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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

HaCat cells

" in MedChemExpress (MCE) Product Catalog:

42

Inhibitors & Agonists

6

Biochemical Assay Reagents

2

Peptides

14

Natural
Products

4

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2540
    (±)-Pinocembrin

    (±)-5,7-Dihydroxyflavanone; NSC 43318

    		 Free Fatty Acid Receptor Others
    (±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line .
    (±)-Pinocembrin
  • HY-N1428
    Citric acid
    Maximum Cited Publications
    28 Publications Verification

    		 Apoptosis Endogenous Metabolite Antibiotic Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .
    Citric acid
  • HY-N1428R
    Citric acid (standard)
    3 Publications Verification

    		 Apoptosis Endogenous Metabolite Antibiotic Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Citric acid (Standard) is the analytical standard of Citric acid. This product is intended for research and analytical applications. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .
    Citric acid (standard)
  • HY-N8593
    Undecane

    		TNF Receptor Infection
    Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α [
    Undecane
  • HY-N2540R
    (±)-Pinocembrin (Standard)

    		Free Fatty Acid Receptor Others
    (±)-Pinocembrin (Standard) is the analytical standard of (±)-Pinocembrin. This product is intended for research and analytical applications. (±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line .
    (±)-Pinocembrin (Standard)
  • HY-115927
    8A8

    		NO Synthase Inflammation/Immunology
    8A8 is a potent proinflammatory factor NO inhibitor with an IC50 of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation .
    8A8
  • HY-169118
    EGR-1-IN-2

    		TNF Receptor Inflammation/Immunology
    EGR-1-IN-2 (compound 2) is an EGR-1 inhibitor with anti-inflammatory activity. EGR-1-IN-2 inhibits the formation of EGR-1-DNA complexes induced by TNF-α in HaCaT cells .
    EGR-1-IN-2
  • HY-N10623
    5-epi-Arvestonate A

    		Tyrosinase Cancer
    5-epi-Arvestonate A is a sesquiterpenoid isolated from the whole plants of Seriphidium transiliense. 5-epi-Arvestonate A promotes melanogenic production by activating the transcription of microphthalmia-associated transcription factor (MITF) and tyrosinase family genes. 5-epi-Arvestonate A inhibits the expression of IFN-γ-chemokine through the JAK/STAT signaling pathway in immortalized human keratinocyte (HaCaT) cells .
    5-epi-Arvestonate A
  • HY-138875
    Tetraacetylphytosphingosine

    		p38 MAPK Apoptosis Cardiovascular Disease Cancer
    Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphingosine exerts its inhibitory action on angiogenesis through the inhibition of MAPK activation and intracellular calcium increase . Tetraacetylphytosphingosine induces apoptosis in HaCaT cells .
    Tetraacetylphytosphingosine
  • HY-N11262
    Sudachitin

    		p38 MAPK ERK Inflammation/Immunology
    Sudachitin, a polymethoxyflavone that can be isolated from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells. Sudachitin can activate the p38MAPK pathway and inhibit the ERK1/2 pathway in HaCaT cells .
    Sudachitin
  • HY-161864
    STAT3-IN-29

    		STAT Inflammation/Immunology
    STAT3-IN-29 (Compound B20) is an inhibitor for STAT3. STAT3-IN-29 inhibits the proliferation of HaCaT cell with IC50 of 0.09 µM, ameliorates the IMQ-induced psoriasis in mouse models .
    STAT3-IN-29
  • HY-168335
    hDHODH-IN-16

    		Dihydroorotate Dehydrogenase Others
    hDHODH-IN-16 (Compound 3t) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC50 of 0.11 μM. hDHODH-IN-16 shows very low cytotoxicity to healthy HaCaT cells, with an IC50 value greater than 200 µM .
    hDHODH-IN-16
  • HY-N8593S
    Undecane-d24

    		TNF Receptor Infection
    Undecane-d24 is the deuterium labeled Undecane[1]. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[2].
    Undecane-d24
  • HY-N8593R
    Undecane (Standard)

    		TNF Receptor Infection
    Undecane (Standard) is the analytical standard of Undecane. This product is intended for research and analytical applications. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[
    Undecane (Standard)
  • HY-13451R
    Finafloxacin (Standard)

    		Bacterial Antibiotic Infection
    Citric acid (Standard) is the analytical standard of Citric acid. This product is intended for research and analytical applications. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .
    Finafloxacin (Standard)
  • HY-N1428S6
    Citric acid-d4-1

    		Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Antibiotic Cancer
    Citric acid-d4-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.
    Citric acid-d4-1
  • HY-146454
    Antiproliferative agent-6

    		DNA/RNA Synthesis Cancer
    Antiproliferative agent-6 (compound 8a) is a potent antitumor agent. Antiproliferative agent-6 has antiproliferative activity against cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI50s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively .
    Antiproliferative agent-6
  • HY-169290
    JAK/HDAC-IN-4

    		JAK HDAC Inflammation/Immunology
    JAK/HDAC-IN-4 (compound 11 i) is a JAK/HDAC inhibitor with the IC50 values of 0.49 nM and 12 nM for JAK2 and HDAC6, respectively. JAK/HDAC-IN-4 inhibits the cell proliferation and the production of nitric oxide. JAK/HDAC-IN-4 ameliorates psoriasis-like skin lesions in an Imiquimod (HY-B0180)-induced murine model with low toxicity .
    JAK/HDAC-IN-4
  • HY-131821
    5'-TMPS

    Thymidine-5'-O-monophosphorothioate

    		 P2Y Receptor Others
    5'-TMPS (Thymidine-5'-O-monophosphorothioate) is a selective partial agonist of P2Y6R and an antagonist of P2Y14R. Additionally, 5'-TMPS acts as a positive regulator of angiogenesis, exhibiting pro-angiogenic effects
    5'-TMPS
  • HY-N1428S3
    Citric acid-13C3

    		Apoptosis Endogenous Metabolite Antibiotic Cancer
    Citric acid- 13C3 is the 13C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].
    Citric acid-13C3
  • HY-169007
    STAT3-IN-34

    		STAT Inflammation/Immunology
    STAT3-IN-34 (Compound 15E) is an inhibitor for STAT3, and inhibits the nuclear translocation and transcriptional regulator activity of STAT3. STAT3-IN-34 inhibits the proliferation of cell HaCaT with IC50 of 0.008 μM. STAT3-IN-34 inhibits IL-17A expression and ameliorates Imiquimod (HY-B0180)-induced psoriasis in mice .
    STAT3-IN-34
  • HY-123230
    Trifloxystrobin

    CGA 279202

    		 Fungal Caspase PARP Apoptosis Infection Neurological Disease
    Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases .
    Trifloxystrobin
  • HY-159144
    Anti-inflammatory agent 91

    		NF-κB STAT Interleukin Related TNF Receptor Inflammation/Immunology
    Anti-inflammatory agent 91 (Compound 4o) is an anti-inflammatory agent that can reduce inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. Anti-inflammatory agent 91 can be used in research to improve skin inflammation associated with psoriasis .
    Anti-inflammatory agent 91
  • HY-168526
    Keap1-Nrf2-IN-24

    		Keap1-Nrf2 Inflammation/Immunology
    Keap1-Nrf2-IN-24 (compound 57) is a potent Keap1-Nrf2 inhibitor with a Ki value of 13 nM. Keap1-Nrf2-IN-24 increases the protein expression of TRXR1 and NQO1. Keap1-Nrf2-IN-24 increases the AKR1B10 mRNA expression. Keap1-Nrf2-IN-24 shows good metabolic stability .
    Keap1-Nrf2-IN-24
  • HY-163454
    NorA-IN-2

    		Bacterial Infection
    NorA-IN-2 (compound DZ-3) is a potent NorA inhibitor. NorA-IN-2 shows NorA efflux pump inhibitors (EPI) activity .
    NorA-IN-2
  • HY-154861
    Anticancer agent 118

    		Bacterial Apoptosis Necroptosis Cancer
    Anticancer agent 118, a N‑acylated ciprofloxacin derivative, has anti-bacterial and anticancer activities. Anticancer agent 118 shows high activity against Gram-positive strains and antiproliferative activities against prostate PC3 cells. Anticancer agent 118 can be used for antitumor research .
    Anticancer agent 118
  • HY-P3161
    Lactoferrin from Bovine milk

    		HSV Infection Inflammation/Immunology Cancer
    Lactoferrin from Bovine milk is a substance released by neutrophils. Lactoferrin from Bovine milk is an orally active multifunctional iron binding glycoprotein. Lactoferrin from Bovine milk prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin from Bovine milk also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin from Bovine milk has anti-inflammatory, immunomodulatory, and anti-cancer activities .
    Lactoferrin from Bovine milk
  • HY-149700
    ROCK2-IN-7

    		ROCK MMP STAT Others
    ROCK2-IN-7 is a kinase inhibitor targeting to ROCK2. ROCK2-IN-7 inhibits ROCK2/pSTAT3 Signaling. ROCK2-IN-7 suppresses systemic immunity activation and attenuates inflammation in psoriasis model .
    ROCK2-IN-7
  • HY-163176
    WB518

    		STAT Inflammation/Immunology
    WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod (HY-B0180) and TPA (HY-18739)-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17 .
    WB518
  • HY-W127530R
    α-Tocopherol phosphate (disodium) (Standard)

    		Apoptosis Reactive Oxygen Species Cardiovascular Disease Cancer
    Ginsenoside Rd (Standard) is the analytical standard of Ginsenoside Rd. This product is intended for research and analytical applications. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.
    α-Tocopherol phosphate (disodium) (Standard)
  • HY-W127530
    α-Tocopherol phosphate disodium
    4 Publications Verification

    alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium

    		 Apoptosis Reactive Oxygen Species Cardiovascular Disease Cancer
    α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis .
    α-Tocopherol phosphate disodium
  • HY-113599
    Isoprocurcumenol

    		EGFR ERK Akt Others
    Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes .
    Isoprocurcumenol
  • HY-N12960
    Artobiloxanthone

    		Apoptosis Bcl-2 Family Caspase COX MMP STAT Cancer
    Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC50 of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9 .
    Artobiloxanthone
  • HY-168971
    Paeoniflorin-6′-O-benzene sulfonate

    CP-25

    		 G Protein-coupled Receptor Kinase (GRK) JAK STAT IFNAR TNF Receptor Interleukin Related CXCR Inflammation/Immunology
    Paeoniflorin-6′-O-benzene sulfonate (CP-25) is the inhibitor for G protein-coupled receptor kinase 2 (GRK2) that inhibits the translocation of GRK2 to the cell membrane, inhibits JAK1/STAT3 signaling pathway. Paeoniflorin-6′-O-benzene sulfonate inhibits IL-17A/CXCL2-induced proliferation of HaCaT. Paeoniflorin-6′-O-benzene sulfonate reduces the levels of inflammatory factors and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3 and CXCL9, alleviates Imiquimod (HY-B0180)-induced psoriasis in mouse model .
    Paeoniflorin-6′-O-benzene sulfonate
  • HY-P3513
    β-Neo-Endorphin

    		ERK MMP Neurological Disease
    β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9 .
    β-Neo-Endorphin
  • HY-P3513A
    β-Neo-Endorphin acetate

    		ERK MMP Neurological Disease
    β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the Erk1/2, MMP-2 and MMP-9 .
    β-Neo-Endorphin acetate
  • HY-N9093
    (3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane

    		Others Inflammation/Immunology Cancer
    (3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane, a diarylheptanoid from the rhizomes of Curcuma kwangsiensis, possesses a variety of biological and pharmacological activities including antioxidant, antihepa totoxic, anti-inflammatory, antiproliferative, antiemetic, and antitumor activities .
    (3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane
  • HY-41404
    Piperonylic acid

    2H-1,3-benzodioxole-5-carboxylic acid

    		 Cytochrome P450 Interleukin Related EGFR IGF-1R Infection Others Cancer
    Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities .
    Piperonylic acid
  • HY-B2201
    Citric acid trisodium
    Maximum Cited Publications
    28 Publications Verification

    Sodium citrate; Trisodium citrate anhydrous

    		 Apoptosis Endogenous Metabolite Metabolic Disease Cancer
    Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice .
    Citric acid trisodium
  • HY-N1428A
    Citric acid monohydrate
    Maximum Cited Publications
    28 Publications Verification

    		 Endogenous Metabolite Apoptosis Antibiotic Metabolic Disease Inflammation/Immunology Cancer
    Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .
    Citric acid monohydrate
  • HY-N1428AR
    Citric acid monohydrate (Standard)

    		Endogenous Metabolite Apoptosis Antibiotic Metabolic Disease Inflammation/Immunology Cancer
    Citric acid (monohydrate) (Standard) is the analytical standard of Citric acid (monohydrate). This product is intended for research and analytical applications. Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .
    Citric acid monohydrate (Standard)
  • HY-162600
    CDK8-IN-15

    		CDK Inflammation/Immunology
    CDK8-IN-15 (Compound 46) is a potent CDK8 inhibitors with an IC50 value of 57 nM. It can enhance the thermal stability of CDK8 along with inhibition against NF-κB and have favourable selectivity across the CDK family and tyrosine kinase. Additionally, it also demostrates a positive effect in vitro psoriasis model induced by TNF-α and alleviats the inflammatory response enhancing the expression of Foxp3 and IL-10, which is promising for research of psoriasis diseases .
    CDK8-IN-15

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