Pentadecanoic acid

Name: Pentadecanoic acid
Brand: MedChemExpress
SKU: HY-W004283
Rating: 4.5 (1 reviews)

Cat. No.: HY-W004283 Purity: ≥98.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.

For research use only. We do not sell to patients.

Pentadecanoic acid Chemical Structure

CAS No. : 1002-84-2

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pentadecanoic acid:

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

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JAK1 JAK2 JAK3 Tyk2 JAK

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STAT3 STAT5 STAT6 STAT1

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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JNK1 JNK2 JNK3 JNK

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ERK ERK1 ERK2 ERK5 ERK8

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

Biological Activity
Purity & Documentation
References
Customer Review

Description

Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Pentadecanoic acid (50-200 μM, 48 hours) induces apoptosis in MCF-7/SC breast cancer stem-like cells by inhibiting the JAK2/STAT3 signaling pathway and suppresses their proliferation and migration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MCF-7/SC breast cancer stem-like cells
Concentration:	50, 100, 150, 200 μM
Incubation Time:	48 hours
Result:	Significantly reduced MCF-7/SC cell viability, showing time- and dose-dependent cytotoxic effects.

Cell Invasion Assay^[1]

Cell Line:	MCF-7/SC breast cancer stem-like cells
Concentration:	100 μM
Incubation Time:	48 hours
Result:	Significantly reduced the ability of MCF-7/SC cells to penetrate Matrigel, with a markedly lower number of invasive cells compared to the control group.

Cell Cycle Analysis^[1]

Cell Line:	MCF-7/SC breast cancer stem-like cells
Concentration:	50, 100, 150, 200 μM
Incubation Time:	48 hours
Result:	Led to a significant accumulation of MCF-7/SC cells in the Sub-G1 phase and reduced the proportion of S-phase and G2/M-phase cells, suggesting cell cycle arrest.

In Vivo

Pentadecanoic acid (1% w/w, dietary intake, from gestation to the end of lactation) induces mild glucose intolerance during pregnancy in C57BL6/J mice, partly mediated through activation of PPARα and MAPK signaling pathways, and promoted offspring growth and enhanced antioxidant capacity during lactation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	1% Pentadecanoic acid (PA) diet-induced gestational glucose intolerance C57BL6/J mouse model^[2]
Dosage:	1% (Pentadecanoic acid ethyl ester was incorporated into a low-fat diet (LFD) by replacing 10 g/kg soybean oil, achieving a final concentration of 1% (w/w), with a total feed composition of 1000 g/kg as an example)
Administration:	Dietary intake, from gestation to the end of lactation
Result:	Increased PA and heptadecanoic acid (C17:0) levels in maternal and fetal tissues; Induced mild insulin resistance during pregnancy and activated PPARα and MAPK signaling pathways; Increased maternal oxidative stress but reduced maternal fat deposition and promoted offspring growth during lactation; Reduced plasma and liver triglyceride (TG) levels in offspring and enhanced antioxidant capacity.

Clinical Trial

Molecular Weight

242.40

Formula

C₁₅H₃₀O₂

CAS No.

1002-84-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCCCCCCCCCCC)O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (257.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1254 mL	20.6271 mL	41.2541 mL
5 mM	0.8251 mL	4.1254 mL	8.2508 mL
10 mM	0.4125 mL	2.0627 mL	4.1254 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (8.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (8.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (238 KB) HNMR (170 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. To N B, et al. Pentadecanoic acid, an odd-chain fatty acid, suppresses the stemness of MCF-7/SC human breast cancer stem-like cells through JAK2/STAT3 signaling[J]. Nutrients, 2020, 12(6): 1663. [Content Brief]

[2]. Wang J, et al. Pentadecanoic acid (C15: 0, PA) induces mild maternal glucose intolerance and promotes the growth of the offspring partly through up-regulating liver PPARα and MAPK signaling pathways[J]. Food & Function, 2024, 15(23): 11400-11414. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1254 mL	20.6271 mL	41.2541 mL	103.1353 mL
	5 mM	0.8251 mL	4.1254 mL	8.2508 mL	20.6271 mL
	10 mM	0.4125 mL	2.0627 mL	4.1254 mL	10.3135 mL
	15 mM	0.2750 mL	1.3751 mL	2.7503 mL	6.8757 mL
	20 mM	0.2063 mL	1.0314 mL	2.0627 mL	5.1568 mL
	25 mM	0.1650 mL	0.8251 mL	1.6502 mL	4.1254 mL
	30 mM	0.1375 mL	0.6876 mL	1.3751 mL	3.4378 mL
	40 mM	0.1031 mL	0.5157 mL	1.0314 mL	2.5784 mL
	50 mM	0.0825 mL	0.4125 mL	0.8251 mL	2.0627 mL
	60 mM	0.0688 mL	0.3438 mL	0.6876 mL	1.7189 mL
	80 mM	0.0516 mL	0.2578 mL	0.5157 mL	1.2892 mL
	100 mM	0.0413 mL	0.2063 mL	0.4125 mL	1.0314 mL