Species
Albiflorin (Standard) is the analytical standard of Albiflorin. This product is intended for research and analytical applications. Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

HY-N7044

Vitexin arginine	Cardiovascular Disease Flavonoids other families Classification of Application Fields Neurological Disease Flavones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Others
Vitexin arginine is a c-glycosylated flavone, and is found in various medicinal plants species such as Ficus deltoid and Spirodela polyrhiza. Vitexin arginine has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N5086

Picroside IV	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Monophenols Iridoids Terpenoids Phenols Scrophulariaceae Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	HBV
Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0820R

Catalpol (Standard)	Structural Classification Iridoids Terpenoids Source classification Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey	HBV
Catalpol (Standard) is the analytical standard of Catalpol. This product is intended for research and analytical applications. Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0748R

Oxypaeoniflorin (Standard)	Structural Classification Other Monoterpenes Monophenols Paeonia lactiflora Pall. Terpenoids Source classification Phenols Plants Paeoniaceae	Others
Oxypaeoniflorin (Standard) is the analytical standard of Oxypaeoniflorin. This product is intended for research and analytical applications. Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects .

HY-Y1314

Dimethyl sulfone 1 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Bacterial
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-N14039

Pinus pinaster bark extract	Structural Classification Natural Products Pinaceae Pinus pinaster. Source classification Plants	Toll-like Receptor (TLR) Interleukin Related
Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases toll-like receptor (TLR) activity, inducing production of IL-10 .

HY-N2388

Auraptene	Structural Classification other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	MMP PPAR Bacterial
Auraptene is an orally active geranyloxycoumarin that can be isolated from plants in the Brassicaceae family, antibacterial, anti-pathogen, antioxidant, anti-tumor, and neuroprotective effects. Auraptene plays an important role in the treatment of various chronic diseases such as hypertension and cystic fibrosis ^[1][2].

HY-N0006

Demethoxycurcumin 3 Publications Verification Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin	Zingiber officinale Roscoe Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Zingiberaceae Cancer	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase
Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-N0013R

Vitexin (Standard)	Structural Classification Flavonoids Flavones Leguminosae Source classification Phenols Polyphenols Plants Trigonella foenum-graecum Linn.	Autophagy
Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N10431

Stigmane B	Zea mays L. Terpenoids Gramineae Source classification Diterpenoids Plants	Keap1-Nrf2
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-N0408

Picroside II 1 Publications Verification	Infection Structural Classification Iridoids Neurological Disease Classification of Application Fields Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	NF-κB Reactive Oxygen Species Apoptosis Influenza Virus
Picroside II is an antioxidant with oral activity that can reduce the production of ROS and protect the blood-brain barrier (BBB) after CI/R injury, offering neuroprotective effects. Picroside II has antioxidant, immune-regulating, antiviral properties, and inhibits apoptosis. Picroside II alleviates the inflammatory response in sepsis by suppressing the activation of the NLRP3 inflammasome and NF-κB pathways .

HY-N0188

Esculin 4 Publications Verification	Structural Classification Monophenols other families Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Cancer	p38 MAPK
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-Y1314R

Dimethyl sulfone (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Drug Metabolite Endogenous Metabolite
Dimethyl sulfone (Standard) is the analytical standard of Dimethyl sulfone. This product is intended for research and analytical applications. Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-N0664

Aucubin 5+ Cited Publications	Infection Structural Classification Eucommia ulmoides Oliver Iridoids Neurological Disease Classification of Application Fields Terpenoids Source classification Eucommiaceae Plants Inflammation/Immunology Disease Research Fields	Bacterial
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

HY-N2393

Kukoamine B	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Solanaceae Plants Lycium chinense Miller Inflammation/Immunology Disease Research Fields	Apoptosis MMP MAPKAPK2 (MK2) p38 MAPK PI3K Akt Reactive Oxygen Species DNA/RNA Synthesis
Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with K_d values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis .

HY-N2388R

Auraptene (Standard)	Structural Classification other families Source classification Coumarins Phenylpropanoids Plants	MMP PPAR Bacterial
Auraptene (Standard) is the analytical standard of Auraptene. This product is intended for research and analytical applications. Auraptene is an orally active geranyloxycoumarin that can be isolated from plants in the Brassicaceae family, antibacterial, anti-pathogen, antioxidant, anti-tumor, and neuroprotective effects. Auraptene plays an important role in the treatment of various chronic diseases such as hypertension and cystic fibrosis .

HY-122267

Clovamide trans-Clovamide	Alkaloids Structural Classification other families Other Alkaloids Source classification Phenols Polyphenols Plants	Reactive Oxygen Species Bacterial Influenza Virus Apoptosis
Clovamide (trans-Clovamide), a natural phenolic compound, is a potent antioxidant. Clovamide is an excellent ROS and oxygen radical scavenger. Clovamide also has anti-inflammatory and neuroprotective effects . Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, *Trypanosoma evansi, and Heliobacter pylori* .

HY-N0573

Umbelliferone 2 Publications Verification 7-Hydroxycoumarin; Hydrangin; NSC 19790	Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer	Apoptosis Fluorescent Dye
Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-N0006R

Demethoxycurcumin (Standard)	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase
Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-N0272

Eleutheroside E 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae	Apoptosis NF-κB
Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects .

HY-N0188R

Esculin (Standard)	Structural Classification Monophenols other families Source classification Coumarins Phenols Phenylpropanoids Plants	p38 MAPK
Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-W012531

2-Hydroxycinnamic acid	Infection Structural Classification Monophenols Cinnamomum cassia (L.) D. Don Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Lauraceae Disease Research Fields	HIV SARS-CoV Endogenous Metabolite Bacterial
2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against *Staphylococcus aureus* and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC₅₀ of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity .

HY-W011641

(±)-Naringenin 3 Publications Verification	Cardiovascular Disease Structural Classification Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields	Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

HY-N6967

Levomenol (-)-α-Bisabolol	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants	Apoptosis
Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .

HY-N1430

Oxyresveratrol trans-Oxyresveratrol	Structural Classification other families Stilbenes Classification of Application Fields Anti-aging Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Tyrosinase HSV Autophagy
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-N0664R

Aucubin (Standard)	Structural Classification Eucommia ulmoides Oliver Iridoids Terpenoids Source classification Eucommiaceae Plants	Bacterial
Aucubin (Standard) is the analytical standard of Aucubin. This product is intended for research and analytical applications. Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

HY-121389

Hexadecanamide Palmitamide	Infection Structural Classification Alkaloids Cannabis sativa L Classification of Application Fields Other Alkaloids Source classification Plants Moraceae Inflammation/Immunology Disease Research Fields	Bacterial NF-κB PPAR
Hexadecanamide (Palmitamide), a fatty acid amide, has orally active anti-allergic, antioxidant, and neuroprotective effects. Hexadecanamide alleviate S. aureus-caused mastitis by depressing inflammatory response and maintaining blood-milk barrier integrity. Hexadecanamide depresses S. aureus-induced activation of the NF-κB pathway in mouse mammary epithelial cells (MMECs). Hexadecanamide activates PPARα. Hexadecanamide enhances sperm motility in vitro .

HY-N2393R

Kukoamine B (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Phenols Polyphenols Solanaceae Plants Lycium chinense Miller	Apoptosis MMP MAPKAPK2 (MK2) p38 MAPK PI3K Akt ROS Kinase DNA/RNA Synthesis
Kukoamine B (Standard) is the analytical standard of Kukoamine B. This product is intended for research and analytical applications. Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with K_d values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis .

HY-W011978

N-Acetyl-L-tryptophan	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-N6778

Paxilline 5+ Cited Publications	Alkaloids Structural Classification Microorganisms other families Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Indole Alkaloids	Potassium Channel Calcium Channel Reactive Oxygen Species
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

HY-N6967R

Levomenol (Standard)	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants	Apoptosis
Levomenol (Standard) is the analytical standard of Levomenol. This product is intended for research and analytical applications. Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .

HY-N1430R

Oxyresveratrol (Standard)	Structural Classification other families Stilbenes Source classification Phenols Polyphenols Plants	Tyrosinase HSV Autophagy
Oxyresveratrol (Standard) is the analytical standard of Oxyresveratrol. This product is intended for research and analytical applications. Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .

HY-W012531R

2-Hydroxycinnamic acid (Standard)	Structural Classification Monophenols Cinnamomum cassia (L.) D. Don Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Lauraceae	HIV SARS-CoV Endogenous Metabolite Bacterial
2-Hydroxycinnamic acid (Standard) is the analytical standard of 2-Hydroxycinnamic acid. This product is intended for research and analytical applications. 2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against *Staphylococcus aureus* and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC₅₀ of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity .

HY-N0784

Ginkgolide B 5+ Cited Publications BN-52021	Structural Classification Ginkgoaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Endogenous metabolite Ginkgo biloba Disease Research Fields Cancer	Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-N9736

6,4'-Dihydroxy-7-methoxyflavanone	Structural Classification Flavonoids Dalbergia odorifera T. Chen Flavones Leguminosae Source classification Plants	Calcineurin
6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis .

HY-120149

Inotodiol	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	Toll-like Receptor (TLR) MDM-2/p53 MMP Caspase SOD p38 MAPK NF-κB Apoptosis
Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC₅₀ in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active .

HY-N0784R

Ginkgolide B (Standard)	Structural Classification Ginkgoaceae Terpenoids Source classification Diterpenoids Plants Endogenous metabolite Ginkgo biloba	Platelet-activating Factor Receptor (PAFR) Apoptosis
Ginkgolide B (Standard) is the analytical standard of Ginkgolide B. This product is intended for research and analytical applications. Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments .

HY-N0028

Forsythiaside A 3 Publications Verification	Structural Classification Oleaceae Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields	Others
Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ_25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice. Forsythiaside A inhibits the interaction between KLRB1 and CLEC2D .

HY-N0028R

Forsythiaside A (Standard)	Structural Classification Oleaceae Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants	Others
Forsythiaside A (Standard) is the analytical standard of Forsythiaside A. This product is intended for research and analytical applications. Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice .

HY-N8572

3',4'-Dimethoxyflavone	Structural Classification Flavonoids other families Flavones Coniogramme japonica (Thunb.) Diels Plants	PARP Reactive Oxygen Species Aryl Hydrocarbon Receptor
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .

Cat. No.	Product Name	Chemical Structure

HY-N2393S

Kukoamine B-d5 dihydrochloride
Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with K_d values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis. .

HY-117727S

Leriglitazone-d4

Leriglitazone-d₄ (MIN-102-d₄; Hydroxypioglitazone-d₄) is deuterium labeled Leriglitazone. Leriglitazone is an orally active and a BBB-penatrable PPARγ agonist with an EC₅₀ of 9 μM. Leriglitazone, as a regulator of mitochondrial function, has neuroprotective, anti-inflammatory and antioxidant effects. Leriglitazone can be used in the study of neuroinflammatory and neurodegenerative diseases .

HY-W012531S2

2-Hydroxycinnamic acid-d4

2-Hydroxycinnamic acid-d₄ is deuterium labeled 2-Hydroxycinnamic acid. 2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against Staphylococcus aureus and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC₅₀ of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity .

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