2. Gene
  3. KPNA2 - karyopherin subunit alpha 2 Gene

KPNA2 - karyopherin subunit alpha 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as QIP2; RCH1; IPOA1; PTAC58; SRP1alpha; SRP1-alpha

Gene ID: 3838 | Gene type: protein coding

About KPNA2

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:68,035,735-68,046,854 (from NCBI)

This gene has 21 transcripts (splice variants), 131 orthologues and 6 paralogues. Broad expression in testis (RPKM 102.8), bone marrow (RPKM 35.5) and 20 other tissues.

Summary

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic Amino acids or 2 such regions spaced about 10 Amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

KPNA2 Products(2)

mRNA Protein Name
NM_001320611.2 NP_001307540.1 importin subunit alpha-1
NM_002266.4 NP_002257.1 importin subunit alpha-1

KPNA2 Protein Structure

IBB

IBB: Importin beta binding domain (6 - 99)

Arm

Arm: Armadillo/beta-catenin-like repeat (109 - 149)

Arm

Arm: Armadillo/beta-catenin-like repeat (151 - 190)

Arm

Arm: Armadillo/beta-catenin-like repeat (196 - 238)

Arm

Arm: Armadillo/beta-catenin-like repeat (249 - 280)

Arm

Arm: Armadillo/beta-catenin-like repeat (284 - 321)

Arm

Arm: Armadillo/beta-catenin-like repeat (324 - 364)

Arm

Arm: Armadillo/beta-catenin-like repeat (367 - 405)

Arm

Arm: Armadillo/beta-catenin-like repeat (410 - 447)

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  • 500
  • 529 a.a.
Protein Preferred Names Protein Names

importin subunit alpha-1

RAG cohort protein 1

Recombinant KPNA2 Proteins

Cat. No. Product Name Accession Purity
HY-P70371 Importin alpha-1/KPNA2 Protein, Human (His) P52292 (M1-F529) ≥95%

Related Diseases

Diseases Alias
Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
Nijmegen Breakage Syndrome

Berlin Breakage Syndrome

NBS

Microcephaly, Normal Intelligence And Immunodeficiency

Ataxia-Telangiectasia Variant

Ataxia-Telangiectasia Variant V1

Seemanova Syndrome Ii

Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome

Seemanova Syndrome Type 2

At-V1

Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies

Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence

Immunodeficiency, Microcephaly, And Chromosomal Instability

Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome

Microcephaly Immunodeficiency Lymphoreticuloma

Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies

Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence

Seemanova Syndrome 2

Ataxia-Telangiectasia Variant 1

Seemanova Syndrome

At V1

Ataxia-Telangiectasia, Variant 1

Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome

V-At

Ataxia Telangiectasia Variant V1
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Ovarian Endodermal Sinus Tumor

Endodermal Sinus Tumor Of Ovary

Ovarian Yolk Sac Tumor

Endodermal Sinus Tumour Of Ovary

Ovarian Endodermal Sinus Tumour

Ovarian Yolk Sac Tumour
Ovarian Primitive Germ Cell Tumor
Ovarian Dysgenesis 2

Premature Ovarian Failure 4

ODG2

Ovarian Dysgenesis, Hypergonadotropic, X-Linked

Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

X-Linked Hypergonadotropic Ovarian Dysgenesis

POF4

Dysgenesis, Ovarian, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07416 KPNA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KPNA2 VGNC VGNC:97476
Bos taurus KPNA2 VGNC VGNC:30701
Rattus norvegicus KPNA2 RGD RGD:621419
Mus musculus KPNA2 MGD MGI:103561
Others KPNA2 NCBI