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Results for "

SM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (17) Acyltransferase (1) ADC Cytotoxin (2) Adrenergic Receptor (5) Antibiotic (10) Apoptosis (8) Bacterial (14) Beta-lactamase (1) c-Kit (1) Calcium Channel (1) Caspase (1) CD22 (1) CDK (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (3) Dopamine Receptor (11) Drug Derivative (1) Endogenous Metabolite (8) FGFR (3) Fluorescent Dye (1) Fungal (4) GHSR (1) Glucocorticoid Receptor (1) HDAC (1) IAP (7) IFNAR (1) Isotope-Labeled Compounds (16) Lactate Dehydrogenase (1) LIM Kinase (LIMK) (2) Liposome (6) mAChR (1) MAP3K (2) MMP (1) Na+/Ca2+ Exchanger (1) NF-κB (2) NOD-like Receptor (NLR) (2) Nucleoside Antimetabolite/Analog (1) p38 MAPK (1) Parasite (3) Penicillin-binding protein (PBP) (4) Phospholipase (2) Potassium Channel (2) Ribosomal S6 Kinase (RSK) (2) Src (2) TGF-β Receptor (1) Toll-like Receptor (TLR) (3) Topoisomerase (2) TSH Receptor (1) Wnt (2)
By Research Areas:	Cancer (38) Cardiovascular Disease (6) Endocrinology (1) Infection (21) Inflammation/Immunology (14) Metabolic Disease (4) Neurological Disease (25)
Oligonucleotides:	Liposomal Film-forming Agents (1) Emulsifiers (1) Cationic Lipids (2) Phospholipids (1)

122

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134541

SM-102 15+ Cited Publications	Liposome	Infection
SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-116626

SM-7368	NF-κB p38 MAPK MMP	Cancer
SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation . SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis .

HY-123291

SM-276001	Toll-like Receptor (TLR) IFNAR	Inflammation/Immunology Cancer
SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer .

HY-15989

SM-164 Maximum Cited Publications 36 Publications Verification	IAP Apoptosis	Cancer
SM-164 is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC₅₀ value of 1.39 nM and functions as an extremely potent antagonist of XIAP.

HY-116959

SM-130686	GHSR	Metabolic Disease
SM-130686 is an oxindole derivative and an active GH secretagogue (GHS). SM-130686 stimulates GH release with a Half-maximum stimulation of 6.3 nM. SM-130686 has an orally active .

HY-14223

SM-21	Others	Neurological Disease
SM-21 is a derivative of R-(+)-hyoscyamine with potent antinociceptive and cognitive enhancing activities. SM-21 works by affecting the release of acetylcholine .

HY-129585

SM-4470	Fungal	Infection
SM-4470 is an orally active antifungal compound. SM-4470 has inhibitory activity against yeast, Aspergillus, and dermatophytes in vitro .

HY-19037

SM-2470	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
SM-2470 is a potent α1-adrenoceptor antagonist, has sympathetic nerve activity in anesthetized rats . SM-2470 is an antihypertensive agent. SM-2470 exhibits hypocholesterolaemic effect by the inhibition of cholesterol absorption related to the reduction of cholesterol solubilization .

HY-114952

SM-32504	Acyltransferase	Cardiovascular Disease
SM-32504 is an effective ACAT inhibitor that can significantly reduce serum cholesterol levels in mouse models fed with high-fat and high-cholesterol diets. SM-32504 can be used for research on hypercholesterolemia and atherosclerosis .

HY-134541A

SM-102 (Excipient)	Liposome	Infection
SM-102 Excipient is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 Excipient has higher transfection efficiency. SM-102 Excipient plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-15989A

SM-164 hydrochloride Maximum Cited Publications 36 Publications Verification	IAP Apoptosis	Cancer
SM-164 hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC₅₀ value of 1.39 nM and functions as an extremely potent antagonist of XIAP.

HY-116940

Sm4 1 Publications Verification	Others	Cancer
Sm4 is a SOX18 inhibitor. Sm4 shows SOX18-DNA binding inhibitory activity. Sm4 selectively affects SOX18 transcriptional output in vitro. Sm4 blocks SoxF transcriptional activity in vivo. Sm4 can be used for cancer metastasis and vascular cancers research .

HY-138059

SM-433	IAP Apoptosis	Cancer
SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC₅₀<1 μM (patent WO2008128171A2) .

HY-138059A

SM-433 hydrochloride	IAP Apoptosis	Cancer
SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC₅₀<1 μM (patent WO2008128171A2) .

HY-125390

SM-360320 CL-087	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response . SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity .

HY-16325

Miriplatin hydrate SM-11355 hydrate	DNA Alkylator/Crosslinker	Cancer
Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents.

HY-16325A

Miriplatin 3 Publications Verification SM-11355	DNA Alkylator/Crosslinker	Cancer
Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents.

HY-B0067

Amrubicin SM-5887	Topoisomerase Bacterial	Cancer
Amrubicin (SM-5887) is a DNA topoisomerase II inhibitor, used for the research of cancer.

HY-B0067A

Amrubicin hydrochloride SM-5887 hydrochloride	Topoisomerase Bacterial	Cancer
Amrubicin (SM-5887) hydrochloride is a DNA topoisomerase II inhibitor, used for the research of cancer.

HY-B0032

Lurasidone Hydrochloride 5+ Cited Publications SM-13496 Hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM.

HY-B0032A

Lurasidone 5+ Cited Publications SM-13496	5-HT Receptor Dopamine Receptor	Neurological Disease
Lurasidone (SM-13496) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM.

HY-19062

SM-6586	Calcium Channel Na+/Ca2+ Exchanger	Cardiovascular Disease
SM-6586 is a calcium channel antagonist and inhibitor of Na ⁺/H ⁺ and Na ⁺/Ca ²⁺ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

HY-110207

SM-324405	Toll-like Receptor (TLR)	Inflammation/Immunology
SM-324405 is a TLR7 agonistic antedrug (EC₅₀ = 50 nM), with pEC₅₀ values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively. SM-324405 is used for immunoresearch of allergic diseases. An antedrug is defined as a locally active compound that is designed to be rapidly metabolized to an inactive form upon entry into the circulation and prevents systemic toxicity by losing its agonistic activity in a plasmatic environment .

HY-160962

SM1044	Caspase Apoptosis	Cancer
SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC₅₀ < 3.6 μM . SM1044 inhbits tumor growth in RL95-2 xenograft mouse model .

HY-105110

SCH 39304 SM-8668	Fungal	Infection
SM-8668 is an effective orally active antifungal agent, with median effective doses (ED₅₀) of 0.18, 3.7, and 5.9 mg/kg for systemic candidiasis, aspergillosis, and cryptococcosis in mice, respectively. Pharmacokinetic studies in mice and rats indicate that SM-8668 has a long half-life and a high total exposure. SM-8668 can be used in anti-infective research .

HY-111482

SM 16 2 Publications Verification	TGF-β Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
SM 16 is a ALK5/ALK4 kinase inhibitor with K_is of 10 and 1.5 nM, respectively.

HY-120148A

SM19712	Others	Others
SM19712 serves as an inhibitor of the nonpeptide endothelin converting enzyme.

HY-158306

SM45a	Others	Others
SM45a is a small molecule targeting ligand. SM45a can be linked to the 3' or 5' end of a sense strand or an antisense strand of a DUX4 RNAi agent for promoting it entry into cells .

HY-158305

SM51a	Others	Others
SM51a is a small molecule targeting ligand. SM51a can be linked to the 3' or 5' end of a sense strand or an antisense strand of a DUX4 RNAi agent for promoting it entry into cells .

HY-B0798

Cefpiramide sodium SM-1652; Wy-44635	Bacterial Antibiotic	Infection
Cefpiramide sodium (SM-1652; Wy-44635) is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.

HY-124181

SM-1295	IAP Apoptosis	Cancer
SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with K_d values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively .

HY-136848

SM1-71	MAP3K Src FGFR Ribosomal S6 Kinase (RSK) LIM Kinase (LIMK)	Cancer
SM1-71 (compound 5) is a potent TAK1 inhibitor, with a K_i of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines .

HY-101197

SM-21 maleate	mAChR	Others
SM 21 maleate, 2-phenoxyalkanoic acid ester, binds to central muscarinic recrptor with affinity of 0.174 μM .

HY-14558

Tandospirone 2 Publications Verification SM-3997	5-HT Receptor	Neurological Disease
Tandospirone (SM-3997) is a potent and selective 5-HT_1A receptor partial agonist, with a K_i of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms .

HY-110053

Tandospirone hydrochloride SM-3997 hydrochloride	5-HT Receptor	Neurological Disease
Tandospirone (SM-3997) hydrochloride is a potent and selective 5-HT_1A receptor partial agonist, with a K_i of 27 nM. Tandospirone hydrochloride has anxiolytic and antidepressant activities. Tandospirone hydrochloride can be used for the research of the central nervous system disorders and the underlying mechanisms .

HY-158815

SM-102 N-Oxide Lipid H N-Oxide; LNP-102 N-Oxide	Drug Derivative	Infection
SM-102 N-oxide (Lipid H N-Oxide) is an impurity of SM-102 (HY-134541).

HY-123453

SM27 NSC 37204	FGFR	Cancer
SM27 (NSC 37204) is an inhibitor for fibroblast growth factors (FGF). SM27 inhibits angiogenesis through block of FGF2/HSPGs/FGFR1 complex formation .

HY-B0731

Perospirone hydrochloride SM-9018	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT_2A receptor (K_i of 0.6 nM) and dopamine D₂ receptor (K_i of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT_1A receptor (K_i of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-B0032AS

Lurasidone-d8 SM-13496-d₈	5-HT Receptor Dopamine Receptor	Neurological Disease
Lurasidone-d₈ is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

HY-137435

Cirtuvivint 1 Publications Verification SM08502	CDK	Cancer
Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor. Cirtuvivint can be used for solid tumors research .

HY-14558S

Tandospirone-d8 SM-3997-d₈	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Tandospirone-d₈ (SM-3997-d₈) is deuterium labeled Tandospirone. Tandospirone (SM-3997) is a potent and selective 5-HT_1A receptor partial agonist, with a K_i of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms .

HY-120148

SM19712 free acid	Others	Others
SM19712 (free acid) is an endothelin-converting enzyme-1-related compound that affects corticotropin-releasing factor receptor 1 (CRF1).

HY-N9480

Vinaxanthone SM-345431	Phospholipase Bacterial	Infection Cancer
Vinaxanthone (SM-345431) is a potent and selective semaphorin3A, phospholipase C (PLC) and FabI inhibitor, with IC₅₀s of 0.1-0.2 μM and 0.9 mM for semaphorin3A and FabI. Vinaxanthone inhibits the substrate (t-o-NAC thioester) and the cofactor (NADPH) with K_is of 3.1 μM and 1.0 μM, respectively. Vinaxanthone can be used to handle infections caused by multidrug-resistant pathogens .

HY-135516

Dalosirvat 1 Publications Verification SM-04554; Wnt pathway activator 1	Wnt	Cancer
Dalosirvat (SM-04554) is a potent Wnt activator extracted from patent WO2012024404A1, compound 1, has an EC₅₀s of 28-29 nM .

HY-W654010

Lurasidone-d8-1 hydrochloride SM-13496-d₈-1 hydrochloride	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Lurasidone-d₈-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM .

HY-B1354

Cefpiramide SM-1652 free acid; Wy-44635 free acid	Beta-lactamase Antibiotic Bacterial	Infection
Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase .

HY-13678

Meropenem 10+ Cited Publications SM 7338	Penicillin-binding protein (PBP) Bacterial Antibiotic	Infection Cancer
Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant *N. gonorrhoeae* (MIC value of 0.02-0.06 mg/mL), *H. influenzae* (MIC value of 0.03-0.12 mg/mL), and *H. ducreyi* (MIC value of 0.015-0.12 mg/mL) .

HY-121160

Amiprilose SM1213; Therafectin	Bacterial	Infection Cancer
Amiprilose (SM1213; Therafectin) is a potent inhibitor against Hepatocellular carcinoma (HCC). Amiprilose induces lymphokine-induced macrophage activation directly to kill Listeria monocytogenes .

HY-B0731A

Perospirone SM-9018 free base	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT_2A receptor (K_i=0.6 nM) and dopamine D₂ receptor (K_i=1.4 nM), and also a partial agonist of 5-HT_1A receptor (K_i=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-114848

Amiprilose hydrochloride SM1213 hydrochloride; Therafectin hydrochloride	Others	Others
Amiprilose (SM1213) hydrochloride is a novel synthetic carbohydrate with anti-inflammatory and immunomodulatory properties, which can restore the number of painful and swollen joints, joint pain and swelling index, and grip strength to baseline levels.

Cat. No.	Product Name	Type

HY-120959

DAUDA	Fluorescent Dyes/Probes
DAUDA (11-(dansylamino) undecanoic acid) is an environment-sensitive fluorescent fatty acid analogue. DAUDA alters its intensities and fluorescent emission spectra on entry into binding proteins. DAUDA is used to determine the relative affinity of natural fatty acids for polymorphs of the Schistosoma mansoni Sm14 fatty acid-binding protein[1].

Cat. No.	Product Name	Type

HY-134541

SM-102 15+ Cited Publications	Drug Delivery
SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-141629

N-Palmitoyl-D-sphingomyelin Sphingomyelin 16:0	Drug Delivery
N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .

Cat. No.	Product Name	Target	Research Area

HY-P4461

Ala-Ala-Pro-pNA	Peptides	Others
Ala-Ala-Pro-pNA is a tripeptide, including chromophoric amino acids Pro-pNA. Ala-Ala-Pro-pNA is targeted by tripeptidyl aminopeptidase (SM-TAP) .

Cat. No.	Product Name	Target	Research Area

HY-P990781

Suciraslimab SM03	CD22	Inflammation/Immunology
Suciraslimab is an anti-CD22 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13678

Meropenem Maximum Cited Publications 15 Publications Verification SM 7338	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Beta-lactam Antibiotics	Penicillin-binding protein (PBP) Bacterial Antibiotic
Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant *N. gonorrhoeae* (MIC value of 0.02-0.06 mg/mL), *H. influenzae* (MIC value of 0.03-0.12 mg/mL), and *H. ducreyi* (MIC value of 0.015-0.12 mg/mL) .

HY-N0402

Artemether 1 Publications Verification Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer	Parasite
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .

HY-141629

N-Palmitoyl-D-sphingomyelin Sphingomyelin 16:0	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Liposome Endogenous Metabolite
N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .

HY-N9480

Vinaxanthone SM-345431	Structural Classification Microorganisms Xanthones Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	Phospholipase Bacterial
Vinaxanthone (SM-345431) is a potent and selective semaphorin3A, phospholipase C (PLC) and FabI inhibitor, with IC₅₀s of 0.1-0.2 μM and 0.9 mM for semaphorin3A and FabI. Vinaxanthone inhibits the substrate (t-o-NAC thioester) and the cofactor (NADPH) with K_is of 3.1 μM and 1.0 μM, respectively. Vinaxanthone can be used to handle infections caused by multidrug-resistant pathogens .

HY-N10805

Schisanlignone C	Structural Classification Terpenoids Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra viridis A. C. Smith	Others
Schisanlignone C is a chemical component of Schisandra viridis a. c. sm .

HY-N10806

Schisanlignone D	Source classification Plants Schisandraceae Schisandra viridis A. C. Smith	Others
Schisanlignone D is a chemical component of Schisandra viridis a. c. sm .

HY-N3833

Epipterosin L	Structural Classification Natural Products Source classification Cibotiaceae Plants Cibotium barometz (L.) J. Sm.	Others
Epipterosin L is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N2836

Alepterolic acid	Structural Classification Terpenoids Source classification Diterpenoids Cibotiaceae Plants Cibotium barometz (L.) J. Sm.	Others
Alepterolic acid is a Diterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N1573

Pterosin Z	Structural Classification Terpenoids Sesquiterpenes Source classification Cibotiaceae Plants Cibotium barometz (L.) J. Sm.	Others
Pterosin Z is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N3834

Epipterosin L 2'-O-glucoside	Structural Classification Terpenoids Sesquiterpenes Source classification Cibotiaceae Plants Cibotium barometz (L.) J. Sm.	Others
Epipterosin L 2'-O-glucoside is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N1572

Pterosin D 3-O-glucoside	Structural Classification Terpenoids Sesquiterpenes Source classification Cibotiaceae Plants Cibotium barometz (L.) J. Sm.	Others
Pterosin D 3-O-glucoside is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N1808

3-Acetoxy-8(17),13E-labdadien-15-oic acid	Structural Classification Terpenoids Source classification Diterpenoids Cibotiaceae Plants Cibotium barometz (L.) J. Sm.	Others
3-Acetoxy-8(17),13E-labdadien-15-oic acid is a Diterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-N8881

Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate Jacaranone ethyl ester	Quinones Structural Classification Erinacea anthyllis Link Source classification Benzene Quinones Plants Compositae	Others
Ethyl(1-hydroxy-4-oxocyclohexa-2,5-dien-1-yl)acetate (Jacaranone ethyl ester) is a Sesquiterpenoids product that can be isolated from the rhizomes of Cibotium barometz (L.) J.Sm. .

HY-13678R

Meropenem (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Beta-lactam Antibiotics	Penicillin-binding protein (PBP) Bacterial Antibiotic
Meropenem (Standard) is the analytical standard of Meropenem. This product is intended for research and analytical applications. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .

Species:	Human (5) Rat (1) Mouse (2)
Tag:	His (5) Fc (2)
Source:	HEK293 (5) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P75915

	LSM3 Protein, Human (His) U6 snRNA-associated SM-like protein LSM3; LSM3; MDS017	Human	E. coli
	The LSM3 protein plays a crucial role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex involved in spliceosome assembly and as part of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex (including LSM3) specifically binds to the 3'-end U strand of U6 snRNA. LSM3 Protein, Human (His) is the recombinant human-derived LSM3 protein, expressed by E. coli , with N-His labeled tag.

HY-P701114

	TAGLN2 Protein, Human (HEK293, C-His) Transgelin-2; Epididymis tissue protein Li 7e; SM22-alpha homolog	Human	HEK293
	Expressed in HEK 293 cells with a C-His tag, the human isoform of TAGLN2 Protein shares similarity with transgelin, an early marker of differentiated smooth muscle. While its specific function remains unclear, TAGLN2 is proposed as a tumor suppressor. The gene has multiple transcript variants, contributing to its potential roles' complexity. TAGLN2 demonstrates ubiquitous expression, notably in the lung (RPKM 268.8), stomach (RPKM 231.0), and 25 other tissues, suggesting involvement in diverse physiological contexts across multiple organs. TAGLN2 Protein,Human (HEK 293, C-His) is the recombinant human-derived TAGLN2 protein,Human(HEK 293, C-His), expressed by HEK293 , with C-6*His labeled tag. The total length of TAGLN2 Protein,Human (HEK 293, C-His) is 199 a.a., with molecular weight of ~25-30 kDa.

HY-P76226

	TCblR/CD320 Protein, Rat (HEK293, Fc) CD320 antigen; 8D6 antigen; FDC-signaling molecule 8D6; FDC-SM-8D6; Transcobalamin receptor	Rat	HEK293
	The TCblR/CD320 protein is a receptor for cobalamin-saturated transcobalamin (TCbl) and is critical for cobalamin uptake and can influence cell physiology. At the plasma membrane, it is expressed on follicular dendritic cells (FDC), where it helps interact with germinal center B cells and promotes immune responses. TCblR/CD320 Protein, Rat (HEK293, Fc) is the recombinant rat-derived TCblR/CD320 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TCblR/CD320 Protein, Rat (HEK293, Fc) is 182 a.a., with molecular weight of ~47.3 KDa.

HY-P72456

	TCblR/CD320 Protein, Human (HEK293, His) CD320 antigen; 8D6 antigen; FDC-signaling molecule 8D6; FDC-SM-8D6; Transcobalamin receptor; TCblR; CD320	Human	HEK293
	TCblR/CD320 is the receptor for cobalamin (TCbl) and is critical for cellular cobalamin homeostasis and B cell responses. It is expressed on follicular dendritic cells, interacts with germinal center B cells, and coordinates immune responses. TCblR/CD320 Protein, Human (HEK293, His) is the recombinant human-derived TCblR/CD320 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76798

	TCblR/CD320 Protein, Mouse (HEK293, His) CD320 antigen; 8D6 antigen; FDC-signaling molecule 8D6; FDC-SM-8D6; Transcobalamin receptor; TCblR; CD320	Mouse	HEK293
	TCblR/CD320 Protein, the receptor for cobalamin-saturated transcobalamin (TCbl), plays a pivotal role in cobalamin uptake, expressed on the plasma membrane and notably on follicular dendritic cells (FDC). As a costimulator, TCblR promotes B cell responses, fostering differentiation and proliferation. It's particularly influential in differentiating germinal center-B cells, engaging in collaborative interactions with T-cells and FDC. CD320 enhances IL-10-induced precursor proliferation, underscoring its significance in cobalamin homeostasis and cellular processes through interactions with TCN2. TCblR/CD320 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TCblR/CD320 protein, expressed by HEK293, with C-His labeled tag. The total length of TCblR/CD320 Protein, Mouse (HEK293, His) is 208 a.a., with molecular weight of ~47.7 kDa.

HY-P70198

	LSM1 Protein, Human (His) rHuU6 snRNA-associated SM-like protein LSM1, His; U6 snRNA-Associated SM-Like Protein LSM1; Cancer-Associated SM-Like; SMall Nuclear Ribonuclear CaSM; LSM1; CASM	Human	E. coli
	LSM1 protein participates in the degradation of histone mRNAs, unique among eukaryotic mRNAs for lacking polyadenylation.Likely part of an LSm subunit-containing complex involved in general mRNA degradation.It interacts with SLBP, particularly during rapid histone mRNA degradation in the S phase.The LSm subunits collectively form a donut-shaped heteromer.LSM1 Protein, Human (His) is the recombinant human-derived LSM1 protein, expressed by E.coli , with C-6*His labeled tag.

HY-P70944

	LSM4 Protein, Human (His) U6 snRNA-Associated SM-Like Protein LSM4; Glycine-Rich Protein; GRP; LSM4	Human	E. coli
	The LSM4 protein plays a crucial role in pre-mRNA splicing, participating in the U4/U6-U5 tri-snRNP complex during spliceosome assembly, and as a component of the precatalytic spliceosome (spliceosome B complex).In the heptameric LSM2-8 complex, LSM4 specifically binds to the 3' U region of U6 snRNA.LSM4 Protein, Human (His) is the recombinant human-derived LSM4 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P76797

	TCblR/CD320 Protein, Mouse (HEK293, Fc) CD320 antigen; 8D6 antigen; FDC-signaling molecule 8D6; FDC-SM-8D6; Transcobalamin receptor; TCblR; CD320	Mouse	HEK293
	TCblR/CD320 Protein, the receptor for cobalamin-saturated transcobalamin (TCbl), plays a pivotal role in cobalamin uptake, expressed on the plasma membrane and notably on follicular dendritic cells (FDC). As a costimulator, TCblR promotes B cell responses, fostering differentiation and proliferation. It's particularly influential in differentiating germinal center-B cells, engaging in collaborative interactions with T-cells and FDC. CD320 enhances IL-10-induced precursor proliferation, underscoring its significance in cobalamin homeostasis and cellular processes through interactions with TCN2. TCblR/CD320 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TCblR/CD320 protein, expressed by HEK293, with C-hFc labeled tag. The total length of TCblR/CD320 Protein, Mouse (HEK293, Fc) is 208 a.a., with molecular weight of ~72.5 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-13678S

Meropenem-d6
Meropenem-d₆ is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL)[1][2].

HY-N0402S

Artemether-d3
Artemether-d₃ is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.

HY-B0032AS

Lurasidone-d8
Lurasidone-d₈ is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

HY-14558S

Tandospirone-d8
Tandospirone-d₈ (SM-3997-d₈) is deuterium labeled Tandospirone. Tandospirone (SM-3997) is a potent and selective 5-HT_1A receptor partial agonist, with a K_i of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms .

HY-W654010

Lurasidone-d8-1 hydrochloride
Lurasidone-d₈-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D₂ and 5-HT₇ with IC₅₀s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT_1A receptor with an IC₅₀ of 6.75 nM .

HY-B0731AS

Perospirone-d8

Perospirone-d₈ (SM-9018-d₈ (free base)) is deuterium labeled Perospirone. Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT_2A receptor (K_i=0.6 nM) and dopamine D₂ receptor (K_i=1.4 nM), and also a partial agonist of 5-HT_1A receptor (K_i=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-13678S1

Meropenem-d6-1
Meropenem-d6-1 (SM 7338-d6-1) is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .

HY-B0032S

Lurasidone-d8 hydrochloride
Lurasidone-d₈ (hydrochloride) is the deuterium labeled Lurasidone, which is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C.

HY-13458S1

Droxidopa-13C2,15N hydrochloride
Droxidopa- ¹³C₂, ¹⁵N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2].

HY-146800S

18:1 SM-d9
18:1 SM-d₉ is deuterium labeled 18:1 SM.

HY-146901S

15:0 SM (d18:1/15:0)-d9
15:0 SM (d18:1/15:0)-d₉ is deuterium labeled 15:0 SM (d18:1/15:0).

HY-146929S

18:1 SM (d18:1/18:1)-d9
18:1 SM (d18:1/18:1)-d₉ is deuterium labeled 18:1 SM (d18:1/18:1).

HY-146930S

16:1 SM (d18:1/16:1)-d9
16:1 SM (d18:1/16:1)-d₉ is deuterium labeled 16:1 SM (d18:1/16:1).

HY-146931S

20:1 SM (d18:1/20:1)-d9
20:1 SM (d18:1/20:1)-d₉ is deuterium labeled 20:1 SM (d18:1/20:1).

HY-146932S

22:1 SM (d18:1/22:1)-d9
22:1 SM (d18:1/22:1)-d₉ is deuterium labeled 22:1 SM (d18:1/22:1).

HY-146933S

24:1 SM (d18:1/24:1)-d9
24:1 SM (d18:1/24:1)-d₉ is deuterium labeled 24:1 SM (d18:1/24:1).

HY-141629S1

N-Palmitoyl-D-sphingomyelin-13C
N-Palmitoyl-D-sphingomyelin-13C is a deuterated labeled N-Palmitoyl-D-sphingomyelin . N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .

HY-141629S2

N-Palmitoyl-D-sphingomyelin-d9
N-Palmitoyl-D-sphingomyelin-d₉ (Sphingomyelin 16:0-d₉) is deuterium labeled N-Palmitoyl-D-sphingomyelin. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .

HY-15660S

Efinaconazole-d4
Efinaconazole-d₄ is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1].

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HY-P82281

	SNRPD3 Antibody (YA2026) SMD3; SM-D3	WB	Human, Rat
	SNRPD3 Antibody (YA2026) is a biotin-conjugated non-conjugated IgG antibody, targeting SNRPD3, with a predicted molecular weight of 14 kDa (observed band size: 14 kDa). SNRPD3 Antibody (YA2026) can be used for WB experiment in human, rat background.

HY-P81094

	Calponin 1 Antibody Basic calponin; Calponin-1; Calponin 1 basic SMooth muscle; Calponin H1 SMooth muscle; Calponin1; Calponins basic; CNN 1; CNN1; SM Calp; SMCC; CNN1_HUMAN; Calponin H1; Calponin1; SM Calp; SMooth muscle.	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Calponin 1 Antibody is an unconjugated, approximately 33 kDa, rabbit-derived, anti-Calponin 1 monoclonal antibody. Calponin 1 Antibody can be used for: WB,IHC-P,ICC/IF expriments in human, mouse, rat, and predicted: dog, pig background without labeling.

HY-P82686

	PHD2 Antibody (YA2431) EGLN1; C1orf12; ECYT3; HIFPH2; HPH2; PHD2; SM-20; SM20; ZMYND6; PHD2	WB, IP	Human
	PHD2 Antibody (YA2431) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2431), targeting PHD2, with a predicted molecular weight of 46 kDa (observed band size: 46 kDa). PHD2 Antibody (YA2431) can be used for WB, IP experiment in human background.

HY-P81461

	TAGLN/Transgelin Antibody (YA1206) TAGLN; Transgelin; SM22; WS3-10; 22 kDa actin-binding protein; Protein WS3-10; SMooth muscle protein 22-alpha (SM22-alpha)	IHC-P	Human
	TAGLN/Transgelin Antibody (YA1206) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1206), targeting TAGLN/Transgelin. TAGLN/Transgelin Antibody (YA1206) can be used for IHC-P experiment in human background.

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Cat. No.	Product Name		Classification

HY-134541

SM-102 15+ Cited Publications		Cationic Lipids
SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

HY-141629

N-Palmitoyl-D-sphingomyelin Sphingomyelin 16:0		Phospholipids
N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles .

HY-160552

244cis		Cationic Lipids
244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .

HY-134541A

SM-102 (Excipient)		Emulsifiers Liposomal Film-forming Agents
SM-102 Excipient is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 Excipient has higher transfection efficiency. SM-102 Excipient plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .

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