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Results for "

P2X receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P2X Receptor (78) 5-HT Receptor (4) Adiponectin Receptor (1) Antibiotic (2) Apoptosis (5) Autophagy (4) Bacterial (2) Calcium Channel (2) CaMK (1) Dengue virus (2) Endogenous Metabolite (1) Flavivirus (2) Histamine Receptor (2) HIV (3) HSV (2) Influenza Virus (1) Interleukin Related (2) Isotope-Labeled Compounds (1) Melatonin Receptor (1) MicroRNA (1) Mitophagy (2) MMP (1) Na+/Ca2+ Exchanger (1) NOD-like Receptor (NLR) (1) P2Y Receptor (4) Parasite (2) SARS-CoV (2) Sodium Channel (1) Topoisomerase (1) TRP Channel (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (10) Infection (5) Inflammation/Immunology (32) Metabolic Disease (2) Neurological Disease (32)

By Targets:

P2X Receptor (78)

5-HT Receptor (4)

Adiponectin Receptor (1)

Antibiotic (2)

Apoptosis (5)

Autophagy (4)

Bacterial (2)

Calcium Channel (2)

CaMK (1)

Dengue virus (2)

Endogenous Metabolite (1)

Flavivirus (2)

Histamine Receptor (2)

HIV (3)

HSV (2)

Influenza Virus (1)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

Melatonin Receptor (1)

MicroRNA (1)

Mitophagy (2)

MMP (1)

Na+/Ca2+ Exchanger (1)

NOD-like Receptor (NLR) (1)

P2Y Receptor (4)

Parasite (2)

SARS-CoV (2)

Sodium Channel (1)

Topoisomerase (1)

TRP Channel (1)

By Research Areas:

Cancer (20)

Cardiovascular Disease (10)

Infection (5)

Inflammation/Immunology (32)

Metabolic Disease (2)

Neurological Disease (32)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: P2X Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108667

TNP-ATP triethylammonium	P2X Receptor	Others
TNP-ATP triethylammonium is a selective **P2X receptor** antagonist. TNP-ATP triethylammonium shows antinociceptive effects in rats .

HY-N5025

Bullatine A	P2X Receptor Apoptosis	Inflammation/Immunology Cancer
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent *P2X7* antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses . Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed .

HY-136254

BzATP triethylammonium salt 4 Publications Verification	P2X Receptor	Inflammation/Immunology Cancer
BzATP triethylammonium salt acts as a **P2X receptor agonist with pEC₅₀*s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively . BzATP triethylammonium salt is potent at P2X7 receptors* with EC₅₀s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively .

HY-19978

RO-3	P2X Receptor	Neurological Disease
RO-3 is a potent, CNS-penetrant, and orally active *P2X₃* and *P2X_2/3* antagonist with pIC₅₀s of 5.9 and 7.0 for human homomultimeric P2X₃ and heteromultimeric P2X_2/3 receptors, respectively. RO-3 shows selectivity for P2X₃ and P2X_2/3 over all other functional homomultimeric P2X receptors (IC₅₀ >10 μM at P2X_1,2,4,5,7) .

HY-139627

P2X receptor-1	P2X Receptor	Inflammation/Immunology
P2X receptor-1 is a potential inhibitor of **P2X receptor** for the research of pain and inflammation.

HY-101077

Iso-PPADS tetrasodium	P2X Receptor	Inflammation/Immunology
Iso-PPADS tetrasodium is a *P2X-purinoceptor* antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC₅₀s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI) .

HY-134370

Ap4G	P2X Receptor	Cardiovascular Disease
Ap4G is a dinucleoside polyphosphate compound with vasoconstrictor activity. Ap4G regulates vasoconstriction through P2 receptors, especially *P2X* receptors, and is an important tool for studying vascular physiology and pathology .

HY-134262

8-Bromo-ATP 8-Bromoadenosine 5'-triphosphate; 8-Br-ATP	P2X Receptor	Cancer
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic **P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC₅₀** of 23.1 μM .

HY-18745

BzATP triethylammonium Benzoylbenzoyl-ATP triethylammonium	P2X Receptor	Inflammation/Immunology Cancer
BzATP triethylammonium acts as a **P2X receptor agonist with pEC₅₀*s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively . BzATP triethylammonium is potent at P2X7 receptors* with EC₅₀s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively .

HY-148558

P2X7 receptor antagonist-3	P2X Receptor	Neurological Disease
P2X7 receptor antagonist-3 is a potent *P2X7* receptor antagonist with P2X7R IC₅₀ values of 4.2 nM in humans and 6.8 nM in rats .

HY-150059

P2X7 receptor antagonist-2	P2X Receptor	Neurological Disease Inflammation/Immunology
P2X7 receptor antagonist-2 is a potent **P2X7 receptor antagonist with a pIC₅₀** value of 6.5-7.5. P2X7 receptor antagonist-2 has efficacy of combating neuroinflammation .

HY-162951

P2X7 receptor antagonist-5	P2X Receptor	Cancer
P2X7 receptor antagonist-5 (compund 13a) is a potent, orally active and long-lasting *P2X7* receptor antagonist .

HY-101044

PPADS tetrasodium 2 Publications Verification	P2X Receptor Na+/Ca2+ Exchanger	Neurological Disease
PPADS tetrasodiuma is a non-selective **P2X receptor** antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca ²⁺ exchanger in guinea pig airway smooth muscle .

HY-161914

P2X3 antagonist 39	P2X Receptor	Neurological Disease
P2X3 antagonist 39 (compound 26a) is a selective *P2X3* receptor antagonist with an IC₅₀ value of 54.9 nM. P2X3 antagonist 39 can be used in the study of neuropathic pain model .

HY-137325A

2-Chloro-ATP sodium	Calcium Channel	Metabolic Disease
2-Chloro-ATP sodium (2-Chloro ATP) is an adenine nucleotide and an analog of ATP. It is an antagonist of the purinergic P2Y1 receptor and inhibits intracellular calcium mobilization induced by ADP (HY-W010918) in Jurkat cells expressing the human receptor (Ki=2.3 μM). 2-Chloro-ATP sodium is an agonist of the purinergic P2X receptor and induces inward currents in HEK293 cells expressing human bladder smooth muscle or rat PC12 forms of the receptor (EC50=0.5 and 2.5 μM). 2-Chloro-ATP sodium induces relaxation of precontracted guinea pig cecal strips in a concentration-dependent manner. 2-Chloro-ATP sodium has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases such as protein kinase A (PKA) and PKG.

HY-101588

Gefapixant MK-7264; AF-219	P2X Receptor	Inflammation/Immunology
Gefapixant is an orally active and potent purinergic **P2X3 receptor** (P2X3R) antagonist, with IC₅₀ values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis .

HY-101588A

Gefapixant citrate MK-7264 citrate; AF-219 citrate	P2X Receptor	Inflammation/Immunology
Gefapixant citrate is an orally active and potent purinergic **P2X3 receptor** (P2X3R) antagonist, with IC₅₀ values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis .

HY-131502

Taspine	P2X Receptor	Inflammation/Immunology
Taspine is a natural product with anti-inflammatory activity. Taspine suppresses *P2X4* receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage .

HY-101588R

Gefapixant (Standard)	P2X Receptor	Inflammation/Immunology
Gefapixant (Standard) is the analytical standard of Gefapixant. This product is intended for research and analytical applications. Gefapixant is an orally active and potent purinergic **P2X3 receptor** (P2X3R) antagonist, with IC₅₀ values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis .

HY-108673

Ro 0437626	P2X Receptor	Cancer
Ro 0437626 is a selective purinergic *(P2X₁)* receptor antagonist (IC₅₀ = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC₅₀ > 100 μM) .

HY-135976

P2X3 antagonist 34	P2X Receptor	Neurological Disease Inflammation/Immunology
P2X3 antagonist 34 is a potent, selective and orally active **P2X3 homotrimeric receptor antagonist with IC₅₀*s of 25?nM, 92?nM and 126?nM for human P2X3, rat P2X3* and guinea pig P2X3 receptors, respectively. P2X3 antagonist 34 is less active against human, rat and guinea pig P2X2/3 heterotrimeric receptors. P2X3 antagonist 34 has strong anti-tussive effect .

HY-128402

P2X3-IN-1	P2X Receptor	Neurological Disease
P2X3-IN-1 (example 7) is an inhibitor of **P2X3 receptor*. P2X*3-IN-1 can be used for neurogenic diseases research .

HY-14483A

AF-353 hydrochloride Ro-4 hydrochloride	P2X Receptor	Cancer
AF-353 hydrochloride is a potent, selective and orally bioavailable **P2X3/P2X2/3 receptor antagonist, with a pIC₅₀** of 8.0 for both human and rat P2X3, and with a pIC₅₀ of 7.3 for human P2X2/3 .

HY-18725

P2X7-IN-2	P2X Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
P2X7-IN-2 (compound 58) is a *P2X7* receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC₅₀ value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease .

HY-134440A

α,β-Methylene-ATP	P2X Receptor	Inflammation/Immunology
α,β-Methylene ATP, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP is a highly selective agonist for *P2X1* and *P2X3, with practically no activity at P2X*2,4-7 .

HY-14483

AF-353 1 Publications Verification Ro-4	P2X Receptor	Cancer
AF-353 (Ro-4) is a potent, selective and orally bioavailable **P2X3/P2X2/3 receptor antagonist, with a pIC₅₀** of 8.0 for both human and rat P2X3, and with a pIC₅₀ of 7.3 for human P2X2/3 .

HY-18725A

P2X7-IN-2 TFA	P2X Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
P2X7-IN-2 TFA (compound 58) is a *P2X7* receptor inhibitor. P2X7-IN-2 TFA inhibits IL-Iβ release with an IC₅₀ value of 0.01 nM. P2X7-IN-2 TFA can be used for the research of autoimmunity, inflammation and cardiovascular disease .

HY-108652

α,β-Methylene-ATP trisodium	P2X Receptor	Inflammation/Immunology
α,β-Methylene-ATP trisodium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand . α,β-Methylene-ATP trisodium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7 .

HY-134440

α,β-Methylene-ATP dilithium	P2X Receptor	Inflammation/Immunology
α,β-Methylene ATP dilithium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand . α,β-Methylene ATP dilithium is a highly selective agonist for *P2X1* and *P2X3, with practically no activity at P2X*2,4-7 .

HY-108676

NF023 hexasodium	P2X Receptor	Neurological Disease
NF023 hexasodium is a selective and competitive **P2X₁ receptor antagonist, with IC₅₀** values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X₁, P2X₃, P2X₂, and P2X₄-mediated responses respectively .

HY-50697

A-740003 10+ Cited Publications	P2X Receptor	Neurological Disease
A-740003 is a potent, selective and competitive **P2X7 receptor antagonist with IC₅₀** values are 18 and 40 nM for rat and human P2X7 receptors, respectively.

HY-137451

Sivopixant S-600918	P2X Receptor	Neurological Disease
Sivopixant (S-600918) is a potent and selective **P2X3 receptor** antagonist (P2X3 IC₅₀=4.2 nM; P2X2/3 IC₅₀=1100 nM). Sivopixant shows strong analgesic effect .

HY-145466

EVT-401	P2X Receptor	Neurological Disease
EVT-401 (P2X7 receptor antagonist-1) is a purinergic **P2X7 receptor** antagonist. EVT-401 has efficacy of combating neuroinflammation .

HY-15568

A-317491 4 Publications Verification	P2X Receptor	Neurological Disease Inflammation/Immunology
A-317491 is a potent, selective and non-nucleotide antagonist of *P2X₃* and **P2X_2/3 receptors, with K_is of 22, 22, 9, and 92 nM for hP2X₃, rP2X₃, hP2X_2/3, and rP2X_2/3, respectively. A-317491 is highly selective (IC50*>10 μM) over other P2 receptors* and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X₃ and P2X_2/3 receptor-mediated calcium flux .

HY-15568A

A-317491 sodium salt hydrate 4 Publications Verification	P2X Receptor	Neurological Disease Inflammation/Immunology
A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of *P2X₃* and **P2X_2/3 receptors, with K_is of 22, 22, 9, and 92 nM for hP2X₃, rP2X₃, hP2X_2/3, and rP2X_2/3, respectively. A-317491 sodium salt hydrate is highly selective (IC50*>10 μM) over other P2 receptors* and other neurotransmitter receptors, ion channels, and enzymes. A-317491 sodium salt hydrate reduces inflammatory and neuropathic pain by blocking P2X₃ and P2X_2/3 receptor-mediated calcium flux .

HY-124300

JNJ-54166060	P2X Receptor	Others
JNJ-54166060 is a potent and selective **P2X7 receptor antagonist, with IC₅₀*s of 4/115/72 nM for human/rat/mouse P2X7 receptor*, respectively .

HY-102063

MRS 2219 Pyridoxol, cyclic 3,4-hydrogen phosphate	P2X Receptor	Neurological Disease
MRS 2219 (Pyridoxol) is a selective pharmacological probe of **P2X1 receptor*. MRS 2219 selectively potentiated ATP-evoked responses at P2X1 receptors* with an EC₅₀ of 5.9 μM .

HY-100483

A-804598 3 Publications Verification	P2X Receptor	Cancer
A-804598 is a CNS penetrant, competitive and selective *P2X7* receptor antagonist with IC₅₀s of 9 nM, 10 nM and 11 nM for mouse, rat and human *P2X7* receptors, respectively .

HY-13954

A 839977 1 Publications Verification	P2X Receptor	Neurological Disease Inflammation/Immunology
A 839977 is a *P2X7* selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC₅₀ values are 20 nM, 42 nM and 150 nM respectively) and reduces inflammatory and neuropathic pain in animal models; the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta .

HY-15487

CE-224535 PF-04905428	P2X Receptor	Neurological Disease
CE-224535 is a selective **P2X₇ receptor** antagonist.

HY-143576

P2X3 antagonist 37	P2X Receptor	Neurological Disease
P2X3 antagonist 37 is a potent **P2X3 receptor antagonist with an IC₅₀** of 32.45 nM for hP2X3 (WO2021115225A1, example 68) .

HY-101308

MRS2179 tetrasodium	P2Y Receptor	Cardiovascular Disease
MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors . MRS2179 tetrasodium inhibits platelet aggregation .

HY-101308A

MRS2179 tetrasodium hydrate 1 Publications Verification	P2Y Receptor	Cardiovascular Disease
MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors . MRS2179 tetrasodium hydrate inhibits platelet aggregation .

HY-D0976

NF279	P2X Receptor HIV	Infection
NF279 is a potent selective and reversible **P2X1 receptor antagonist, with an IC₅₀** of 19 nM. NF279 displays good selectivity over P2X2, P2X3 (IC₅₀=1.62 μM), P2X4 (IC₅₀>300 μM). NF279 is a dual HIV-1 coreceptor inhibitor that interferes with the functional engagement of CCR5 and CXCR4 by Env .

HY-151546

MRS4596	P2X Receptor	Neurological Disease
MRS4596 is a potent and selective **P2X4 receptor antagonist with an IC₅₀** value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke .

HY-19888

GSK-1482160	P2X Receptor	Inflammation/Immunology
GSK-1482160 is an orally available negative allosteric modulator of the *P2X7* receptor. P2X7 receptors are involved in the production of pro-inflammatory cytokines, such as Il-1β, by central and peripheral immune cells. GSK-1482160 has the potential for the research of inflammation diseases .

HY-N1478

Gardenoside	P2X Receptor	Neurological Disease
Gardenoside is a natural compound found in Gardenia fruits, with hepatoprotective properties. Gardenoside suppresses the pain of chronic constriction injury by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis .

HY-16322

Minodronic acid YM-529	P2X Receptor Apoptosis	Cancer
Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic *P2X2/3* receptors involved in pain .

HY-16322A

Minodronic acid hydrate YM-529 hydrate	P2X Receptor Apoptosis	Cancer
Minodronic acid (YM-529) hydrate is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic *P2X2/3* receptors involved in pain .

HY-15469

GW791343 dihydrochloride	P2X Receptor	Neurological Disease
GW791343 dihydrochloride is a potent human *P2X7* receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human *P2X7* receptor, with a pIC₅₀ of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease .

Cat. No.	Product Name	Target	Research Area

HY-P1137

10Panx	Peptides	Others
10Panx is a biological active peptide. (This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1b (IL-1b) in response to P2X7R activation.)

HY-P1330

Purotoxin 1	P2X Receptor	Inflammation/Immunology
Purotoxin 1 is a **P2X3 receptor** inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5025

Bullatine A	Structural Classification Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields	P2X Receptor Apoptosis
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent *P2X7* antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses . Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed .

HY-N1478

Gardenoside	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis	P2X Receptor
Gardenoside is a natural compound found in Gardenia fruits, with hepatoprotective properties. Gardenoside suppresses the pain of chronic constriction injury by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis .

HY-N7740

Adenosine 2',5'-diphosphate sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	P2Y Receptor Endogenous Metabolite
Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist. Adenosine 2',5'-diphosphate sodium exhibits non-selective antagonism at recombinant and human platelet *P2X1* receptors .

HY-N9182

Zeaxanthin dipalmitate Physalien	Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Solanaceae Lycium chinense Miller Disease Research Fields Inflammation/Immunology	Adiponectin Receptor P2X Receptor Autophagy
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with **p2X7 receptor (K_d=81.2 nM) and adiponectin receptor 1 (AdipoR1; K_d=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy** functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) .

HY-15310

Ivermectin 20+ Cited Publications MK-933; CD-5024; K-237	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer	Flavivirus Dengue virus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of *P2X₄* and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

HY-15310R

Ivermectin (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antiviral Anti-parasitic Disease Research	Dengue virus Flavivirus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (Standard) is the analytical standard of Ivermectin. This product is intended for research and analytical applications. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of *P2X₄* and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

Cat. No.	Compare	Product Name	Species	Source

HY-P703172

	P2X3 Protein, Human (HEK293) P2X purinoceptor 3; ATP receptor; Purinergic receptor; P2RX3; Homo sapiens; Human; P2X3; Ion channel; Ligand-gated ion channel; receptor	Human	HEK293
	P2X3 Protein, Human (HEK293) is the recombinant human-derived P2X3, expressed by HEK293 , with tag Free labeled tag. ,

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HY-16322S

Minodronic acid-d4
Minodronic acid-d₄ is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].

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