GOLM1 - golgi membrane protein 1 Gene

Homo sapiens

Also known as GP73; HEL46; GOLPH2; C9orf155; PSEC0257; bA379P1.3

Gene ID: 51280 | Gene type: protein coding

About GOLM1

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:86,026,146-86,100,149 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues and 1 paralogue. Broad expression in stomach (RPKM 210.4), colon (RPKM 117.5) and 14 other tissues.

Summary

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral Infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]

GOLM1 Products(2)

mRNA	Protein	Name
NM_016548.4	NP_057632.2	Golgi membrane protein 1
NM_177937.3	NP_808800.1	Golgi membrane protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21280149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Golgi membrane protein 1

epididymis luminal protein 46

GOLM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GOLM1	Q8NBJ4	SLC30A3	Homo sapiens	Q99726	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	SLC35B2	Homo sapiens	Q8TB61	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMEM109	Homo sapiens	Q9BVC6	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMUB1	Homo sapiens	Q9BVT8	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	CLDND2	Homo sapiens	Q8NHS1	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	SLC5A4	Homo sapiens	Q9NY91	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	ST6GAL2	Homo sapiens	Q96JF0-2	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	SLCO3A1	Homo sapiens	Q9UIG8-2	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	GOLM1	Q8NBJ4	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	GOLM1	Q8NBJ4	TMEM176A	Homo sapiens	Q96HP8	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	NINJ1	Homo sapiens	Q92982	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	CNPY3	Homo sapiens	Q9BT09	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Anti Bait CoIP	27569582
Intra	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27569582
Intra	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Confocal	27569582
Intra	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Pull Down	27569582
Intra	GOLM1	Q8NBJ4	THSD7A	Homo sapiens	Q9UPZ6	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	FUT9	Homo sapiens	Q9Y231	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	NDUFV2	Homo sapiens	P19404	Y2H Prey Pooling	32296183
Intra	GOLM1	Q8NBJ4	NDUFV2	Homo sapiens	P19404	Y2H Array	32296183
Intra	GOLM1	Q8NBJ4	NEU1	Homo sapiens	Q99519	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	TMEM98	Homo sapiens	Q9Y2Y6	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	GOLM1	Q8NBJ4	INSIG2	Homo sapiens	Q9Y5U4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GOLM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70879	GOLM1 Protein, Human (HEK293, His)	Q8NBJ4-1 (S36-L401)	≥95%
HY-P72209	GOLM1 Protein, Human (His)	Q8NBJ4-1 (S36-L401)	≥95%
HY-P72209A	GOLM1 Protein, Human (His, Solution)	Q8NBJ4-1 (S36-L401)	≥95%

GOLM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83002	GOLPH2 Antibody (YA2747)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Autoimmune Hepatitis

Aih	Hepatitis, Autoimmune
Autoimmune Chronic Active Hepatitis	Autoimmune Hepatitis With Centrilobular Necrosis
Autoimmune Chronic Hepatitis	Hepatitis Autoimmune

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Wilson Disease

Hepatolenticular Degeneration	WD
Wilson'S Disease	WND
Westphal-Strumpell Syndrome	Copper Storage Disease
Cerebral Pseudosclerosis	Westphal Pseudosclerosis
Hepatolenticular Degeneration Syndrome	Copper Retention
Hepatocerebral Degeneration	Kinnier-Wilson Disease
Neurohepatic Degeneration	Progressive Hepatolenticular Degeneration
Lenticular Degenerative Disease	Wilson'S Syndrome
Lenticular Syndrome

Spinocerebellar Ataxia 44

SCA44

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05592	GOLM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990421	Anti-GOLM1 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GOLM1	VGNC	VGNC:41345
Mus musculus	GOLM1	MGD	MGI:1917329
Rattus norvegicus	GOLM1	RGD	RGD:1589384
Macaca mulatta	GOLM1	VGNC	VGNC:72946
Felis catus	GOLM1	VGNC	VGNC:62643
Bos taurus	GOLM1	VGNC	VGNC:29491
Others	GOLM1	NCBI

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