Aminoguanidine (Synonyms: Pimagedine; GER-11(free base) ; Aminoguanidinium)

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Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research.

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Aminoguanidine Chemical Structure

CAS No. : 79-17-4

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Other In-stock Forms of Aminoguanidine:

Aminoguanidine hydrochloride

Other Forms of Aminoguanidine:

Aminoguanidine hydrochloride In-stock
Aminoguanidine hemisulfate Get quote

4 Publications Citing Use of MCE Aminoguanidine

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nNOS iNOS eNOS

Biological Activity
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	> 1000 μM Compound: 4	Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells Inhibitory activity against synthesis of inducible nitric oxide synthase by DLD-1 cells	[PMID: 12620067]
DLD-1	IC₅₀	4.5 μM Compound: 4	Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells	[PMID: 11327580]
DLD-1	IC₅₀	54 μM Compound: 1	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells. Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from human DLD-1 cells.	10.1016/0960-894X(95)00273-V
HUVEC	IC₅₀	72 μM Compound: 4	Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells Ability to inhibit conversion of [3H]L-Arg to [3H]L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells	[PMID: 11327580]
J774	IC₅₀	9 μM Compound: 1	Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells Tested to inhibit the conversion of [3H]L-arginine to [3H]L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells	10.1016/0960-894X(95)00273-V
RAW264.7	CC₅₀	> 100 μM Compound: Aminoguanidine	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 3 hrs by alamar blue assay	[PMID: 22148193]
RAW264.7	IC₅₀	0.021 mM Compound: AG	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 18986199]
RAW264.7	IC₅₀	0.05 μM Compound: AG	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs	[PMID: 20192236]
RAW264.7	IC₅₀	0.2 μM Compound: AG	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method	[PMID: 21924800]
RAW264.7	IC₅₀	0.23 μM Compound: AG	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method	[PMID: 25176187]
RAW264.7	IC₅₀	1.8 μM Compound: Aminoguanidine	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay	[PMID: 33454546]
RAW264.7	IC₅₀	11.91 μM Compound: AG	Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method Anti-inflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of nitric oxide production incubated for 20 mins before LPS induction by Griess method	[PMID: 26280922]
RAW264.7	IC₅₀	16.3 μM Compound: AG	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production treated 3 hrs before LPS challenge assessed after 24 hrs by Griess reagent assay	[PMID: 11809076]
RAW264.7	IC₅₀	16.6 μM Compound: AG	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method	[PMID: 24035341]
RAW264.7	IC₅₀	16.6 μM Compound: aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 23743282]
RAW264.7	IC₅₀	16.9 μM Compound: Aminoguanidine	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method	[PMID: 24813739]
RAW264.7	IC₅₀	17.5 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method	[PMID: 22079762]
RAW264.7	IC₅₀	17.5 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay Antiinflammatory activity in mouse RAW 264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 48 hrs by Griess reagent assay	[PMID: 29280630]
RAW264.7	IC₅₀	18.4 μM Compound: Aminoguanidine	Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay Antiinflammatory activity against LPS-induced mouse RAW264.7 cells assessed as inhibition of NO production pretreated for 1 hr followed by LPS stimulation for 24 hrs by Griess assay	[PMID: 27634197]
RAW264.7	IC₅₀	18.7 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess method	[PMID: 27246615]
RAW264.7	IC₅₀	18.7 μM Compound: Aminoguanidine	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 26702644]
RAW264.7	IC₅₀	18.7 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay	[PMID: 25592708]
RAW264.7	IC₅₀	18.7 μM Compound: Aminoguanidine	Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay	[PMID: 33476145]
RAW264.7	IC₅₀	18.7 μM Compound: AG	Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry Inhibition of LPS-induced NO production in mouse RAW264.7 cells pretreated for 20 mins before LPS challenge measured after 18 hrs post LPS challenge by spectrophotometry	[PMID: 23454014]
RAW264.7	IC₅₀	19.9 μM Compound: Aminoguanidine	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 hrs by Griess reagent-based assay	[PMID: 31860303]
RAW264.7	IC₅₀	2.7 μM Compound: AG	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs	[PMID: 20515062]
RAW264.7	IC₅₀	20.6 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method	[PMID: 26073007]
RAW264.7	IC₅₀	20.6 μM Compound: AG	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells after 24 hrs by Griess reaction	[PMID: 26331882]
RAW264.7	IC₅₀	20.7 μM Compound: Aminoguanidine	Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay	[PMID: 33667099]
RAW264.7	IC₅₀	21.4 μM Compound: aminoguanidine	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay	[PMID: 24963714]
RAW264.7	IC₅₀	21.7 μM Compound: Aminoguanidine	Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay Inhibition of lipopolysaccharide-induced nitric oxide production in mouse RAW264.7 cells by Griess reagent based assay	[PMID: 31244142]
RAW264.7	IC₅₀	22.3 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by spectrophotometric analysis	[PMID: 24597849]
RAW264.7	IC₅₀	22.6 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method	[PMID: 22325804]
RAW264.7	IC₅₀	24.2 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO production after 24 hrs in presence of LPS by colorimetric analysis	[PMID: 27865705]
RAW264.7	IC₅₀	24.7 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production compound treated prior to LPS challenge by Griess assay	[PMID: 27976895]
RAW264.7	IC₅₀	25.5 μM Compound: Aminoguanidine	Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs in presence of LPS by Griess reagent based assay	[PMID: 31642320]
RAW264.7	IC₅₀	26.55 μM Compound: Aminoguanidine	Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 21846089]
RAW264.7	IC₅₀	28 μM Compound: AG	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay	[PMID: 19113968]
RAW264.7	IC₅₀	28.47 μM Compound: Aminoguanidine	Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method	[PMID: 22148193]
RAW264.7	IC₅₀	32.17 μM Compound: aminoguanidine	Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs Inhibition of NO production in LPS-stimulated RAW264.7 cells after 24 hrs	[PMID: 17338565]
RAW264.7	IC₅₀	32.2 μM Compound: Aminoguanidine	Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells assessed as nitrite formation after 24 hrs	[PMID: 21273070]
RAW264.7	IC₅₀	4.06 μM Compound: AG	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess method	[PMID: 14510600]
RAW264.7	IC₅₀	4.6 μM Compound: aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production treated for 2 hrs before LPS challenge measured after 24 hrs by ELISA	[PMID: 21090796]
RAW264.7	IC₅₀	43.3 μM Compound: AG	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite production after 22 hrs by Griess method	[PMID: 24996142]
RAW264.7	IC₅₀	6.5 μM Compound: Aminoguanidine	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated NO production pretreated for 30 mins before LPS challenge measured after 24 hrs by MTT assay	[PMID: 22691179]
RAW264.7	IC₅₀	7.29 μM Compound: Aminoguanidine	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 30 mins by microplate reader analysis	[PMID: 25703295]
RAW264.7	IC₅₀	7.9 μM Compound: Aminoguanidine	Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction	[PMID: 21894898]
RAW264.7	IC₅₀	8.68 μM Compound: AG	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at after 18 hrs by Griess method relative to control	[PMID: 24974350]

Molecular Weight

74.09

Formula

CH₆N₄

CAS No.

79-17-4

SMILES

N=C(NN)N

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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References

[1]. Sabuncuoglu S. Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. Mol Cell Biochem. 2014 Sep;394(1-2):129-35. [Content Brief]

[2]. Chowdhury P. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. Ann Clin Lab Sci. 2017 Sep;47(5):572-580. PMID: 29066484. [Content Brief]

[3]. Al-Shabanah OA, et al. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci. 2000;66(3):265-70. [Content Brief]

[4]. Abraham P, et al. Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats. Redox Rep. 2011;16(1):8-14. [Content Brief]

Aminoguanidine Related Classifications

Endocrinology

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminoguanidine79-17-4Pimagedine GER-11(free base) AminoguanidiniumNO SynthaseApoptosisNitric oxide synthasesNOSInhibitorA549AR42J cellinhibitorinhibit

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Aminoguanidine (Synonyms: Pimagedine; GER-11(free base) ; Aminoguanidinium)

Other Forms of Aminoguanidine:

Aminoguanidine Related Antibodies

4 Publications Citing Use of MCE Aminoguanidine

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Aminoguanidine Related Classifications

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