Akt

PKB; Protein kinase B

Akt

Akt Isoform Specific Products:

Akt Isoform Comparison

Akt Related Products (559)
Recombinant Proteins (6)
Antibodies (11)
Akt Isoform Comparison

By Effects:	Control (1) Inhibitors (385) Agonist (1) Degraders (3) Activators (97) Modulators (12) Inducers (7)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W008947

SEW2871	Activator	99.53%
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC₅₀ of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.

HY-15449

Kaempferide	Activator	99.80%
Kaempferide is an orally active flavonol isolated from Hippophae rhamnoides L. Kaempferide has anticancer, anti-inflammatory, antioxidant, antidiabetic, antiobesity, antihypertensive, and neuroprotective activities. Kaempferide induces apoptosis. Kaempferide promotes osteogenesis through antioxidants and can be used in osteoporosis research.

HY-155747

FDW028	Inhibitor	99.51%
FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research.

HY-N0281

Daphnetin	Inhibitor	99.86%
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.

HY-N0371

Pachymic acid	Inhibitor	99.94%
Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibits Akt and ERK signaling pathways.

HY-15985

CTX-0294885	Inhibitor	99.43%
CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer.

HY-104047

LM22B-10	Activator	99.92%
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.

HY-D0885

Phosphocreatine	Activator
Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway..

HY-N7264

7α-Hydroxycholesterol		99.99%
7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. 7α-Hydroxycholesterol has cytotoxic and pro-inflammatory activities. 7α-Hydroxycholesterol can also inhibit sterol synthesis and reduce the activity of HMG-CoA reductase. 7α-Hydroxycholesterol can be used in the research of diseases such as diabetes and atherosclerosis.

HY-A0183

Phosphatidylserine		≥98.0%
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses.

HY-13254

A-674563	Inhibitor	99.87%
A-674563 is an orally active Akt1 inhibitor with a K_i of 11 nM.

HY-13065

Isobavachalcone	Inhibitor	99.01%
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC₅₀ value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity.

HY-15186A

Ipatasertib dihydrochloride	Inhibitor	99.27%
Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively.

HY-101017

Palmitoylcarnitine chloride	Inhibitor	≥98.0%
Palmitoylcarnitine chloride is a fatty acid-derived mitochondrial substrate, and selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca²⁺ influx, and DHT-like effects.

HY-101985

BV02	Activator	99.75%
BV02 is a 14-3-3 inhibitor and an antibacterial agent. BV02 enhances the cleavage of PARP and caspase-3. BV02 induces Apoptosis, Autophagy, and enhances Akt activation. BV02 has anti-B. melitensis infection and epilepsy-promoting effects. BV02 can also be used in colitis research.

HY-124284

Hexamethylene bisacetamide	Inhibitor	99.56%
Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice.

HY-N0448

10-Gingerol	Inhibitor	99.66%
10-Gingerol is an AMPK agonist, which is found in the ginger oleoresin from fresh rhizome with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. 10-Gingerol exhibits substantial scavenging activities with an IC₅₀ value of 10.47 μM against DPPH radical, an IC₅₀ value of 1.68 μM against superoxide radical and an IC₅₀ value of 1.35 μM against hydroxyl radical. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC₅₀ of 12.1 μM. 10-Gingerol suppresses the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. 10-Gingerol is promising for research of ulcerative colitis.

HY-108719

Insulin glargine	Activator
Insulin glargine is a long-acting insulin analog. Insulin glargine has the effect of lowering blood sugar and can be used in the research of diabetes. In addition, high doses of Insulin glargine can promote the proliferation of bladder cancer cells.

HY-N0103

Sophocarpine	Inhibitor	98.63%
Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer.

HY-16071

AT13148	Inhibitor	99.21%
AT13148 is an orally active and ATP-competitive, multi-AGC kinase inhibitor with IC₅₀s of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.

MK-2206 dihydrochloride			Akt2, IC₅₀: 12 nM	Akt3, IC₅₀: 65 nM	99.99%
Capivasertib			Akt2, IC₅₀: 7 nM	Akt3, IC₅₀: 7 nM	99.95%
Ipatasertib			Akt2, IC₅₀: 18 nM	Akt3, IC₅₀: 8 nM	99.88%
Oridonin			Akt2, IC₅₀: 8.9 μM		99.89%
AKT inhibitor VIII			Akt2, IC₅₀: 210 nM	Akt3, IC₅₀: 2119 nM	98.97%
GSK-690693			Akt2, IC₅₀: 13 nM	Akt3, IC₅₀: 9 nM	99.03%
Miransertib			Akt2, IC₅₀: 14 nM	Akt3, IC₅₀: 8.1 nM	99.32%
Afuresertib			Akt2, Ki: 2 nM	Akt3, Ki: 2.6 nM	99.53%
Uprosertib			Akt2, IC₅₀: 328 nM	Akt3, IC₅₀: 38 nM	99.74%
Thymoquinone	Akt				99.59%
Rizavasertib			Akt2, Ki: 160 pM	Akt3, Ki: 160 pM	99.71%
Triciribine	Akt, IC₅₀: 130 nM (cell assay)				99.81%
BAY1125976			Akt2, IC₅₀: 18 nM (at 10 μM ATP)	Akt3, IC₅₀: 427 nM (at 10 μM ATP)	99.52%
LM22B-10	Akt				99.92%
Ipatasertib dihydrochloride			Akt2, IC₅₀: 18 nM	Akt3, IC₅₀: 8 nM	99.27%
AT13148			Akt2, IC₅₀: 402 nM	Akt3, IC₅₀: 50 nM	99.21%
AT7867			Akt2, IC₅₀: 17 nM	Akt3, IC₅₀: 47 nM	99.88%
Engasertib			Akt2, IC₅₀: 0.09 μM	Akt3, IC₅₀: 2.75 μM	99.65%
INY-03-041			Akt2, IC₅₀: 6.8 nM	Akt3, IC₅₀: 3.5 nM	99.74%
H-Ile-Lys-Val-Ala-Val-OH	Akt				99.42%
CCT128930			Akt2, IC₅₀: 6 nM		99.69%
Vevorisertib trihydrochloride			Akt2, IC₅₀: 0.81 nM	Akt3, IC₅₀: 1.31 nM	99.13%
Pifusertib hydrochloride			Akt2, IC₅₀: 1.6 nM	Akt3, IC₅₀: 44 nM
M2698				Akt3, IC₅₀: 1 nM	99.87%
MS170			Akt2, Kd: 77 nM	Akt3, Kd: 6.5 nM	99.72%
Afuresertib hydrochloride			Akt2, Ki: 2 nM	Akt3, Ki: 2.6 nM	99.95%
AT7867 dihydrochloride			Akt2, IC₅₀: 17 nM	Akt3, IC₅₀: 47 nM	99.75%
4-Methylbenzylidene camphor	Akt				99.87%
MK-2206		Akt1, IC₅₀: 8 nM	Akt2, IC₅₀: 12 nM	Akt3, IC₅₀: 65 nM	99.39%
Akt1/Akt2-IN-1			Akt2, IC₅₀: 42 nM		99.30%
AT-533	Akt				98.86%
AKT-IN-6			Akt2	Akt3	99.08%
Miransertib hydrochloride			Akt2, IC₅₀: 174 nM	Akt3, IC₅₀: 8.1 nM	99.74%
3CAI			Akt2		98.32%
Deltonin	Akt				99.94%
INY-03-041 trihydrochloride		Akt1, IC₅₀: 2.0 nM	Akt2, IC₅₀: 6.8 nM	Akt3, IC₅₀: 3.5 nM	99.27%
Isoprocurcumenol	Akt
CCT128930 hydrochloride			Akt2, IC₅₀: 6 nM		98.97%
AKT-IN-3			Akt2, IC₅₀: 1.2 nM	Akt3, IC₅₀: 1.7 nM	99.29%
PTP1B-IN-24	Akt, IC₅₀: 1.4 μM
Hu7691			Akt2, IC₅₀: 97.5 nM	Akt3, IC₅₀: 28 nM	99.91%
MS15			Akt2, IC₅₀: 90 ± 2.8 nM	Akt3, IC₅₀: 544 ± 2.9 nM
Vevorisertib			Akt2, IC₅₀: 0.81 nM	Akt3, IC₅₀: 1.31 nM	98.03%
Pifusertib			Akt2, IC₅₀: 1.6 nM	Akt3, IC₅₀: 44 nM
Akt1/Akt2-IN-2		Akt1, IC₅₀: 138 nM	Akt2, IC₅₀: 212 nM	Akt3, IC₅₀: 7.2 mM	98.57%
Akt1&PKA-IN-1	Akt, IC₅₀: 0.11 μM
Akt1&PKA-IN-2		Akt1, IC₅₀: 0.007 μM
Hu7691 free base			Akt2, IC₅₀: 97.5 nM	Akt3, IC₅₀: 28 nM
MS98			Akt2, : 140 nM	Akt3, : 8.1 nM
MK-2206 free base			Akt2, IC₅₀: 12 nM	Akt3, IC₅₀: 65 nM
AKT-IN-5			Akt2, IC₅₀: 400 nM
TRPM7-IN-1	Akt
Gamendazole		Akt1
Coelonin	Akt
AKT-IN-8			Akt2, IC₅₀: 2.44 nM	Akt3, IC₅₀: 9.47 nM
PD-1/PD-L1-IN-54	Akt
AKT-IN-13			Akt2, IC₅₀: 2.4 nM	Akt3, IC₅₀: 0.3 nM
Eudebeiolide B	Akt
Tanshinol borneol ester	Akt
Akt1-IN-5		Akt1, IC₅₀: <15 nM
Ipatasertib tosylate		Akt1, IC₅₀: 5 nM	Akt2, IC₅₀: 18 nM	Akt3, IC₅₀: 8 nM
AKT1-IN-9		AKT1(E17K)
Akt1-IN-6		Akt1, IC₅₀: <15 nM
Akt1-IN-7		Akt1, IC₅₀: <15 nM
Akt1-IN-4		Akt1
AKT-IN-18	Akt, IC₅₀: 69.45 μM
Uprosertib hydrochloride			Akt2, IC₅₀: 328 nM	Akt3, IC₅₀: 38 nM
Akt1-IN-2		Akt1, IC₅₀: 4.6 μM	Akt2, IC₅₀: >250 μM	Akt3, IC₅₀: >250 μM

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Akt

Akt

Akt Isoform Specific Products:

Akt Isoform Specific Products:

Akt Related Products (559)

Recombinant Proteins (6)

Antibodies (11)

Akt Isoform Comparison

Akt Related Products (559):