Search Result

Results for "

p38/JNK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	JNK (29) p38 MAPK (38) Adrenergic Receptor (1) Akt (2) Apoptosis (14) Aryl Hydrocarbon Receptor (1) Autophagy (12) Bcl-2 Family (1) Calcium Channel (6) Caspase (4) CDK (2) Cholinesterase (ChE) (1) COX (1) Cytochrome P450 (1) Dengue Virus (1) Endogenous Metabolite (3) ERK (9) Eukaryotic Initiation Factor (eIF) (1) Flavivirus (1) FLT3 (1) HDAC (1) HIV (4) IKK (1) Influenza Virus (1) Interleukin Related (3) Isotope-Labeled Compounds (1) JAK (2) Keap1-Nrf2 (1) MAP3K (2) MAPKAPK2 (MK2) (1) MDM-2/p53 (1) MEK (1) Mitophagy (2) MMP (1) MNK (1) mTOR (1) NF-κB (8) NO Synthase (1) Organoid (2) Phosphatase (2) PI3K (2) PKA (6) PKC (6) Prostaglandin Receptor (2) Raf (1) Reactive Oxygen Species (5) ROCK (6) SOD (1) STAT (1) TGF-beta/Smad (1) TNF Receptor (5) Toll-like Receptor (TLR) (2) Topoisomerase (1) Tyrosinase (3) VEGFR (1) Virus Protease (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (38) Infection (5) Inflammation/Immunology (30) Metabolic Disease (9) Neurological Disease (10)

By Targets:

JNK (29)

p38 MAPK (38)

Adrenergic Receptor (1)

Akt (2)

Apoptosis (14)

Aryl Hydrocarbon Receptor (1)

Autophagy (12)

Bcl-2 Family (1)

Calcium Channel (6)

Caspase (4)

CDK (2)

Cholinesterase (ChE) (1)

COX (1)

Cytochrome P450 (1)

Dengue Virus (1)

Endogenous Metabolite (3)

ERK (9)

Eukaryotic Initiation Factor (eIF) (1)

Flavivirus (1)

FLT3 (1)

HDAC (1)

HIV (4)

IKK (1)

Influenza Virus (1)

Interleukin Related (3)

Isotope-Labeled Compounds (1)

JAK (2)

Keap1-Nrf2 (1)

MAP3K (2)

MAPKAPK2 (MK2) (1)

MDM-2/p53 (1)

MEK (1)

Mitophagy (2)

MMP (1)

MNK (1)

mTOR (1)

NF-κB (8)

NO Synthase (1)

Organoid (2)

Phosphatase (2)

PI3K (2)

PKA (6)

PKC (6)

Prostaglandin Receptor (2)

Raf (1)

Reactive Oxygen Species (5)

ROCK (6)

SOD (1)

STAT (1)

TGF-beta/Smad (1)

TNF Receptor (5)

Toll-like Receptor (TLR) (2)

Topoisomerase (1)

Tyrosinase (3)

VEGFR (1)

Virus Protease (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (38)

Infection (5)

Inflammation/Immunology (30)

Metabolic Disease (9)

Neurological Disease (10)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: p38 MAPK JNK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113756A

Latanoprost acid 1 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology
Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .

HY-108646

SX 011	p38 MAPK JNK	Inflammation/Immunology
SX 011 is a *p38* inhibitor with IC₅₀s of 9 nM and 90 nM against p38α and p38β, respectively. SX 011 also inhibits *JNK-2* with an IC₅₀ of 100 nM. SX-011 is orally bioavailable .

HY-144761

*TOPK-p38/JNK-IN-1*	JNK	Cancer
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active *TOPK-p38/JNK* signaling pathway inhibitor with the IC₅₀ value of 2.14 µM for NO production. TOPK-p38/JNK-IN-1 shows anti-inflammatory activities. TOPK-p38/JNK-IN-1 also inhibits phosphorylate downstream related proteins and avoids degradation of TOPK .

HY-N11536

erythro-Austrobailignan-6	Topoisomerase Apoptosis	Cancer
erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK .

HY-170879

JD123	p38 MAPK JNK	Cancer
JD123 inhibits *JNK1* activity and the expression of cJun (1-135). JD123 is a ATP-competitive p38-γ MAPK inhibitor, but not effect to ERK1, ERK2, or p38-α, p38-β or p38-δ. .

HY-134000

Emodic acid NSC624610	p38 MAPK NF-κB ERK JNK VEGFR MMP	Cancer
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of *p38, ERK* and *JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF* and MMP, thereby inhibiting the invasion and migration potential of cancer cells .

HY-117248

SR-3737	JNK p38 MAPK	Neurological Disease
SR-3737 is a *JNK3* and *p38* inhibitor (IC₅₀: 12 and 3 nM) .

HY-120349

LL-Z1640-4	p38 MAPK JNK Apoptosis Reactive Oxygen Species	Cancer
LL-Z1640-4 is a potent *p38/JNK* signaling inhibitor. LL-Z1640-4 significantly diminishes *p38* and *JNK* activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4 .

HY-171296

p38 Kinase inhibitor 8	p38 MAPK JNK	Inflammation/Immunology
p38 Kinase inhibitor 8 (Compound CCLXXVIII) is the orally active inhibitor for *p38β* and *JNK2α2* with IC₅₀s of 6.3 nM and 53.6 nM. p38 Kinase inhibitor 8 exhibits anti-inflammatory effect in rats collagen-induced arthritis models .

HY-113756AR

Latanoprost acid (Standard)	Prostaglandin Receptor	Inflammation/Immunology
Latanoprost acid (Standard) is the analytical standard of Latanoprost acid. This product is intended for research and analytical applications. Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .

HY-10256

Adezmapimod Maximum Cited Publications 489 Publications Verification SB 203580; RWJ 64809	Organoid p38 MAPK Autophagy Mitophagy	Inflammation/Immunology Cancer
Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for *SAPK2a/p38* and *SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK* activity and is an autophagy and mitophagy activator .

HY-10256A

Adezmapimod hydrochloride Maximum Cited Publications 489 Publications Verification SB 203580 hydrochloride; RWJ 64809 hydrochloride	Organoid p38 MAPK Autophagy Mitophagy	Inflammation/Immunology Cancer
Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for *SAPK2a/p38* and *SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK* activity and is an autophagy and mitophagy activator .

HY-146323

Antitumor agent-58	Apoptosis	Cancer
Antitumor agent-58 (Compound C18) is an anti-tumor agent. Antitumor agent-58 effectively inhibits colony formation and cell migration of MGC-803 cells. Antitumor agent-58 induces apoptosis of MGC-803 cells through activation of the p38 and JNK signaling pathways. Antitumor agent-58 induces mitochondrial dysfunction of MGC-803 cells. Antitumor agent-58 effectively inhibits tumor growth of xenograft model bearing MGC-803 cells .

HY-N1966

(E)-Osmundacetone 2 Publications Verification	p38 MAPK JNK ERK	Neurological Disease
(E)-Osmundacetone is the isomer of Osmundacetone. Osmundacetone significantly suppresses the phosphorylation of MAPKs, including JNK, ERK, and p38 kinases. Osmundacetone has a neuroprotective effect against oxidative stress .

HY-N2179

Hypaphorine 1 Publications Verification	p38 MAPK JNK	Neurological Disease Metabolic Disease Inflammation/Immunology
Hypaphorine is an indole found in Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) (HY-D1056)-mediated acute lung injury (ALI) and proinflammatory response via inactivating the *p38/JNK* signaling pathway by upregulating DUSP1 .

HY-N6826

Asatone 3 Publications Verification	NF-κB	Inflammation/Immunology
Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways .

HY-111431A

p-Cresyl sulfate potassium 5 Publications Verification p-Tolyl sulfate potassium	Endogenous Metabolite JNK p38 MAPK	Metabolic Disease Inflammation/Immunology
p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the *JNK* and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity .

HY-P2319

OVA-E1 peptide	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes .

HY-P2319A

OVA-E1 peptide TFA	p38 MAPK JNK	Inflammation/Immunology
OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264). OVA-E1 peptide, activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes .

HY-N13121

Daphnegiravone D	HDAC Apoptosis p38 MAPK	Cancer
Daphnegiravone D (compound 70) is an HDAC6 inhibitor with anti-hepatocellular carcinoma activity. Daphnegiravone D can induce apoptosis and selectively inhibit the proliferation of liver cancer cells through the p38 and JNK MAPK pathways .

HY-10542

GW 5074 5+ Cited Publications	Raf Apoptosis	Cancer
GW 5074 is a potent and selective c-Raf inhibitor with IC₅₀ of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms .

HY-10520

CGP 57380 4 Publications Verification	MNK Apoptosis	Cancer
CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC₅₀ of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.

HY-N9866

Grasshopper ketone	Others	Inflammation/Immunology
It is a bioactive compound with anti-inflammatory activity that inhibits LPS-induced NO production in RAW 264.7 cells and acts by inhibiting the phosphorylation of MAPK (ERK, JNK and p38) and NF-κB p65. Grasshopper ketone, as an ingredient, has shown its potential in anti-inflammatory inhibition .

HY-137135

Cantharidic acid	Phosphatase Apoptosis ERK p38 MAPK JNK	Cancer
Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway .

HY-13241

Ralimetinib dimesylate 10+ Cited Publications LY2228820 dimesylate	p38 MAPK Autophagy Apoptosis	Inflammation/Immunology Cancer
Ralimetinib dimesylate (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC₅₀s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38a MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc.

HY-N12561

Pestanoid A	ERK p38 MAPK JNK	Others
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .

HY-W654121

p-Cresol sulfate-d4 potassium p-Tolyl sulfate-d₄ potassium	Isotope-Labeled Compounds Endogenous Metabolite p38 MAPK JNK	Inflammation/Immunology
p-Cresol sulfate-d₄ (potassium) is deuterium labeled p-Cresyl sulfate (potassium). p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the *JNK* and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity .

HY-N2208

4-Hydroxylonchocarpin 1 Publications Verification	p38 MAPK	Infection Metabolic Disease Inflammation/Immunology Cancer
4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin increases phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin has diverse pharmacological activities, including antibacterial, antifungal, anticancer, antireverse transcriptase, antitubercular, antimalarial, anti-inflammatory and antioxidant activities .

HY-N0809

Sesamolin 2 Publications Verification	p38 MAPK JNK Caspase Reactive Oxygen Species NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology
Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesamolin inhibits lipid peroxidation and shows neuroprotection effect. Sesamolinl potently inhibits MAPK cascades by preventing phosphorylation of *JNK, p38* MAPKs, and caspase-3 but not ERK-MAPK expression. Sesamolin is orally active .

HY-13241A

Ralimetinib LY2228820	p38 MAPK Autophagy	Inflammation/Immunology Cancer
Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC₅₀s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc .

HY-E70291

N-Acetylgalactosaminyltransferase 4 GALNT4	MAP3K p38 MAPK JNK NF-κB Endogenous Metabolite	Cancer
N-Acetylgalactosaminyltransferase 4 (GALNT4) is a glycosyltransferase capable of inhibiting the activation of ASK1. By directly binding to ASK1, N-Acetylgalactosaminyltransferase 4 suppresses its N-terminal dimerization and subsequent phosphorylation, leading to robust inactivation of downstream *JNK/p38* and NF-κB signals, and thereby improving the prognosis of liver surgery .

HY-162317

AMPK-IN-5	JAK p38 MAPK	Infection
AMPK-IN-5 (compound 7m) is a Osthole (HY-N0054) derivative, and blocks MAPK signal transduction by inhibiting the phosphorylation of *JNK* and *p38*, thereby inhibiting the release of inflammatory cytokines. AMPK-IN-5 reduce DSS-induced ulcerative colitis and LPS (HY-D1056)-induced acute lung injury .

HY-156420

ATUX-1215	Phosphatase	Others
ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in BLM-treated animals. ATUX-1215 can slow the progression of lung fibrosis .

HY-N0809R

Sesamolin (Standard)	p38 MAPK JNK Caspase	Neurological Disease Metabolic Disease
Sesamolin (Standard) is the analytical standard of Sesamolin. This product is intended for research and analytical applications. Sesamolin, isolated from Sesamum indicum, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesamolin potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression .

HY-N0270

Ononin 5+ Cited Publications Ononoside; Formononetin 7-O-β-D-glucopyranoside	ERK JNK p38 MAPK PI3K Akt mTOR Apoptosis	Neurological Disease Metabolic Disease Cancer
Ononin is an orally active isoflavone. Ononin inhibits the *ERK/JNK/p38* and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy .

HY-124421

5F-203 NSC-703786	Aryl Hydrocarbon Receptor	Others
5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38 .

HY-W018643

Ferulic acid methyl ester Methyl ferulate	p38 MAPK Autophagy	Neurological Disease Inflammation/Immunology Cancer
Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties . Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders . Ferulic acid methyl ester inhibits COX-2 expression, blocks *p-p38* and p-JNK in primary bone marrow derived-macrophages .

HY-N0270R

Ononin (Standard)	Others	Others Neurological Disease Cancer
Ononin (Standard) is the analytical standard of Ononin. Ononin is an orally active isoflavone. Ononin inhibits the *ERK/JNK/p38* and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy .

HY-N0619

Mulberroside A 3 Publications Verification	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-15496

E6201 ER-806201	MEK FLT3	Cancer
E6201 (ER-806201) is an ATP-competitive dual kinase inhibitor of MEK1 and FLT3. E6201 inhibits MEK1- induced ERK2 phosphorylation with an IC₅₀ value of 5.2 nM, MKK4-induced JNK phosphorylation with an IC₅₀ value of 91 nM, and MKK6-induced p38 MAPK phosphorylation with an IC₅₀ value of 19 nM. Anti-tumor and anti-psoriasis efficacy .

HY-N9541

Chaetoglobosin Vb	Others	Inflammation/Immunology
Chaetoglobosin Vb is a novel cytotoxic alkaloid with anti-inflammatory and antioxidant activities. Chaetoglobosin Vb can inhibit oxidative stress induced by LPS stimulation, reduce the production of reactive oxygen species and increase the expression of the antioxidant enzyme superoxide dismutase (SOD). Chaetoglobosin Vb significantly reduced the gene and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) induced by LPS, and alleviated the production of proinflammatory cytokines such as TNF-α, IL-6 and IL-1β. Chaetoglobosin Vb exerts its biological activity through the TLR4-mediated MyD88-dependent signaling pathway and the TRIF-dependent signaling pathway, which is specifically manifested by inhibiting the phosphorylation of p38, ERK, and JNK MAPK and the translocation of NF-κB p65 subunit to the nucleus. Chaetoglobosin Vb showed no cytotoxic effect in the concentration range of 25-100 μM and promoted SOD enzyme activity and phosphorylation of p38, ERK1/2 and JNK in a dose-dependent manner .

HY-111431

p-Cresyl sulfate 5 Publications Verification p-Tolyl sulfate	JNK p38 MAPK Reactive Oxygen Species	Metabolic Disease
p-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT). p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways .

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N0619R

Mulberroside A (Standard)	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A (Standard) is the analytical standard of Mulberroside A. This product is intended for research and analytical applications. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-150795

SY-LB-35	TGF-beta/Smad PI3K Akt ERK JNK	Others
SY-LB-35 is a potent bone morphogenetic protein (BMP) receptor agonist. SY-LB-35 can stimulate significant increases in cell number and cell viability in the C2C12 myoblast cell line, and causes shifts towards the S and G2/M phases of the cell cycle. SY-LB-35 stimulates canonical Smad and non-canonical PI3K/Akt, ERK, *p38* and *JNK* intracellular signaling pathways .

HY-N6969A

Dicentrine hydrochloride	Adrenergic Receptor	Cancer
Dicentrine hydrochloride is a drug with anti-inflammatory and anti-cancer activity. Dicentrine hydrochloride exerts its effects by enhancing TNF-α-induced apoptosis in A549 lung adenocarcinoma cells. Dicentrine hydrochloride increases caspase-8, -9, -3 and poly(ADP-ribose) polymerase (PARP) activities. Dicentrine hydrochloride inhibits TNF-α-induced invasion and migration of A549 cells. Dicentrine hydrochloride significantly inhibited the TNF-α-activated TAK1, p38, JNK and Akt signaling pathways, and reduced the transcriptional activities of NF-κB and AP-1 .

HY-N13294

Cernuumolide J TMJ-105	Apoptosis JAK STAT p38 MAPK JNK ERK	Cancer
Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of *JNK* and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC₅₀ value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy .

HY-121605

RL71	Others	Cancer
RL71 is a curcuminoid anticancer agent that exhibits potent cytotoxicity against a variety of ER-negative breast cancer cells. RL71 (1 μM) induces cell cycle arrest in the G2/M phase and induces apoptosis in SKBr3 cells. RL7 also decreases HER2/neu phosphorylation and increases p27. RL71 also significantly reduced the phosphorylation of Akt and transiently increased the stress kinases JNK1/2 and p38 MAPK. Furthermore, RL71 exhibited anti-angiogenic potential in vitro, inhibiting the migration of HUVEC cells and the ability of these cells to form tubular networks .

HY-168482

NF-κB/MAPK-IN-2	NF-κB p38 MAPK	Cancer
NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis .

HY-138844

3-AP-Me	Eukaryotic Initiation Factor (eIF) p38 MAPK JNK Apoptosis	Cancer
3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and *p38* mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research .

Cat. No.	Product Name

HY-L010

MAPK Compound Library

705 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 705 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

Cat. No.	Product Name	Target	Research Area