2. Gene
  3. MAPRE3 - microtubule associated protein RP/EB family member 3 Gene

MAPRE3 - microtubule associated protein RP/EB family member 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EB3; RP3; EBF3; EBF3-S

Gene ID: 22924 | Gene type: protein coding

About MAPRE3

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,970,637-27,027,219 (from NCBI)

This gene has 10 transcripts (splice variants), 279 orthologues and 2 paralogues. Broad expression in brain (RPKM 45.3), testis (RPKM 13.7) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]

MAPRE3 Products(3)

mRNA Protein Name
NM_001303050.2 NP_001289979.1 microtubule-associated protein RP/EB family member 3 isoform 1
NM_001410716.1 NP_001397645.1 microtubule-associated protein RP/EB family member 3 isoform 2
NM_012326.4 NP_036458.2 microtubule-associated protein RP/EB family member 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
27107012 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10644998 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
26323690 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of protein kinase activity IDA
IDA: Inferred from direct assay
26323690 GOA
involved in regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
23159740 GOA
Cellular Component GO Annotation Evidence Reference Source
colocalizes with cytoplasmic microtubule IDA
IDA: Inferred from direct assay
10644998 GOA
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
10644998 GOA
located in mitotic spindle astral microtubule end IDA
IDA: Inferred from direct assay
23509069 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10644998 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPRE3 Protein Structure

CH

CH: Calponin homology (CH) domain (18 - 115)

EB1

EB1: EB1-like C-terminal motif (218 - 257)

  • 0
  • 100
  • 200
  • 281 a.a.
Protein Preferred Names Protein Names

microtubule-associated protein RP/EB family member 3

APC binding protein

MAPRE3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAPRE3 Q9UPY8 MAPRE1 Homo sapiens Q15691
SLC
27107012
Intra
MAPRE3 Q9UPY8 MAPRE1 Homo sapiens Q15691
Y2H Array
31515488
Intra
MAPRE3 Q9UPY8 MAPRE1 Homo sapiens Q15691
Validated Y2H
25416956
Intra
MAPRE3 Q9UPY8 MAPRE1 Homo sapiens Q15691
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 MAPRE1 Homo sapiens Q15691
Y2H Prey Pooling
25416956
Intra
MAPRE3 Q9UPY8 MAPRE1 Homo sapiens Q15691
Y2H
27107012
Intra
MAPRE3 Q9UPY8 MAPRE1 Homo sapiens Q15691
BFG-2H
27107012
Intra
MAPRE3 Q9UPY8 MAPRE1 Homo sapiens Q15691
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 CRTAC1 Homo sapiens Q9NQ79
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 CRTAC1 Homo sapiens Q9NQ79
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 GTF2F2 Homo sapiens P13984
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 GTF2F2 Homo sapiens P13984
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 APC2 Homo sapiens O95996
Pull Down
10644998
Intra
MAPRE3 Q9UPY8 APC2 Homo sapiens O95996
Confocal
10644998
Intra
MAPRE3 Q9UPY8 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 ZNF526 Homo sapiens Q8TF50
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 ZNF526 Homo sapiens Q8TF50
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 HROB Homo sapiens Q8N3J3-3
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 HROB Homo sapiens Q8N3J3-3
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 FOXD4L1 Homo sapiens Q9NU39
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 FOXD4L1 Homo sapiens Q9NU39
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 SIAH1 Homo sapiens Q8IUQ4-2
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 SPMIP2 Homo sapiens Q96LM5
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 SPMIP2 Homo sapiens Q96LM5
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 CHRDL2 Homo sapiens Q6WN34-2
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 CHRDL2 Homo sapiens Q6WN34-2
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 ZNF547 Homo sapiens Q8IVP9
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 ZNF547 Homo sapiens Q8IVP9
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 FOXD4L4 Homo sapiens Q8WXT5
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 FOXD4L4 Homo sapiens Q8WXT5
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 POU4F1 Homo sapiens Q01851
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 POU4F1 Homo sapiens Q01851
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 TRAIP Homo sapiens Q9BWF2
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 TRAIP Homo sapiens Q9BWF2
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 CCSER1 Homo sapiens Q9C0I3-2
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 CCSER1 Homo sapiens Q9C0I3-2
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 SPMIP10 Homo sapiens Q6ZNM6
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 SPMIP10 Homo sapiens Q6ZNM6
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 C20orf202 Homo sapiens A1L168
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 C20orf202 Homo sapiens A1L168
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 LAP3 Homo sapiens P28838
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 LAP3 Homo sapiens P28838
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 TRIM14 Homo sapiens Q14142
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 TRIM14 Homo sapiens Q14142
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 TXN2 Homo sapiens Q99757
Y2H Prey Pooling
25416956
Intra
MAPRE3 Q9UPY8 TXN2 Homo sapiens Q99757
Y2H Array
25416956
Intra
MAPRE3 Q9UPY8 MRPL12 Homo sapiens P52815
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 MRPL12 Homo sapiens P52815
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra
MAPRE3 Q9UPY8 MAPT Homo sapiens P10636
Affinity Chrom
30668577
Intra
MAPRE3 Q9UPY8 PSMB1 Homo sapiens P20618
Y2H Prey Pooling
25416956
Intra
MAPRE3 Q9UPY8 KNSTRN Homo sapiens Q9Y448
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 KNSTRN Homo sapiens Q9Y448
Validated Y2H
32296183
Intra
MAPRE3 Q9UPY8 KNSTRN Homo sapiens Q9Y448
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 EIF4E2 Homo sapiens O60573
Validated Y2H
25416956
Intra
MAPRE3 Q9UPY8 EIF4E2 Homo sapiens O60573
Y2H Array
25416956
Intra
MAPRE3 Q9UPY8 ZC2HC1A Homo sapiens Q96GY0
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 ZC2HC1A Homo sapiens Q96GY0
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 ANKRD1 Homo sapiens Q15327
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 ANKRD1 Homo sapiens Q15327
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 FAM161B Homo sapiens Q96MY7
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 FAM161B Homo sapiens Q96MY7
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
MAPRE3 Q9UPY8 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
MAPRE3 Q9UPY8 PSRC1 Homo sapiens Q6PGN9
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 PSRC1 Homo sapiens Q6PGN9
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
MAPRE3 Q9UPY8 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra
MAPRE3 Q9UPY8 MAPRE2 Homo sapiens Q15555
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 MAPRE2 Homo sapiens Q15555
Y2H Array
31515488
Intra
MAPRE3 Q9UPY8 MAPRE2 Homo sapiens Q15555
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 APPL2 Homo sapiens Q8NEU8
Y2H Array
25814554
Intra
MAPRE3 Q9UPY8 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Cross
MAPRE3 Q9UPY8 Map1b Mus musculus P14873
FRAP
23572079
Cross
MAPRE3 Q9UPY8 Map1b Mus musculus P14873
Pull Down
23572079
Cross
MAPRE3 Q9UPY8 Map1b Mus musculus P14873
Anti Bait CoIP
23572079
Cross
MAPRE3 Q9UPY8 Srcin1 Mus musculus Q9QWI6-2
Pull Down
19146815
Cross
MAPRE3 Q9UPY8 Srcin1 Mus musculus Q9QWI6-2
Fluorescence
19146815
Cross
MAPRE3 Q9UPY8 Srcin1 Mus musculus Q9QWI6-2
IF
19146815
Intra
MAPRE3 Q9UPY8 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 GAS2L2 Homo sapiens Q8NHY3
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 GAS2L2 Homo sapiens Q8NHY3
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 JUN Homo sapiens P05412
Display Tech
20195357
Intra
MAPRE3 Q9UPY8 JUN Homo sapiens P05412
TAP
20195357
Intra
MAPRE3 Q9UPY8 KLHDC7B Homo sapiens Q96G42
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 KLHDC7B Homo sapiens Q96G42
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 MARCHF7 Homo sapiens Q9H992
Y2H Prey Pooling
32296183
Intra
MAPRE3 Q9UPY8 MARCHF7 Homo sapiens Q9H992
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 PDE4DIP Homo sapiens Q5VU43-2
Y2H Array
32296183
Intra
MAPRE3 Q9UPY8 PDE4DIP Homo sapiens Q5VU43-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPRE3 Proteins

Cat. No. Product Name Accession Purity
HY-P75275 EB3/MAPRE3 Protein, Human (His) Q9UPY8-1 (M1-Y281) ≥95%

MAPRE3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82030 EB3 Antibody (YA1775) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Distal Hereditary Motor Neuronopathy Type 7

Dhmn7

Dhmnvpy

Distal Spinal Muscular Atrophy With Vocal Cord Paralysis
Neuronopathy, Distal Hereditary Motor, Type Viib

HMN7B

Hmn Viib

Dhmn7b

Neuropathy, Distal Hereditary Motor, Type Viib

Distal Hereditary Motor Neuronopathy Type 7b

Distal Hereditary Motor Neuropathy Type Viib

Neuronopathy, Distal Hereditary Motor, Type 7b

Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type Viib

Lower Motor Neuron Disease, Dynactin Type

Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7b

Harper-Young Myopathy

Neuronopathy, Distal Hereditary Motor, 7b

Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Type Viib

Lower Motor Neuron Disease Dynactin Type

Plmnd

Progressive Lower Motor Neuron Disease

Neuropathy, Motor, Distal, Hereditary, Type Viib
Marburg Hemorrhagic Fever

Marburg Virus Disease

Marburg Disease

Green Monkey Disease

Mhf

Vervet Monkey Disease

Mard - [Marburg Disease]

Mvd - [Marburg Virus Disease]

Marburg Haemorrhagic Fever

Mhf - [Marburg Haemorrhagic Fever]
Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified
Arthrogryposis, Distal, Type 4

Distal Arthrogryposis Type 4

DA4

Daiid

Arthrogryposis-Severe Scoliosis Syndrome

Distal Arthrogryposis Type Iid

Arthrogryposis With Severe Scoliosis

Arthrogryposis, Distal, Type Iid
Bolivian Hemorrhagic Fever

Machupo Hemorrhagic Fever

Hemorrhagic Fever, Bolivian

Bhf - [Bolivian Haemorrhagic Fever]

Machupo Haemorrhagic Fever
Omsk Hemorrhagic Fever

Ohf

Hemorrhagic Fever, Omsk

Ohf - [Omsk Haemorrhagic Fever]

Spring-Fall Haemorrhagic Fever
Nipah Virus Encephalitis

Equine Morbillivirus
Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS
Helsmoortel-Van Der Aa Syndrome

HVDAS

Mrd28

Adnp Syndrome

Adnp-Related Syndromic Intellectual Disability-Autism Spectrum Disorder

Mental Retardation, Autosomal Dominant 28

Adnp-Related Multiple Congenital Anomalies - Intellectual Disability - Autism Spectrum Disorder

Mental Retardation, Autosomal Dominant 28, Formerly

Mrd28, Formerly

Autosomal Dominant Mental Retardation 28

Adnp-Related Intellectual Disability And Autism Spectrum Disorder

Adnp-Related Multiple Congenital Anomalies-Intellectual Disability-Autism Spectrum Disorder
Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles

Cfeom

Feom

Congenital External Ophthalmoplegia

Congenital Fibrosis Syndrome

General Fibrosis Syndrome
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08139 MAPRE3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MAPRE3 VGNC VGNC:31234
Macaca mulatta MAPRE3 VGNC VGNC:74657
Felis catus MAPRE3 VGNC VGNC:68181
Mus musculus MAPRE3 MGD MGI:2140967
Rattus norvegicus MAPRE3 RGD RGD:1359297
Canis familiaris MAPRE3 VGNC VGNC:43011
Others MAPRE3 NCBI