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carbonic anhydrase II inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Carbonic Anhydrase (83) Adenosine Receptor (1) Apoptosis (6) Bacterial (2) Calcium Channel (2) CDK (2) Cholinesterase (ChE) (4) COX (2) Dipeptidyl Peptidase (1) Drug Metabolite (1) Fungal (1) Isotope-Labeled Compounds (3) Phosphatase (1) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (1) Sodium Channel (3)
By Research Areas:	Cancer (41) Cardiovascular Disease (3) Endocrinology (4) Infection (6) Inflammation/Immunology (11) Metabolic Disease (5) Neurological Disease (21)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: Carbonic Anhydrase Photosystem II CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142849

Carbonic anhydrase inhibitor 2	Carbonic Anhydrase	Endocrinology
Carbonic anhydrase inhibitor 1 (compound 7c) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits .

HY-142853

Carbonic anhydrase inhibitor 3	Carbonic Anhydrase	Endocrinology
Carbonic anhydrase inhibitor 3 (compound 11g) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits .

HY-144264

hCAII-IN-6	Carbonic Anhydrase	Endocrinology
hCAII-IN-6 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor with a K_i of 4.4 nM. hCAII-IN-6 also inhibits other hCAs isoforms I, IV and IX, with K_i values of 9.2 nM, 480.2 nM and 14.7 nM, respectively. hCAII-IN-6 can be used for glaucoma research .

HY-149498

Carbonic anhydrase inhibitor 15	Carbonic Anhydrase	Neurological Disease Inflammation/Immunology
Carbonic anhydrase inhibitor 15 (Compound 8) is a **carbonic anhydrase** inhibitor (K_i: 8.5 nM for hCA II). Carbonic anhydrase inhibitor 15 has analgesic effect .

HY-163753

Carbonic anhydrase inhibitor 25	Carbonic Anhydrase	Others
Carbonic anhydrase inhibitor 25 (compound 6a) is a potent **carbonic anhydrase** inhibitor. Carbonic anhydrase inhibitor 25 shows inhibition for hCA I and hCA II receptor .

HY-161374

Carbonic anhydrase inhibitor 20	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 20 (compound 11) is an inhibitor of piperazinosulfonamide carbonic anhydrase (Carbonic *Anhydrase). The Ki of Carbonic* anhydrase inhibitor 20 for hCA I, hCA II, hCA IX, and hCA XII are 47.6 nM, 36.5 nM, 8.3 nM, and 2.7 nM respectively .

HY-115998

Carbonic anhydrase inhibitor 11	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 11 (compound VI) is a potent, selective carbonic anhydrase inhibitor. Carbonic anhydrase inhibitor 11 shows K_i values of 40, 39, 200 and 900 nM against CA II, IX, and XII, respectively .

HY-161174

Carbonic anhydrase inhibitor 17	Carbonic Anhydrase	Neurological Disease
Carbonic anhydrase inhibitor 17 (compound 7c) ,pyridazine-tethered sulfonamide, is a carbonic anhydrase II inhibitor with IC₅₀ of 0.63 nM .

HY-168124

Carbonic anhydrase inhibitor 26	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 26 (compund 6T) is a carbonic anhydrase II inhibitor with IC₅₀ of 9.10 ± 0.26 μM .

HY-144807

Carbonic anhydrase inhibitor 9	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 9 is a potent carbonic anhydrase (CA) inhibitor with K_is of 56.4 and 56.9 nM for hCA II and IX, respectively. Antiproliferative activity .

HY-137966A

N-Desethyl Brinzolamide oxalate AL-8520 oxalate	Carbonic Anhydrase	Cancer
N-Desethyl Brinzolamide oxalate is a dual inhibitor of Carbonic anhydrase II and Carbonic anhydrase IV with IC₅₀s of 1.28 and 128 nM, respectively .

HY-163109

Carbonic anhydrase inhibitor 16	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 16 (compound 1) is a dengue protease inhibitor with inhibitory activity against **carbonic anhydrase hCA I and hCA II** (K_i: 28.5 nM, 2.2 nM) .

HY-163660

Carbonic anhydrase inhibitor 23	Carbonic Anhydrase	Infection
Carbonic anhydrase inhibitor 23 (compound 40) is a potent inhibitor of carbonic anhydrase (CA), with the K_i of 617.2 nM and 434.1 nM for hCA I (α) and hCA II (α), respectively .

HY-150570

Carbonic anhydrase inhibitor 14	Carbonic Anhydrase CDK	Cancer
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with K_i values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC₅₀ of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity .

HY-129986

hCAI/II-IN-9	Others	Others
hCAI/II-IN-9 is a carbonic anhydrase inhibitor with inhibitory activity against human carbonic anhydrase isoforms I, II, IX, and XII. The inhibition constants (Ki) of hCAI/II-IN-9 for hCA I are in the range of 7.9-894 nM, for hCA II are in the range of 7.5-1645 nM, for hCA IX are in the range of 5.0-240 nM, and for hCA XII are in the range of 0.47-2.83 nM. hCAI/II-IN-9 may have potential applications in inhibiting a variety of pathologies involving these carbonic anhydrase isoforms .

HY-151493

CAII-IN-1	Carbonic Anhydrase	Cancer
CAII-IN-1 (compound 3n), a thiosemicarbazide derivative, is a potent, selective **carbonic anhydrase-II (CA-II)** inhibitor with an IC₅₀ value of 10.3 µM for bovine CA-II. CAII-IN-1 can be used in research of carbonic anhydrase related biological disorders .

HY-151494

CAII-IN-2	Carbonic Anhydrase	Cancer
CAII-IN-2 (compound 3g), a thiosemicarbazide derivative, is a potent, selective **carbonic anhydrase-II (CA-II)** inhibitor with an IC₅₀ value of 12.1 µM for bovine CA-II. CAII-IN-2 can be used in research of carbonic anhydrase related biological disorders .

HY-163268

Carbonic anhydrase inhibitor 18	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 18 (Compound 9) is a human carbonic anhydrase (hCA) isoform inhibitor, with K_is of 604.8, 333.6, 1.9 and 6.7 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 18 can be used for the research of cancer .

HY-161142

Carbonic anhydrase/AChE-IN-1	Carbonic Anhydrase Cholinesterase (ChE)	Neurological Disease
Carbonic anhydrase/AChE-IN-1 (compound 16) is a **carbonic anhydrase and AChE** inhibitor with K_is of 24.42 nM, 19.95 nM, and 5.07 nM for hCA I, hCA II, and AChE, respectively .

HY-115999

Carbonic anhydrase inhibitor 12	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (K_is of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines .

HY-144639

Carbonic anhydrase inhibitor 5	Carbonic Anhydrase	Infection Inflammation/Immunology Cancer
Carbonic anhydrase inhibitor 5 is a potent and selective *human carbonic* anhydrase (hCA)** inhibitor with IC₅₀s of 42.9, 47,6 and 6.7 nM for hCA II, hCA IX and hCA XII, respectively .

HY-147353

Phenylsulfamide	Carbonic Anhydrase	Others
Phenylsulfamide (Compound 10) is a human carbonic anhydrase-II (hCA-II) inhibitor with a K_d of 45.50 μM and a K_i of 79.60 μM .

HY-162226

Carbonic anhydrase inhibitor 19	Carbonic Anhydrase	Others
Carbonic anhydrase inhibitor 19 (compound 26a) inhibits the Glaucoma related isoforms hCA II and hCA XII with K_is of 9.4 nM and 6.7 nM, respectively. Carbonic anhydrase inhibitor 19 reveals an intraocular pressure (IOP) lowering effect .

HY-144641

Carbonic anhydrase inhibitor 7	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 7 (compound 5b) is a potent inhibitor of *human carbonic* anhydrase (hCA), with K_is of 6.5 nM, 7.1 nM, 72.1 nM, and 255.8 nM for hCA IX, hCA II, hCA XII and hCA I**, respectively .

HY-144640

Carbonic anhydrase inhibitor 6	Carbonic Anhydrase	Cancer
Carbonic anhydrase inhibitor 6 (compound 9b) is a potent inhibitor of *human carbonic* anhydrase (hCA), with K_is of 9.7 nM, 35.2 nM, 88.5 nM, and 91.8 nM for hCA IX, hCA II, hCA XII and hCA I**, respectively .

HY-B0553

Methazolamide 2 Publications Verification L584601	Carbonic Anhydrase	Inflammation/Immunology Cancer
Methazolamide (L584601) is a sulfonamide derivative used as a **carbonic anhydrase** inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-101087

Benzenesulphonamide	Carbonic Anhydrase	Cancer
Benzenesulphonamide (compound 1) is a potent **carbonic anhydrase** inhibitor. Benzenesulphonamide shows CA II inhibitory activity .

HY-125375

L-662583	Carbonic Anhydrase	Endocrinology
L-662583 is a locally active carbonic anhydrase II inhibitor with an IC₅₀ value of 0.7 nM .

HY-157139

ALP/Carbonic anhydrase-IN-1	Carbonic Anhydrase Phosphatase	Inflammation/Immunology
ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC₅₀ values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively .

HY-132156

Carbonic anhydrase inhibitor 22	Carbonic Anhydrase	Neurological Disease
Carbonic anhydrase inhibitor 22 (Compd 2g), a sulfonamide **carbonic anhydrase** inhibitor, with K_i values of 762 nM (hCA I), 20.3 nM (hCA II), 8.3 nM (hCA VII), 17.9 nM (hCA IX) and 10.5 nM (hCA XII), repectively .

HY-151495

CAII-IN-3	Carbonic Anhydrase	Cancer
CAII-IN-3 (compound 3h), a thiosemicarbazones derivatives, is a potent carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀ value of 13.4 µM .

HY-151916

Enpp/Carbonic anhydrase-IN-1	Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)	Cancer
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and **carbonic anhydrase** inhibitor with IC₅₀s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis .

HY-32933

4-Acetylphenylboronic acid	Carbonic Anhydrase	Metabolic Disease
4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrases II(CA II), with IC₅₀s of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II), respectively .

HY-B0588S

Brinzolamide-d5 AL-4862-d₅	Carbonic Anhydrase	Others
Brinzolamide-d₅ is the deuterium labeled Brinzolamide. Brinzolamide (AL 4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.

HY-B0553S

Methazolamide-d6 L584601-d₆	Isotope-Labeled Compounds Carbonic Anhydrase	Inflammation/Immunology
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders[1][2].

HY-152140

hCAII-IN-8	Carbonic Anhydrase	Cancer
hCAII-IN-8, an amide, is a highly selective carbonic anhydrase (CA) inhibitor with an IC₅₀ value of 0.18 μM against hCA II .

HY-146385

hCAI/II-IN-1	Carbonic Anhydrase	Cancer
hCAI/II-IN-1 (Compound 3h) is a *human carbonic* anhydrase I** and II (hCA I/II) inhibitor with IC₅₀ values of 0.047 µM and 0.024 µM against hCA I and hCA II, respectively .

HY-158372

hCA I-IN-3	Carbonic Anhydrase	Cancer
hCA I-IN-3 (compound 24), an aryl ether derivative, is a potent carbonic anhydrase inhibitor. hCA I-IN-3 can inhibit carbonic anhydrase hCA I and hCA II isoenzymes, with IC₅₀ values of 4.77 and 9.66 nM, respectively. hCA I-IN-3 can be used for cancer research .

HY-157321

hCAI/II-IN-7	Carbonic Anhydrase	Neurological Disease
hCAI/II-IN-7 (compound 1F) is a potent carbonic anhydrase (CA) inhibitor with K_i values of 23 nM, 44 nM and 20.57 µM for hCA-I, hCA-II and bovine CA, respectively .

HY-B0553R

Methazolamide (Standard)	Carbonic Anhydrase	Inflammation/Immunology Cancer
Methazolamide (Standard) is the analytical standard of Methazolamide. This product is intended for research and analytical applications. Methazolamide (L584601) is a sulfonamide derivative used as a **carbonic anhydrase** inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-B0109A

Dorzolamide hydrochloride 4 Publications Verification L671152 hydrochloride; MK507 hydrochloride	Carbonic Anhydrase	Cardiovascular Disease Others
Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0109

Dorzolamide L671152; MK507	Carbonic Anhydrase	Cancer
Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-W424792A

O-Desmethyl Brinzolamide hydrochloride	Carbonic Anhydrase Drug Metabolite	Neurological Disease
O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a K_d of 0.136 nM for CA II and an IC₅₀ of 165 nM for CA IV .

HY-B0588A

Brinzolamide hydrochloride AL-4862 hydrochloride	Carbonic Anhydrase	Neurological Disease
Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research .

HY-B0588

Brinzolamide 3 Publications Verification AL-4862	Carbonic Anhydrase	Cardiovascular Disease Others Neurological Disease
Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research .

HY-B1386

Halazone	Bacterial Carbonic Anhydrase Sodium Channel	Infection
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K_d value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water .

HY-144268

hCAII-IN-7	Carbonic Anhydrase	Cancer
hCAII-IN-7 (Compound R-13) is a potent human carbonic anhydrase (hCA) inhibitor with K_is of 60.7, 320.7, 2298, and 35.2 nM for hCA I, II, IV and IX, respectively .

HY-B0109S

Dorzolamide-d5	Isotope-Labeled Compounds Carbonic Anhydrase	Cancer
Dorzolamide-d₅ is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1][2].

HY-146982

hCAII-IN-1	Carbonic Anhydrase	Cancer
hCAII-IN-1 (compound 7f) is a potent and selective inhibitor of carbonic anhydrase (CA II/IX) with K_is of 1.2 and 113.6 nM, respectively. hCAII-IN-1 has the potential for the research of cancer diseases .

HY-146983

hCAIX-IN-3	Carbonic Anhydrase	Cancer
hCAII-IN-3 (compound 7e) is a potent and selective inhibitor of carbonic anhydrase (CA II/IX) with K_is of 124.2 and 30.5 nM, respectively. hCAII-IN-3 has the potential for the research of cancer diseases .

Cat. No.	Product Name	Chemical Structure

HY-B0124S

Zonisamide-d4
Zonisamide-d₄ is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease[1][2].

HY-B0588S

Brinzolamide-d5
Brinzolamide-d₅ is the deuterium labeled Brinzolamide. Brinzolamide (AL 4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.

HY-B0553S

Methazolamide-d6
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders[1][2].

HY-B0109S

Dorzolamide-d5
Dorzolamide-d₅ is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1][2].

HY-B0109AS

Dorzolamide-d3 hydrochloride
Dorzolamide-d₃ hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity .

HY-B0588AS

Brinzolamide-d5 hydrochloride

Brinzolamide-d₅ (hydrochloride) is the deuterium labeled Brinzolamide hydrochloride[1]. Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research[2][3].

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