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Aryl Hydrocarbon Receptor

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By Targets:	Aryl Hydrocarbon Receptor (73) Adenosine Receptor (3) Androgen Receptor (2) Apoptosis (5) Autophagy (3) Bacterial (2) CDK (1) Checkpoint Kinase (Chk) (1) Cytochrome P450 (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (15) Epigenetic Reader Domain (1) ERK (1) Estrogen Receptor/ERR (3) Ferroptosis (1) Fungal (4) Glucosidase (2) GSK-3 (1) HIF/HIF Prolyl-Hydroxylase (3) Isotope-Labeled Compounds (4) LXR (1) MDM-2/p53 (1) MEK (1) Na+/K+ ATPase (1) NF-κB (1) p38 MAPK (4) PARP (1) PPAR (1) PROTACs (1) Pyroptosis (1) Reactive Oxygen Species (1) VD/VDR (1) VEGFR (1)
By Research Areas:	Cancer (46) Cardiovascular Disease (7) Endocrinology (3) Infection (2) Inflammation/Immunology (26) Metabolic Disease (4) Neurological Disease (11)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

MeBIO	Aryl Hydrocarbon Receptor GSK-3 CDK	Others
MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC₅₀ of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively .

Skatole 4 Publications Verification 3-Methylindole; 3-Methyl-1H-indole	Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Apoptosis	Others
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .

BAY-218 AHR antagonist 1	Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC₅₀ of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses .

FICZ 10+ Cited Publications 6-Formylindolo[3,2-b]carbazole	Aryl Hydrocarbon Receptor	Others
FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a K_d of 70 pM.

Stemregenin 1 10+ Cited Publications SR1	Aryl Hydrocarbon Receptor	Cancer
Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC₅₀ of 127 nM.

L-Kynurenine sulfate	Endogenous Metabolite Aryl Hydrocarbon Receptor	Inflammation/Immunology
L-Kynurenine sulfate, an **aryl hydrocarbon receptor (AHR**) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

AhR agonist 8	Aryl Hydrocarbon Receptor	Inflammation/Immunology
AhR agonist 8 (compound 9) is a potent Aryl Hydrocarbon Receptor (AhR) agonist with an EC₅₀ of 0.154 nM. AhR agonist 8 can be used in the study of psoriasis and atopic dermatitis .

Skatole (Standard)	Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Apoptosis	Others
Skatole (Standard) is the analytical standard of Skatole. This product is intended for research and analytical applications. Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .

CHD-5	Aryl Hydrocarbon Receptor	Others
CHD-5 is a potent AhR (aryl hydrocarbon receptor) antagonist .

Mivotilate YH439	Aryl Hydrocarbon Receptor	Others
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.

Diosmin 5 Publications Verification	Aryl Hydrocarbon Receptor	Cardiovascular Disease Cancer
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the **aryl hydrocarbon receptor (AhR**).

L-Kynurenine 5+ Cited Publications	Aryl Hydrocarbon Receptor Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an **aryl hydrocarbon receptor** agonist.

1,4-Chrysenequinone Chrysene-1,4-dione	Aryl Hydrocarbon Receptor	Cancer
1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

PDM2 2 Publications Verification	Aryl Hydrocarbon Receptor	Inflammation/Immunology
PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an K_i of 1.2±0.4 nM.

AHR antagonist 6	Aryl Hydrocarbon Receptor	Cancer
AHR antagonist 6 (Compound 44) is an aryl hydrocarbon receptor (AHR) antagonist used in cancer research .

AhR agonist 6	Aryl Hydrocarbon Receptor	Inflammation/Immunology
AhR agonist 6 (Compound 6) is an agonist for aryl hydrocarbon receptor (AhR), with an EC₅₀ of 0.01 nM .

ITE 5+ Cited Publications	Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a K_i of 3 nM. ITE also has immunosuppressive activity.

Tapinarof 5+ Cited Publications WBI-1001; Benvitimod; GSK2894512	Aryl Hydrocarbon Receptor	Inflammation/Immunology
Tapinarof (WBI-1001) is a natural **aryl hydrocarbon receptor (AhR) agonist with an EC₅₀** of 13 nM. Tapinarof resolves skin inflammation in mice .

CAY10464 AHR antagonist 7	Aryl Hydrocarbon Receptor	Cancer
CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a K_i of 1.4 nM .

6,2',4'-Trimethoxyflavone	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
6,2',4'-Trimethoxyflavone is a potent aryl hydrocarbon receptor (AHR) antagonist. 6,2',4'-Trimethoxyflavone represses AHR-mediated gene induction .

Diosmin (Standard)	Aryl Hydrocarbon Receptor	Cardiovascular Disease Cancer
Diosmin (Standard) is the analytical standard of Diosmin. This product is intended for research and analytical applications. Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

Pifithrin-α hydrobromide 55+ Cited Publications Pifithrin hydrobromide; PFTα hydrobromide	MDM-2/p53 Aryl Hydrocarbon Receptor Ferroptosis Apoptosis	Cancer
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.

Brevifolincarboxylic acid	Aryl Hydrocarbon Receptor Glucosidase	Metabolic Disease Inflammation/Immunology
Brevifolincarboxylic acid is extracted from Polygonum capitatum , has inhibitory effect on the aryl hydrocarbon receptor (AhR) . Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC₅₀ of 323.46 μM .

L-Kynurenine (Standard)	Aryl Hydrocarbon Receptor Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
L-Kynurenine (Standard) is the analytical standard of L-Kynurenine. This product is intended for research and analytical applications. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an **aryl hydrocarbon receptor** agonist.

Norisoboldine hydrochloride (+)-Laurelliptine hydrochloride	Adenosine Receptor	Inflammation/Immunology
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

Norisoboldine (+)-Laurelliptine	Adenosine Receptor	Inflammation/Immunology
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

AFP464 dihydrochloride NSC710464 dihydrochloride	HIF/HIF Prolyl-Hydroxylase	Cancer
AFP464 (dihydrochloride) (NSC710464 (dihydrochloride)) is the hydrochloride form of AFP464 and is a potent HIF-1α inhibitor with an IC₅₀ value of 0.25 μM. It is also an activator of aryl hydrocarbon receptor (AhR).

AFP464 free base NSC710464 free base	HIF/HIF Prolyl-Hydroxylase	Cancer
AFP464 free base (NSC710464 free base), is an active HIF-1α inhibitor with an IC₅₀ of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

GNF351 3 Publications Verification	Aryl Hydrocarbon Receptor	Others
GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC₅₀ of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes .

Carbidopa (S)-(-)-Carbidopa	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa ((S)-(-)-Carbidopa), a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

Carbidopa monohydrate (S)-(-)-Carbidopa monohydrate	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

Tapinarof (Standard)	Aryl Hydrocarbon Receptor	Inflammation/Immunology
Tapinarof (Standard) is the analytical standard of Tapinarof. This product is intended for research and analytical applications. Tapinarof (WBI-1001) is a natural **aryl hydrocarbon receptor (AhR) agonist with an EC₅₀** of 13 nM. Tapinarof resolves skin inflammation in mice .

DiMNF 3',4'-Dimethoxy-αNF	Aryl Hydrocarbon Receptor	Inflammation/Immunology
DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC₅₀ = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent .

Prochloraz BTS 40542	Fungal Estrogen Receptor/ERR Androgen Receptor Aryl Hydrocarbon Receptor	Infection Endocrinology
Prochloraz is an imidazole antifungal. Prochloraz is as an *estrogen receptor* (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC₅₀** values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC₅₀ of 1 μM .

Indole-3-carbinol 5+ Cited Publications Indole-3-methanol	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite	Cancer
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an **Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1** (WW domain-containing ubiquitin E3 ligase 1).

AHR antagonist 2 1 Publications Verification	Aryl Hydrocarbon Receptor	Cancer
AHR antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2019101641A1, compound example 1, with IC₅₀s of 0.885 and 2.03 nM for human and mouse AhR .

BAY 2416964	Aryl Hydrocarbon Receptor	Cancer
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC₅₀ of 341 nM. BAY 2416964 has the potential for solid tumors treatment .

Stemregenin 1 hydrochloride SR1 hydrochloride	Aryl Hydrocarbon Receptor	Others
Stemregenin 1 hydrochloride is a purine derivative that antagonizes **aryl hydrocarbon receptor signaling in CD34+ cells. IC₅₀** The value is 127 nM. Stemregenin 1 hydrochloride can be used to expand the pluripotency of hematopoietic stem cells (HSC) in stem cell studies .

Species:	Human (2)
Tag:	His (1) Tag Free (1) Strep (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701572

	IVNS1ABP Protein, Human (Sf9) IVNS1ABP; Influenza virus NS1A-binding protein; NS1-BP; NS1-binding protein; Aryl Hydrocarbon Receptor-associated protein 3; Kelch-like protein 39	Human	Sf9 insect cells
	The IVNS1ABP protein is intricately involved in multiple cellular functions, including pre-mRNA splicing, aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination. It binds to F-actin through Kelch repeats, thereby stabilizing actin filaments and thereby protecting cells from actin instability-induced cell death. IVNS1ABP Protein, Human (Sf9) is the recombinant human-derived IVNS1ABP protein, expressed by Sf9 insect cells , with tag free. The total length of IVNS1ABP Protein, Human (Sf9) is 641 a.a., .

HY-P701573

	IVNS1ABP Protein, Human (Sf9, His, Strep) IVNS1ABP; Influenza virus NS1A-binding protein; NS1-BP; NS1-binding protein; Aryl Hydrocarbon Receptor-associated protein 3; Kelch-like protein 39	Human	Sf9 insect cells
	The IVNS1ABP protein is intricately involved in multiple cellular functions, including pre-mRNA splicing, aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination. It binds to F-actin through Kelch repeats, thereby stabilizing actin filaments and thereby protecting cells from actin instability-induced cell death. IVNS1ABP Protein, Human (Sf9, His, Strep) is the recombinant human-derived IVNS1ABP protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of IVNS1ABP Protein, Human (Sf9, His, Strep) is 641 a.a., .

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Cat. No.	Product Name	Chemical Structure

HY-104026CS

L-Kynurenine-13C10 sulfate hemihydrate
L-Kynurenine- ¹³C10 (sulfate hemihydrate) is the ¹³C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-104026S

L-Kynurenine-d4
L-Kynurenine-d₄ is the deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist[1][2].

HY-W007355S1

Skatole-d8
Skatole-d₈ is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

HY-W007355S

Skatole-d3
Skatole-d₃ is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38[1].

HY-104026S2

L-Kynurenine-d4-1 hydrochloride
L-Kynurenine-d₄-1 hydrochloride is the deuterium labeled L-Kynurenine (HY-104026). L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an **aryl hydrocarbon receptor** agonist .

HY-B0311AS

Carbidopa-d3 monohydrate
Carbidopa-d₃ (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].

HY-104026BS

L-Kynurenine-13C10 sulfate
L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-104026S1

L-Kynurenine-d4-1
L-Kynurenine-d₄-1 is deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

HY-104026S5

L-Kynurenine-13C10 sulfate hydrate
L-Kynurenine-13C10 sulfate hydrate is the C13 labeled L-Kynurenine sulfate hydrate. L-Kynurenine is an aryl hydrocarbon receptor agonist .

HY-104026S3

L-Kynurenine-13C4,15N-1
L-Kynurenine- ¹³C₄, ¹⁵N-1 is the ¹³C and ¹⁵N labled L-Kynurenine (HY-104026) . L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an **aryl hydrocarbon receptor** agonist.

HY-B0311S1

Carbidopa-d3-1
Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-W011338S

Benzyl butyl phthalate-d4

Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs)[2][3][4].

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HY-P80378

	AHR Antibody Ah Receptor; Aromatic Hydrocarbon Receptor; Aryl Hydrocarbon Receptor; Aryl Hydrocarbon Receptor precursor; BHLHE76; Class E basic helix loop helix protein 76; HGNC:348; AHR_HUMAN.	WB, ICC/IF	Human
	Aryl hydrocarbon Receptor Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 96 kDa, targeting to Aryl hydrocarbon Receptor. It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P80705

	HIF1 beta Antibody ARNT; BHLHE2; Aryl Hydrocarbon Receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin Receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta	WB, IHC-P	Human, Mouse, Rat, Hamster
	HIF1 beta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to HIF1 beta. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat, Hamster.

HY-P82417

	Aryl Hydrocarbon Receptor Antibody (YA2162) Ah Receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76; AHR	WB	Human
	Aryl Hydrocarbon Receptor Antibody (YA2162) is a biotin-conjugated non-conjugated IgG antibody, targeting Aryl Hydrocarbon Receptor, with a predicted molecular weight of 96 kDa (observed band size: 100 kDa). Aryl Hydrocarbon Receptor Antibody (YA2162) can be used for WB experiment in human background.

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Cat. No.	Product Name		Classification

HY-155505

AHR agonist 4		Alkynes
AHR agonist 4 (compound 24e) is an agonist of **Aryl hydrocarbon receptor (AHR**), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion . AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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