2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Alfuzosin hydrochloride

Alfuzosin hydrochloride  (Synonyms: SL 77499-10)

Cat. No.: HY-B0192A Purity: 99.82%
SDS COA Handling Instructions

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Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH).

For research use only. We do not sell to patients.

Alfuzosin hydrochloride Chemical Structure

Alfuzosin hydrochloride Chemical Structure

CAS No. : 81403-68-1

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 34 In-stock
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50 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Alfuzosin hydrochloride:

Alfuzosin hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Alfuzosin hydrochloride

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH)[1][2].

IC50 & Target

α adrenergic receptor

 

In Vivo

Alfuzosin hydrochloride (10 mg/kg, p.o.; single) potently antagonizes phenylephrine-induced increases in urethral and arterial pressures up to 6 hours post dosing[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (250-450 g)[1].
Dosage: 10 mg/kg
Administration: Oral administration; single.
Result: Increased prostatic concentrations to 4.1-8.6 times higher than plasma concentration.
Clinical Trial
Molecular Weight

425.91

Formula

C19H28ClN5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1OCCC1)NCCCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (117.40 mM; Need ultrasonic)

DMSO : 25 mg/mL (58.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3479 mL 11.7396 mL 23.4791 mL
5 mM 0.4696 mL 2.3479 mL 4.6958 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.82%

SDS (252 KB)

COA (249 KB) HNMR (284 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.3479 mL 11.7396 mL 23.4791 mL 58.6978 mL
5 mM 0.4696 mL 2.3479 mL 4.6958 mL 11.7396 mL
10 mM 0.2348 mL 1.1740 mL 2.3479 mL 5.8698 mL
15 mM 0.1565 mL 0.7826 mL 1.5653 mL 3.9132 mL
20 mM 0.1174 mL 0.5870 mL 1.1740 mL 2.9349 mL
25 mM 0.0939 mL 0.4696 mL 0.9392 mL 2.3479 mL
30 mM 0.0783 mL 0.3913 mL 0.7826 mL 1.9566 mL
40 mM 0.0587 mL 0.2935 mL 0.5870 mL 1.4674 mL
50 mM 0.0470 mL 0.2348 mL 0.4696 mL 1.1740 mL
H2O 60 mM 0.0391 mL 0.1957 mL 0.3913 mL 0.9783 mL
80 mM 0.0293 mL 0.1467 mL 0.2935 mL 0.7337 mL
100 mM 0.0235 mL 0.1174 mL 0.2348 mL 0.5870 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Alfuzosin hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alfuzosin81403-68-1SL 77499-10Adrenergic ReceptorBeta ReceptorBPHprostaticurinationbladder neckInhibitorinhibitorinhibit

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