GABARAP - GABA type A receptor-associated protein Gene

Homo sapiens

Also known as MM46; ATG8A; GABARAP-a

Gene ID: 11337 | Gene type: protein coding

About GABARAP

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,240,008-7,242,449 (from NCBI)

This gene has 6 transcripts (splice variants), 133 orthologues and 6 paralogues. Ubiquitous expression in adrenal (RPKM 212.0), ovary (RPKM 206.1) and 25 other tissues.

Summary

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with LIGHT chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the Cytoskeleton. [provided by RefSeq, Jul 2008]

GABARAP Products(1)

mRNA	Protein	Name
NM_007278.2	NP_009209.1	gamma-aminobutyric acid receptor-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GABA receptor binding	IPI IPI: Inferred from physical interaction	9892355	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	9892355	GOA
enables phosphatidylethanolamine binding	IDA IDA: Inferred from direct assay	15169837	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9892355	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25127057	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	15977068	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	25684205	GOA
involved in positive regulation of protein K48-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	25684205	GOA
involved in regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	25684205	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	19056683	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	15169837	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABARAP Protein Structure

Atg8

0
100
117 a.a.

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor-associated protein

GABA(A) receptor-associated protein

Recombinant GABARAP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70861	GABARAP Protein, Human (GST)	Q6IAW1 (M1-L117)	≥95%
HY-P72639	GABARAP Protein, Human (His, Fc)	Q6IAW1 (M1-L117)	≥95%
HY-P76942	GABARAP Protein, Human (His-MBP)	O95166 (M1-L117)	≥95%

Related Diseases

Diseases

Alias

Stiff-Person Syndrome

SPS	Stiff-Man Syndrome
Stiff Man Syndrome	Stiff Person Syndrome
Moersch-Woltman Syndrome	Sms
Stiff-Trunk Syndrome	Morsch Woltman Syndrome
Stiff Person Syndrome And Related Disorders	Stiff Person Spectrum Disorder
Classic Stiff Person Syndrome	Classic Sps
Focal Stiff Limb Syndrome	Focal Stiff-Person Syndrome
Stiff Leg Syndrome	Progressive Encephalomyelitis With Rigidity

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Retinitis Pigmentosa 84

RP84	Retinitis Pigmentosa, Type 84

Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I	Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome
Hsan1e	Hsan1
Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy	Hsn1e
Hsnie	Hereditary Sensory Neuropathy Type Ie
Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory And Autonomic Neuropathy Type 1e	Hereditary Sensory Neuropathy With Hearing Loss And Dementia
Dnmt1-Complex Disorder	Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss
Hsn Ie	Hereditary Sensory Autonomic Neuropathy, Type 1
Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16121	CAA-0225	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05201	GABARAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GABARAP	RGD	RGD:61911
Mus musculus	GABARAP	MGD	MGI:1861742
Bos taurus	GABARAP	VGNC	VGNC:29185
Canis familiaris	GABARAP	VGNC	VGNC:41046
Felis catus	GABARAP	VGNC	VGNC:62414
Others	GABARAP	NCBI

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