Search Result
Results for "
Fungal metabolite
" in MedChemExpress (MCE) Product Catalog:
2
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-111238
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-
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- HY-P1703
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-
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- HY-N10186
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-
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- HY-125684
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- HY-W714833
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- HY-N8548
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- HY-N10238
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- HY-125705
-
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Herqueline A
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Influenza Virus
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Infection
Cardiovascular Disease
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Herquline A (Herqueline A) is a fungal piperazine alkaloid. Herquline A is a fungal metabolite that inhibits platelet aggregation and replication of the influenza virus .
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-
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- HY-125344
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-
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- HY-N12877
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Bacterial
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Infection
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Ophiobolin H is a fungal metabolite that can be isolated from Aspergillus ustus. Ophiobolin H inhibits growth of Bacillus subtilis cultures. Ophiobolin H induces hyperacusia in day-old chicks at rates up to 375 mg/kg .
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-
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- HY-118427
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Parasite
Endogenous Metabolite
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Infection
Cancer
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Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC50 of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits Tritrichomonas foetus .
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-
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- HY-124551
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-
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- HY-N10234
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Acyltransferase
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Infection
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Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 0.8 μM .
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-
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- HY-N10270
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-
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- HY-N10220
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-
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- HY-121133
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Endogenous Metabolite
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Others
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(-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .
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-
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- HY-125411
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Endogenous Metabolite
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Others
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Berninamycin D is a cyclic peptide fungal metabolite isolated from ermentation of Streptomyces bernensis .
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- HY-W145584
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-
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- HY-125060
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-
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- HY-126603
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Endogenous Metabolite
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Infection
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Asperlactone has anti-inflammatory activity. Asperlactone inhibits superoxide anion generation. Asperlactone is a fungal metabolite that can be isolated from isolated from Aspergillus ochraceus .
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-
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- HY-135154
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GABA Receptor
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Neurological Disease
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epi-Aszonalenin A is a benzodiazepine fungal metabolite originally isolated from Aspergillus novofumigatus. epi-Aszonalenin A can be used as a psychoactive agent .
|
-
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- HY-165114
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Endogenous Metabolite
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Cancer
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6-Hydroxyramulosin is a fungal metabolite with antiancer effects. 6-Hydroxyramulosin shows cytotoxic effects against A549 and T24, showing IC50 values of 14.2 µg/mL and 15.3 µg/mL, respectively .
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- HY-N8349
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Parasite
Endogenous Metabolite
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Infection
Cancer
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19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .
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-
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- HY-N8385
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Parasite
Endogenous Metabolite
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Infection
Cancer
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19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .
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-
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- HY-137956
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Endogenous Metabolite
Bacterial
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Infection
Cancer
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Previridicatumtoxin is a fungal metabolite with antibacterial and anticancer activities. Previridicatumtoxin can be extracted from P. aethiopicum and utilized in research related to cancer as well as infections .
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- HY-N10194
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Parasite
Endogenous Metabolite
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Infection
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P-orlandin, a fungal metabolite, prevents FREP1 from binding to gametocytes or ookinetes. P-orlandin effectively inhibits P. falciparum infection in mosquitoes .
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- HY-N8541
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- HY-N10228
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Endogenous Metabolite
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Infection
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Gliorosein is a fungal metabolite isolated from Gliocladium. Gliorosein is isomeric with the quinol but shows a different ultraviolet absorption spectrum .
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-
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- HY-W017445
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Fungal
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Infection
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Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .
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- HY-N10190
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Parasite
Endogenous Metabolite
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Infection
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Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells .
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- HY-N10227
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- HY-114646
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Endogenous Metabolite
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Cancer
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TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter .
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- HY-N10192
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Endogenous Metabolite
Bacterial
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Infection
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Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .
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- HY-125170
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STAT
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Cancer
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Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer .
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- HY-P3107
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Endogenous Metabolite
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Inflammation/Immunology
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Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC50 value of 0.86 μM .
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- HY-136901
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FC-101
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Reactive Oxygen Species
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Cardiovascular Disease
Cancer
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Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .
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- HY-119552
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LL-S490β
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Endogenous Metabolite
Neurokinin Receptor
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Neurological Disease
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Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ 3H]-SP binding to human astrocytoma cells with a Ki of 170 μM .
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- HY-N10322
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Drug Metabolite
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Others
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2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system .
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- HY-N6735
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OSI 2040
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HDAC
Parasite
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Infection
Cancer
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Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research .
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- HY-120607
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Parasite
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Infection
Cancer
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Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC50 value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines .
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-
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- HY-126989
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Arp2/3 Complex
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Cancer
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19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .
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- HY-W099579
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Kojic dipalmitate
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Tyrosinase
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Endocrinology
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Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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- HY-163113
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Endogenous Metabolite
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Cancer
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Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .
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- HY-W099579R
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Tyrosinase
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Endocrinology
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Kojic acid dipalmitate (Standard) is the analytical standard of Kojic acid dipalmitate. This product is intended for research and analytical applications. Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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- HY-N6798
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Myriocin
Maximum Cited Publications
6 Publications Verification
Thermozymocidin; ISP-I
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HCV
Antibiotic
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Infection
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Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection .
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- HY-120733
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FKI-4905
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Bacterial
Endogenous Metabolite
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Infection
Inflammation/Immunology
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Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .
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- HY-N6798R
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Thermozymocidin (Standard); ISP-I (Standard)
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HCV
Antibiotic
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Infection
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Myriocin (Standard) is the analytical standard of Myriocin. This product is intended for research and analytical applications. Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection[1][2][3].
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- HY-129319
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- HY-117713
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- HY-N14063
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Others
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Others
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Cycloleucomelone, a secondary metabolite, is a fungal pigment .
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- HY-168756
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Fungal
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Infection
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Byssochlamic acid is a secondary metabolite produced by fungal metabolism .
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- HY-N10282
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- HY-125596
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Parasite
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Infection
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Lachnumon is a fungal metabolite with nematicidal and antimicrobial activities .
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- HY-N6217
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- HY-N10257
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- HY-N8325
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- HY-172007
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- HY-136871
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- HY-N7718
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- HY-116290
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- HY-167831
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Fungal
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Infection
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Vermistatin is a metabolite of the fungal strain Guignardia that has cytotoxic and antifungal activity .
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- HY-155164
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- HY-119328
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- HY-116290A
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- HY-N14818
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Fungal
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Infection
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O-Acetylbenzeneamidinocarboxylic acid is a fungal metabolite that shows inhibitory to variety of plant pathogenic fungi .
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- HY-129515
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Fungal
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Others
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Trichodecenin II is a fungal metabolite that can be found in conidia of the fungus, Trichoderma viride .
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- HY-130214
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- HY-168396
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Fungal
Drug Derivative
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Others
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Glioroseinol is a fungal metabolite that can be found in Gliocladium, and is a derivative of Gliorosein (HY-N10228) .
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- HY-N13889
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Fungal
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Infection
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Altiloxin A, a fungal metabolite, is a drimane-type sesquiterpenoid. Altiloxin A shows phytotoxic activity on the lettuce seedlings .
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- HY-121395
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Antibiotic
Fungal
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Infection
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Lepiochlorin is an antibiotic metabolite produced by a fungus (Lepiota species) that is cultivated by ants, which can prevent fungal contamination .
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- HY-N7731
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Others
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Others
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(±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .
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- HY-118100
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Cyclo(L-Tyr-L-Val)
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Drug Metabolite
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Others
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Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.
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- HY-129493
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- HY-153671
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Fungal
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Infection
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4'-Methyl-β-naphthoflavone is a metabolite of Naphthoflavones (benzoflavones) in fungal. Naphthoflavones are activators or inhibitors of CYP-450 .
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- HY-N10261
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- HY-142908
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Endogenous Metabolite
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Cancer
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Maximiscin, a fungal metabolite, induces DNA damage and shows selective cytotoxic activity against a subtype of triple-negative breast cancer.
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- HY-P10916
-
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Drug Metabolite
Fungal
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Infection
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Micafungin metabolite M1 is an active metabolite of Micafungin (HY-17579), which is metabolized by arylsulfatase and exhibits antifungal activity. Micafungin metabolite M1 can be used for research on deep fungal infections caused by Candida and Aspergillus species .
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- HY-N7291
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Others
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Others
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Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939 .
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- HY-N1734
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Others
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Others
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2-Hydroxydiplopterol is a Triterpenoids product that can be isolated from the metabolites of the fungal strain Aspergillus variecolor B-17. .
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- HY-103382
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Fungal
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Infection
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Arcyriaflavin A is a fungal metabolite obtained from the fungi, Nocardiopsis. Arcyriaflavin A is an inhibitor of CDK4 (IC50 = 140 nM) and CaMKII (IC50 = 25 nM) .
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- HY-W596782
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- HY-125319
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Acyltransferase
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Metabolic Disease
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Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .
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- HY-N10262
-
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Endogenous Metabolite
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Others
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Piliformic acid is a fungal metabolite found in the endophytic fungus Xylariasp sp.(No. 2508) from mangrove trees from the coast of the South China Sea .
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- HY-129295
-
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Acyltransferase
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Metabolic Disease
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Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .
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- HY-N8400
-
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Endogenous Metabolite
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Others
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Roridin L2, a fungal metabolite, is a biosynthetic precursor of Satratoxin G. Roridin L2 possesses little in vitro or in vivo toxic activity .
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- HY-N6781
-
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Phosphodiesterase (PDE)
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Infection
Cancer
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Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity .
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- HY-121532
-
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Ras
Apoptosis
Autophagy
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Cancer
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(-)-Rasfonin is a fungal secondary metabolite and inhibits small G proteins Ras. (-)-Rasfonin induces apoptosis, necrosis and autophagy in ACHN cells (a renal carcinoma cell line) .
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- HY-137801
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Parasite
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Infection
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Sesquicillin A is an insecticidal antibiotic, a fungal metabolite isolated from white plantain. Sesquicillin A inhibits the growth of A. salina brine shrimp with the MIC value of 6.25 µg/mL .
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- HY-N8846
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Fungal
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Infection
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dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .
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- HY-136767
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Antibiotic
Fungal
Bacterial
Parasite
DNA/RNA Synthesis
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Infection
|
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Cladosporin is an antibiotic and an an antifungal metabolite that can be produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin exhibits inhibitory activity against various dermatophytes, plant pathogens, and bacteria. Cladosporin also exhibits antimalarial activity through inhibition of cytoplasmic lysine-tRNA synthetase of Plasmodium (PfKrs1) .
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- HY-129824
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Endogenous Metabolite
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Neurological Disease
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3-Methyl orsellinic acid is the fungal metabolite. 3-Methyl orsellinic acid can be used for synthesis of tripodalsporormielones AeC, and exhibits potential in researches related to memory and cognition .
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- HY-N7731A
-
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(R)-Lavandulol
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Others
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Others
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(-)-Lavandulol is the isomer of (±)-Lavandulol (HY-N7731). (±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .
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- HY-N15186
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Fungal
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Cardiovascular Disease
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Gymnoascolide A, identified as a fungal metabolite in M. filamentosa, demonstrates vasodilatory effects. At a concentration of 1 µM, it effectively inhibits contractions induced by calcium in isolated rat aortic rings .
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- HY-N6770
-
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(S)-Curvularin
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NO Synthase
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Infection
Inflammation/Immunology
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Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM .
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- HY-P2228
-
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HDAC
Apoptosis
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Cancer
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Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .
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-
- HY-N0894B
-
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(3S,5S)-Hexahydrobisdemethoxycurcumin
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Drug Metabolite
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Infection
|
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(3S,5S)-Octahydrocurcumin ((3S,5S)-Hexahydrobisdemethoxycurcumin) is a fungal metabolite that can be isolated from Curcuma longa .
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- HY-133154
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CAIR; 4-Carboxy-AIR
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Endogenous Metabolite
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Infection
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Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .
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- HY-N7731R
-
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Others
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Others
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(±)-Lavandulol (Standard) is the analytical standard of (±)-Lavandulol. This product is intended for research and analytical applications. (±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .
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- HY-137989A
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Voriconazole oxynitride hydrochloride
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Drug Metabolite
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Infection
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Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity .
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- HY-N14366
-
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HIV
Endogenous Metabolite
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Infection
|
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Fleephilone is a fungal metabolite that can be isolated from Trichoderma harzianum. Fleephilone is a HIV REV/RRE binding inhibitor. Fleephilone inhibits the binding of REV-protein to RRE RNA with an IC50 of 7.6 μM .
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- HY-111321
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-
- HY-125706
-
-
- HY-N10265
-
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Endogenous Metabolite
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Cancer
|
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Stephacidin B is a fungal metabolite. Stephacidin B shows in vitro cytotoxicity against a panel of human tumor cell lines. Stephacidin B shows the strongest cytotoxicity against testosterone-dependent prostate LNCaP cancer cells .
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- HY-N6772
-
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Autophagy
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Cancer
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Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .
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- HY-W145584S
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- HY-N8285
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Parasite
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Infection
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Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC50 value of 1.53 μM, and also has certain cytotoxicity .
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-
- HY-N15185
-
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(-)-Pyrenophorin
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Herbicide
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Cancer
|
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Pyrenophorin ((-)-Pyrenophorin) is a fungal metabolite that has been found in D. avenae and has phytotoxic activity. Pyrenophorin shows strong cytotoxicity against several cancer cell lines with IC50 values ranging from 0.07 to 7.8 μM .
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-
- HY-146190
-
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Bacterial
Antibiotic
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Infection
Inflammation/Immunology
|
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Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candida albicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules .
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-
- HY-W001146
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Drug Intermediate
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Metabolic Disease
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3-Chloro-4-hydroxyphenylacetic acid is a fungal metabolite. 3-Chloro-4-hydroxyphenylacetic acid is an active small molecule, that can be used as building block in synthesis of 17β-HSD2 inhibitors .
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- HY-116700
-
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HIV Protease
HIV
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Infection
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Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum .
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- HY-121184
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- HY-121004
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Lycopersin
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Fungal
Antibiotic
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Infection
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Bikaverin (Lycopersin) is a reddish pigment produced by different fungal species. Bikaverin shows antibiotic properties against certain protozoa and fungi .
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- HY-N10205
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Endogenous Metabolite
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Cancer
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Rostratin C, a cytotoxic disulfide, shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 value of 0.76μg /mL .
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- HY-129578
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- HY-N6027
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Fungal
Bacterial
|
Infection
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Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. Cyclosporin C is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs=0.1-5 μg/ml).
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- HY-100618
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- HY-100618R
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- HY-135766
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(+)-Colletodiol
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Influenza Virus
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Infection
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Colletodiol is a fungal metabolite that has been found in D. grovesii and has immunosuppressant and antiviral activities. It inhibits concanavalin A- or LPS-induced proliferation of isolated mouse splenocytes (IC50s=12 and 5 μg/mL, respectively).1 Colletodiol inhibits influenza A viral replication in HeLa-IAV-Luc cells.
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- HY-N7374
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Endogenous Metabolite
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Infection
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Cyperine is a phytotoxic fungal metabolite that has been found in A. cypericola. It inhibits A. thaliana enoyl-acyl carrier protein reductase (ENR; IC50=89 μM). Cyperine induces necrosis in a panel of nine plant species in a leaf bioassay and inhibits root growth in A. thaliana seedlings (IC50=38.4 μM).
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- HY-N6801
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Caspase
Bacterial
Apoptosis
Antibiotic
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Infection
Inflammation/Immunology
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Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .
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- HY-N8472
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GABA Receptor
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Infection
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Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on?B.?mori GABAR RDL with an IC50?of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50?of 1.66 nM.?Chrodrimanin B, a meroterpenoid, shows insecticidal activity .
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- HY-121003
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Fungal
Parasite
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Infection
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Aspyrone is a polyketide fungal metabolite that has been found in Aspergillus and has diverse biological activities. It is active against a panel of 13 fungi when used at a concentration of 20 μg/mL and a panel of 21 bacteria in a disc assay when used at a concentration of 100 μg per disc.1 Aspyrone (10-1,000 mg/L) is nematocidal against P. penetrans.
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- HY-129578R
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Reference Standards
Autophagy
Cathepsin
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Infection
Inflammation/Immunology
Cancer
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Asperphenamate (Standard) is the analytical standard of Asperphenamate. This product is intended for research and analytical applications. Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC50 values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively[1][2].
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- HY-N4096R
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Others
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Inflammation/Immunology
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Kojic acid dipalmitate (Standard) is the analytical standard of Kojic acid dipalmitate. This product is intended for research and analytical applications. Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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- HY-W714837
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4-Oxo-5-phenylpentanoic acid; 5-Phenyl-4-oxopentanoic acid
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Bacterial
Fungal
Antibiotic
Drug Intermediate
Endogenous Metabolite
Sigma Receptor
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Infection
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5-Phenyllevulinic acid (4-Oxo-5-phenylpentanoic acid) is an endogenous fungal metabolite with inhibitory activity against the bacterium B. megaterium, the plant pathogenic fungus S. tritici, and the alga C. fusca. 5-Phenyllevulinic acid is also an intermediate in the synthesis of σ receptor ligands. 5-Phenyllevulinic acid holds potential for research in the field of anti-infection studies .
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- HY-N10196
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- HY-138035
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Fungal
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Infection
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Tenellin is a fungal metabolite that has been found in Beauveria. It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes by 51, 57, and 74%, respectively, when used at a concentration of 200 μg/mL.1 Tenellin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of- 4.84 and 11.95 μM, respectively.
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- HY-119843
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Dimethylosoic acid; RES-1214-1; TAN 1415A
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Antibiotic
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Infection
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Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET)-1 to the ETA receptor in A10 cells at 0.1 μM.1 Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 μM, which suggests its usefulness as an antiangiogenic agent.
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- HY-N6801R
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Caspase
Bacterial
Apoptosis
Antibiotic
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Infection
Inflammation/Immunology
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Nivalenol (Standard) is the analytical standard of Nivalenol. This product is intended for research and analytical applications. Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .
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- HY-N6801S
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Isotope-Labeled Compounds
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Infection
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Nivalenol- 13C15 is the 13C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .
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- HY-N11642
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Others
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Others
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Ganodermacetal is a highly oxidized lanostane triterpene, that can be isolated from G. amboinense. Ganodermacetal shows a marked toxicity to brine shrimp larvae .
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- HY-W781265
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L-755,805
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Endothelin Receptor
Bacterial
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Infection
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BE 24566B is a polyketide fungal metabolite originally isolated from S. violaceusniger. It is active against B. subtilis, B. cereus, S. aureus, M. luteus, E. faecalis, and S. thermophilus (MICs=1.56, 1.56, 1.56, 1.56, 3.13, and 3.13 μg/mL, respectively). BE 24566B is an endothelin (ET) receptor antagonist (IC50s=11 and 3.9 μM for ETA and ETB receptors, respectively).
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- HY-113205
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15-keto-PGE2
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Endogenous Metabolite
Prostaglandin Receptor
STAT
PPAR
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Cancer
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15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth .
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- HY-N8353
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Others
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Metabolic Disease
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Stachybotramide is a natural fungal metabolite with the property of modulating the activity of cholesteryl ester transfer protein (CETP). Stachybotramide stimulates the transfer of cholesteryl esters (CE) from high-density lipoprotein (HDL) to very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), increasing the transfer efficiency by 1.3- to 1.5-fold. Stachybotramide slightly reduced the transfer of cholesteryl esters from LDL and VLDL to HDL at 0.5 mM. The effect of Stachybotramide on the transfer of triglycerides (TG) from HDL was not significant. By these results, Stachybotramide was shown to preferentially stimulate the CETP-mediated transfer of cholesteryl esters from HDL to VLDL and LDL .
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- HY-N8301
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LL-Z 1272ζ
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Bacterial
|
Infection
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Ilicicolin F is a fungal metabolite that has been found in Fusarium and has diverse biological activities. It inhibits T. vivax alternative oxidase and the E. coli ubiquinol oxidase cytochrome bo (IC50s=0.43 and 0.37 μM, respectively) but not the E. coli ubiquinol oxidase cytochrome bd (IC50=85 μM).2 Ilicicolin F is active against the fungi A. fumigatus and C. albicans (MICs=1.66-3.33 and 6.66-13.33 μg/mL, respectively). It is cytotoxic to HeLa cells with an EC50 value of 0.003 μg/mL.
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-
-
-
HY-L0117V
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|
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1,412 compounds
|
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Glycomimetics are designed to mimic the structure of natural carbohydrates and modulate their disease-related functions. Macrocyclic glycomimetics are an extremely interesting class of glycomimetics as they occupy space between small and macro molecules. Macrocyclic glycomimetics are mostly represented by naturally occurring molecules derived from marine microorganisms and bacterial or fungal metabolites.
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P3107
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Endogenous Metabolite
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Inflammation/Immunology
|
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Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC50 value of 0.86 μM .
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- HY-P10916
-
|
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Drug Metabolite
Fungal
|
Infection
|
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Micafungin metabolite M1 is an active metabolite of Micafungin (HY-17579), which is metabolized by arylsulfatase and exhibits antifungal activity. Micafungin metabolite M1 can be used for research on deep fungal infections caused by Candida and Aspergillus species .
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-
- HY-P2228
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|
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HDAC
Apoptosis
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Cancer
|
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Chlamydocin, a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin exhibits potent antiproliferative and anticancer activities. Chlamydocin induces apoptosis by activating caspase-3 .
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-W145584S
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D-Iditol- 13C is the 13C labeled D-Iditol. D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity[1][2][3].
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- HY-N6801S
-
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Nivalenol- 13C15 is the 13C labeled Nivalenol (HY-N6801) . Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product . Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect .
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-
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