GTF2B - general transcription factor IIB Gene

Homo sapiens

Also known as TF2B; TFIIB

Gene ID: 2959 | Gene type: protein coding

About GTF2B

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:88,852,633-88,891,567 (from NCBI)

This gene has 7 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 18.5), gall bladder (RPKM 11.2) and 25 other tissues.

Summary

This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

GTF2B Products(1)

mRNA	Protein	Name
NM_001514.6	NP_001505.1	transcription initiation factor IIB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	9722567	GOA
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	8413225	GOA
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7675079	GOA
enables RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	27193682	GOA
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	9841876	GOA
enables acetyltransferase activity	IDA IDA: Inferred from direct assay	12931194	GOA
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	8524305	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	12931194	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1517211	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	11045620	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA polymerase II core complex assembly	IMP IMP: Inferred from mutant phenotype	8515820	GOA
involved in RNA polymerase II preinitiation complex assembly	IDA IDA: Inferred from direct assay	3029109	GOA
involved in RNA polymerase II preinitiation complex assembly	IMP IMP: Inferred from mutant phenotype	8413225	GOA
involved in positive regulation of core promoter binding	IDA IDA: Inferred from direct assay	9841876	GOA
involved in protein acetylation	IDA IDA: Inferred from direct assay	12931194	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	27193682	GOA
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	1517211	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	3029109	GOA
involved in transcription initiation at RNA polymerase II promoter	IMP IMP: Inferred from mutant phenotype	9420329	GOA
involved in transcriptional start site selection at RNA polymerase II promoter	IMP IMP: Inferred from mutant phenotype	10318856	GOA
involved in viral transcription	IDA IDA: Inferred from direct assay	24441171	GOA
involved in viral transcription	IMP IMP: Inferred from mutant phenotype	14644612	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	1876184	GOA
part of RNA polymerase II transcription regulator complex	IMP IMP: Inferred from mutant phenotype	7601352	GOA
located in chromosome	IDA IDA: Inferred from direct assay	24441171	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9841876	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	8413225	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	27193682	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2B Protein Structure

TF_Zn_Ribbon

TFIIB

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

transcription initiation factor IIB

RNA polymerase II transcription factor IIB

GTF2B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GTF2B	Q00403	ZSCAN22	Homo sapiens	P10073	Y2H Pooling	32814053
Intra	GTF2B	Q00403	ZSCAN22	Homo sapiens	P10073	Validated Y2H	32814053
Intra	GTF2B	Q00403	ZSCAN22	Homo sapiens	P10073	Y2H Array	32814053
Intra	GTF2B	Q00403	ASCL4	Homo sapiens	Q6XD76	Y2H Array	32814053
Intra	GTF2B	Q00403	ASCL4	Homo sapiens	Q6XD76	Validated Y2H	32814053
Intra	GTF2B	Q00403	ASCL4	Homo sapiens	Q6XD76	Y2H Pooling	32814053
Intra	GTF2B	Q00403	JADE3	Homo sapiens	Q92613	Validated Y2H	32814053
Intra	GTF2B	Q00403	JADE3	Homo sapiens	Q92613	Y2H Pooling	32814053
Intra	GTF2B	Q00403	JADE3	Homo sapiens	Q92613	Y2H Array	32814053
Intra	GTF2B	Q00403	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32814053
Intra	GTF2B	Q00403	PBX4	Homo sapiens	Q9BYU1	Y2H Pooling	32814053
Intra	GTF2B	Q00403	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32814053
Intra	GTF2B	Q00403	USP2	Homo sapiens	O75604-3	Validated Y2H	32814053
Intra	GTF2B	Q00403	USP2	Homo sapiens	O75604-3	Y2H Array	32814053
Intra	GTF2B	Q00403	USP2	Homo sapiens	O75604-3	Y2H Pooling	32814053
Intra	GTF2B	Q00403	C14orf93	Homo sapiens	Q9H972-2	Validated Y2H	32814053
Intra	GTF2B	Q00403	C14orf93	Homo sapiens	Q9H972-2	Y2H Array	32814053
Intra	GTF2B	Q00403	C14orf93	Homo sapiens	Q9H972-2	Y2H Pooling	32814053
Intra	GTF2B	Q00403	CBX2	Homo sapiens	Q14781-2	Validated Y2H	32814053
Intra	GTF2B	Q00403	CBX2	Homo sapiens	Q14781-2	Y2H Array	32814053
Intra	GTF2B	Q00403	CBX2	Homo sapiens	Q14781-2	Y2H Pooling	32814053
Intra	GTF2B	Q00403	ZSCAN1	Homo sapiens	Q8NBB4-2	Validated Y2H	32814053
Intra	GTF2B	Q00403	ZSCAN1	Homo sapiens	Q8NBB4-2	Y2H Pooling	32814053
Intra	GTF2B	Q00403	ZSCAN1	Homo sapiens	Q8NBB4-2	Y2H Array	32814053
Intra	GTF2B	Q00403	ZNF829	Homo sapiens	Q3KNS6-3	Y2H Pooling	32814053
Intra	GTF2B	Q00403	ZNF829	Homo sapiens	Q3KNS6-3	Validated Y2H	32814053
Intra	GTF2B	Q00403	ZNF829	Homo sapiens	Q3KNS6-3	Y2H Array	32814053
Intra	GTF2B	Q00403	NVL	Homo sapiens	O15381-5	Validated Y2H	32814053
Intra	GTF2B	Q00403	NVL	Homo sapiens	O15381-5	Y2H Array	32814053
Intra	GTF2B	Q00403	NVL	Homo sapiens	O15381-5	Y2H Pooling	32814053
Intra	GTF2B	Q00403	PHF19	Homo sapiens	Q5T6S3	Y2H Array	32814053
Intra	GTF2B	Q00403	PHF19	Homo sapiens	Q5T6S3	Y2H Pooling	32814053
Intra	GTF2B	Q00403	PHF19	Homo sapiens	Q5T6S3	Validated Y2H	32814053
Intra	GTF2B	Q00403	ANXA8	Homo sapiens	P13928	Y2H Pooling	32814053
Intra	GTF2B	Q00403	ANXA8	Homo sapiens	P13928	Validated Y2H	32814053
Intra	GTF2B	Q00403	ANXA8	Homo sapiens	P13928	Y2H Array	32814053
Intra	GTF2B	Q00403	ZNF488	Homo sapiens	Q96MN9-2	Validated Y2H	32814053
Intra	GTF2B	Q00403	ZNF488	Homo sapiens	Q96MN9-2	Y2H Array	32814053
Intra	GTF2B	Q00403	ZNF488	Homo sapiens	Q96MN9-2	Y2H Pooling	32814053
Intra	GTF2B	Q00403	DCAF8	Homo sapiens	Q5TAQ9-2	Validated Y2H	32814053
Intra	GTF2B	Q00403	DCAF8	Homo sapiens	Q5TAQ9-2	Y2H Pooling	32814053
Intra	GTF2B	Q00403	DCAF8	Homo sapiens	Q5TAQ9-2	Y2H Array	32814053
Intra	GTF2B	Q00403	HES4	Homo sapiens	Q9HCC6	Validated Y2H	32814053
Intra	GTF2B	Q00403	HES4	Homo sapiens	Q9HCC6	Y2H Pooling	32814053
Intra	GTF2B	Q00403	HES4	Homo sapiens	Q9HCC6	Y2H Array	32814053
Intra	GTF2B	Q00403	KLF15	Homo sapiens	Q9UIH9	Y2H Pooling	32814053
Intra	GTF2B	Q00403	KLF15	Homo sapiens	Q9UIH9	Validated Y2H	32814053
Intra	GTF2B	Q00403	KLF15	Homo sapiens	Q9UIH9	Y2H Array	32814053
Cross	GTF2B	Q00403	Vdr	Mus musculus	P48281	Y2H	12529369
Cross	GTF2B	Q00403	Vdr	Mus musculus	P48281	Pull Down	12529369
Intra	GTF2B	Q00403	RPS4X	Homo sapiens	P62701	Y2H Array	32814053
Intra	GTF2B	Q00403	RPS4X	Homo sapiens	P62701	Y2H Pooling	32814053
Intra	GTF2B	Q00403	RPS4X	Homo sapiens	P62701	Validated Y2H	32814053
Intra	GTF2B	Q00403	TBP	Homo sapiens	P20226	Anti Bait CoIP	15207618
Intra	GTF2B	Q00403	TNIP1	Homo sapiens	Q15025	Y2H Array	31515488
Intra	GTF2B	Q00403	TNIP1	Homo sapiens	Q15025	Validated Y2H	25416956
Intra	GTF2B	Q00403	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	32296183
Intra	GTF2B	Q00403	TNIP1	Homo sapiens	Q15025	Validated Y2H	32296183
Intra	GTF2B	Q00403	TNIP1	Homo sapiens	Q15025	Y2H Array	25416956
Intra	GTF2B	Q00403	TNIP1	Homo sapiens	Q15025	Y2H Array	32296183
Intra	GTF2B	Q00403	RPP25	Homo sapiens	Q9BUL9	Validated Y2H	32814053
Intra	GTF2B	Q00403	RPP25	Homo sapiens	Q9BUL9	Y2H Array	32814053
Intra	GTF2B	Q00403	RPP25	Homo sapiens	Q9BUL9	Y2H Pooling	32814053
Intra	GTF2B	Q00403	POLR2E	Homo sapiens	P19388	Validated Y2H	32814053
Intra	GTF2B	Q00403	POLR2E	Homo sapiens	P19388	Y2H Array	32814053
Intra	GTF2B	Q00403	POLR2E	Homo sapiens	P19388	Y2H Pooling	32814053
Intra	GTF2B	Q00403	EP300	Homo sapiens	Q09472	Pull Down	10330164
Intra	GTF2B	Q00403	MYC	Homo sapiens	P01106	Validated Y2H	32814053
Intra	GTF2B	Q00403	MYC	Homo sapiens	P01106	Y2H Array	32814053
Intra	GTF2B	Q00403	MYC	Homo sapiens	P01106	Y2H Pooling	32814053
Intra	GTF2B	Q00403	LPIN1	Homo sapiens	Q14693	Y2H Pooling	32814053
Intra	GTF2B	Q00403	LPIN1	Homo sapiens	Q14693	Validated Y2H	32814053
Intra	GTF2B	Q00403	LPIN1	Homo sapiens	Q14693	Y2H Array	32814053
Intra	GTF2B	Q00403	FAM98C	Homo sapiens	Q17RN3	Validated Y2H	32814053
Intra	GTF2B	Q00403	FAM98C	Homo sapiens	Q17RN3	Y2H Array	32814053
Intra	GTF2B	Q00403	FAM98C	Homo sapiens	Q17RN3	Y2H Pooling	32814053
Intra	GTF2B	Q00403	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	GTF2B	Q00403	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	GTF2B	Q00403	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32814053
Intra	GTF2B	Q00403	RUSC1	Homo sapiens	Q9BVN2	Y2H Pooling	32814053
Intra	GTF2B	Q00403	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32814053
Intra	GTF2B	Q00403	SAP30	Homo sapiens	O75446	Validated Y2H	32814053
Intra	GTF2B	Q00403	SAP30	Homo sapiens	O75446	Y2H Array	32814053
Intra	GTF2B	Q00403	SAP30	Homo sapiens	O75446	Y2H Pooling	32814053
Intra	GTF2B	Q00403	VSX2	Homo sapiens	P58304	Validated Y2H	32814053
Intra	GTF2B	Q00403	VSX2	Homo sapiens	P58304	Y2H Array	32814053
Intra	GTF2B	Q00403	VSX2	Homo sapiens	P58304	Y2H Pooling	32814053
Intra	GTF2B	Q00403	SPATA22	Homo sapiens	Q8NHS9	Validated Y2H	32814053
Intra	GTF2B	Q00403	SPATA22	Homo sapiens	Q8NHS9	Y2H Pooling	32814053
Intra	GTF2B	Q00403	SPATA22	Homo sapiens	Q8NHS9	Y2H Array	32814053
Intra	GTF2B	Q00403	DRAP1	Homo sapiens	Q14919	Y2H Prey Pooling	32296183
Intra	GTF2B	Q00403	DRAP1	Homo sapiens	Q14919	Y2H Array	32296183
Intra	GTF2B	Q00403	DRAP1	Homo sapiens	Q14919	Validated Y2H	32296183
Intra	GTF2B	Q00403	DRAP1	Homo sapiens	Q14919	Y2H Array	25416956
Intra	GTF2B	Q00403	IK	Homo sapiens	Q13123	Validated Y2H	32814053
Intra	GTF2B	Q00403	IK	Homo sapiens	Q13123	Y2H Array	32814053
Intra	GTF2B	Q00403	IK	Homo sapiens	Q13123	Y2H Pooling	32814053
Intra	GTF2B	Q00403	BAHD1	Homo sapiens	Q8TBE0	Validated Y2H	32814053
Intra	GTF2B	Q00403	BAHD1	Homo sapiens	Q8TBE0	Y2H Pooling	32814053
Intra	GTF2B	Q00403	BAHD1	Homo sapiens	Q8TBE0	Y2H Array	32814053
Intra	GTF2B	Q00403	RNF183	Homo sapiens	Q96D59	Validated Y2H	32814053
Intra	GTF2B	Q00403	RNF183	Homo sapiens	Q96D59	Y2H Pooling	32814053
Intra	GTF2B	Q00403	RNF183	Homo sapiens	Q96D59	Y2H Array	32814053
Intra	GTF2B	Q00403	CBLB	Homo sapiens	Q13191	Validated Y2H	32814053
Intra	GTF2B	Q00403	CBLB	Homo sapiens	Q13191	Y2H Pooling	32814053
Intra	GTF2B	Q00403	CBLB	Homo sapiens	Q13191	Y2H Array	32814053
Intra	GTF2B	Q00403	RYBP	Homo sapiens	Q8N488	Y2H Array	32814053
Intra	GTF2B	Q00403	RYBP	Homo sapiens	Q8N488	Y2H Pooling	32814053
Intra	GTF2B	Q00403	RYBP	Homo sapiens	Q8N488	Validated Y2H	32814053
Intra	GTF2B	Q00403	SEM1	Homo sapiens	P60896	Y2H Pooling	32814053
Intra	GTF2B	Q00403	SEM1	Homo sapiens	P60896	Validated Y2H	32814053
Intra	GTF2B	Q00403	SEM1	Homo sapiens	P60896	Y2H Array	32814053
Intra	GTF2B	Q00403	SPPL2B	Homo sapiens	Q8TCT7-2	Validated Y2H	32814053
Intra	GTF2B	Q00403	SPPL2B	Homo sapiens	Q8TCT7-2	Y2H Array	32814053
Intra	GTF2B	Q00403	SPPL2B	Homo sapiens	Q8TCT7-2	Y2H Pooling	32814053
Intra	GTF2B	Q00403	FAM9A	Homo sapiens	Q8IZU1	Y2H Pooling	32814053
Intra	GTF2B	Q00403	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32814053
Intra	GTF2B	Q00403	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32814053
Intra	GTF2B	Q00403	MLC1	Homo sapiens	Q15049	Validated Y2H	32814053
Intra	GTF2B	Q00403	MLC1	Homo sapiens	Q15049	Y2H Array	32814053
Intra	GTF2B	Q00403	MLC1	Homo sapiens	Q15049	Y2H Pooling	32814053
Intra	GTF2B	Q00403	TIMM44	Homo sapiens	O43615	Y2H Pooling	32814053
Intra	GTF2B	Q00403	TIMM44	Homo sapiens	O43615	Validated Y2H	32814053
Intra	GTF2B	Q00403	TIMM44	Homo sapiens	O43615	Y2H Array	32814053
Intra	GTF2B	Q00403	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	GTF2B	Q00403	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	GTF2B	Q00403	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053
Cross	GTF2B	Q00403	GRF4	Arabidopsis thaliana	P46077	Pull Down	10449590

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GTF2B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71357	TFIIB Protein, Human (GST)	Q00403 (M1-L316)	≥95%

Related Diseases

Diseases

Alias

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05894	GTF2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GTF2B	VGNC	VGNC:67493
Mus musculus	GTF2B	MGD	MGI:2385191
Bos taurus	GTF2B	VGNC	VGNC:29693
Rattus norvegicus	GTF2B	RGD	RGD:619735
Macaca mulatta	GTF2B	VGNC	VGNC:73306
Canis familiaris	GTF2B	VGNC	VGNC:41543
Others	GTF2B	NCBI

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