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Results for "

Human neutrophils

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) AP-1 (1) Apoptosis (3) Bacterial (6) Biochemical Assay Reagents (1) c-Fms (2) Calcium Channel (2) Cathepsin (1) Complement System (2) CXCR (1) Drug Metabolite (1) EGFR (1) Elastase (29) Endogenous Metabolite (11) Epoxide Hydrolase (1) FLAP (2) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) Free Fatty Acid Receptor (1) Fungal (2) HIV (1) Isotope-Labeled Compounds (1) LDLR (1) Leukotriene Receptor (11) Lipoxygenase (6) NF-κB (3) NO Synthase (2) Parasite (3) Phospholipase (2) Platelet-activating Factor Receptor (PAFR) (1) PPAR (1) Proteasome (3) Reactive Oxygen Species (4) SARS-CoV (4) Ser/Thr Protease (3) TGF-β Receptor (2)
By Research Areas:	Cancer (14) Cardiovascular Disease (9) Endocrinology (2) Infection (9) Inflammation/Immunology (60) Metabolic Disease (10) Neurological Disease (3)

By Targets:

Antibiotic (1)

AP-1 (1)

Apoptosis (3)

Bacterial (6)

Biochemical Assay Reagents (1)

c-Fms (2)

Calcium Channel (2)

Cathepsin (1)

Complement System (2)

CXCR (1)

Drug Metabolite (1)

EGFR (1)

Elastase (29)

Endogenous Metabolite (11)

Epoxide Hydrolase (1)

FLAP (2)

Fluorescent Dye (1)

Formyl Peptide Receptor (FPR) (1)

Free Fatty Acid Receptor (1)

Fungal (2)

HIV (1)

Isotope-Labeled Compounds (1)

LDLR (1)

Leukotriene Receptor (11)

Lipoxygenase (6)

NF-κB (3)

NO Synthase (2)

Parasite (3)

Phospholipase (2)

Platelet-activating Factor Receptor (PAFR) (1)

PPAR (1)

Proteasome (3)

Reactive Oxygen Species (4)

SARS-CoV (4)

Ser/Thr Protease (3)

TGF-β Receptor (2)

By Research Areas:

Cancer (14)

Cardiovascular Disease (9)

Endocrinology (2)

Infection (9)

Inflammation/Immunology (60)

Metabolic Disease (10)

Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70227

Cathepsin G, human neutrophils CTSH; ACC4; ACC5	Ser/Thr Protease	Inflammation/Immunology
Cathepsin G, human neutrophils (CTSH; ACC4) a serine protease found in polymorphonuclear neutrophils (PMNs), functions in inflammation .

HY-155414

Neutrophil elastase inhibitor 5	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC₅₀ values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases .

HY-19254

ZD-0892	Elastase	Cardiovascular Disease
ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with K_is of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

HY-163411

Neutrophil elastase inhibitor 6	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 6 (compound 113) is an irreversible phosphonic-type inhibitor of human neutrophil elastase .

HY-112742

CP-195543	Leukotriene Receptor	Inflammation/Immunology
CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC₅₀s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration .

HY-122536

Ricinelaidic acid	Leukotriene Receptor Calcium Channel Endogenous Metabolite	Inflammation/Immunology
Ricinelaidic acid,a 12-hydroxy fatty acid，is a leukotriene B4 (LTB4) receptor antagonist with the K_i of 2 µM in porcine neutrophil membranes. Ricinelaidic acid inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC₅₀values = 10 and 7 µM, respectively). Ricinelaidic acid inhibits bronchoconstriction induced by LTB4 in rats .

HY-106448

Midesteine MR 889	Ser/Thr Protease	Inflammation/Immunology
Midesteine (MR 889) is a proteinase inhibitor that can inhibit porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. Midesteine has the potential for chronic obstructive pulmonary disease (COPD) and chronic bronchitis research .

HY-121140

AZ1729	Free Fatty Acid Receptor	Metabolic Disease
AZ1729 is a potent free fatty acid 2 receptor (FFA2) activator, acting as a direct allosteric agonist and as a positive allosteric modulator. AZ1729 increases the activity of the endogenously produced short chain fatty acid propionate in G_i-mediated pathways, but not at those transduced by G_q/G₁₁. AZ1729 induces inhibition of isoproterenol-induced lipolysis in mouse adipocytes. AZ1729 also can Induce migration of human neutrophils. AZ1729 can be used for researching the signaling pathways of the physiological roles of FFA2 .

HY-P1068B

Lysozyme, Human Neutrophil	Others	Infection
Lysozyme, Human Neutrophil is found to be present in all three types of human neutrophil granules (azurophil-, specific- and gelatinase granules). Lysozyme, Human Neutrophil takes part in antibacterial activity of leukocytes .

HY-117668

MDL 101146	Elastase	Infection Inflammation/Immunology
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a K_i value of 25 nM. MDL 101146 can be used for the research of arthritis .

HY-P5995

MeOSuc-AAPA-CMK	Elastase	Cancer
MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase .

HY-P2311

Defensin HNP-2 human	Endogenous Metabolite Antibiotic	Inflammation/Immunology
Defensin HNP-2 human is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils.

HY-U00256

ZD8321	Elastase	Inflammation/Immunology Cancer
ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a K_i of 13±1.7 nM.

HY-19406

AE-3763	Elastase	Cardiovascular Disease Inflammation/Immunology
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC₅₀ of 29 nM.

HY-145542S

Isovalerylcarnitine-d9 chloride	Proteasome Endogenous Metabolite	Metabolic Disease
Isovalerylcarnitine-d₉ (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].

HY-155231

Neutrophil elastase inhibitor 4	Elastase	Cancer
Neutrophil elastase inhibitor 4 (compound 4f) is a competitive human neutrophil elastase (HNE) inhibitor (IC₅₀: 42.30 nM, K_i: 8.04 nM). Neutrophil elastase inhibitor 4 induces T47D cell apoptosis. Neutrophil elastase inhibitor 4 inhibits cell proliferation with IC₅₀s of 21.25, 34.17, 29.93, 99.11 nM for T47D, RPMI 8226, A549, and HSF cells .

HY-100240

Lodelaben SC-39026; Declaben	Elastase	Cardiovascular Disease Metabolic Disease
Lodelaben is a human neutrophil elastase inhibitor with an IC₅₀ and K_i of 0.5 and 1.5 μM, respectively.

HY-N8217

4-O-Cinnamoylquinic acid	Others	Inflammation/Immunology
4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .

HY-19908

BAY-85-8501 4 Publications Verification	Elastase	Metabolic Disease
BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC₅₀ of 65 pM.

HY-145542

Isovalerylcarnitine chloride	Proteasome Endogenous Metabolite	Metabolic Disease
Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca ²⁺-dependent proteinase (calpain) of human neutrophils .

HY-19269

FK706	Elastase	Inflammation/Immunology
FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC₅₀ of 83 nM and a K_i of 4.2 nM. FK706 also inhibits *mouse neutrophil* elastase and porcine pancreatic elastase with IC₅₀*s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human* pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect .

HY-N6946

Mitraphylline	NF-κB	Inflammation/Immunology
Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .

HY-123753

MDL 27399	Cathepsin	Inflammation/Immunology
MDL 27399 is an inhibitor of human neutrophil cathepsin G (K_i = 7 μM). MDL 27399 can be used for research of inflammatory diseases .

HY-P99913

Eflapegrastim	c-Fms	Inflammation/Immunology Cancer
Eflapegrastim is a human IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia .

HY-P3648

Ala-Ala-Pro-Val-chloromethylketone AAPV-CMK	Elastase	Inflammation/Immunology
Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases .

HY-N11934

Piperkadsin A	Reactive Oxygen Species	Inflammation/Immunology Cancer
Piperkadsin A is a potent inhibitor of ROS. Piperkadsin inhibits PMA-induced ROS production in human polymorphonuclear neutrophils with an IC₅₀ of 4.3 μM .

HY-N3566

Cepharadione A	Others	Inflammation/Immunology
Cepharadione A can be isolated from the roots of Piper betle Linn. Cepharadione A inhibits FMLP/CB induced elastase release by human neutrophils .

HY-106216

Tiprelestat	Elastase	Infection Inflammation/Immunology
Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease .

HY-15891

GW311616 5+ Cited Publications	Elastase	Inflammation/Immunology
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC₅₀ value of 22 nM and K_i value of 0.31 nM .

HY-15891A

GW311616 hydrochloride 5+ Cited Publications GW311616A	Elastase	Inflammation/Immunology
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC₅₀ value of 22 nM and K_i value of 0.31 nM .

HY-P2310

Defensin HNP-1 human	Bacterial Parasite	Infection Cardiovascular Disease
Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human exhibits broad antimicrobial and anti-leishmanial activities .

HY-16992A

W-54011 5 Publications Verification	Complement System Reactive Oxygen Species	Inflammation/Immunology
W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of ¹²⁵I-labeled C5a to human neutrophils with a K_i value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca ²⁺ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC₅₀s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively .

HY-P99440

Anumigilimab CSL-324	c-Fms	Inflammation/Immunology
Anumigilimab (CSL-324) is an human IgG4 mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation .

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite	Infection Cardiovascular Disease
Defensin HNP-1 human TFA is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human TFA exhibits broad antimicrobial and anti-leishmanial activities .

HY-N8152

Randialic acid B	Reactive Oxygen Species	Inflammation/Immunology
Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo .

HY-W345359

PAF C-18:1	Endogenous Metabolite	Inflammation/Immunology
PAF C-18:1 is a naturally occurring phospholipid produced by cells upon inflammatory responses. PAF C-18:1 is a chemoattractant, and induces human neutrophil chemotaxis .

HY-P3293

Lonodelestat POL6014	Elastase	Inflammation/Immunology
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) .

HY-117706

LY 292728	Leukotriene Receptor	Inflammation/Immunology
LY 292728 is a potent leukotriene B4 (LTB4) receptor antagonist. LY 292728 binds to human neutrophils with a K_i of 0.47 nM and binds to guinea pig lung membranes with a K_i of 0.04 nM .

HY-E70356

**Neutrophil Elastase (NEG),Human** ELA-2, Elastase, hne, leukocyte elastase, serine elastase, elaszym	Others	Others
Neutrophil Elastase (NEG), Human (ELA-2, Elastase, hne, leukocyte elastase, serine elastase, elaszym) is a biological material or organic compound that can be used in life science research .

HY-P1619

ICI 186756	Others	Others
ICI 186756 is a compound that inhibits the activity of human neutrophil elastase, has a competitive inhibitory effect on the enzyme, can inhibit enzyme-induced lung changes, and can also modulate hamster lung lesions.

HY-W654243

Isovalerylcarnitine-d9-1 chloride	Isotope-Labeled Compounds Proteasome Endogenous Metabolite	Metabolic Disease
Isovalerylcarnitine-d₉-1 (chloride) is deuterium labeled Isovalerylcarnitine (chloride). Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca ²⁺-dependent proteinase (calpain) of human neutrophils .

HY-113628

ABT-080 VML-530	Leukotriene Receptor	Inflammation/Immunology
ABT-080 is an orally active inhibitor of leukotriene biosynthesis. ABT-080 simultaneously blocks the leukotriene pathways leading to the synthesis of LTB₄ and LTC₄, but does not inhibit PGH2 biosynthesis. ABT-080 can block bronchoconstriction and be used in the research of asthma and related inflammations

HY-N12126

Sydowinin B MS-347b	Others	Inflammation/Immunology
Sydowinin B (MS-347b) is a active compound and can be isolated from A. sydowii. Sydowinin B shows has immunosuppressant activity .

HY-19908B

(R)-BAY-85-8501 1 Publications Verification	Others	Metabolic Disease
(R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC₅₀ of 65 pM .

HY-P3293A

Lonodelestat TFA POL6014 TFA	Elastase	Inflammation/Immunology
Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF) .

HY-119038

ML-7	Endogenous Metabolite	Cardiovascular Disease
ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion (O(2)(-)) release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O(2)(-) release of stimulated cells, but has no effect on the intracellular O(2)(-) production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury .

HY-116638

AHR-5333	Lipoxygenase	Endocrinology
AHR-5333 is a selective human blood neutrophil 5-lipoxygenase inhibitor. AHR-5333 exhibits potent, long-acting activity in rat and guinea pig in vivo models of immediate hypersensitivity .

HY-N6946R

Mitraphylline (Standard)	NF-κB	Inflammation/Immunology
Mitraphylline (Standard) is the analytical standard of Mitraphylline. This product is intended for research and analytical applications. Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .

HY-120606

A-78773	Lipoxygenase	Inflammation/Immunology
A-78773 is a 5-lipoxygenase inhibitor. A-78773 can inhibit the formation of LTB₄ in human whole blood and human neutrophils, with IC₅₀ values of 85 nM and 20 nM, respectively. A-78773 can be used in the study of inflammation-related diseases .

HY-131670

(±)9,10-DiHOME	AP-1 PPAR NF-κB	Inflammation/Immunology
(±)9,10-DiHOME is the racemate of 9,10-DiHOME. 9,10-DiHOME is a leukotoxin derivative of linoleic acid diol that has been reported to be toxic in human's tissue preparations, and is produced by inflammatory leukocytes such as neutrophils and macrophages .

Cat. No.	Product Name	Type

HY-113058

3-Hydroxyoctanoic acid

Biochemical Assay Reagents

3-Hydroxyoctanoic acid is a hydroxylated fatty acid that has been found in the LPS of Pseudomonas aeruginosa and in methyl-branched poly(3-hydroxyalkanoate) (PHA) polymers produced by Pseudomonas oleophores. It is an agonist of the orphan receptor GPR109B, increasing intracellular calcium in human neutrophils endogenously expressing GPR109B. 3-Hydroxycaprylic acid prevents lipolysis in human adipocytes and is upregulated in human plasma in response to a ketogenic diet. Plasma levels of 3-hydroxyoctanoic acid were also increased 3.41-fold in human male runners exhausted on a treadmill and in a mouse model of autism spectrum disorder (ASD) fed a high-glycemic diet.

Cat. No.	Product Name	Target	Research Area

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite	Infection Cardiovascular Disease
Defensin HNP-1 human TFA is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human TFA exhibits broad antimicrobial and anti-leishmanial activities .

HY-P3293

Lonodelestat POL6014	Elastase	Inflammation/Immunology
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) .

HY-P3293A

Lonodelestat TFA POL6014 TFA	Elastase	Inflammation/Immunology
Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF) .

HY-P5995

MeOSuc-AAPA-CMK	Elastase	Cancer
MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil elastase .

HY-P2311

Defensin HNP-2 human	Endogenous Metabolite Antibiotic	Inflammation/Immunology
Defensin HNP-2 human is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils.

HY-P3648

Ala-Ala-Pro-Val-chloromethylketone AAPV-CMK	Elastase	Inflammation/Immunology
Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases .

HY-106216

Tiprelestat	Elastase	Infection Inflammation/Immunology
Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease .

HY-P2310

Defensin HNP-1 human	Bacterial Parasite	Infection Cardiovascular Disease
Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human exhibits broad antimicrobial and anti-leishmanial activities .

HY-P4663

Val-Gly-Ser-Glu NSC 350591	Peptides	Cancer
Val-Gly-Ser-Glu (NSC 350591) is an ECF-A tetrapeptide. Val-Gly-Ser-Glu dose-dependently increases the number of human eosinophils, but not neutrophils, rosetting with complement-coated sheep erythrocytes (EAC3b) .

HY-P5459

Elafin(human)	Bacterial Elastase	Infection
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus .

HY-P0308

[Glu1]-Fibrinopeptide B	Peptides	Cardiovascular Disease
[Glu1]-Fibrinopeptide B is derived from fibrinopeptide B amino acid residues 1-14. Human fibrinopeptide B (hFpB), a thrombin-derived proteolytic cleavage product of the fibrinogen B beta-chain, to stimulate neutrophils (PMN), monocytes, and fibroblasts.

HY-P2573

Suc-AAPF-pNA Suc-Ala-Ala-Pro-Phe-pNA	Peptides	Others
Suc-AAPF-pNA (Suc-Ala-Ala-Pro-Phe-pNA) is a chromogenic p-nitroanilide (pNA) substrate with the K_m of 1.7 mM. Cleavage of Suc-AAPF-pNA releases 4-nitroaniline, which is yellow in colour and can be measured spectrophotometrically. Suc-AAPF-pNA can be used for the measurement of free and membrane-bound cathepsin G in human neutrophils .

HY-P1640

(Trp63,Trp64)-C3a(63-77)	Complement System	Inflammation/Immunology
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca ²⁺ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC₅₀ of 9.5, 2.0 and 0.8 nM, respectively .

HY-P2294

pm26TGF-β1 peptide	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P2294A

pm26TGF-β1 peptide TFA 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P5446

BMAP-18	Bacterial	Others
BMAP-18 is a biological active peptide. (BMAP-18 is a truncated form of the antimicrobial peptide BMAP-27. Bovine myeloid antimicrobial peptide-27 (BMAP-27) belongs to the Cathelicidin family of peptides which displays rapid bactericidal activity against Staphylococcus aureus, Streptococcus uberis, and Escherichia coli. BMAP-27 is cytotoxic to human erythrocytes and neutrophils, although at higher than microbicidal concentrations. BMAP-18 displays much higher cell selectivity as compared to parental BMAP-27 because of its decreased hemolytic activity and retained antimicrobial activity.)

Cat. No.	Product Name	Target	Research Area

HY-P99440

Anumigilimab CSL-324	c-Fms	Inflammation/Immunology
Anumigilimab (CSL-324) is an human IgG4 mAb against human granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation .

HY-P99913

Eflapegrastim	c-Fms	Inflammation/Immunology Cancer
Eflapegrastim is a human IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-145542

Isovalerylcarnitine chloride	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Proteasome Endogenous Metabolite
Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca ²⁺-dependent proteinase (calpain) of human neutrophils .

HY-N6946

Mitraphylline	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Inflammation/Immunology Disease Research Fields	NF-κB
Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .

HY-N8152

Randialic acid B	Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants Disease Research Fields Inflammation/Immunology	Reactive Oxygen Species
Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo .

HY-N1942

5-O-Demethylnobiletin 1 Publications Verification 5-Demethylnobiletin	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavones Rutaceae Plants Citrus Disease Research Fields Cancer	Lipoxygenase Leukotriene Receptor
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB₄) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-N8217

4-O-Cinnamoylquinic acid	Structural Classification Viscum Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields Loranthaceae	Others
4-O-Cinnamoylquinic acid could inhibit superoxide anion generation in human neutrophils .

HY-N11934

Piperkadsin A	Structural Classification Monophenols Source classification Phenols Piperaceae Plants Piper kadsura (Choisy) Ohwi	Reactive Oxygen Species
Piperkadsin A is a potent inhibitor of ROS. Piperkadsin inhibits PMA-induced ROS production in human polymorphonuclear neutrophils with an IC₅₀ of 4.3 μM .

HY-N3566

Cepharadione A	Structural Classification Natural Products Liliaceae Piper betle L. Source classification Piperaceae Allium cepa L. Plants	Others
Cepharadione A can be isolated from the roots of Piper betle Linn. Cepharadione A inhibits FMLP/CB induced elastase release by human neutrophils .

HY-N12126

Sydowinin B MS-347b	Structural Classification Microorganisms Xanthones Source classification Phenols	Others
Sydowinin B (MS-347b) is a active compound and can be isolated from A. sydowii. Sydowinin B shows has immunosuppressant activity .

HY-N6946R

Mitraphylline (Standard)	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants	NF-κB
Mitraphylline (Standard) is the analytical standard of Mitraphylline. This product is intended for research and analytical applications. Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .

HY-N1942R

5-O-Demethylnobiletin (Standard)	Structural Classification Flavonoids Flavones Rutaceae Plants Citrus	Lipoxygenase Leukotriene Receptor
5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	Structural Classification Source classification Phenols Polyphenols Hypoxis angustifolia Lam. Plants Asparagaceae Juss.	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-156241

Meliadubin B	Melia dubia Cav. Triterpenes Structural Classification Terpenoids Source classification Plants Meliaceae	NO Synthase Fungal
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC₅₀ of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC₅₀ of 182.50 μM.

Cat. No.	Product Name	Chemical Structure

HY-145542S

Isovalerylcarnitine-d9 chloride
Isovalerylcarnitine-d₉ (chloride) is the deuterium labeled Isovalerylcarnitine (chloride)[1]. Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca2+-dependent proteinase (calpain) of human neutrophils[2].

HY-W654243

Isovalerylcarnitine-d9-1 chloride
Isovalerylcarnitine-d₉-1 (chloride) is deuterium labeled Isovalerylcarnitine (chloride). Isovalerylcarnitine chloride, a product of the catabolism of L-leucine, is a potent activator of the Ca ²⁺-dependent proteinase (calpain) of human neutrophils .

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Human neutrophils

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