Search Result

Results for "

G4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Apoptosis (9) Autophagy (2) c-Met/HGFR (1) c-Myc (6) CD3 (1) CD47 (1) Complement System (2) DAGL (1) DNA/RNA Synthesis (7) Endothelin Receptor (1) Eukaryotic Initiation Factor (eIF) (3) FATP (1) Ferroptosis (2) G-quadruplex (20) HDAC (1) HIV (1) MAGL (1) PD-1/PD-L1 (2) PROTACs (1) Reactive Oxygen Species (1) RGS Protein (3) Small Interfering RNA (siRNA) (7) Telomerase (4) Tie (1) TNF Receptor (1) Topoisomerase (1) Virus Protease (1)
By Research Areas:	Cancer (41) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (10) Metabolic Disease (2) Neurological Disease (6)
Oligonucleotides:	Pre-designed siRNA Sets (7) siRNAs (7)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135776

BMVC2 o-BMVC	G-quadruplex	Cancer
BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer .

HY-148012

SOP1812 QN-302	G-quadruplex	Cancer
SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with K_D values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer .

HY-P99029

Magrolimab 1 Publications Verification Hu5F9-G4	CD47	Cancer
Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab can block the "don't eat me" signal of CD47, thereby promoting macrophage mediated phagocytosis. Magrolimab has antitumor activity in malignant bone tumors and breast cancer .

HY-151263

G4/HDAC-IN-1	HDAC G-quadruplex	Cancer
G4/HDAC-IN-1 (compound a6) is a *G4/HDAC* dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC₅₀ value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of cancer .

HY-160485

G-4'G-7S	Others	Endocrinology
G-4'G-7S is a endogenous metabolite of genistein (HY-14596). G-4'G-7S can be used for the research of estrogenic activity .

HY-146812

DIZ-3	G-quadruplex	Cancer
DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells .

HY-161693

Telomeric G4s ligand 1	G-quadruplex DNA/RNA Synthesis Apoptosis	Cancer
Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells .

HY-120102

Emicoron	G-quadruplex	Cancer
Emicoron is a new promising G4 ligand and bind G-rich oncogene promoters. Emicoron possesses a marked antitumoral activity? alone or in combination with chemotherapeutics in vivo. Emicoron can be used for cancer research .

HY-152538

Antitumor agent-85	G-quadruplex	Cancer
Antitumor agent-85 is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-85 has highly effective anti-tumor properties .

HY-152537

Antitumor agent-84	G-quadruplex	Cancer
Antitumor agent-84 (compound 21a) is a G-quadruplex (G4)-ligand with the ability to stabilize different G4-DNA structures. Antitumor agent-84 has highly effective anti-tumor properties .

HY-162294

c-Myc inhibitor 13	c-Myc	Cancer
c-Myc inhibitor 13 (compound A6) is a c-MYC transcription inhibitor. c-Myc inhibitor 13 selectively stabilizes c-MYC G4 and inhibits G4-associated c-MYC transcription .

HY-111297

BMVC4	Others	Cancer
BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3(T2AG3)3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.

HY-P99938

Pucotenlimab HX008	PD-1/PD-L1	Cancer
Pucotenlimab (HX008) is a humanized immunoglobulin G4 (IgG4) anti programmed cell death protein 1 (anti-PD-1) monoclonal antibody. Pucotenlimab can be used for the research of tumor .

HY-162796

TS-2	Apoptosis G-quadruplex c-Myc	Cancer
TS-2 is a fluorescent ligand of c-Myc G4 with anticancer activity. TS-2 inhibits the growth of cancer cells and induces apoptosis of cancer cells by targeting the c-MYC oncogene promoter G4, causing transcriptional repression of the c-Myc oncogene .

HY-P990089

Patecibart	Endothelin Receptor	Cardiovascular Disease
Patecibart is a humanized immunoglobulin G4-kappa, anti-EDNRA monoclonal antibody. Patecibart is an endothelin receptor antagonist .

HY-P990753

Omoprubart	Others Complement System	Inflammation/Immunology
Omoprubart is an anti-C5 human?IgG2-G4 κ monoclonal antibody .

HY-135775

BMVC 1 Publications Verification	G-quadruplex Telomerase DNA/RNA Synthesis	Cancer
BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC₅₀ of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC₅₀ of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities .

HY-P990095

Vonsetamig	CD3 TNF Receptor	Cancer
Vonsetamig is a humanised immunoglobulin G4-kappa, anti-TNFRSF17 and CD3E monoclonal antibody. Vonsetamig is an antineoplastic .

HY-15595

360A	G-quadruplex Telomerase	Cancer
360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC₅₀ of 300 nM for telomerase in TRAP-G4 assay.

HY-P990073

Davutamig REGN-5093	c-Met/HGFR	Cancer
Davutamig (REGN-5093) is a human immunoglobulin G4-kappa, anti-MET monoclonal antibody targeting two different nonoverlapping epitopes on MET. Davutamig is an antineoplastic .

HY-15595A

360A iodide 2 Publications Verification 360 A iodide	G-quadruplex Telomerase	Cancer
360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC₅₀ of 300 nM for telomerase in TRAP-G4 assay.

HY-168150

Topoisomerase I/II inhibitor 5	Topoisomerase	Cancer
Topoisomerase I/II inhibitor 5 (compund 1) simultaneously inhibits activities of TopoI and II by binding to and stabilizing the G4 structure .

HY-147973

IZTZ-1	c-Myc Apoptosis	Cancer
IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research .

HY-P99510

Zansecimab LY-3127804	Tie	Inflammation/Immunology Cancer
Zansecimab (LY-3127804) is an immunoglobulin G4-kappa, a monoclonal antibody against angiopoietin 2 (Ang 2). Zansecimab has potential applications in angiogenesis and immune regulation .

HY-15594

Phen-DC3	DNA/RNA Synthesis	Cancer
Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-15594A

Phen-DC3 Trifluoromethanesulfonate 5 Publications Verification Phen-DC3 Triflate	G-quadruplex	Cancer
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC₅₀s of 65±6 and 50±10 nM, respectively.

HY-151471

Anticancer agent 84	c-Myc	Cancer
Anticancer agent 84 is an anticancer agent. Anticancer agent 84 represses the transcription of c-MYC by stabilizing the G-quadruplex (G4) structure. Anticancer agent 84 can be used for the research of cancer .

HY-P99607

Clenoliximab IDEC-151	HIV	Inflammation/Immunology
Clenoliximab (IDEC-151) is a macaque-human chimeric monoclonal antibody (immunoglobulin G4) specific for the *CD4* molecule on the surface of T lymphocytes. Clenoliximab can be used for the research of rheumatoid arthritis .

HY-N10579

Chrexanthomycin C	DNA/RNA Synthesis	Neurological Disease
Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity for DNA (G4C2) ⁴ G4 with a K_d value of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS) .

HY-145843

c-Myc inhibitor 5	c-Myc	Cancer
c-Myc inhibitor 5 (DA3) is a fluorescent, long chain-bridged bispurine that selectively targets the c-MYC G-quadruplex (K_D of 16 μM). c-Myc inhibitor 5 shows inhibition on c-MYC expression rather than other G4-driven oncogenes .

HY-121862

CM03	DNA/RNA Synthesis	Cancer
CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells .

HY-P99767

Olendalizumab ALXN1007	Complement System	Infection
Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (K_i=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus .

HY-P99114

Sugemalimab	PD-1/PD-L1	Cancer
Sugemalimab is a fully human, full length, anti-programmed death ligand 1 (PD-L1) immunoglobulin G4 (IgG4) monoclonal antibody (mAb). Sugemalimab shows anticancer activities and can be used for non-small cell lung cancer research .

HY-144712

L5-DA	G-quadruplex Apoptosis	Cancer
L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC₅₀=4.3 μM). L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest .

HY-135009

2-Di-1-ASP DASPI	G-quadruplex	Others
2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .

HY-149513

EP12	c-Myc Apoptosis	Cancer
EP12 is a c-Myc inhibitor. EP12 is a c-Myc G4 stabilizer. EP12 induces apoptosis and DNA damage in multiple myeloma cells. EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway. EP12 inhibits multiple myeloma growth .

HY-158049

Anticancer agent 199	Apoptosis Ferroptosis	Cancer
Anticancer agent 199 (Compound G-4) induces apoptosis in triple negative breast cancer (TNBC) cells via the mitochondrial pathway through inhibiting EGFR, AKT and MAPK pathways. Anticancer agent 199 also induces Ferroptosis by down-regulating LCN2. Anticancer agent 199 inhibits TNBC cell viability and migration, and induces S phase cell cycle arrest. Anticancer agent 199 is a derivate of cyclin-dependent kinase inhibitor Rocovitine .

HY-162456

Anticancer agent 205	Apoptosis Reactive Oxygen Species	Cancer
Anticancer agent 205 (compound 9) is a potent anticancer agent. Anticancer agent 205 binds to G4-mtDNA target and inhibits the replication, transcription, and translation of mtDNA (mitochondrial genome). Anticancer agent 205 causes mitochondrial dysfunction, increases ROS production, induces DNA damage and cellular senescence. Anticancer agent 205 induces apoptosis and cell cycle arrests at G0/G1 phase. Anticancer agent 205 has the potential for the research of colorectal cancer .

HY-D2380

H2S probe 1	G-quadruplex	Cancer
H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC₅₀=77.9 nM) and has a high affinity for human telomeric G-quadruplex (G4) (K_d=1.72 μM). H2S probe 1 can be used in cancer research .

HY-162688

Anticancer agent 239	Telomerase G-quadruplex Apoptosis Ferroptosis	Others
Anticancer agent 239 (Compound 5) is a ligand of hTERT promoter G-quadruplex DNA structures (hTERT G4) (K_d = 1.1 μM), and downregulates hTERT expression. Anticancer agent 239 decreases telomerase activity, shortens telomere length, and induces DNA damage, acute cellular senescence, and apoptosis. Anticancer agent 239 causes mitochondrial dysfunction, disrupts iron metabolism and activates ferroptosis in cancer cells. Anticancer agent 239 inhibits tumor growth in MDA-MB-231 xenograft mouse model .

HY-RS09947

PA2G4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PA2G4 Human Pre-designed siRNA Set A contains three designed siRNAs for PA2G4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PA2G4 Human Pre-designed siRNA Set A PA2G4 Human Pre-designed siRNA Set A

HY-RS10626

PLA2G4A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PLA2G4A Human Pre-designed siRNA Set A contains three designed siRNAs for PLA2G4A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PLA2G4A Human Pre-designed siRNA Set A PLA2G4A Human Pre-designed siRNA Set A

HY-RS10627

PLA2G4B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PLA2G4B Human Pre-designed siRNA Set A contains three designed siRNAs for PLA2G4B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PLA2G4B Human Pre-designed siRNA Set A PLA2G4B Human Pre-designed siRNA Set A

HY-RS10628

PLA2G4C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PLA2G4C Human Pre-designed siRNA Set A contains three designed siRNAs for PLA2G4C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PLA2G4C Human Pre-designed siRNA Set A PLA2G4C Human Pre-designed siRNA Set A

HY-RS10629

PLA2G4D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PLA2G4D Human Pre-designed siRNA Set A contains three designed siRNAs for PLA2G4D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PLA2G4D Human Pre-designed siRNA Set A PLA2G4D Human Pre-designed siRNA Set A

HY-RS10630

PLA2G4E Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PLA2G4E Human Pre-designed siRNA Set A contains three designed siRNAs for PLA2G4E gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PLA2G4E Human Pre-designed siRNA Set A PLA2G4E Human Pre-designed siRNA Set A

HY-RS10631

PLA2G4F Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PLA2G4F Human Pre-designed siRNA Set A contains three designed siRNAs for PLA2G4F gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PLA2G4F Human Pre-designed siRNA Set A PLA2G4F Human Pre-designed siRNA Set A

HY-100733

4E2RCat 3 Publications Verification	Eukaryotic Initiation Factor (eIF) Autophagy Virus Protease	Neurological Disease
4E2RCat is an inhibitor of *eIF4E-eIF4G* interaction with an IC₅₀ of 13.5 μM.

HY-110054

CCG-2046	RGS Protein	Inflammation/Immunology
CCG-2046 is a *RGS4* inhibitor with an IC₅₀ of 4.3 μM against RGS4-Gα_o interaction signal .

HY-U00431

CCG 203769	RGS Protein	Neurological Disease
CCG 203769 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gα_o protein-protein interaction in vitro with an IC₅₀ of 17 nM.

Cat. No.	Product Name	Type

HY-135009

2-Di-1-ASP DASPI	Fluorescent Dyes/Probes
2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .

HY-D2380

H2S probe 1	Fluorescent Dyes/Probes
H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC₅₀=77.9 nM) and has a high affinity for human telomeric G-quadruplex (G4) (K_d=1.72 μM). H2S probe 1 can be used in cancer research .

Cat. No.	Product Name	Type

HY-158490

A4G4 glycan A4G4 N-linked oligosaccharide	Carbohydrates
A4G4 glycan (A4G4 N-linked oligosaccharide) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158491

A4G4 glycan, 2-AA labelled A4G4 N-linked oligosaccharide, 2-AA labelled	Carbohydrates
A4G4 glycan, 2-AA labelled (A4G4 N-linked oligosaccharide, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158492

A4G4 glycan, 2-AB labelled A4G4 N-linked oligosaccharide, 2-AB labelled	Carbohydrates
A4G4 glycan, 2-AB labelled (A4G4 N-linked oligosaccharide, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158442

A2G2 glycan (G2) A2G2 N-linked oligosaccharide; A2G(4)2 glycan	Carbohydrates
A2G2 glycan (G2) (A2G2 N-linked oligosaccharide; A2G(4)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158452

A3G3 glycan (G3) A3G3 N-linked oligosaccharide; A3G(4)3 glycan	Carbohydrates
A3G3 glycan (G3) (A3G3 N-linked oligosaccharide; A3G(4)3 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158489

A3G3 glycan (G3), procainamide labelled A3G3 N-linked oligosaccharide, procainamide labelled; A3G(4)3 glycan, procainamide labelled	Carbohydrates
A3G3 glycan (G3), procainamide labelled (A3G3 N-linked oligosaccharide, procainamide labelled; A3G(4)3 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158447

A2G2 glycan (G2), procainamide labelled A2G2 N-linked oligosaccharide, procainamide labelled; A2G(4)2 glycan, procainamide labelled	Carbohydrates
A2G2 glycan (G2), procainamide labelled (A2G2 N-linked oligosaccharide, procainamide labelled; A2G(4)2 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158475

A2G2S1 glycan (G2S1) A2G2S1 N-linked oligosaccharide; A2G(4)2S(6)1 glycan	Carbohydrates
A2G2S1 glycan (G2S1) (A2G2S1 N-linked oligosaccharide; A2G(4)2S(6)1 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158506

A2G2S2 glycan (G2S2) A2G2S2 N-linked oligosaccharide; A2G(4)2S(6)2 glycan	Carbohydrates
A2G2S2 glycan (G2S2) (A2G2S2 N-linked oligosaccharide; A2G(4)2S(6)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158513

FA2G2S2 glycan (G2FS2) FA2G2S2 N-linked oligosaccharide; F(6)A2G(4)2S(6)2 glycan	Carbohydrates
FA2G2S2 glycan (G2FS2) (FA2G2S2 N-linked oligosaccharide; F(6)A2G(4)2S(6)2 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158510

A2G2S2 glycan (G2S2), APTS labelled A2G2S2 N-linked oligosaccharide, APTS labelled; A2G(4)2S(6)2 glycan, APTS labelled	Carbohydrates
A2G2S2 glycan (G2S2), APTS labelled (A2G2S2 N-linked oligosaccharide, APTS labelled; A2G(4)2S(6)2 glycan, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158517

FA2G2S2 glycan (G2FS2), APTS labelled FA2G2S2 N-linked oligosaccharide, APTS labelled; F(6)A2G(4)2S(6)2 glycan, APTS labelled	Carbohydrates
FA2G2S2 glycan (G2FS2), APTS labelled (FA2G2S2 N-linked oligosaccharide, APTS labelled; F(6)A2G(4)2S(6)2 glycan, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158508

A2G2S2 glycan (G2S2), 2-AA labelled A2G2S2 N-linked oligosaccharide, 2-AA labelled; A2G(4)2S(6)2 glycan, 2-AA labelled	Carbohydrates
A2G2S2 glycan (G2S2), 2-AA labelled (A2G2S2 N-linked oligosaccharide, 2-AA labelled; A2G(4)2S(6)2 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158512

A2G2S2 glycan (G2S2), 2-AB labelled A2G2S2 N-linked oligosaccharide, 2-AB labelled; A2G(4)2S(6)2 glycan, 2-AB labelled	Carbohydrates
A2G2S2 glycan (G2S2), 2-AB labelled (A2G2S2 N-linked oligosaccharide, 2-AB labelled; A2G(4)2S(6)2 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158515

FA2G2S2 glycan (G2FS2), 2-AB labelled FA2G2S2 N-linked oligosaccharide, 2-AB labelled; F(6)A2G(4)2S(6)2 glycan, 2-AB labelled	Carbohydrates
FA2G2S2 glycan (G2FS2), 2-AB labelled (FA2G2S2 N-linked oligosaccharide, 2-AB labelled; F(6)A2G(4)2S(6)2 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158518

FA2G2S2 glycan (G2FS2), 2-AA labelled FA2G2S2 N-linked oligosaccharide, 2-AA labelled; F(6)A2G(4)2S(6)2 glycan, 2-AA labelled	Carbohydrates
FA2G2S2 glycan (G2FS2), 2-AA labelled (FA2G2S2 N-linked oligosaccharide, 2-AA labelled; F(6)A2G(4)2S(6)2 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158477

FA2G2S1 glycan (G2FS1) FA2G2S1 N-linked oligosaccharide; α(2,6)/FA2G2S(6)1 glycan; F(6)A2G(4)2S(6)1 glycan	Carbohydrates
FA2G2S1 glycan (G2FS1) (FA2G2S1 N-linked oligosaccharide; α(2,6)/FA2G2S(6)1 glycan; F(6)A2G(4)2S(6)1 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

HY-158476

FA2G2S1 glycan (G2FS1), procainamide labelled FA2G2S1 N-linked oligosaccharide, procainamide labelled; α(2,6)/FA2G2S(6)1 glycan, procainamide labelled; F(6)A2G(4)2S(6)1 glycan, procainamide labelled	Carbohydrates
FA2G2S1 glycan (G2FS1), procainamide labelled (FA2G2S1 N-linked oligosaccharide, procainamide labelled; α(2,6)/FA2G2S(6)1 glycan, procainamide labelled; F(6)A2G(4)2S(6)1 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .

Cat. No.	Product Name	Target	Research Area

HY-P6022

G4RGDSP, integrin-binding peptide	Peptides	Others
G4RGDSP, Integrin-binding peptide is a cell integrin-binding peptide that targets integrin receptors. G4RGDSP, integrin-binding peptide is coupled to alginate to increase the viability of cells in the scaffold. G4RGDSP, integrin-binding peptide can be used as an extrudable carrier for chondrocyte delivery for the study of 3D printing technology

HY-P1771A

OVA G4 peptide TFA	Peptides	Inflammation/Immunology
OVA G4 peptide TFA is a variant of the agonist ovalbumin (OVA) peptide SIINFEKL (257-264). SIINFEKL is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel .

HY-P1771

OVA G4 peptide	Peptides	Inflammation/Immunology
OVA G4 peptide is a variant of the agonist ovalbumin (OVA) peptide SIINFEKL (257-264). SIINFEKL is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel .

HY-P10722

Efpegerglucagon HM15136	Peptides	Inflammation/Immunology
Efpegerglucagon is an Fc fragment of human immunoglobulin G4 (IgG4), formed as a disulfide-bonded dimer. One of the Fc chains is linked via a bifunctional maleimide-polyethylene glycol-aldehyde linker to a glucagon peptide analogue .

HY-20841

Boc-(2S)-Gly-4-pyranoyl (S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid; Boc-4-Pyranoyl-Gly-OH	Amino Acid Derivatives	Others
Boc-(2S)-Gly-4-pyranoyl ((S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid) is an amino-terminally protected glycine derivative that can be used to synthesize dipeptidyl peptidase IV with antidiabetic activity .

Cat. No.	Product Name	Target	Research Area

HY-P99029

Magrolimab 1 Publications Verification Hu5F9-G4	CD47	Cancer
Magrolimab (Hu5F9-G4) is a humanized anti-CD47 antibody. Magrolimab can block the "don't eat me" signal of CD47, thereby promoting macrophage mediated phagocytosis. Magrolimab has antitumor activity in malignant bone tumors and breast cancer .

HY-P990095

Vonsetamig	CD3 TNF Receptor	Cancer
Vonsetamig is a humanised immunoglobulin G4-kappa, anti-TNFRSF17 and CD3E monoclonal antibody. Vonsetamig is an antineoplastic .

HY-P990068

Perenostobart SRF617	Inhibitory Antibodies	Cancer
Perenostobart is a human immunoglobulin G4-kappa, anti-ENTPD1/CD39 monoclonal antibody. Perenostobart is an immunostimulant and antineoplastic .

HY-P990081

Oloctinebart	Inhibitory Antibodies	Neurological Disease
Oloctinebart is a humanized immunoglobulin G4-kappa, anti-LGALS3 monoclonal antibody. Oloctinebart is used for reduction of amyloid beta oligomers formation .

HY-P990092

Rolistobart	Inhibitory Antibodies	Cancer
Rolistobart is a humanized immunoglobulin G4-kappa, *anti-LILRB4/CD85k* monoclonal antibody. Rolistobart is an immunostimulant and antineoplastic .

HY-P99938

Pucotenlimab HX008	PD-1/PD-L1	Cancer
Pucotenlimab (HX008) is a humanized immunoglobulin G4 (IgG4) anti programmed cell death protein 1 (anti-PD-1) monoclonal antibody. Pucotenlimab can be used for the research of tumor .

HY-P990089

Patecibart	Endothelin Receptor	Cardiovascular Disease
Patecibart is a humanized immunoglobulin G4-kappa, anti-EDNRA monoclonal antibody. Patecibart is an endothelin receptor antagonist .

HY-P990753

Omoprubart	Inhibitory Antibodies Complement System	Inflammation/Immunology
Omoprubart is an anti-C5 human?IgG2-G4 κ monoclonal antibody .

HY-P990074

Enlonstobart	Inhibitory Antibodies	Inflammation/Immunology
Enlonstobart is a human immunoglobulin G4-kappa, anti-PDCD1 monoclonal antibody. Enlonstobart is an immunostimulant and antineoplastic .

HY-P990073

Davutamig REGN-5093	c-Met/HGFR	Cancer
Davutamig (REGN-5093) is a human immunoglobulin G4-kappa, anti-MET monoclonal antibody targeting two different nonoverlapping epitopes on MET. Davutamig is an antineoplastic .

HY-P99510

Zansecimab LY-3127804	Tie	Inflammation/Immunology Cancer
Zansecimab (LY-3127804) is an immunoglobulin G4-kappa, a monoclonal antibody against angiopoietin 2 (Ang 2). Zansecimab has potential applications in angiogenesis and immune regulation .

HY-P99607

Clenoliximab IDEC-151	HIV	Inflammation/Immunology
Clenoliximab (IDEC-151) is a macaque-human chimeric monoclonal antibody (immunoglobulin G4) specific for the *CD4* molecule on the surface of T lymphocytes. Clenoliximab can be used for the research of rheumatoid arthritis .

HY-P99767

Olendalizumab ALXN1007	Complement System	Infection
Olendalizumab (ALXN1007) is a mouse-derived and humanized IgG2-G4-κ antibody, targeting to Complement protein C5a (K_i=60 pM). Olendalizumab targets the complement inflammatory pathway. Moreover, Olendalizumab can be used for research of complement mediated disorder caused by corona virus .

HY-P99114

Sugemalimab	PD-1/PD-L1	Cancer
Sugemalimab is a fully human, full length, anti-programmed death ligand 1 (PD-L1) immunoglobulin G4 (IgG4) monoclonal antibody (mAb). Sugemalimab shows anticancer activities and can be used for non-small cell lung cancer research .

HY-P990181

Anti-Mouse myeloperoxidase/MPO Antibody (6G4)	Inhibitory Antibodies	Others
Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is a mouse-derived IgG2c, κ type antibody inhibitor, targeting to mouse myeloperoxidase/MPO.

HY-P990151

Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6)	Inhibitory Antibodies	Others
Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse TL1A/TNFSF15.

Species:	Human (3)
Tag:	His (3) SUMO (1)
Source:	E. coli Cell-free (1) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75726

	EBP1 Protein, Human (His) Proliferation-associated protein 2G4; hG4-1; ErbB3-binding protein 1; PA2G4	Human	E. coli
	EBP1 protein participates in the signal transduction pathway regulated by ERBB3 and is related to growth regulation. As an androgen receptor (AR) corepressor, it is regulated by the ERBB3 ligand neregulin-1/heregulin (HRG). EBP1 Protein, Human (His) is the recombinant human-derived EBP1 protein, expressed by E. coli , with N-His labeled tag.

HY-P702611

	Arylsulfatase B/ARSB Protein, Human (His-SUMO) Arylsulfatase B; ASB; N-acetylgActosamine-4-sulfatase; G4S	Human	E. coli Cell-free
	The arylsulfatase B (ARSB) protein is critical for cellular homeostasis by removing the sulfate group from chondroitin 4-sulfate (C4S), thereby directing its degradation. Its enzymatic activity affects the adhesion, migration and invasion of colon epithelial cells. Arylsulfatase B/ARSB Protein, Human (His-SUMO) is the recombinant human-derived Arylsulfatase B/ARSB, expressed by E. coli Cell-free , with N-SUMO, N-6*His labeled tag. The total length of Arylsulfatase B/ARSB Protein, Human (His-SUMO) is 497 a.a.,

HY-P702612

	Arylsulfatase B/ARSB Protein, Human (P.pastoris, His) Arylsulfatase B; ASB; N-acetylgActosamine-4-sulfatase; G4S	Human	P. pastoris
	The arylsulfatase B (ARSB) protein is critical for cellular homeostasis by removing the sulfate group from chondroitin 4-sulfate (C4S), thereby directing its degradation. Its enzymatic activity affects the adhesion, migration and invasion of colon epithelial cells. Arylsulfatase B/ARSB Protein, Human (P.pastoris, His) is the recombinant human-derived Arylsulfatase B/ARSB, expressed by P. pastoris , with N-6*His labeled tag. The total length of Arylsulfatase B/ARSB Protein, Human (P.pastoris, His) is 497 a.a.,

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HY-P82764

	EBP1 Antibody (YA2509) PA2G4; EBP1; Proliferation-associated protein 2G4; Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	EBP1 Antibody (YA2509) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2509), targeting EBP1, with a predicted molecular weight of 44 kDa (observed band size: 48 kDa). EBP1 Antibody (YA2509) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.