Akt

PKB; Protein kinase B

Akt

Akt Isoform Specific Products:

Akt Isoform Comparison

Akt Related Products (591)
Recombinant Proteins (6)
Antibodies (11)
Akt Isoform Comparison

By Effects:	Control (1) Inhibitors (411) Agonist (1) Degraders (3) Activators (101) Modulators (13) Inducers (7)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P10605

GSK3β-peptide
GSK3β-peptide is a substrate mimetic peptide of glycogen synthase kinase 3-β (GSK3-β) that can bind to the active site of GSK3-β and mimic the behavior of a real substrate. GSK3β-peptide can be used to develop substrate mimetic inhibitors of Akt as potential anticancer drugs.

HY-N3612

Communic acid	Inhibitor
Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging.

HY-169407

AKT-IN-24	Inhibitor
KT-IN-24 (Compound M17) is a AKT allosteric inhibitor with anti-tumor activity. KT-IN-24 can target the AKT/mTOR and MEK/ERK signaling pathways and inhibit epithelial-mesenchymal transition, which has a synergistic suppressive effect on TNBC, promoting cell apoptosis while inhibiting proliferation and migration when used in combination with Trametinib (HY-10999).

HY-168893

K882	Inhibitor
K882 (Compound 4e) is a Src inhibitor, with K_D of 0.315 μM. K882 induces Apoptosis. K882 inhibits XIAP and Survivin. K882 inhibits the activation of PI3K/Akt/mTOR, Jak1/Stat3, Ras/MAPK signaling pathways. K882 shows anti-tumor activity against non-small cell lung cancer.

HY-169413

AKT-IN-25	Inhibitor
AKT-IN-25 (Compound 14a) is an inhibitor for Akt, that inhibits the phosphorylation of Akt, and thereby inhibits the PI3K/Akt/mTOR signaling pathway. AKT-IN-25 arrests the cell cycle at G1 phase, inhibits the cell migration of PANC-1, and inhibits the proliferation of cancer cells PANC-1, PATU-T, and SUIT-2 with IC₅₀s of 3.05, 1.32, and 3.85 μM, respectively.

HY-P4790

Acetyl-Exenatide	Inhibitor
Acetyl-Exenatideyes is an acetylated derivative of Exenatide. Exenatide has the function similar to insulin, which can be used for research of type 2 diabetes. Exenatide can promote Th17 differentiation, inhibits Tregs differentiation, downregulates PI3K/Akt/FoxO1 phosphorylation.

HY-159577

Nic-15	Modulator
Nic-15 (compound 4n) is an anti-constrictive agent used to antagonize the hypovascularity of pancreatic tumors. The hypovascularity allows cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop drug resistance. Nic-15 can regulate the PI3K/Akt/mTOR pathway and alleviate ER stress induced by Gemcitabine (HY-17026). Nic-15 can significantly inhibit the migration and colony formation of MIA PaCa-2 and PANC-1 pancreatic cancer cells. The combination of Nic-15 and Gemcitabine can effectively solve the problem of pancreatic tumor resistance. In an in vivo xenograft model, Nic-15 can significantly enhance the efficacy of Gemcitabine.

HY-161861

VEGFR-2/AKT-IN-1	Inhibitor
VEGFR-2/AKT-IN-1 (compound 17) is a dual inhibitor of VEGFR-2 and AKT, with the IC₅₀s of 0.164 μM and 0.452 μM, respectively. VEGFR-2/AKT-IN-1 has antitumor activity.

HY-100702

SH-5	Inhibitor
SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke.

HY-P0141A

Akt/SKG Substrate Peptide TFA
Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1.

HY-16461

Solenopsin	Inhibitor
Solenopsin ((-)-Solenopsin A) is an ATP-competitive AKT inhibitor with IC₅₀ value of 10 μM.

HY-RS00549

AKT3 Human Pre-designed siRNA Set A	Inhibitor
AKT3 Human Pre-designed siRNA Set A contains three designed siRNAs for AKT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AKT3 Human Pre-designed siRNA Set A AKT3 Human Pre-designed siRNA Set A

HY-143883

MS143
MS143 is a potent PROTAC AKT degrader (DC₅₀=46 nM and GI₅₀=0.8 μM in PC3 cells). MS143 induces rapid and robust AKT degradation in a concentration- and time-dependent manner via hijacking the ubiquitin-proteasome system. MS143 can suppress cancer cell growth (Pink: AKT ligand (HY-15431); Blue: E3 ligase ligand (HY-125845); Black: linker).

HY-N0716AR

Berberine (hemisulfate) (Standard)	Activator
Berberine (hemisulfate) (Standard) is the analytical standard of Berberine (hemisulfate). This product is intended for research and analytical applications. Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity.

HY-147913

PI3K/Akt/mTOR-IN-3	Inhibitor
PI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC₅₀ values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest.

HY-172201

NF-κB-IN-19	Inhibitor
NF-κB-IN-19 (Compound 8) is an NF-κB inhibitor. NF-κB-IN-19 effectively induces DNA damage, promotes the generation of ROS, and induces autophagy and apoptosis through the NF-κB signaling pathway in tumor cells. In addition, NF-κB-IN-19 can inhibit the levels of VEGF and HIF-1α, and exert antiproliferative activity in tumor cells through the PI3K/AKT and STAT-3 pathways. NF-κB-IN-19 can effectively overcome cisplatin resistance and has anti-tumor activity.

HY-173155

AKT1-IN-9	Inhibitor
AKT1-IN-9 (4) is a selective mutant AKT1(E17K) inhibitor, with EC₅₀ values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively.

HY-N2393R

Kukoamine B (Standard)	Inhibitor
Kukoamine B (Standard) is the analytical standard of Kukoamine B. This product is intended for research and analytical applications. Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with K_d values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis.

HY-115385R

Lumichrome (Standard)	Inhibitor
Lumichrome (Standard) is the analytical standard of Lumichrome. This product is intended for research and analytical applications. Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway.

HY-164400

SIJ1777	Inhibitor
SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations.

MK-2206 dihydrochloride			Akt2, IC₅₀: 12 nM	Akt3, IC₅₀: 65 nM	99.99%
Capivasertib			Akt2, IC₅₀: 7 nM	Akt3, IC₅₀: 7 nM	99.95%
Ipatasertib			Akt2, IC₅₀: 18 nM	Akt3, IC₅₀: 8 nM	99.88%
Oridonin			Akt2, IC₅₀: 8.9 μM		99.89%
AKT inhibitor VIII			Akt2, IC₅₀: 210 nM	Akt3, IC₅₀: 2119 nM	98.97%
GSK-690693			Akt2, IC₅₀: 13 nM	Akt3, IC₅₀: 9 nM	99.03%
Miransertib			Akt2, IC₅₀: 14 nM	Akt3, IC₅₀: 8.1 nM	99.32%
Afuresertib			Akt2, Ki: 2 nM	Akt3, Ki: 2.6 nM	99.53%
Uprosertib			Akt2, IC₅₀: 328 nM	Akt3, IC₅₀: 38 nM	99.93%
Thymoquinone	Akt				99.59%
Rizavasertib			Akt2, Ki: 160 pM	Akt3, Ki: 160 pM	99.71%
Triciribine	Akt, IC₅₀: 130 nM (cell assay)				99.81%
BAY1125976			Akt2, IC₅₀: 18 nM (at 10 μM ATP)	Akt3, IC₅₀: 427 nM (at 10 μM ATP)	99.52%
LM22B-10	Akt				99.92%
Ipatasertib dihydrochloride			Akt2, IC₅₀: 18 nM	Akt3, IC₅₀: 8 nM	99.27%
AT13148			Akt2, IC₅₀: 402 nM	Akt3, IC₅₀: 50 nM	99.21%
Engasertib			Akt2, IC₅₀: 0.09 μM	Akt3, IC₅₀: 2.75 μM	99.65%
AT7867			Akt2, IC₅₀: 17 nM	Akt3, IC₅₀: 47 nM	99.88%
INY-03-041			Akt2, IC₅₀: 6.8 nM	Akt3, IC₅₀: 3.5 nM	99.74%
CCT128930			Akt2, IC₅₀: 6 nM		99.69%
H-Ile-Lys-Val-Ala-Val-OH	Akt				99.42%
Vevorisertib trihydrochloride			Akt2, IC₅₀: 0.81 nM	Akt3, IC₅₀: 1.31 nM	99.13%
Pifusertib hydrochloride			Akt2, IC₅₀: 1.6 nM	Akt3, IC₅₀: 44 nM
M2698				Akt3, IC₅₀: 1 nM	99.87%
Afuresertib hydrochloride			Akt2, Ki: 2 nM	Akt3, Ki: 2.6 nM	99.95%
MS170			Akt2, Kd: 77 nM	Akt3, Kd: 6.5 nM	99.72%
MK-2206		Akt1, IC₅₀: 8 nM	Akt2, IC₅₀: 12 nM	Akt3, IC₅₀: 65 nM	99.39%
AT7867 dihydrochloride			Akt2, IC₅₀: 17 nM	Akt3, IC₅₀: 47 nM	99.75%
4-Methylbenzylidene camphor	Akt				99.87%
Akt1/Akt2-IN-1			Akt2, IC₅₀: 42 nM		99.30%
AKT-IN-6			Akt2	Akt3	99.08%
AT-533	Akt				98.86%
Miransertib hydrochloride			Akt2, IC₅₀: 174 nM	Akt3, IC₅₀: 8.1 nM	99.74%
3CAI			Akt2		98.32%
Deltonin	Akt				99.94%
INY-03-041 trihydrochloride		Akt1, IC₅₀: 2.0 nM	Akt2, IC₅₀: 6.8 nM	Akt3, IC₅₀: 3.5 nM	99.27%
Isoprocurcumenol	Akt
CCT128930 hydrochloride			Akt2, IC₅₀: 6 nM		98.97%
AKT-IN-3			Akt2, IC₅₀: 1.2 nM	Akt3, IC₅₀: 1.7 nM	99.29%
Akt1/Akt2-IN-2		Akt1, IC₅₀: 138 nM	Akt2, IC₅₀: 212 nM	Akt3, IC₅₀: 7.2 mM	98.57%
PTP1B-IN-24	Akt, IC₅₀: 1.4 μM
Hu7691			Akt2, IC₅₀: 97.5 nM	Akt3, IC₅₀: 28 nM	99.91%
MS15			Akt2, IC₅₀: 90 ± 2.8 nM	Akt3, IC₅₀: 544 ± 2.9 nM
Vevorisertib			Akt2, IC₅₀: 0.81 nM	Akt3, IC₅₀: 1.31 nM	98.03%
Pifusertib			Akt2, IC₅₀: 1.6 nM	Akt3, IC₅₀: 44 nM
Coelonin	Akt
Akt1&PKA-IN-1	Akt, IC₅₀: 0.11 μM
Akt1&PKA-IN-2		Akt1, IC₅₀: 0.007 μM
Hu7691 free base			Akt2, IC₅₀: 97.5 nM	Akt3, IC₅₀: 28 nM
MS98			Akt2, : 140 nM	Akt3, : 8.1 nM
MK-2206 free base			Akt2, IC₅₀: 12 nM	Akt3, IC₅₀: 65 nM
AKT-IN-5			Akt2, IC₅₀: 400 nM
TRPM7-IN-1	Akt
Gamendazole		Akt1
AKT-IN-8			Akt2, IC₅₀: 2.44 nM	Akt3, IC₅₀: 9.47 nM
PD-1/PD-L1-IN-54	Akt
AKT-IN-13			Akt2, IC₅₀: 2.4 nM	Akt3, IC₅₀: 0.3 nM
Eudebeiolide B	Akt
Tanshinol borneol ester	Akt
Akt1-IN-5		Akt1, IC₅₀: <15 nM
Ipatasertib tosylate		Akt1, IC₅₀: 5 nM	Akt2, IC₅₀: 18 nM	Akt3, IC₅₀: 8 nM
AKT1-IN-9		AKT1(E17K)
Akt1-IN-8		Akt1, IC₅₀: 8.8 nM
Akt1-IN-6		Akt1, IC₅₀: <15 nM
Akt1-IN-7		Akt1, IC₅₀: <15 nM
Akt1-IN-4		Akt1
AKT-IN-18	Akt, IC₅₀: 69.45 μM
Uprosertib hydrochloride			Akt2, IC₅₀: 328 nM	Akt3, IC₅₀: 38 nM
Akt1-IN-2		Akt1, IC₅₀: 4.6 μM	Akt2, IC₅₀: >250 μM	Akt3, IC₅₀: >250 μM

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Akt

Akt

Akt Isoform Specific Products:

Akt Isoform Specific Products:

Akt Related Products (591)

Recombinant Proteins (6)

Antibodies (11)

Akt Isoform Comparison

Akt Related Products (591):