Akt

PKB; Protein kinase B

Akt

Akt Isoform Specific Products:

Akt Isoform Comparison

Akt Related Products (640)
Recombinant Proteins (6)
Antibodies (11)
Akt Isoform Comparison

By Effects:	Control (1) Inhibitors (448) Agonist (1) Degraders (3) Activators (114) Modulators (13) Inducers (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-171558

PI3K-IN-56	Inhibitor
PI3K-IN-56 (Compound 1) is an orally active, potent and selective irreversible inhibitor of phosphoinositide 3-kinase (PI3K). PI3K-IN-56 irreversibly blocks the phosphatidylinositol-3,4,5-triphosphate (PIP3) production and downstream AKT signaling pathway. PI3K-IN-56 is promising for research of PI3Kα-driven cancers, such as breast and ovarian cancers.

HY-161891

EGFR/Akt-IN-1	Inhibitor
EGFR/Akt-IN-1 (compound 17) is a potent inhibitor of EGFR/Akt, with the IC₅₀s of 12.89 μM and 10.88 μM in A549 cells, respectively. EGFR/Akt-IN-1 arrestes the cell cycle at the S phase.

HY-N0591R

Dehydrocostus Lactone (Standard)	Inhibitor
Dehydrocostus Lactone (Standard) ((-)-Dehydrocostus lactone (Standard)) is the analytical standard of Dehydrocostus Lactone (HY-N0591). This product is intended for research and analytical applications. Dehydrocostus Lactone is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells.

HY-108052R

Delphinidin 3-glucoside (chloride) (Standard)	Inhibitor
Delphinidin 3-glucoside (chloride) (Standard) is the analytical standard of Delphinidin 3-glucoside (chloride). This product is intended for research and analytical applications. Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL). Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM. Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 µM. Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction.

HY-N0361R

Dihydrocapsaicin (Standard)	Modulator
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat.

HY-P0141

Akt/SKG Substrate Peptide
Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1.

HY-14575

Nastorazepide hemicalcium	Inhibitor
Nastorazepide (Z-360) hemicalcium is an orally active 1,5-benzodiazepine derivative and gastrin/CCK-2 receptor antagonist. Nastorazepide hemicalcium inhibits the specific binding of [³H]CCK-8 to the human CCK-2 receptor with a K_i value of 0.47 nM. Nastorazepide hemicalcium inhibits IL-1β, ephrin B1, VEGF, and HIF-1alpha, reduces Akt and NR2B phosphorylation. Nastorazepide hemicalcium has antitumor activity against pancreatic cancer. Nastorazepide hemicalcium inhibits colorectal cancer liver metastasis and relieves pain.

HY-149989

Ack1 inhibitor 1	Inhibitor
Ack1 inhibitor 1 is a potent, selective, and orally active inhibitor of ACK1 kinase with an IC₅₀ value of 2.1 nM. Ack1 inhibitor 1 inhibits the phosphorylation of ACK1 and activation of downstream AKT. Ack1 inhibitor 1 has anti-tumor activity.

HY-N1904

4′-Hydroxywogonin	Inhibitor
4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis.

HY-N0392R

Polygalasaponin F (Standard)	Inhibitor
Polygalasaponin F (Standard) is the analytical standard of Polygalasaponin F. This product is intended for research and analytical applications. Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the TLR4-PI3K/AKT-NF-kB signaling pathway .

HY-144396

SHP2-IN-8	Inhibitor
SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC₅₀ value of 23 nM and K_i of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 ℃. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells.

HY-146216

MMP-9-IN-3	Inhibitor
MMP-9-IN-3 is a MMP-9 inhibitor (IC₅₀: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC₅₀: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers.

HY-162285

Anticancer agent 189	Inhibitor
Anticancer agent 189 (compound 4) is an anticancer agent that antagonizes CRC effects by targeting AKT1.

HY-172259

Toyaburgine	Inhibitor
Toyaburgine is a unique isoquinoline compound that exhibits anti-tumor activity. It packs a punch by disrupting the PI3K/AKT/mTOR signaling pathway, causing significant morphological changes and cell death in MIA PaCa-2 cells. On top of that, it puts the brakes on cell migration and colony formation. This compound is showing a lot of promise in the realm of pancreatic cancer research.

HY-W009141R

1-Monopalmitin (Standard)	Activator
1-Monopalmitin (Glyceryl palmitate) (Standard) is the analytical standard of 1-Monopalmitin (HY-W009141). This product is intended for research and analytical applications. 1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells.

HY-161144

AKT-IN-21	Inhibitor
AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway.

HY-N0047R

Polyphyllin I (Standard)	Inhibitor
Polyphyllin I (Standard) is the analytical standard of Polyphyllin I. This product is intended for research and analytical applications. Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis.

HY-P10320

T3 Peptide	Activator
T3 Peptide is an active fragment of tumstatin. T3 Peptide binds integrin α_vβ₃/α_vβ₅, activates the PI3K/Akt/p70S6K signaling pathway, and thus stimulates the proliferation and migration of rat cardiac fibroblasts.

HY-133804

Arteanoflavone	Inhibitor
Arteanoflavone, a natural compound that can be isolated from A. iwayomogi, possess inhibitory activities on AGEs formation.

HY-163577

Akt1-IN-5	Inhibitor
Akt1-IN-5 (Compound 115) is an Akt1 inhibitor (IC₅₀: <15 nM)

MK-2206 dihydrochloride			Akt2, IC₅₀: 12 nM	Akt3, IC₅₀: 65 nM	99.99%
Capivasertib			Akt2, IC₅₀: 7 nM	Akt3, IC₅₀: 7 nM	99.95%
Ipatasertib			Akt2, IC₅₀: 18 nM	Akt3, IC₅₀: 8 nM	99.88%
Oridonin			Akt2, IC₅₀: 8.9 μM		99.89%
AKT inhibitor VIII			Akt2, IC₅₀: 210 nM	Akt3, IC₅₀: 2119 nM	98.97%
GSK-690693			Akt2, IC₅₀: 13 nM	Akt3, IC₅₀: 9 nM	99.03%
Miransertib			Akt2, IC₅₀: 14 nM	Akt3, IC₅₀: 8.1 nM	99.32%
Afuresertib			Akt2, Ki: 2 nM	Akt3, Ki: 2.6 nM	99.53%
Uprosertib			Akt2, IC₅₀: 328 nM	Akt3, IC₅₀: 38 nM	99.93%
Thymoquinone	Akt				99.80%
Rizavasertib			Akt2, Ki: 160 pM	Akt3, Ki: 160 pM	99.71%
Triciribine	Akt, IC₅₀: 130 nM (cell assay)				99.81%
BAY1125976			Akt2, IC₅₀: 18 nM (at 10 μM ATP)	Akt3, IC₅₀: 427 nM (at 10 μM ATP)	99.52%
LM22B-10	Akt				99.92%
Ipatasertib dihydrochloride			Akt2, IC₅₀: 18 nM	Akt3, IC₅₀: 8 nM	99.27%
Engasertib			Akt2, IC₅₀: 0.09 μM	Akt3, IC₅₀: 2.75 μM	99.65%
AT13148			Akt2, IC₅₀: 402 nM	Akt3, IC₅₀: 50 nM	99.21%
AT7867			Akt2, IC₅₀: 17 nM	Akt3, IC₅₀: 47 nM	99.88%
INY-03-041			Akt2, IC₅₀: 6.8 nM	Akt3, IC₅₀: 3.5 nM	99.74%
CCT128930			Akt2, IC₅₀: 6 nM		99.69%
H-Ile-Lys-Val-Ala-Val-OH	Akt				99.42%
Vevorisertib trihydrochloride			Akt2, IC₅₀: 0.81 nM	Akt3, IC₅₀: 1.31 nM	99.13%
Pifusertib hydrochloride			Akt2, IC₅₀: 1.6 nM	Akt3, IC₅₀: 44 nM
Serplulimab		Akt1	Akt2	Akt3	99.30%
MK-2206		Akt1, IC₅₀: 8 nM	Akt2, IC₅₀: 12 nM	Akt3, IC₅₀: 65 nM	99.39%
M2698				Akt3, IC₅₀: 1 nM	99.87%
Afuresertib hydrochloride			Akt2, Ki: 2 nM	Akt3, Ki: 2.6 nM	99.95%
MS170			Akt2, Kd: 77 nM	Akt3, Kd: 6.5 nM	99.72%
AT7867 dihydrochloride			Akt2, IC₅₀: 17 nM	Akt3, IC₅₀: 47 nM	99.75%
4-Methylbenzylidene camphor	Akt				99.87%
Akt1/Akt2-IN-1			Akt2, IC₅₀: 42 nM		99.30%
AT-533	Akt				98.86%
AKT-IN-6			Akt2	Akt3	99.08%
Miransertib hydrochloride			Akt2, IC₅₀: 174 nM	Akt3, IC₅₀: 8.1 nM	99.74%
3CAI			Akt2		98.32%
Deltonin	Akt				99.94%
CCT128930 hydrochloride			Akt2, IC₅₀: 6 nM		98.97%
INY-03-041 trihydrochloride		Akt1, IC₅₀: 2.0 nM	Akt2, IC₅₀: 6.8 nM	Akt3, IC₅₀: 3.5 nM	99.27%
Isoprocurcumenol	Akt
Hu7691			Akt2, IC₅₀: 97.5 nM	Akt3, IC₅₀: 28 nM	99.91%
AKT-IN-3			Akt2, IC₅₀: 1.2 nM	Akt3, IC₅₀: 1.7 nM	99.29%
PTP1B-IN-24	Akt, IC₅₀: 1.4 μM
Akt1/Akt2-IN-2		Akt1, IC₅₀: 138 nM	Akt2, IC₅₀: 212 nM	Akt3, IC₅₀: 7.2 mM	98.57%
MS15			Akt2, IC₅₀: 90 ± 2.8 nM	Akt3, IC₅₀: 544 ± 2.9 nM
Vevorisertib			Akt2, IC₅₀: 0.81 nM	Akt3, IC₅₀: 1.31 nM	98.03%
Pifusertib			Akt2, IC₅₀: 1.6 nM	Akt3, IC₅₀: 44 nM
Coelonin	Akt				≥98.0%
Akt1&PKA-IN-1	Akt, IC₅₀: 0.11 μM
Akt1&PKA-IN-2		Akt1, IC₅₀: 0.007 μM
Hu7691 free base			Akt2, IC₅₀: 97.5 nM	Akt3, IC₅₀: 28 nM
MS98			Akt2, : 140 nM	Akt3, : 8.1 nM
MK-2206 free base			Akt2, IC₅₀: 12 nM	Akt3, IC₅₀: 65 nM
AKT-IN-5			Akt2, IC₅₀: 400 nM
TRPM7-IN-1	Akt
Gamendazole		Akt1			99.44%
AKT-IN-8			Akt2, IC₅₀: 2.44 nM	Akt3, IC₅₀: 9.47 nM
PD-1/PD-L1-IN-54	Akt
AKT-IN-13			Akt2, IC₅₀: 2.4 nM	Akt3, IC₅₀: 0.3 nM
Eudebeiolide B	Akt
Tanshinol borneol ester	Akt
Akt1-IN-5		Akt1, IC₅₀: <15 nM
Ipatasertib tosylate		Akt1, IC₅₀: 5 nM	Akt2, IC₅₀: 18 nM	Akt3, IC₅₀: 8 nM
AKT1-IN-9		AKT1(E17K)
Akt1-IN-8		Akt1, IC₅₀: 8.8 nM
Akt1-IN-6		Akt1, IC₅₀: <15 nM
Akt1-IN-7		Akt1, IC₅₀: <15 nM
Akt1-IN-4		Akt1
AKT-IN-18	Akt, IC₅₀: 69.45 μM
Uprosertib hydrochloride			Akt2, IC₅₀: 328 nM	Akt3, IC₅₀: 38 nM
Akt1-IN-2		Akt1, IC₅₀: 4.6 μM	Akt2, IC₅₀: >250 μM	Akt3, IC₅₀: >250 μM

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Akt

Akt

Akt Isoform Specific Products:

Akt Isoform Specific Products:

Akt Related Products (640)

Recombinant Proteins (6)

Antibodies (11)

Akt Isoform Comparison

Akt Related Products (640):