Btk - Bruton tyrosine kinase Gene

Rattus norvegicus

Gene ID: 367901 | Gene type: protein coding

About Btk

Primary_assembly X: 97,722,802-97,761,853 reverse strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 36 phenotypes. Biased expression in Spleen (RPKM 217.2), Thymus (RPKM 46.2) and 3 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including cellular response to molecule of Fungal origin; histamine secretion by mast cell; and positive regulation of hypersensitivity. Located in perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human Btk (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Btk Products(1)

mRNA	Protein	Name
NM_001007798.2	NP_001007799.2	tyrosine-protein kinase BTK

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7696342	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to molecule of fungal origin	IDA IDA: Inferred from direct assay	10744701	RGD
involved in cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	10744701	RGD
involved in eosinophil homeostasis	IMP IMP: Inferred from mutant phenotype	32484067	RGD
involved in histamine secretion by mast cell	IMP IMP: Inferred from mutant phenotype	12220673	RGD
involved in monocyte proliferation	IMP IMP: Inferred from mutant phenotype	32484067	RGD
involved in negative regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	25545336	RGD
involved in negative regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	28352114	RGD
involved in negative regulation of leukocyte proliferation	IMP IMP: Inferred from mutant phenotype	32484067	RGD
involved in neutrophil homeostasis	IMP IMP: Inferred from mutant phenotype	32484067	RGD
involved in peptidyl-tyrosine autophosphorylation	IMP IMP: Inferred from mutant phenotype	21521773	RGD
involved in positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	28352114	RGD
involved in positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	28352114	RGD
involved in positive regulation of interleukin-17A production	IMP IMP: Inferred from mutant phenotype	28352114	RGD
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	28352114	RGD
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	28352114	RGD
involved in positive regulation of synoviocyte proliferation	IMP IMP: Inferred from mutant phenotype	28352114	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	28352114	RGD
involved in positive regulation of type I hypersensitivity	IMP IMP: Inferred from mutant phenotype	22228807	RGD
involved in positive regulation of type III hypersensitivity	IMP IMP: Inferred from mutant phenotype	22228807	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7696342	RGD
involved in proteoglycan catabolic process	IMP IMP: Inferred from mutant phenotype	32083858	RGD
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	28352114	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12220673	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Btk Protein Structure

PH_Btk

SH3_BTK

SH2_Tec_Btk

PTKc_Btk_Bmx

0
200
400
600
661 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase BTK

Bruton agammaglobulinemia tyrosine kinase

Related Agents

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10997	Ibrutinib	Inhibitor	99.97%	Yes
HY-17600	Acalabrutinib	Inhibitor	99.88%	Yes
HY-101474A	Zanubrutinib	Inhibitor	99.71%	Yes
HY-129390	Orelabrutinib	Inhibitor	99.97%	Yes
HY-15771	Tirabrutinib	Inhibitor	99.71%	Yes
HY-10997A	Ibrutinib Racemate	Inhibitor	95.13%	Unkown
HY-15771A	Tirabrutinib hydrochloride	Inhibitor	99.43%	Yes
HY-101474AR	Zanubrutinib (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Phase
HY-131328	Pirtobrutinib	Inhibitor	99.88%	Phase 3
HY-19834	Fenebrutinib	Inhibitor	99.42%	Phase 3
HY-128757	Remibrutinib	Inhibitor	99.76%	Phase 3
HY-109192	Tolebrutinib	Inhibitor	99.79%	Phase 3
HY-112166	Rilzabrutinib	Inhibitor	99.37%	Phase 3
HY-132842	Sunvozertinib	Inhibitor	99.71%	Phase 3
HY-19816	Avitinib	Inhibitor	99.95%	Phase 3
HY-19816A	Avitinib maleate	Inhibitor	99.86%	Phase 3
HY-112215	Nemtabrutinib	Inhibitor	98.64%	Phase 2
HY-18012	Spebrutinib	Inhibitor	99.22%	Phase 2
HY-101215	Evobrutinib	Inhibitor	99.60%	Phase 2
HY-112161	Branebrutinib	Inhibitor	99.82%	Phase 2
HY-109078	Vecabrutinib	Inhibitor	99.76%	Phase 2
HY-109010	Poseltinib	Inhibitor	98.08%	Phase 2
HY-101856	BMS-986142	Inhibitor	99.38%	Phase 2
HY-18012A	Spebrutinib besylate	Inhibitor	/	Phase 2
HY-153220	NX-2127	Inhibitor	99.72%	Phase 1
HY-153321	NX-5948	Degrader	99.33%	Phase 1
HY-139535	Luxeptinib	Inhibitor	99.30%	Phase 1
HY-139984	BIIB091	Inhibitor	99.85%	Phase 1
HY-132879	TAK-020	Inhibitor	99.93%	Phase 1

Pre-clinical Phase

Bioactive Molecules (163)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100342	Ibrutinib-biotin	Inhibitor	99.93%	Unkown
HY-80003	QL47	Inhibitor	98.11%	Unkown
HY-11999	CGI-1746	Inhibitor	99.39%	Unkown
HY-122562	MT-802	Inhibitor	98.94%	Unkown
HY-18009	(Z)-LFM-A13	Inhibitor	99.80%	Unkown
HY-80002	BMX-IN-1	Inhibitor	99.04%	Unkown
HY-133137	SJF620	Inhibitor	98.98%	Unkown
HY-P5438	Srctide	Substrate	99.93%	Unkown
HY-101474	(±)-Zanubrutinib	Inhibitor	99.70%	Unkown
HY-109143	Elsubrutinib	Inhibitor	≥98.0%	Unkown
HY-139481	TL-895	Inhibitor	99.86%	Unkown
HY-108691	PF-06465469	Inhibitor	99.48%	Unkown
HY-13943	CNX-774	Inhibitor	99.92%	Unkown
HY-100335	PCI-33380	Inhibitor	≥98.0%	Unkown
HY-43521	Ibrutinib-MPEA		99.71%	Unkown
HY-144288	BLK-IN-2	Inhibitor	98.72%	Unkown
HY-18010	PCI 29732	Inhibitor	99.86%	Unkown
HY-153803	GBD-9	Inhibitor	99.76%	Unkown
HY-130983	N-piperidine Ibrutinib hydrochloride	Inhibitor	98.06%	Unkown
HY-100338	CNX-500	Inhibitor	99.88%	Unkown
HY-18018	RN486	Inhibitor	99.87%	Unkown
HY-153357	NRX-0492	Degrader	98.16%	Unkown
HY-18951	ONO-4059 analog	Inhibitor	99.54%	Unkown
HY-160141	Catadegbrutinib	Inhibitor	97.79%	Unkown
HY-15805	KIN-8194	Inhibitor	98.01%	Unkown
HY-101941	BTK IN-1	Inhibitor	98.01%	Unkown
HY-15427	GDC-0834	Inhibitor	98.05%	Unkown
HY-13036A	IBT6A	Inhibitor	99.43%	Unkown
HY-150023	BI-1622	Inhibitor	98.97%	Unkown
HY-153110A	Larotinib mesylate hydrate	Inhibitor	98.66%	Unkown
HY-78727	Ibrutinib deacryloylpiperidine	Inhibitor	99.97%	Unkown
HY-124645	QL-X-138	Inhibitor	99.77%	Unkown
HY-131342	BIIB068	Inhibitor	99.69%	Unkown
HY-122830	DD-03-171	Degrader	98.72%	Unkown
HY-101474B	(R)-Zanubrutinib		98.97%	Unkown
HY-135334	ACP-5862	Inhibitor	98.41%	Unkown
HY-17600S	Acalabrutinib-d4	Inhibitor	99.50%	Unkown
HY-132808	Atuzabrutinib	Inhibitor	98.01%	Unkown
HY-147943	PROTAC BTK Degrader-1		98.87%	Unkown
HY-163565	BIIB129	Inhibitor	99.54%	Unkown
HY-10997S	Ibrutinib-d5	Inhibitor	98.08%	Unkown
HY-101766	Btk inhibitor 2	Inhibitor	99.57%	Unkown
HY-101793	BMS-935177	Inhibitor	99.11%	Unkown
HY-100659	Dihydrodiol-Ibrutinib	Inhibitor	99.92%	Unkown
HY-101474S	Zanubrutinib-d5	Inhibitor	≥99.0%	Unkown
HY-160246A	QL47B TFA	Inhibitor	/	Unkown
HY-15427A	GDC-0834 Racemate		98.04%	Unkown
HY-15427B	GDC-0834 (S-enantiomer)		98.03%	Unkown
HY-136531	XMU-MP-3	Inhibitor	98.27%	Unkown
HY-125997	BTK inhibitor 10	Inhibitor	99.66%	Unkown
HY-153220A	(R)-NX-2127	Degrader	/	Unkown
HY-133137A	SJF620 hydrochloride	Inhibitor	99.28%	Unkown
HY-153110	Larotinib	Inhibitor	99.50%	Unkown
HY-132842A	(S)-Sunvozertinib	Inhibitor	99.14%	Unkown
HY-153245	JNJ-64264681	Inhibitor	98.14%	Unkown
HY-137438	Edralbrutinib	Inhibitor	99.75%	Unkown
HY-131705	BTK inhibitor 17	Inhibitor	99.53%	Unkown
HY-149051	BGB-8035	Inhibitor	99.00%	Unkown
HY-131328A	(R)-Pirtobrutinib		99.78%	Unkown
HY-110002	LFM-A13	Inhibitor	99.65%	Unkown
HY-101522	CHMFL-EGFR-202	Inhibitor	99.75%	Unkown
HY-163962	L18I		/	Unkown
HY-160246	QL47B	Inhibitor	/	Unkown
HY-110013	Terreic acid	Inhibitor	/	Unkown
HY-109143B	(R)-Elsubrutinib	Inhibitor	≥98.0%	Unkown
HY-160245	QL47R		99.94%	Unkown
HY-13036B	IBT6A hydrochloride	Inhibitor	99.72%	Unkown
HY-13036	(Rac)-IBT6A	Inhibitor	98.18%	Unkown
HY-130255	BTK inhibitor 13	Inhibitor	/	Unkown
HY-157763	PROTAC BTK Degrader-8	Degrader	/	Unkown
HY-151808	JS25	Inhibitor	98.37%	Unkown
HY-156746	DBt-10	Degrader	/	Unkown
HY-115876	BTK-IN-5	Inhibitor	/	Unkown
HY-132196	BTK inhibitor 18	Inhibitor	/	Unkown
HY-145373	BMS-986143	Inhibitor	/	Unkown
HY-101521	CHMFL-BTK-01	Inhibitor	/	Unkown
HY-102036	G-744	Inhibitor	/	Unkown
HY-117900	PF-06250112	Inhibitor	/	Unkown
HY-156604	Cinsebrutinib	Inhibitor	/	Unkown
HY-149391	PROTAC BTK Degrader-6	Degrader	/	Unkown
HY-147784	HZ-A-005	Inhibitor	/	Unkown
HY-143716	JAK3/BTK-IN-1	Inhibitor	/	Unkown
HY-163827	ABBV-992	Inhibitor	/	Unkown
HY-143717	JAK3/BTK-IN-2	Inhibitor	/	Unkown
HY-153536	PROTAC BTK Degrader-3	Inhibitor	/	Unkown
HY-143900	BTK-IN-7	Inhibitor	/	Unkown
HY-151920	BTK-IN-17	Inhibitor	/	Unkown
HY-143718	JAK3/BTK-IN-3	Inhibitor	/	Unkown
HY-162280	PROTAC BTK Degrader-9	Degrader	/	Unkown
HY-162407	I-As-1	Inhibitor	/	Unkown
HY-147584	BTK-IN-14	Inhibitor	/	Unkown
HY-163183	JAK3/BTK-IN-7	Inhibitor	/	Unkown
HY-123117	VA5	Inhibitor	/	Unkown
HY-143719	JAK3/BTK-IN-4	Inhibitor	/	Unkown
HY-147580	BTK-IN-10	Inhibitor	/	Unkown
HY-152212	BTK-IN-19	Inhibitor	/	Unkown
HY-157159	BTK-IN-28	Inhibitor	/	Unkown
HY-170413	PROTAC BTK Degrader-12	Degrader	/	Unkown
HY-147741	DPPY	Inhibitor	/	Unkown
HY-151961	RSH-7	Inhibitor	99.07%	Unkown
HY-122828	PROTAC BTK Degrader-2	Degrader	/	Unkown
HY-169228	WS-11	Inhibitor	/	Unkown
HY-143901	EGFR-IN-40	Inhibitor	/	Unkown
HY-148585	BTK-IN-22	Inhibitor	/	Unkown
HY-147754	JAK3/BTK-IN-6	Inhibitor	/	Unkown
HY-139881	BTK inhibitor 19	Inhibitor	/	Unkown
HY-147581	BTK-IN-11	Inhibitor	/	Unkown
HY-164002	PF-303	Inhibitor	/	Unkown
HY-153951S	BTK-IN-26	Inhibitor	/	Unkown
HY-168427	Avitinib maleate dihydrate	Inhibitor	/	Unkown
HY-117900A	(Rac)-PF-06250112		/	Unkown
HY-142621	BCPyr	Inhibitor	/	Unkown
HY-101474BS	(R)-Zanubrutinib-d5		/	Unkown
HY-115944	BTK-IN-9	Inhibitor	/	Unkown
HY-148832	BTK-IN-20	Inhibitor	/	Unkown
HY-169307	BTK-IN-38	Inhibitor	/	Unkown
HY-156743	DCAF1 binder 2	Degrader	/	Unkown
HY-124153	GNE-431	Inhibitor	/	Unkown
HY-156969	Topoisomerase I inhibitor 11		/	Unkown
HY-158064	BTK-IN-36	Inhibitor	/	Unkown
HY-150885	BTK ligand 1	Degrader	/	Unkown
HY-144283	BLK-IN-1	Inhibitor	/	Unkown
HY-110113	CTA056	Inhibitor	/	Unkown
HY-161876	GSTO1-IN-2	Inhibitor	/	Unkown
HY-143720	JAK3/BTK-IN-5	Inhibitor	/	Unkown
HY-168302	BTK ligand 10		/	Unkown
HY-163295	BTK degrader-1	Degrader	/	Unkown
HY-159947	PROTAC BTK Degrader-11	Degrader	/	Unkown
HY-155072	PROTAC BTK Degrader-5	Degrader	/	Unkown
HY-136113	Ibrutinib dimer	Inhibitor	/	Unkown
HY-147582	BTK-IN-12	Inhibitor	/	Unkown
HY-151211	BTK-IN-16	Inhibitor	/	Unkown
HY-154860	PTD10	Degrader	/	Unkown
HY-150752	BTK-IN-15	Inhibitor	/	Unkown
HY-171131	BTK-IN-41	Inhibitor	/	Unkown
HY-141689	BTK-IN-3	Inhibitor	/	Unkown
HY-160167	Birelentinib	Inhibitor	/	Unkown
HY-W062695	(R)-Acalabrutinib	Inhibitor	/	Unkown
HY-153705	BTK-IN-25	Inhibitor	/	Unkown
HY-160966	PROTAC BTK Degrader-10	Degrader	/	Unkown
HY-111781	Civorebrutinib	Inhibitor	/	Unkown
HY-170324	BTK-IN-40	Inhibitor	/	Unkown
HY-100659S	Dihydrodiol-Ibrutinib-d5	Inhibitor	/	Unkown
HY-162081	BTK-IN-32	Inhibitor	/	Unkown
HY-156745	DDa-1	Degrader	/	Unkown
HY-135334S	ACP-5862-d4	Inhibitor	/	Unkown
HY-143730	BTK inhibitor 20	Inhibitor	/	Unkown
HY-P10609	Btk substrate peptide		/	Unkown
HY-156553	BTK-IN-27	Inhibitor	/	Unkown
HY-152201	BTK-IN-18	Inhibitor	/	Unkown
HY-160219S	BTK-IN-33	Inhibitor	/	Unkown
HY-142932	BTK-IN-6	Inhibitor	/	Unkown
HY-162257	BTK-IN-34	Inhibitor	/	Unkown
HY-144170	RET-IN-14	Inhibitor	/	Unkown
HY-159589	BTK-IN-37	Inhibitor	/	Unkown
HY-145884	BTK-IN-8	Inhibitor	/	Unkown
HY-148594	BTK-IN-23	Inhibitor	/	Unkown
HY-160142	UBX-382	Degrader	96.20%	Unkown
HY-160168	BTK-IN-31	Inhibitor	/	Unkown
HY-18016	CGI 560	Inhibitor	/	Unkown
HY-168292	BTK ligand 9		/	Unkown
HY-13036C	(Rac)-IBT6A hydrochloride	Inhibitor	/	Unkown
HY-128403	BTK inhibitor 8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Btk	NCBI	NCBI:695

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