Search Result

Results for "

paw

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adenosine Kinase (1) Adrenergic Receptor (1) Angiotensin Receptor (1) Apoptosis (2) Bacterial (2) Bradykinin Receptor (1) Caspase (3) COX (9) Dopamine Transporter (1) EBI2/GPR183 (1) EBV (2) Endogenous Metabolite (1) Enterovirus (1) Fluorescent Dye (1) Histamine Receptor (2) Interleukin Related (2) Isotope-Labeled Compounds (1) Kallikrein (1) Keap1-Nrf2 (1) Lipoxygenase (2) MALT1 (1) Melanocortin Receptor (1) nAChR (2) NO Synthase (1) P2X Receptor (1) p38 MAPK (2) Parasite (1) Phosphodiesterase (PDE) (1) PPAR (1) Prostaglandin Receptor (1) Protease Activated Receptor (PAR) (1) Reactive Oxygen Species (1) ROS Kinase (1) SARS-CoV (1) Sodium Channel (1) TRP Channel (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Endocrinology (1) Infection (5) Inflammation/Immunology (39) Metabolic Disease (3) Neurological Disease (13)

By Targets:

5-HT Receptor (2)

Adenosine Kinase (1)

Adrenergic Receptor (1)

Angiotensin Receptor (1)

Apoptosis (2)

Bacterial (2)

Bradykinin Receptor (1)

Caspase (3)

COX (9)

Dopamine Transporter (1)

EBI2/GPR183 (1)

EBV (2)

Endogenous Metabolite (1)

Enterovirus (1)

Fluorescent Dye (1)

Histamine Receptor (2)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

Kallikrein (1)

Keap1-Nrf2 (1)

Lipoxygenase (2)

MALT1 (1)

Melanocortin Receptor (1)

nAChR (2)

NO Synthase (1)

P2X Receptor (1)

p38 MAPK (2)

Parasite (1)

Phosphodiesterase (PDE) (1)

PPAR (1)

Prostaglandin Receptor (1)

Protease Activated Receptor (PAR) (1)

Reactive Oxygen Species (1)

ROS Kinase (1)

SARS-CoV (1)

Sodium Channel (1)

TRP Channel (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (5)

Inflammation/Immunology (39)

Metabolic Disease (3)

Neurological Disease (13)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2478

Taraxasteryl acetate	Others	Inflammation/Immunology
Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment ^{[1] ^.}

HY-131986

LASSBio-1135	TRP Channel	Neurological Disease Inflammation/Immunology
LASSBio-1135 (Compound 3a) is an orally active TRPV1 antagonist. LASSBio-1135 is an anti-inflammatory and analgesic compound. LASSBio-1135 inhibits moderately the human PGHS-2 enzyme activity (IC₅₀ = 18.5 μM). LASSBio-1135 reverts the Capsaicin (HY-10448)-induced thermal hyperalgesia and reduces the carrageenan-induced rat paw edem .

HY-116597

L-783483 F3MethylAA	PPAR	Inflammation/Immunology
L-783483 (F3MethylAA) is an agonist for PPARδ. L-783483 ameliorates Carrageenan (HY-125474)-induced paw edema in mice .

HY-155405

Anti-inflammatory agent 64	ROS Kinase Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 64 (compound 4b) inhibits the secretion of IL-6 and TNF-α. Anti-inflammatory agent 64 has antioxidant and anti-inflammatory activity in vitro and in vivo. Anti-inflammatory agent 64 can effectively reduce paw edema .

HY-N2478R

Taraxasteryl acetate (Standard)	Others	Inflammation/Immunology
Taraxasteryl acetate (Standard) is the analytical standard of Taraxasteryl acetate. This product is intended for research and analytical applications. Taraxasteryl acetate is isolated from P. sagittalis,and has a broad spectrum of anti-inflammatory activity. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment .

HY-116005

A-286501	Adenosine Kinase	Neurological Disease Inflammation/Immunology
A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC₅₀ value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents .

HY-15791

FR173657 FK-3657	Bradykinin Receptor	Inflammation/Immunology
FR173657 is an orally active bradykinin B2 receptor antagonist (IC₅₀: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED₅₀: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED₅₀: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease .

HY-114565

LY221068	Lipoxygenase Enterovirus	Inflammation/Immunology
LY221068 is an anti-oxidant and an orally active, potent inhibitor of iron-dependent lipid peroxidation and 5-lipoxygenase with antiinflammatory properties. LY221068 inhibits bone damage and paw swelling in the Freund's Complete adjuvant (HY-153808) induced arthritis (FCA) model of rats. LY221068 is promising for research of arthritis .

HY-111164

CBS-3595	p38 MAPK Phosphodiesterase (PDE)	Inflammation/Immunology
CBS-3595 is a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) (HY-153808)-induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases .

HY-D1782

Selenomethylene blue	Fluorescent Dye	Inflammation/Immunology
Selenomethylene blue is an antioxidant and anti-inflammatory agent. Selenomethylene blue effectively inhibits the inflammatory paw edema in rats .

HY-121678

Tetridamine POLI-67	Others	Inflammation/Immunology
Tetridamine ((POLI-67) ) is a non-steroidal anti-inflammatory agent and shows a marked reduction of paw swelling and pain sensibility .

HY-114897

L-167307	p38 MAPK	Inflammation/Immunology
L-167307 is an effective pyrrole-based p38 kinase inhibitor that can reduce secondary paw swelling in rat adjuvant-induced arthritis models .

HY-149961

Anti-inflammatory agent 40	Parasite	Infection Inflammation/Immunology
Anti-inflammatory agent 40 is a potential and orally active anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibits carrageenan induced paw swelling in vivo.

HY-119279

VUF 10214	Histamine Receptor	Inflammation/Immunology
VUF 10214 is a H4 receptor ligand with a pK_i of 8.25. VUF 10214 exhibits significant anti-inflammatory activity in a carrageenan-induced paw edema rat model and can be used for research in the field of inflammatory diseases .

HY-N2196

Ajugasterone C	Others	Inflammation/Immunology
Ajugasterone C is an ecdysteroid isolated from Leuzea carthamoides. Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to Carrageenan-induced inflammation in Sprague Dawley rats .

HY-113042

Prostaglandin B2	Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin B2 is a prostaglandin. Prostaglandin B2 is the main substance in cord blood mesenchymal stem cells, to inhibit DC-T Cell proliferation. Prostaglandin B2 also induces cutaneous vasoconstriction of the canine hind paw .

HY-N8487

7-Methoxyflavone	Others	Neurological Disease Inflammation/Immunology
7-Methoxyflavone is a compound isolated from Zornia brasiliensis. 7-Methoxyflavone has peripheral antinociceptive activity. 7-Methoxyflavone inhibits paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase .

HY-N8458

Cryogenine NSC 272693	Others	Inflammation/Immunology
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC₅₀=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.

HY-120820

LY320954	5-HT Receptor	Neurological Disease
LY320954 is a selective 5-HT2A receptor antagonist, with a K_i of 96 nM. LY320954 potently inhibits Ca ²⁺ influx in the functional assay (EC₅₀ of 35.5 nM). LY320954 inhibits 5-HT-induced paw swelling in rats, with ED₅₀ of 4.8 mg/kg .

HY-155133

COX-2-IN-34	COX	Inflammation/Immunology
COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC₅₀ of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects .

HY-N1205

Spathulenol	Others	Cancer
Spathulenol is isolated from Aristolochia yunnanensis, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC₅₀ of 85.60 μg/mL in the DPPH system ^[1].

HY-134820

MLT-943	MALT1	Inflammation/Immunology
MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. MLT-943 inhibits stimulated-IL-2 secretion in PBMC or in whole blood with a similar IC₅₀ across species (0.07-0.09 μM in PBMC, 0.6-0.8 μM in whole blood). MLT-943 has anti-inflammatory activities and can be used for FcgR-mediated inflammation research .

HY-141622

SDZ 224-015	Interleukin Related Caspase SARS-CoV	Infection Inflammation/Immunology
SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting M ^pro (IC₅₀ of 30 nM) .

HY-A0235

Antrafenine Stakane	Others	Neurological Disease
Antrafenine (Stakane) is a non-narcotic analgesic, shows long duration of action, and excellent tolerance in pharmacological and toxicological studies .

HY-115889

L-NAPNA	NO Synthase	Neurological Disease
L-NAPNA is a nitric oxide synthase (NOS) inhibitor with an IC₅₀ of 1.4 μM. L-NAPNA exhibits analgesic effects by inhibiting formalin-induced paw licking behavior in mice (ED₅₀ of 57.2 mg/kg) and suppressing acetic acid-induced abdominal writhing in mice (ED₅₀ of 25 mg/kg). L-NAPNA can be used in research related to central nervous system diseases .

HY-10794

MF498 1 Publications Verification	Prostaglandin Receptor	Metabolic Disease Inflammation/Immunology Cancer
MF498 is a selective and orally active E prostanoid Receptor 4 (EP4) antagonist with a K_i value of 0.7 nM. MF498 can be used in the research of inflammation, such as rheumatoid and osteoarthritis .

HY-134996

N-Acetyl-2-carboxybenzenesulfonamide	COX	Inflammation/Immunology
N-Acetyl-2-carboxybenzenesulfonamide is an orally active COX-1 and COX-2 inhibitor with IC₅₀s of 0.06 μM and 0.25 μM, respectively. N-Acetyl-2-carboxybenzenesulfonamide shows anti-inflammatory activity .

HY-P5875

P4pal10	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
P4pal10 is an antagonist for protease-activated receptor 4 (PAR4). P4pal10 inhibits the platelet aggregation, inhibits tissue factor (TF)-induced thrombin generation, and exhibits anticoagulant and antithrombotic activities. P4pal10 reduces the oedema and the granulocyte infiltration induced by Carrageenan (HY-125474). P4pal10 ameliorates the injury in mice myocardial ischemia/reperfusion (I/R) models .

HY-14316

Tebanicline Ebanicline; ABT-594	nAChR	Neurological Disease
Tebanicline, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.

HY-14316C

Tebanicline tosylate Ebanicline tosylate; ABT-594 tosylate	nAChR	Neurological Disease
Tebanicline tosylate, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline tosylate exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.

HY-162011

GPR183 antagonist-2	EBI2/GPR183	Inflammation/Immunology
GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases .

HY-162166

COX-2/15-LOX/mPGES1-IN-1	COX Lipoxygenase	Inflammation/Immunology
COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC₅₀ values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments .

HY-19202

rac-Olodanrigan rac-EMA401; rac-PD-126055; EMA400	Angiotensin Receptor	Neurological Disease
rac-Olodanrigan (rac-EMA401; EMA400) is a racemic mixture of the S-enantiomer (EMA401; HY-13106) and R-enantiomer (EMA402). rac-Olodanrigan is a potent and selective AT₂ receptor antagonist with IC₅₀s of 75.2 nM and 2918 nM for AT₂R and AT₁R, respectively. rac-Olodanrigan evokes dose-dependent relief of mechanical allodynia in the ipsilateral hind paws of rats with a chronic constriction injury (CCI) of the sciatic nerve .

HY-124517

Burimamide	Histamine Receptor Adrenergic Receptor	Neurological Disease Inflammation/Immunology
Burimamide is a blocker of histamine H2-receptor. Burimamide inhibits gastric acid secretion evoked by Pentagastrin (HY-A0261) or Gastrin. Burimamide also has alpha-adrenoceptor blocking activity. Burimamide in combination with the H1-receptor antagonist Mepyramine (HY-B1281) shows anti-inflammatory activity in a rat paw edema model induced by Compound 48/80 (HY-115768) .

HY-106093

Eltenac	COX	Inflammation/Immunology
Eltenac, a non-steroidal anti-inflammatory drug (NSAID), is a COX inhibitor. Eltenac shows IC50 of 0.03 μM for both COX-1 and COX-2 in isolated human whole blood .

HY-117792

LY314228	5-HT Receptor	Inflammation/Immunology
LY314228 is an aminoguanidine 5-HT2 antagonist with relative selectivity for 5-HT2A receptors (IC50: 147.9 nM). The Ki values ??of LY314228 targeting different 5-HT subtypes are 65 nM (5-HT 2A), 1214 nM (5-HT 2B), and 168 nM (5-HT 2C), respectively. LY314228 is an effective inhibitor of 5-HT-induced paw edema in rats with an ED50 of 6.4 mg/kg in ovariectomized female rats. .

HY-147719

COX-2-IN-16	COX	Inflammation/Immunology
COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC₅₀ of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity .

HY-14840A

(R)-Phenylpiracetam MRZ 9547	Dopamine Transporter	Neurological Disease Inflammation/Immunology
(R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (K_i: 14.8 μM; IC₅₀: 65.5 μM). (R)-Phenylpiracetam can be used for the research of the neurological or neuropsychiatric disorders .

HY-N8160

Dehydrocurdione	Keap1-Nrf2 Reactive Oxygen Species	Inflammation/Immunology
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .

HY-P99110

Lanadelumab SHP643; DX-2930	Kallikrein	Inflammation/Immunology
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an K_i value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema .

HY-P1441A

Mambalgin 1 TFA	Sodium Channel	Neurological Disease
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

HY-129143

Delphinidin-3-sambubioside chloride Dp3‐Sam chloride	Others	Metabolic Disease Inflammation/Immunology
Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L. .

HY-W109812

Sinapyl alcohol 1 Publications Verification	COX	Inflammation/Immunology
Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and COX-2 .

HY-W109812S

Sinapyl alcohol-d3	Isotope-Labeled Compounds COX	Inflammation/Immunology
Sinapyl alcohol-d₃ is the deuterated labeled Sinapyl alcohol (HY-W109812). Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and COX-2 .

HY-129143R

Delphinidin-3-sambubioside chloride (Standard)	Others	Metabolic Disease Inflammation/Immunology
Delphinidin-3-sambubioside (chloride) (Standard) is the analytical standard of Delphinidin-3-sambubioside (chloride). This product is intended for research and analytical applications. Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L. .

HY-N7015

Zerumbone 1 Publications Verification	EBV Caspase Apoptosis Bacterial	Infection
Zerumbone is an orally active natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet. Zerumbone has anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity .

HY-N7015R

Zerumbone (Standard)	EBV Caspase Apoptosis Bacterial	Infection
Zerumbone (Standard) is the analytical standard of Zerumbone. This product is intended for research and analytical applications. Zerumbone is an orally active natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet. Zerumbone has anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity .

HY-130605

BAY-1797 2 Publications Verification	P2X Receptor	Neurological Disease
BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC₅₀ of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects .

HY-149270

COX-2-IN-31	COX	Inflammation/Immunology
COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC₅₀=60 nM) and 5-LOX (IC₅₀=1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX(K_i=48.9 nM) and hCA XII(K_i=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity .

HY-15616

BMS-470539	Melanocortin Receptor	Cancer
BMS-470539 is a synthetic MC-1R agonist with potent anti-inflammatory properties. BMS-470539 selectively activates human and murine MC-1R with EC50 values ??of 16.8 nM and 11.6 nM, respectively. In vitro studies have shown that BMS-470539 is able to dose-dependently inhibit TNF-alpha-induced NF-kB activation in human melanoma cells expressing MC-1R. In vivo, subcutaneous injection of BMS-470539 into BALB/c mice effectively inhibited LPS-induced TNF-alpha production with an ED50 of approximately 10 μmol/kg and a pharmacodynamic half-life of approximately 8 hours. It also significantly reduced leukocyte infiltration in a lung inflammation model and attenuated paw swelling in a delayed-type hypersensitivity model, highlighting its efficacy as an anti-inflammatory agent through MC-1R modulation .

Cat. No.	Product Name	Target	Research Area

HY-P5581

Alloferon 1	Peptides	Infection Inflammation/Immunology Cancer
Alloferon 1 is an antiviral and antitumoral peptide. Alloferon 1 stimulates natural cytotoxicity of human peripheral blood lymphocytes. Alloferon 1 also induces IFN synthesis, and enhances antiviral and antitumor resistance in mice. Alloferon 1 also shows anti-inflammatory activity in λ-carrageenan-induced paw edema model. Alloferon 1 can be isolated from the blood of the blow fly Calliphora vicina (Diptera) .