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Results for "

α-glucosidase activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amylases (11) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (3) Apoptosis (10) Bacterial (8) Carbonic Anhydrase (1) COX (2) Dipeptidyl Peptidase (2) DNA/RNA Synthesis (2) Endogenous Metabolite (8) Fluorescent Dye (1) Fungal (3) Glutathione Peroxidase (1) Glycosidase (81) HBV (2) HDAC (1) HIV (2) HMG-CoA Reductase (HMGCR) (1) Influenza Virus (2) Interleukin Related (2) Lipoxygenase (2) Opioid Receptor (2) Parasite (2) Phosphatase (3) PKC (1) PPAR (4) Reactive Oxygen Species (1) TNF Receptor (2) Tyrosinase (1) α-synuclein (2)
By Research Areas:	Cancer (18) Cardiovascular Disease (3) Endocrinology (3) Infection (25) Inflammation/Immunology (15) Metabolic Disease (63) Neurological Disease (3)

By Targets:

Amylases (11)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (3)

Apoptosis (10)

Bacterial (8)

Carbonic Anhydrase (1)

COX (2)

Dipeptidyl Peptidase (2)

DNA/RNA Synthesis (2)

Endogenous Metabolite (8)

Fluorescent Dye (1)

Fungal (3)

Glutathione Peroxidase (1)

Glycosidase (81)

HBV (2)

HDAC (1)

HIV (2)

HMG-CoA Reductase (HMGCR) (1)

Influenza Virus (2)

Interleukin Related (2)

Lipoxygenase (2)

Opioid Receptor (2)

Parasite (2)

Phosphatase (3)

PKC (1)

PPAR (4)

Reactive Oxygen Species (1)

TNF Receptor (2)

Tyrosinase (1)

α-synuclein (2)

By Research Areas:

Cancer (18)

Cardiovascular Disease (3)

Endocrinology (3)

Infection (25)

Inflammation/Immunology (15)

Metabolic Disease (63)

Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10413

Diphlorethohydroxycarmalol	Glycosidase	Metabolic Disease
Diphlorethohydroxycarmalol, a kind of phlorotannin, is an orally active *α-glucosidase* and α-amylase inhibitor with IC₅₀s of 0.16 mM and 0.53 mM, respectively. Diphlorethohydroxycarmalol has anti-diabetic activities .

HY-W011411

4-Nitrophenyl a-D-glucopyranoside	Glycosidase	Others
4-Nitrophenyl a-D-glucopyranoside is a chromogenic substrate for α-glucosidase. 4-Nitrophenyl a-D-glucopyranoside can be used to measure of α-glucosidase activity .

HY-155241

α-Amylase/α-Glucosidase-IN-4	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

HY-N10294

Epicoccone B	HIV	Infection Inflammation/Immunology
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC₅₀ value of 10.8 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 27.3 μM. Anti-HIV activity .

HY-N13188

2'-Rhamnoechinacoside Michelioside A	Glycosidase	Cancer
2'-Rhamnoechinacoside (Michelioside A), a compound of phenylethanoid glycosides, is a *α-glucosidase* inhibitor with anti-tumor activity, which is derived from Phlomis stewartii. 2'-Rhamnoechinacoside can be used for research of UV-absorbing and cancers .

HY-156078

α-Glucosidase-IN-32	Glycosidase	Metabolic Disease
α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive and orally active α-glucosidase inhibitor with an IC₅₀ value of 3.07 μM. α-Glucosidase-IN-32 complex with α-glucosidase through hydrogen bonds and hydrophobic interactions, led to changes in the conformation and secondary strictures of α-glucosidase and further the inhibition of the enzymatic activity. α-Glucosidase-IN-32 can be used for diabetic disease research .

HY-149579

α-Glucosidase-IN-36	Glycosidase	Metabolic Disease
α-Glucosidase-IN-36 (compound 5g) is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 6.69 ± 0.18 μM, K_i and K_is of 1.65 μM and 4.54 μM, respectively. α-Glucosidase-IN-36 may inhibit α-glucosidase activity by binding with its active site as well as changing the secondary structure of α-glucosidase. α-Glucosidase-IN-36 can be used for type 2 diabetes mellitus (T2DM) research .

HY-151142

α-Glucosidase-IN-18	Glycosidase	Metabolic Disease
α-Glucosidase-IN-18 (7B) is an orally active *α-glucosidase* inhibitor with an IC₅₀ value of 3.96 μM. α-Glucosidase-IN-18 has antidiabetic activity .

HY-151141

α-Glucosidase-IN-17	Glycosidase	Metabolic Disease
α-Glucosidase-IN-17 (Compound 12B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.79 μM. α-Glucosidase-IN-17 shows antidiabetic activity .

HY-151135

α-Glucosidase-IN-15	Glycosidase	Metabolic Disease
α-Glucosidase-IN-15 (Compound 14B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.34 μM. α-Glucosidase-IN-15 shows antidiabetic activity .

HY-151145

α-Glucosidase-IN-21	Glycosidase	Metabolic Disease
α-Glucosidase-IN-21 (Compound 2B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 2.62 μM. α-Glucosidase-IN-21 shows anti-diabetic activity .

HY-151143

α-Glucosidase-IN-19	Glycosidase	Metabolic Disease
α-Glucosidase-IN-19 (Compound 6B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.63 μM. α-Glucosidase-IN-19 shows anti-diabetic activity .

HY-151144

α-Glucosidase-IN-20	Glycosidase	Metabolic Disease
α-Glucosidase-IN-20 (Compound 3B) is a potent, orally active *α-glucosidase* inhibitor with an IC₅₀ of 3.01 μM. α-Glucosidase-IN-20 shows anti-diabetic activity .

HY-N12689

α-Glucosidase-IN-56	Glycosidase	Metabolic Disease
α-Glucosidase-IN-56 (compound 1) is an orally active, potent *α‐glucosidase* inhibitor with an IC₅₀ value of 45.86 μM. α-Glucosidase-IN-56 has potent anti-glycation activities .

HY-161522

α-Glucosidase-IN-63	Glycosidase Carbonic Anhydrase	Endocrinology
α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of *α-Glucosidase* (IC₅₀=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of K_i= 7.0 nM. α-Glucosidase-IN-63 is orally effective. .

HY-163066

α-Glucosidase-IN-44	Glycosidase	Metabolic Disease
α-Glucosidase-IN-44 (compound IT4) is an inhibitor of *α-glucosidase* with IC₅₀ value of 2.35 μM. α-Glucosidase-IN-44 has an oral activity. α-Glucosidase-IN-44 suppresses fasting blood glucose levels in diabetic mice .

HY-N12347

α-Glucosidase-IN-37	Others	Inflammation/Immunology
α-Glucosidase-IN-37 (Compound 11) moderately inhibits LPS-induced NO production with an IC₅₀ value of 23.7 μM in macrophages. α-Glucosidase-IN-37 has weak inhibitory activity against α-Glucosidase .

HY-N15138

Sativanone	Glycosidase	Infection Metabolic Disease Inflammation/Immunology
Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent *α-glucosidase* inhibitor, with an EC₅₀ of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects .

HY-149668

α-Glucosidase-IN-41	Glycosidase	Metabolic Disease
α-Glucosidase-IN-41 (compound 5o) is a potent *α-glucosidase* inhibitor. α-Glucosidase-IN-41 can arise the changed secondary structure of α-Glu to hinder enzyme catalytic activity. α-Glucosidase-IN-41 can be used for diabetes mellitus research .

HY-149676

α-Glucosidase-IN-42	Glycosidase	Metabolic Disease
α-Glucosidase-IN-42 (Compound 26) is a 9-O-berberrubine carboxylate derivative. α-Glucosidase-IN-42 has potent α-glucosidase inhibitory activities with an IC₅₀ value in the range of 1.61 μM. α-Glucosidase-IN-42 can be used for the research of antidiabetic .

HY-165100

1,3-Dipalmitoleoyl glycerol DG(16:1/0:0/16:1); 1,3-Dipalmitolein	Glycosidase	Others
1,3-Dipalmitoleoyl glycerol (DG(16:1/0:0/16:1)) is a compound isolated from sea cucumber viscera, which has α-glucosidase inhibitory activity and has different degrees of inhibitory effects on α-glucosidase from different sources.

HY-151138

α-Glucosidase-IN-16	Glycosidase	Metabolic Disease
α-Glucosidase-IN-16 is a potent and orally active *α-glucosidase* inhibitor with an IC₅₀ value of 3.28 μM. α-Glucosidase-IN-16 can reduce the level of blood glucose in Streptozotocin-induced diabetic rats. Antidiabetic activity .

HY-149409

α-Glucosidase-IN-31	Glycosidase	Metabolic Disease
α-Glucosidase-IN-31 (compound R1) is an orally active, potent *α-Glucosidase* inhibitor with an IC₅₀ value of 10.1 μM. α-Glucosidase-IN-31 significantly reduces the blood glucose level and has antidiabetic activity .

HY-169117

α-Glucosidase-IN-74	Glycosidase	Metabolic Disease
α-Glucosidase-IN-74 (Compound 7d), an isatin-thiazole derivative, is a *α-glucosidase* inhibitor. α-Glucosidase-IN-74 exhibits antidiabetic activity by decreasing glycaemia and triglyceride levels in Streptozotocin (HY-13753)-induced diabetic animals .

HY-N4258

Panasenoside	Glycosidase	Metabolic Disease
Panasenoside is a flavonoid isolated from Lilium pumilum DC. Panasenoside exhibits *α-glucosidase* inhibitory activity .

HY-W009417

Cedryl acetate	Glycosidase	Metabolic Disease
Cedryl acetate is a tricyclic sesquiterpene isolated from the plant Cunninghamia lanceolata. Cedryl acetate shows α-glucosidase inhibitory activity .

HY-N12761

Penpaxilloids A	Phosphatase Glycosidase	Metabolic Disease Inflammation/Immunology
Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity .

HY-149557

α-Amylase/α-Glucosidase-IN-5	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-5 (compound 4l) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 5.96 μM and 1.62 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

HY-156380

α-Amylase/α-Glucosidase-IN-6	Amylases Glycosidase	Metabolic Disease
α-Amylase/α-Glucosidase-IN-6 (compound 5j) is a potent dual inhibitor of α-amylase and *α-glucosidase, with IC₅₀s of 17.0 and 40.1 µM, respectively. α-Amylase/α-Glucosidase-IN-6 exhibits anti-hyperglycemic activities* .

HY-168185

α-glucosidase/PTP1B-IN-1	Glycosidase Phosphatase Amylases	Metabolic Disease
α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent *α-glucosidase* and PTP1B inhibitor with an IC₅₀ value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against α-amylase with an IC₅₀ of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus .

HY-132179

Fucoidan 2 Publications Verification	Glycosidase	Cardiovascular Disease Metabolic Disease Cancer
Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities .

HY-N13137

Timosaponin N	Glycosidase	Metabolic Disease
Timosaponin N is a natural steroidal saponin that inhibits the activity of *α-Glucosidase*. Timosaponin N can be used in diabetes-related research .

HY-162169

α-Amylase/α-Glucosidase-IN-8	Amylases Glycosidase	Metabolic Disease
α-Amylase/α-Glucosidase-IN-8 (Compound 7p) is a potent dual inhibitor of α-amylase and *α-glucosidase, with IC₅₀s* of 10.19 and 10.33 μM, respectively. α-Amylase/α-Glucosidase-IN-8 has good anti-oxidant activity(IC₅₀ = 14.93 μM). α-Amylase/α-Glucosidase-IN-8 can be used for the research of diabetes .

HY-N9317

Tangshenoside I	Glycosidase	Metabolic Disease
Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC₅₀ of 1.4 mM .

HY-163005

α-Glucosidase-IN-43	Glycosidase	Metabolic Disease
α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor (IC₅₀: 4.32 μM) with acute hypoglycemic activity. *α-Glucosidase*-IN-43 exhibits safety and in vivo efficacy, is nontoxic to normal mouse fibroblasts, and is able to rescue streptozotocin (HY-13753)-induced diabetic rats. α-Glucosidase-IN-43 can be used to study postprandial hyperglycemia in diabetic patients .

HY-162390

α-Amylase/α-Glucosidase-IN-11	Amylases Glycosidase	Endocrinology
α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is a isoxazolidine-isatin hybrid with significant antidiabetic activity. α-Amylase/α-Glucosidase-IN-11 competitively inhibits α-amylase (IC₅₀ = 30.39 μM) and *α-glucosidase* (IC₅₀ = 65.1 μM), two key digestive enzymes. α-Amylase/α-Glucosidase-IN-11 does not cross the blood-brain barrier .

HY-119821

Terphenyllin	Glycosidase	Infection
Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has signiﬁcant *α-glucosidase* inhibitory activity .

HY-N1820

3α-Akebonoic acid	Bacterial Glycosidase	Infection Metabolic Disease
3α-Akebonoic acid is a *α-glucosidase* inhibitor with an IC₅₀ value of 0.035 mM. 3α-Akebonoic acid shows antibacterial activity and cytotoxicity .

HY-N7203

N-Caffeoyl O-methyltyramine	Glycosidase	Metabolic Disease
N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against *α-glucosidase* (IC₅₀ of 103.58 μM) .

HY-N8018

Leucosceptoside A	PKC Glycosidase Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Neurological Disease Metabolic Disease
Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against *α-glucosidase* and PKCα (IC₅₀ of 19.0 μM) .

HY-121811

Pongamol Lanceolatin C	Glycosidase	Metabolic Disease Inflammation/Immunology
Pongamol (Lanceolatin C) is potent *α-glucosidase* inhibitor (IC₅₀=103.5 μM) and has free-radical (DPPH) scavenging,antihyperglycemic, and antihyperglycemic activities .

HY-N10969

(+)-5,7,4'-Trimethoxyafzelechin	Others	Others
(+)-5,7,4'-Trimethoxyafzelechin is a derivative of (+)-Afzelechin HY-N2821. (+)-Afzelechin is an *α-glucosidase* activity inhibitor. (+)-Afzelechin can be isolated from rhizomes of Bergenia ligulata .

HY-N2809

Acantrifoside E	Others	Others
Acantrifoside E (Compound 8) is a nature compound. Acantrifoside E can be isolated from the 90% ethanol extract of Salacia cochinchinensis. Acantrifoside E has none α-glucosidase inhibitory activity .

HY-N11841

Mortatarin G	Glycosidase	Metabolic Disease
Mortatarin G (compound 3) is a prenylated flavonoid, that can be isolated from mulberry leaves. Mortatarin G exhibits good *α-glucosidase* inhibitory activity, with an IC₅₀ of 20.4±1.4 μM .

HY-N12138

Flaccidoside III	Glycosidase	Metabolic Disease
Flaccidoside III is a flavonoid and triterpenoid isolated from the aerial parts of N. sativa (Ranunculaceae). Flaccidoside III inhibits α-Glucosidase (IC₅₀: 256.7 μM) and has potential antioxidant and antidiabetic activities .

HY-N2703

6β-Hydroxyipolamiide	Glycosidase	Metabolic Disease
6β-Hydroxyipolamiide can be isolated from the methanolic extract of S. jamaicensis leaves. 6β-Hydroxyipolamiide has *α-glucosidase* inhibitory activity with an IC₅₀ of 539.17 μg/mL .

HY-169292

Antitumor agent-188	Glycosidase Reactive Oxygen Species	Cancer
Antitumor agent-188 (compound C6) exerts *α-glucosidase* inhibitory activity, and antitumor effects.Antitumor agent-188 induces excessive production of ROS to trigger oxidative stress .

HY-N3431

Kaempferol-7-O-rhamnoside	Glycosidase	Metabolic Disease
Kaempferol-7-O-rhamnoside, isolated from Chimonanthus nitens Oliv. Leaves, is a potent **α-glucosidase activity** inhibitor. Kaempferol-7-O-rhamnoside has the potential for diabetes .

HY-N8517

Malabaricone B	Glycosidase Apoptosis	Infection Metabolic Disease Cancer
Malabaricone B, a naturally occurring plant phenolic, is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities .

HY-N10064

Ficusonolide	Others	Metabolic Disease
Ficusonolide has significant antidiabetic activity with a possible mechanism of interaction with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.

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α-glucosidase activity

Inhibitors & Agonists

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