Search Result
Results for "
coumarins
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
8
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-N4273
-
|
(±)-Heraclenin
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Others
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Others
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Oxyimperatorin ((±)-Heraclenin) is a coumarin isolated from Angelica dahurica.
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-
-
- HY-N0709R
-
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Bacterial
Fungal
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Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
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Coumarin (Standard) is the analytical standard of Coumarin. This product is intended for research and analytical applications. Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity .
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-
-
- HY-126829
-
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HDAC
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Cancer
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Coumarin-SAHA is a fluorescent probe for determining the binding affinities (kd) and the dissociation off-rates (koff) of the HDAC8-inhibitor complexes .
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-
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- HY-W110772
-
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Coumarin 540A
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Others
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Others
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Coumarin153 is a coumarin. Coumarin153 can used as a fluorescence probe of Na dodecyl sulfate and cetyltrimethylammonium bromide .
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-
-
- HY-W077359
-
|
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Others
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Others
|
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7-(Dimethylamino)-4-methylcoumarin is a coumarin. 7-(Dimethylamino)-4-methylcoumarin can be used in study coumarin fluorescent brightener solution .
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-
-
- HY-D2099
-
|
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Fluorescent Dye
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Others
|
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Coumarin-PEG2-SCO, a Coumarin (HY-N0709) deravitive, is a fluorescent dye, and can be used for labeling of small molecules and biomolecules .
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-
-
- HY-137933
-
|
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Others
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Others
|
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5,6,7-Trimethoxycoumarin is a coumarin that can be isolated from Artemisia apiacea .
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-
-
- HY-N10029
-
|
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Others
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Others
|
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Edgeworoside C (compound 5) is a coumarin isolated from the flower buds of Edgeworthia chrysantha .
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-
-
- HY-N9531
-
|
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Bacterial
|
Infection
|
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3'-Hydroxyxanthyletin is a coumarin compound with antimycobacterial activities .
|
-
-
- HY-N8791
-
|
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Others
|
Others
|
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Qianhucoumarin G is a natural coumarin derivative found in Ligustici Radix .
|
-
-
- HY-N4273R
-
|
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Others
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Others
|
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Oxyimperatorin (Standard) is the analytical standard of Oxyimperatorin. This product is intended for research and analytical applications. Oxyimperatorin ((±)-Heraclenin) is a coumarin isolated from Angelica dahurica.
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-
-
- HY-N8817
-
|
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Others
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Others
|
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Decuroside V is a coumarin-glycoside found in a Chinese agent “Qian-Hu” .
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-
-
- HY-N8632
-
|
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Others
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Others
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Qianhucoumarin A is a natural coumarin compound found in the roots of Peucedanum praeruptorum Dunn .
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-
-
- HY-N10169
-
|
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Others
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Others
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Edgeworin is a coumarin compound can be isolated from the root and stem of Edgeworthia .
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-
-
- HY-N7689
-
|
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Others
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Others
|
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Mexoticin is a naturally occurring coumarin that can be isolated from the leaves of Murraya omphalocarpa .
|
-
-
- HY-N0947
-
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(-)-Praeruptorin B
|
Others
|
Inflammation/Immunology
|
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(-)-Anomalin ((-)-Praeruptorin B) is a coumarin derivative isolated from the root of Angelica anomala .
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-
-
- HY-N8712
-
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Others
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Others
|
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Umckalin is a oxygenated coumarin from Pelargonium sidoides .
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-
-
- HY-N2775
-
|
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Others
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Others
|
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8-Hydroxy-5-O-beta-D-glucosylpsoralen is a natural coumarin glucoside .
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-
-
- HY-N9532
-
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Anhydrobyakangelicin
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Others
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Cancer
|
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Isobyakangelicol is a coumarin that can be found in the roots of Angelica dahurica. Isobyakangelicol inhibits the growth of HeLa and HepG2 cells, with IC50s of 70.04 μM and 17.97 μM .
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-
-
- HY-N3258
-
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Micromelumin
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Others
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Others
|
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Micromelin is a coumarin from Micromelum minutum (Forst. f.) Seem (family Rutaceae) .
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-
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- HY-N11791
-
|
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Others
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Others
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Qianhucoumarin B is a coumarin derivative. Qianhucoumarin B can be isolated from from the traditional Chinese medicine Qianhu, roots of Peucedanum praeruptorum .
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-
-
- HY-N2811
-
|
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Others
|
Others
|
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Acetyldihydromicromelin A is a coumarin isolated from the leaves of Micromelum integerrimum .
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-
-
- HY-W072009
-
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5,7-dihydroxychromen-2-one
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Bacterial
|
Infection
|
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5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-Dihydroxycoumarin has antibacterial activities .
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-
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- HY-D0078
-
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Fluorescent Dye
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Others
|
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DCIA is a fluorescent dye. DCIA contains a coumarin fluorophore and conjugates specifically with free cysteines in the protein .
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-
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- HY-N2910
-
|
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Others
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Others
|
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Auraptenol is a coumarin that can be isolated from the leaves of Murraya paniculata .
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-
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- HY-N0947R
-
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Others
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Inflammation/Immunology
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(-)-Anomalin (Standard) is the analytical standard of (-)-Anomalin. This product is intended for research and analytical applications. (-)-Anomalin ((-)-Praeruptorin B) is a coumarin derivative isolated from the root of Angelica anomala .
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-
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- HY-N10662
-
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Glabralactone
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Others
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Others
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Angelicone (Glabralactone) is a coumarin. Angelicone can be isolated from Fatoua villosa .
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-
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- HY-N3986
-
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Others
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Others
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Hainanmurpanin is a coumarin that can be isolated from the aerial parts of Murraya paniculata .
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- HY-148937
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Others
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Others
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Oroselol is a coumarin commonly found in a variety of plants, especially in the roots of angelica plants and the bark of cinnamon trees. Oroselol has potential medicinal properties, including anti-inflammatory, antioxidant and anti-tumor effects. Oroselol can be used in the production of fragrances, flavors and medicines
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-
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- HY-N7672
-
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HCV Protease
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Infection
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Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC50 of 3.63 µg/mL .
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-
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- HY-121770
-
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Others
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Others
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Rutarin is a Coumarin (HY-N0709) derivative, that can be isolated from the aerial parts of the plant Atalantta racemosa .
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-
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- HY-N8712R
-
|
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Others
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Others
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Umckalin (Standard) is the analytical standard of Umckalin. This product is intended for research and analytical applications. Umckalin is a oxygenated coumarin from Pelargonium sidoides .
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-
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- HY-N8340
-
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Others
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Others
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Luvangetin is a coumarin that can be isolated from Zanthoxylum avicennae .
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-
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- HY-N9630
-
|
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Others
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Others
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Qianhucoumarin C is a coumarin derivative, which can be isolated from the roots of Peucedanum praeruptorum. Qianhuoumarin C has been studied for potential medicinal properties, including anti-inflammatory, antioxidant and anticancer effects. Qianhucoumarin C is an important ingredient in a variety of industrial processes, especially in the production of pharmaceuticals and herbal medicines .
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-
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- HY-N2984
-
|
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Bacterial
|
Infection
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Calanolide E is a natural coumarin with weakly inhibitory towards the Bacilli strains with MIC values ranging from 0.25-0.50 mg/mL .
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-
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- HY-N3180
-
-
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- HY-149828
-
-
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- HY-149828A
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-
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- HY-N5092
-
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Others
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Metabolic Disease
|
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7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect .
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-
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- HY-N1278
-
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Secryptotaenin A
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Others
|
Others
|
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Selinidin is a coumarin that can be isolated from Selinum vaginatum clarke .
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-
-
- HY-N8131
-
|
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Bacterial
|
Infection
Cancer
|
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Pangelin is a coumarin that can be found in Ducrosia anethifolia. Pangelin exhibits anti-mycobacterial and anti-tumor activities .
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-
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- HY-W140869
-
|
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Others
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Others
|
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3-Acetyl-6-bromocoumarin is a coumarin. 3-Acetyl-6-bromocoumarin exhibites potent antioxidant activity at 56% .
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-
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- HY-N2958
-
|
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Phosphodiesterase (PDE)
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Inflammation/Immunology
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Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases .
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-
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- HY-N9206
-
|
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Others
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Cardiovascular Disease
|
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Kimcuongin (compound 1)is a coumarin that can be found in Murraya paniculata. Kimcuongin shows vasorelaxant activity with an IC50 value of 37.7 μM. Kimcuongin can be used as a vasodilator .
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-
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- HY-N7252
-
|
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Bacterial
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Infection
|
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Daphnin is one of the major coumarin bioactive components with antibacterial activity. Daphnin is isolated from the whole herb of Daphne odora (Thunb.), which is a folk medicine in China for the relief of fever .
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- HY-N3320
-
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Others
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Neurological Disease
|
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Marmin is a coumarin, that can be isolated from the immature bark of Aegle marmelos Correa. Marmin antagonizes the Histamine (HY-B1204)-induced contraction in competitive manner .
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-
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- HY-N10978
-
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Others
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Others
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(-)-8-Methoxyobliquin is a coumarin that can be extracted from the aerial parts of Helianthus heterophyllus .
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-
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- HY-D0039
-
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Fluorescent Dye
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Others
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3-Cyanoumbelliferone is a coumarin derivative, acting as molecular probe and fluorescent dye. 3-Cyanoumbelliferone is also a macrophage migration inhibitory factor (MIF) tautomerase inhibitor with a Ki of 2.9 μM .
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-
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- HY-W267897
-
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7-BFC
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Cytochrome P450
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Others
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7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies .
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- HY-N3086
-
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Others
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Others
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Phebalosin is a coumarin that can be isolated from Polygala paniculata. Phebalosin shows biological activity but very unstable in aqueous solution .
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- HY-N4287
-
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Others
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Cancer
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Nordalbergin, a coumarin isolated from the wood bark of Dalbergia sissoo. Nordalbergin shows strong activity in the induction of differentiation of HL-60 .
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- HY-N0341
-
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Sirtuin
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Metabolic Disease
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Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades .
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- HY-N5110
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(-)-Marmesinin; Ammijin
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Others
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Neurological Disease
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Marmesinin ((-)-Marmesinin), a natural coumarin, is a biosynthetic precursor of psoralen and linear furanocoumarins. Marmesinin exhibits significant neuroprotective activities against glutamate-induced toxicity .
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- HY-N9535
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Others
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Metabolic Disease
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tert-OMe-byakangelicin is a coumarin that can enhances the adrenaline-induced lipolytic effect and inhibits insulin-stimulated triglyceride synthesis from glucose in fat cells .
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- HY-N3102A
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(E)-p-Hydroxycinnamyl alcohol
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Others
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Inflammation/Immunology
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(E)-p-Coumaryl alcohol is a metabolite of coumarin that has significant cytotoxicity. (E)-p-Coumaryl alcohol can be isolated from Alpinia officinarum and Rhodiola rosea and can be used for inflammation research .
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- HY-D0066
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DCCH
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Fluorescent Dye
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Others
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7-Diethylaminocoumarin-3-carbohydrazide is a coumarin. 7-Diethylaminocoumarin-3-carbohydrazide can be used to detect sugar chains and quantify biological carbonyl compounds .
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- HY-N12548
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Others
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Others
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Thamnosmonin is a coumarin that can be isolated from Sida acuta and Sida rhombifolia. Thamnosmonin has insecticidal activity .
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- HY-N5092R
-
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Others
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Metabolic Disease
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7-Methylcoumarin (Standard) is the analytical standard of 7-Methylcoumarin. This product is intended for research and analytical applications. 7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect .
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- HY-N7252R
-
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Bacterial
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Infection
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Daphnin (Standard) is the analytical standard of Daphnin. This product is intended for research and analytical applications. Daphnin is one of the major coumarin bioactive components with antibacterial activity. Daphnin is isolated from the whole herb of Daphne odora (Thunb.), which is a folk medicine in China for the relief of fever .
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- HY-W003112
-
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Fluorescent Dye
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Others
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4-Fluororesorcinol is a precursor used in the preparation of fluorescent dyes or indicators such as fluorescein, coumarin and resorcinol analogues .
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- HY-N0825
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-
- HY-N2554
-
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Ostenol
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Monoamine Oxidase
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Neurological Disease
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Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B .
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- HY-101887
-
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Fluorescent Dye
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Others
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Calcein Blue, a membrane-impermeant fluorescent dye, is a coumarin derivative that contains an iminodiacetic acid structure. Calcein Blue is also a metallofluorochromic indicator .
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- HY-N0341R
-
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Sirtuin
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Metabolic Disease
|
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Scopolin (Standard) is the analytical standard of Scopolin. This product is intended for research and analytical applications. Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots . Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades .
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- HY-N0564
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-
- HY-163397
-
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Fungal
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Infection
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Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
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- HY-N9359
-
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Apoptosis
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Cardiovascular Disease
|
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Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity .
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- HY-D0092
-
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Cytochrome P450
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Others
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7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6 .
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- HY-N3230
-
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Murraxocin
|
TRP Channel
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Inflammation/Immunology
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Murpanicin (murraxocin) is a coumarin that is a thermosensitive transient receptor potential vanilloid 2 (TRPV2) channel inhibitor. Murpanicin has significant anti-inflammatory and insecticidal effects.
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- HY-N2733
-
|
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Others
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Others
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7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin is a coumarin, that can be isolated from campylotropis hirtella (FRANCH.) SCHINDL. 7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin inhibits PSA secretion in LNCaP cells, with an IC50 of 24.2 μg/mL .
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- HY-N0825R
-
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Cholinesterase (ChE)
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Inflammation/Immunology
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Nodakenin (Standard) is the analytical standard of Nodakenin. This product is intended for research and analytical applications. Nodakenin is a major coumarin glucoside in the root of Angelica decusiva. Nodakenin inhibits acetylcholinesterase (AChE) activity with an IC50 of 84.7 μM .
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-
- HY-W030319
-
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Fluorescent Dye
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Others
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Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection .
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- HY-W027544
-
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Fluorescent Dye
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Others
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MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
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- HY-N0564R
-
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Apoptosis
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Neurological Disease
Inflammation/Immunology
Cancer
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Notopterol (Standard) is the analytical standard of Notopterol. This product is intended for research and analytical applications. Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML) .
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- HY-N10603
-
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Baihuaqianhuoside
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Others
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Inflammation/Immunology
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Praeroside (Baihuaqianhuoside), a coumarin glycoside. Praeroside can be extracted from the root of Peucedanum praeruptorum and Heracleum dissectum. Praeroside shows anti-inflammatory activity in vitro. Praeroside can be used for the research of inflammation .
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- HY-N12070
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Others
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Cardiovascular Disease
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11-O-β-D-glucopyranosyl thamnosmonin, a coumarin glucosides, can be isolated from the roots of Angelica apaensis. 11-O-β-D-glucopyranosyl thamnosmonin has weak inhibitory activity on the aggregation of rabbit platelets induced by PAF, AA, and ADP .
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- HY-N1065
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Apoptosis
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Inflammation/Immunology
Cancer
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Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation .
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- HY-135036
-
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Fluorescent Dye
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Others
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4-Methylumbelliferyl butyrate (4-MUB) is a coumarin-based fluorogenic substrate used for the identification of M. catarrhalis C4- esterase. 4-Methylumbelliferyl butyrate can converse to the blue-emissive 4-methylumbelliferone (4-MU; HY-N0187) .
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- HY-114541
-
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Fluorescent Dye
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Others
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Coumarin-7-pinacolboronate is a fluorescent probe. Taking hydrogen peroxide for instance, Coumarin-7-pinacolboronate and HOO- undergo a nucleophilic reaction to produce INT1. The chemical reaction mechanisms are nearly identical for the reactions of Coumarin-7-pinacolboronate with hydrogen peroxide, hypochlorous acid, peroxynitrite, and tyrosine hydroperoxide, respectively .
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- HY-121930
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- HY-D0027
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Coumarin 120; AMC
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Fluorescent Dye
Antibiotic
Fungal
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Infection
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7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.
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- HY-N8850
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Others
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Cancer
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Angelol G, a coumarin, can be isolated from Campylotropis hirtella. Angelol G shows inhibitory activity for prostate specific antigen (PSA)IC50 value of 152.1μM. Angelol G can be used for the research of benign prostate hyperplasia (BPH) .
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- HY-W268197
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Coumarin 102
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Others
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Others
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Coumarin 480 (Coumarin 102) is a laser dye .
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- HY-D2157
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Coumarin 343-aminohexanoic acid-NHS ester
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Fluorescent Dye
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Others
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Coumarin 343 X NHS ester is a homologue of Coumarin 343 (HY-W267364). Coumarin 343 is a hydrophilic fluorescent probe for use in microfluids.
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- HY-116141
-
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7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate
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Phospholipase
MAGL
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Others
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7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer .
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- HY-N0709
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- HY-W027968
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2-Oxochromene-3-carboxylic acid
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Others
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Cancer
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|
Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line .
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- HY-W324391
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Coumarin 478
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Cholinesterase (ChE)
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Neurological Disease
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Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56) .
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- HY-W180804
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Coumarin 521
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Others
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Others
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Coumarin 334 (Coumarin 521) is a laser dye with rigid structure .
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- HY-125750
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-
- HY-W015551S
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(E)-Dec-2-enal-d2
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Biochemical Assay Reagents
Isotope-Labeled Compounds
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Others
|
|
trans-2-Decenal-d2 is deuterated labeled Coumarin (HY-N0709). Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity .
|
-
- HY-N0709S
-
|
|
Influenza Virus
|
Infection
Inflammation/Immunology
Cancer
|
|
Coumarin-d4 is the deuterium labeled Coumarin. Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.
|
-
- HY-D0027R
-
|
|
Fluorescent Dye
Antibiotic
Fungal
|
Infection
|
|
7-Amino-4-methylcoumarin (Standard) is the analytical standard of 7-Amino-4-methylcoumarin. This product is intended for research and analytical applications. 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively. [4]
|
-
- HY-N11434
-
|
|
Fungal
|
Infection
|
|
Anisocoumarin H is a coumarin that exhibits antifungal activity. Anisocoumarin H shows the activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs of 62.5 µg/mL .
|
-
- HY-157744
-
|
|
Others
|
Cancer
|
|
Coumarin–quinone conjugate is a fluorescent substrate for NADH:ubiquinone oxidoreductases which consists of a coumarin fluorophore and a ubiquinone analog. Coumarin–quinone conjugate can be used to measure the kinetic parameters of AIFM2/FSP1 for researches such as ferroptosis .
|
-
- HY-D0046
-
|
2-Oxo-2H-chromene-6-sulfonyl chloride
|
Biochemical Assay Reagents
|
Others
|
|
Coumarin-6-sulfonyl chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-156302
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-PEG2-endoBCN is a fluorescent dye containing a coumarin fluorophore and can be used as a click chemistry reagent .
|
-
- HY-156304
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-W116606
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin boronic acid is a fluorescent probe. The excitation and emission wavelengths of coumarin boronic acid are set to 360 nm and 430 nm, respectively. Coumarin boronic acid can be used to monitor the formation of amino acid and protein hydroxyl peroxides in real time, which is beneficial for understanding the mechanisms of oxidative stress and protein post-translational modification .
|
-
- HY-D0981
-
|
Coumarin 151; AFC
|
Fluorescent Dye
|
Others
|
|
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.
|
-
- HY-156303
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-PEG2-TCO is a dye derivative of Coumarin (HY-N0709) containing 2 PEG units. Coumarin-PEG2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-156306
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-PEG3-TCO is a dye derivative of Coumarin (HY-N0709) containing 3 PEG units. Coumarin-PEG3-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-156309
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-PEG8-tetrazine is a dye derivative of Coumarin (HY-N0709) containing 8 PEG units. Coumarin-PEG8-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-113791
-
-
- HY-120201S
-
-
- HY-109714
-
|
|
Others
|
Inflammation/Immunology
|
|
3,4-Benzocoumarin is a kind of the expanded structure of coumarin derivatives.Coumarin is a chemical compound in the benzopyrone chemical class that can be found in many natural species. Coumarins possess variety of biological activities and unique photophysical properties . 3,4-Benzocoumarin, a AOH‐like compound , has the sensibility of the antibody with an IC50 of 919.2 ng/mL .
|
-
- HY-N6063
-
|
|
Others
|
Others
|
|
(+)-Peusedanol is a coumarin isolated from Peucedanumjaponicum .
|
-
- HY-N9364
-
|
|
Others
|
Others
|
|
Iso-oxypeucedanin is a coumarin found in Angelica dahurica.
|
-
- HY-121430
-
|
|
Others
|
Others
|
|
Lamellarin H is a benzo-isoquinoline-coumarin .
|
-
- HY-N11904
-
|
|
Others
|
Others
|
|
Notoptol can be isolated from the fruit of Peucedanum alsaticum L .
|
-
- HY-N1254
-
|
|
Others
|
Others
|
|
Scopoletin acetate is a coumarin isolated from Artemisia granatensis .
|
-
- HY-106561
-
-
- HY-N10819
-
|
|
Others
|
Others
|
|
Arteminin is a coumarin that can be found in Artemisia apiacea .
|
-
- HY-N3233
-
|
|
Others
|
Others
|
|
Murrangatin is a coumarin that can be found in Murraya exotica .
|
-
- HY-138088
-
|
R-(+)-Epoxysuberosin
|
Others
|
Others
|
|
(+)-Epoxysuberosin is a coumarin that has been found in Coleonema album.
|
-
- HY-156305
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-C2-exoBCN is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-exoBCN contains the lyophilic bidentate macrocyclic ligand exo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to generate stable triazoles under catalyst-free conditions.
|
-
- HY-N1366
-
|
Methylumbelliferone
|
Others
|
Cancer
|
|
Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.
|
-
- HY-N10783
-
|
|
Others
|
Others
|
|
(-)-Toddanol, a coumarin, can be isolated from the root of Toddalia asiatica .
|
-
- HY-N10785
-
|
|
Others
|
Others
|
|
Toddanone, a coumarin, can be isolated from the root of Toddalia asiatica .
|
-
- HY-N12582
-
|
|
Others
|
Others
|
|
5-Methoxysuberenone is a coumarin that can be found in Toddalia asiatica .
|
-
- HY-116931
-
|
|
Others
|
Others
|
|
Kelletinin I is a coumarin compound with anti-HIV-1 activity.
|
-
- HY-N4178
-
|
(±)-Prantschimgin
|
Others
|
Neurological Disease
|
|
Isopropylidenylacetyl-marmesin ((±)-Prantschimgin) is a coumarin isolated from the roots of F. bracteata .
|
-
- HY-N10811
-
|
|
Others
|
Others
|
|
O-Methylcedrelopsin is a coumarin that can be isolated from the stems of Ticorea longiflora .
|
-
- HY-138545
-
|
|
Others
|
Others
|
|
4-Hydroxy-6-methylcoumarin is a Coumarin product .
|
-
- HY-133182
-
|
|
Others
|
Others
|
|
Chloculol is a Coumarins product that can be isolated from the herbs of Murraya paniculata .
|
-
- HY-N9063
-
|
|
Others
|
Others
|
|
Demethylluvangetin is a Coumarins product that can be isolated from the roots of Toddalia asiatica .
|
-
- HY-N3860
-
|
|
Others
|
Others
|
|
Erythrocentauric acid is a Coumarins product that can be isolated from the roots of Gentiana macrophylla. .
|
-
- HY-N3884
-
|
|
Others
|
Others
|
|
Evodosin A is a Coumarins product that can be isolated from the herbs of Evodia lepta .
|
-
- HY-N3466
-
|
|
Others
|
Others
|
|
Isomurralonginol acetate is a Coumarins product that can be isolated from the herbs of Murraya exotica .
|
-
- HY-N3232
-
|
|
Others
|
Others
|
|
Murrangatin diacetate is a Coumarins product that can be isolated from the herbs of Murraya exotica L. .
|
-
- HY-N1321
-
|
|
Others
|
Others
|
|
Samidin is a Coumarins product that can be isolated from the fruits of Ammi visnaga. .
|
-
- HY-N9126
-
|
|
Others
|
Others
|
|
Hopeyhopin is a Coumarins product that can be isolated from the herbs of Micromelum falcatum. .
|
-
- HY-A0145
-
|
|
Others
|
Others
Cancer
|
|
Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
|
-
- HY-N4052
-
|
|
Bacterial
|
Infection
|
|
Heraclenol, a coumarin, is isolated from the fruits of Angelica lucida, and exhibits antibacterial activities .
|
-
- HY-N4052A
-
|
|
Bacterial
|
Infection
|
|
(±)-Heraclenol, a coumarin, is isolated from the fruits of Angelica lucida, and exhibits antibacterial activities .
|
-
- HY-N10609
-
|
|
Others
|
Others
|
|
3′-O-Angeloylhamaudol is a coumarin that can be isolated from Radix Saposhnikoviae .
|
-
- HY-N8591
-
|
|
Others
|
Others
|
|
cis-Dehydroosthol is a Coumarins product that can be isolated from the herbs of Murraya exotica .
|
-
- HY-N8832
-
|
|
Others
|
Others
|
|
Matsukaze-lactone is a Coumarins product that can be isolated from the leaves of Boenninghausenia albiflora. .
|
-
- HY-N1348
-
|
|
Others
|
Others
|
|
Rivulobirin E is a Coumarins product that can be isolated from the roots of Heracleum candicans .
|
-
- HY-N1146
-
|
|
Others
|
Others
|
|
Toddalosin is a Coumarins product that can be isolated from the root barks of Toddalia asiatica .
|
-
- HY-137015
-
|
|
Others
|
Others
|
|
trans-Khellactone is a Coumarins product that can be isolated from the roots of Peucedanum wulongense. .
|
-
- HY-N1058
-
|
|
Others
|
Others
|
|
Yuehgesin C is a Coumarins product that can be isolated from the herbs of Murraya paniculata .
|
-
- HY-N8941
-
|
|
Others
|
Others
|
|
Hydramicromelin D is a Coumarins product that can be isolated from the twigs of Micromelum integerrimum. .
|
-
- HY-N3468
-
-
- HY-N4280
-
-
- HY-N2859
-
|
Deacetylakuammiline trimethylgallate
|
Others
|
Others
|
|
Alstolenine (Deacetylakuammiline trimethylgallate) is a Coumarins product that can be isolated from the herbs of Coriaria nepalensis .
|
-
- HY-N1233
-
|
Zongoramine
|
Others
|
Others
|
|
Songoramine (Zongoramine) is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .
|
-
- HY-N3300A
-
|
|
Others
|
Others
|
|
(+)-Mellein is a Coumarins product that can be isolated from the leaves and stems of Stevia lucida Lagasca. .
|
-
- HY-N2669
-
|
|
Others
|
Others
|
|
5'-Demethylaquillochin is a Coumarins product that can be isolated from the herbs of Mallotus apelta .
|
-
- HY-N7839
-
|
|
Others
|
Others
|
|
cis-Methylkhellactone is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .
|
-
- HY-N3319
-
|
|
Others
|
Others
|
|
Marmin acetonide is a Coumarins product that can be isolated from the peels of Citrus grandis (L.) Osbeck .
|
-
- HY-N7816
-
|
|
Others
|
Others
|
|
trans-Methylkhellactone is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .
|
-
- HY-N0080
-
|
Peucedanol methyl ether
|
Bacterial
Fungal
|
Infection
|
|
Ulopterol is a coumarin isolated from the leaves of Toddalia asiatica (L.) Lam with potent antibacterial and antifungal activities .
|
-
- HY-N3280
-
|
Clerodermic acid methyl ester
|
Others
|
Others
|
|
Methyl clerodermate (Clerodermic acid methyl ester) is a Coumarins product that can be isolated from the peels of Citrus maxima .
|
-
- HY-N2176
-
|
(+)-Marmesin; (S)-Marmesin
|
COX
Lipoxygenase
|
Others
|
|
S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.
|
-
- HY-N6657
-
|
|
Others
|
Cancer
|
|
7-Hydroxy-4-methyl-8-nitrocoumarin is a coumarin derivative .
|
-
- HY-N4207
-
|
|
Others
|
Others
|
|
Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .
|
-
- HY-W027857
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin 314 is a dye which has an intense absorption in the visible and additionally presents a large solvent dependence .
|
-
- HY-N7804
-
|
|
Others
|
Others
|
|
4'-O-Methylcoumestrol is a Coumarins product that can be isolated from the herbs of Glycyrrhiza pallidiflora Maxim. .
|
-
- HY-N2690
-
|
|
Others
|
Others
|
|
6',7'-Dihydroxybergamottin acetonide is a Coumarins product that can be isolated from the peels of Citrus maxima .
|
-
- HY-N0573
-
|
7-Hydroxycoumarin; Hydrangin; NSC 19790
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
|
Umbelliferone (7-Hydroxycoumarin), a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.
|
-
- HY-N2263
-
Skimmin
1 Publications Verification
Umbelliferone glucoside
|
Others
|
Inflammation/Immunology
|
|
Skimmin (Umbelliferone glucoside) is a coumarin found in Hydrangea paniculata, inhibits immune complex deposition, with anti-inflammatory activity .
|
-
- HY-N4283
-
|
|
Fungal
Endogenous Metabolite
|
Infection
|
|
Coniferyl alcohol is an intermediate in biosynthesis of eugenol and of stilbenoids and coumarin . Coniferyl alcohol specifically inhibits fungal growth .
|
-
- HY-N2623
-
|
Prangenidin
|
Others
|
Cancer
|
|
Alloimperatorin (Prangenidin), a coumarin compound, is extracted from Angelica dahurica. Alloimperatorin (Prangenidin) has antitumor activity .
|
-
- HY-N2356
-
|
Adicardin
|
Others
|
Metabolic Disease
|
|
Apiosylskimmin (Adicardin), a coumarin isolated from Hydrangea macrophylla, has anti-chronic renal failure activity .
|
-
- HY-128410
-
-
- HY-116938
-
|
|
Apoptosis
|
Cancer
|
|
Farnesiferol C is a sesquiterpene coumarin with anti-cancer activity. Farnesiferol C inhibits the proliferative and apoptotic of AGS cells .
|
-
- HY-N4050
-
|
O-Isopropylideneheraclenol
|
Others
|
Others
|
|
Heraclenol acetonide (O-?Isopropylideneheracl?enol) is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .
|
-
- HY-N7732
-
|
|
Others
|
Others
|
|
Peucedanol 3'-O-glucoside is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .
|
-
- HY-N7759
-
|
|
Others
|
Others
|
|
Peucedanol 7-O-glucoside is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .
|
-
- HY-N2488
-
|
7-Demethylsuberosin
|
Others
|
Inflammation/Immunology
|
|
Demethylsuberosin (7-Demethylsuberosin) is a coumarin compound isolated from Angelica gigas Nakai, and has anti-inflammatory activity .
|
-
- HY-N6658
-
|
|
Others
|
Cancer
|
|
6-Hydroxy-4-methylcoumarin (compound 9) is a coumarins secondary metabolites and has anticancer activity .
|
-
- HY-131126S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Metolcarb-d3 is the deuterium labeled Herniarin. Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.
|
-
- HY-N12068
-
|
|
Others
|
Others
|
|
(S)-7-O-Methylpeucedanol 3′-O-β-D-glucopyranoside is a kind of coumarin glycoside .
|
-
- HY-129977
-
-
- HY-N6063R
-
|
|
Others
|
Others
|
|
(+)-Peusedanol (Standard) is the analytical standard of (+)-Peusedanol. This product is intended for research and analytical applications. (+)-Peusedanol is a coumarin isolated from Peucedanumjaponicum .
|
-
- HY-N1366A
-
|
|
Others
|
Cancer
|
|
Herniarin (Standard) is a standard product of Herniarin. Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect .
|
-
- HY-N2748
-
|
|
Others
|
Others
|
|
7-Hydroxy-3-prenylcoumarin is a Coumarins product that can be isolated from the herbs of Coriaria nepalensis .
|
-
- HY-N8576
-
|
|
Others
|
Others
|
|
8-Acetyl-7-methoxycoumarin is a Coumarins product that can be isolated from the herbs of Murraya paniculata .
|
-
- HY-N0362
-
|
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Columbianadin, a natural coumarin from Heracleum hemsleyanum, is known to have various biological activities including anti-inflammatory and anti-cancer effects.
|
-
- HY-155095
-
|
|
Others
|
Infection
|
|
DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, has antiretroviral activity with IC50 value of 134.22 μM .
|
-
- HY-Y1298
-
|
Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .
|
-
- HY-N9538
-
|
|
Others
|
Others
|
|
8-(3-Ethoxy-2-hydroxy-3-methylbutyloxy)psoralen is a coumarin that can be found in Heracleum pyrenaicum Lam.
|
-
- HY-N12968
-
|
|
Others
|
Others
|
|
R-(-)-Columbianetin is a known coumarin isolated from the root and stem bark of Skimmia reevesiana collected in Taiwan, with specific chemical structure and biological activity .
|
-
- HY-W401797
-
|
|
Others
|
Others
|
|
5-Hydroxy-6,7,8-trimethoxycoumarin is a Coumarins product that can be isolated from the herbs of Viola yedonensis Makino .
|
-
- HY-N8782
-
|
|
Others
|
Others
|
|
4,6,7-Trimethoxy-5-methylcoumarin is a Coumarins product that can be isolated from the herbs of Viola yedonensis Makino .
|
-
- HY-N10167
-
|
|
Others
|
Others
|
|
7-(6'R-Hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin is a natural product .
|
-
- HY-W267393
-
|
|
Fluorescent Dye
|
Others
|
|
4,6-Dimethyl-7-ethylaminocoumarin is a laser dye for pulse and continuous operation .
|
-
- HY-146257
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
hCAIX/XII-IN-2 (compound 6a) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 30.0, 3.6 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .
|
-
- HY-146258
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
hCAIX/XII-IN-3 (compound 6q) is a potent and selective hCAIX and hCAXIIinhibitor with Ki values of >10000, >10000, 66.2, 4.4 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .
|
-
- HY-146256
-
|
|
Carbonic Anhydrase
|
Cancer
|
|
hCAXII-IN-5 (compound 6o) is a potent and selective hCAXII inhibitor with Ki values of >10000, >10000, 286.1, 1.0 nM for hCAI, hCAII, hCAIX and hCAXII, respectively .
|
-
- HY-N2157
-
-
- HY-121417
-
|
|
Others
|
Metabolic Disease
|
|
Laserpitin, a coumarin, increases serum HDL levels, especially apoE-HDL, and decreases the hepatic triglyceride content in stroke-prone spontaneously hypertensive rats (SHRSP) .
|
-
- HY-N2750
-
|
|
Others
|
Others
|
|
7-Hydroxy-6-methoxy-3-prenylcoumarin is a Coumarins product that can be isolated from the herbs of Coriaria nepalensis .
|
-
- HY-N4116
-
|
|
Fungal
|
Infection
Cancer
|
|
Xanthyletin is a coumarin isolated from Stauranthus perforatus, with anti-tumor and anti-bacterial activities. Xanthyletin also inhibits symbiotic fungus cultivated by leaf-cutting ants .
|
-
- HY-N4236
-
|
|
Others
|
Others
|
|
Angelol A is a coumarin isolated from the roots of Angelica pubescens f. biserrata, which is passive diffusion as the dominating process in Caco-2 cell monolayer model .
|
-
- HY-129605
-
-
- HY-124197
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin hydrazine is a fluorescent chemical probe (λex=420–450/λem=468nm) to label cellular protein- and lipid-bound carbonyls .
|
-
- HY-N4283A
-
|
|
Fungal
|
Infection
|
|
(E)-Coniferyl alcohol is the isomer of Coniferyl alcohol. Coniferyl alcohol is an intermediate in biosynthesis of eugenol and of stilbenoids and coumarin. Coniferyl alcohol specifically inhibits fungal growth .
|
-
- HY-N9896
-
|
|
NO Synthase
|
Inflammation/Immunology
|
|
Anhydronotoptol is a potent nitric oxide inhibitory coumarin. Anhydronotoptol inhibits NO production in RAW 264.7 cells induced by LPS with an IC50 value of 36.6 μM .
|
-
- HY-W506116
-
|
Ostruthine
|
Bacterial
|
Infection
|
|
Ostruthin (Ostruthine) is an antimycobacterial coumarin, that can be isolated from the roots of Peucedanum ostruthium. Ostruthin causes a marked inhibition of the growth of gram-positive micro-organisms .
|
-
- HY-N8851
-
|
|
Others
|
Others
|
|
trans-3'-O-Benzoyl-4'-O-methylkhellactone is a Coumarins product that can be isolated from the roots of Peucedanum praeruptorum Dunn. .
|
-
- HY-N0573S
-
|
7-Hydroxycoumarin-d5; Hydrangin-d5; NSC 19790-d5
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
|
Umbelliferone-d5 is the deuterium labeled Umbelliferone. Umbelliferone (7-Hydroxycoumarin), a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.
|
-
- HY-N4235
-
|
|
Others
|
Inflammation/Immunology
|
|
Angelol B is a coumarin isolated from the roots of Angelica pubescens f. biserrata, which is passive diffusion as the dominating process in Caco-2 cell monolayer model .
|
-
- HY-N2558
-
|
|
Others
|
Cancer
|
|
Murrayone, a coumarin-containing compound extracted from M. paniculata, is the most bioactive substance in this species and is a cancer metastasis chemopreventive agent based on its unique pharmacological properties .
|
-
- HY-N10015
-
|
|
Others
|
Others
|
|
7-Methoxy-4-methyl-coumarin-8-ol (compound 31) is a compound isolated from sour orange (Citrus aurantium) .
|
-
- HY-155094
-
|
|
DNA/RNA Synthesis
|
Others
|
|
DNA polymerase-IN-3 (Compd 5b) is a coumarin derivative that exhibits inhibitory activity against Taq DNA polymerase and can be used in proliferative disease research .
|
-
- HY-W267364
-
|
C343
|
Others
|
Others
|
|
Coumarin 343 (C343) is a hydrophilic fluorescent probe for the micro water pool. λem is approximately 425 nm andλem is approximately from 425 nm to 550 nm by RF-1500 .
|
-
- HY-138145
-
|
|
Fungal
Bacterial
|
Infection
|
|
8-Acetyl-7-hydroxycoumarin is a coumarin-like compound found in Mexican patchouli (Tagetes lucida) that has anti-bacterial and anti-fungal activities .
|
-
- HY-N3468R
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Isomerazin (Standard) is the analytical standard of Isomerazin. This product is intended for research and analytical applications. Isomerazin is a coumarin isolated from Poncirus trifoliate Raf., and shows cholinesterase inhibition .
|
-
- HY-N9265
-
|
|
Others
|
Others
|
|
3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin is a Coumarins product that can be isolated from the roots of Toddalia asiatica .
|
-
- HY-N6656
-
|
|
Fungal
Bacterial
|
Inflammation/Immunology
Cancer
|
|
6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity .
|
-
- HY-N3907
-
|
|
Bacterial
|
Infection
|
|
Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk .
|
-
- HY-N4022
-
|
Isobocconin; Seravschanin
|
Others
|
Inflammation/Immunology
|
|
Hyuganin D (Isobocconin) is a Coumarin (HY-N0709) constituent that substantially inhibits LPS (HY-D1056)-induced NO production in mouse peritoneal macrophages .
|
-
- HY-N8982
-
|
|
Others
|
Others
|
|
Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside] is a Coumarins product that can be isolated from the roots of Heracleum stenopterum .
|
-
![Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]](//file.medchemexpress.eu/product_pic/hy-n8982.gif)
- HY-N7650
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Dihydroseselin is a derivative of 7-hydroxycoumarin (HY-N0573). 7-hydroxycoumarin, a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent
|
-
- HY-N4207R
-
|
|
Others
|
Others
|
|
Cnidicin (Standard) is the analytical standard of Cnidicin. This product is intended for research and analytical applications. Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .
|
-
- HY-N9288
-
|
|
Others
|
Others
|
|
8-(6-Hydroperoxy-3,7-dimethyl-2,7-octadienyloxy)psoralen is a Coumarins product that can be isolated from the herbs of Psoralea corylifolia L. .
|
-
- HY-N0053
-
|
Ficusin
|
Apoptosis
HIV
Influenza Virus
|
Cancer
|
|
Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al .
|
-
- HY-N8431
-
|
|
Bacterial
Fungal
|
Infection
Cancer
|
|
5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and ?antibacterial?activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis .
|
-
- HY-N0573R
-
|
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
|
Umbelliferone (Standard) is the analytical standard of Umbelliferone. This product is intended for research and analytical applications. Umbelliferone (7-Hydroxycoumarin), a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.
|
-
- HY-D1084
-
-
- HY-138548
-
-
- HY-N4102
-
|
|
Fungal
Bacterial
|
Infection
|
|
5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities .
|
-
- HY-N2746
-
|
7-Geranyloxy-6-methoxycoumarin
|
Others
|
Neurological Disease
Metabolic Disease
|
|
7-O-Geranylscopoletin is a coumarin from the root of Atalantia monophylla. Various parts of this plant have been used for folk medicine for several purposes such as chronic rheumatism, paralysis, antispasmodic, stimulant and hemiplegia .
|
-
- HY-W014081
-
|
Ethyl 2-oxo-2H-chromene-3-carboxylate
|
Others
|
Others
|
|
Ethyl 3-coumarincarboxylate is a coumarin derivative. Ethyl 3-coumarincarboxylate can be used as a pseudo-template to give a molecularly imprinted polymer (MIP) that has a fairly specific recognition capability for aflatoxins .
|
-
- HY-N12933
-
|
|
Bacterial
|
Endocrinology
|
|
11-Octadecenal is a volatile oil isolated from antibacterial components of coumarin, which can be isolated from synthetic insect sex pheromones used for attracting wax moths (Achroia grisella) .
|
-
- HY-N2176R
-
|
|
COX
Lipoxygenase
|
Others
|
|
S-(+)-Marmesin (Standard) is the analytical standard of S-(+)-Marmesin. This product is intended for research and analytical applications. S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.
|
-
- HY-N8626
-
|
|
Others
|
Others
|
|
8-(7-Hydroxy-3,7-dimethyl-2,5-octadienyloxy)psoralen is a Coumarins product that can be isolated from the herbs of Phebalium tuberculosum ssp. megaphyllum .
|
-
- HY-168261
-
|
|
Ferroptosis
|
Cancer
|
|
CQ-ER is a Coumarin (HY-N0709)-Quinazolinone based endoplasmic reticulum (ER)-targeted photosensitizer. CQ-ER can cause ferroptosis, thereby enhancing photodynamic therapy (PDT) .
|
-
- HY-N4113
-
|
|
Keap1-Nrf2
AMPK
|
Cancer
|
|
Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases .
|
-
- HY-N0362R
-
|
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Columbianadin (Standard) is the analytical standard of Columbianadin. This product is intended for research and analytical applications. Columbianadin, a natural coumarin from Heracleum hemsleyanum, is known to have various biological activities including anti-inflammatory and anti-cancer effects.
|
-
- HY-137845
-
|
|
Fluorescent Dye
|
Others
|
|
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase which, when cleaved, produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer .
|
-
- HY-N3231
-
|
CM-c2
|
Lipoxygenase
COX
|
Cancer
|
|
Murraol (CM-c2), a coumarin, can be isolated from the leaves of Madagascar pine cork (Apiaceae). Murraol has cyclooxygenase (COX) and lipoxygenase inhibitory properties and has an inhibitory effect on the growth of cancer cells .
|
-
- HY-155092
-
|
|
DNA/RNA Synthesis
|
Others
|
|
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC50 of 48.25 μM , which can be used in value-added disease research .
|
-
- HY-D2266
-
|
|
Fluorescent Dye
|
Neurological Disease
|
|
FluoBar1 is an imaging fluorescence probe modified by a barbiturate ligand with fluorescent coumarin. FluoBar1 can monitor L-type voltage-gated calcium channels (LTCC) in living cells in real time for the study of neurological diseases .
|
-
- HY-128105
-
|
|
Others
|
Others
|
|
1,2-Dihydroxynaphthalene is an intermediate isolated from the metabolism of naphthalene and has been shown to be a precursor to the formation of naphthoquinones. 1,2-Dihydroxynaphthalene can be further metabolized by some bacteria (such as Pseudomonas) to compounds such as coumarins and salicylic acid .
|
-
- HY-N8618
-
|
|
Others
|
Others
|
|
Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .
|
-
- HY-141442
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Dihydronovobiocin is a bacterial inhibitor and ATPase inhibitor that can bind to GyrB. Dihydronovobiocin can be used to study the interaction between coumarin antibiotics (such as Novobiocin, Chlorobiocin, and Coumermycin) and DNA gyrase. Dihydronovobiocin also has the potential to study bacterial infections .
|
-
- HY-117754
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
PSB-SB1202 (Compound 21a) is a phenyl coumarin compound. PSB-SB1202 is a CB1/CB2 agonist with EC50 values of 56 and 14 nM, and Ki values of 32 and 49 nM, respectively .
|
-
- HY-N7131
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems (λexc=450 nm, λem=505 nm) .
|
-
- HY-W166297
-
|
|
p38 MAPK
|
Cancer
|
|
Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway .
|
-
- HY-Y1298R
-
|
Acetoacetate methyl ester (Standard); Methyl 3-oxobutanoate (Standard); Methyl acetoacetate (Standard)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Methyl acetylacetate (Standard) is the analytical standard of Methyl acetylacetate. This product is intended for research and analytical applications. Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .
|
-
- HY-N12875
-
|
|
Tyrosinase
|
Others
|
|
Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC50 of 14.21 μM .
|
-
- HY-N4051
-
|
|
Others
|
Others
|
|
3"-O-β-D-Glucopyranosyl-(2"R)-heraclenol (compound 4) is a natural product from the roots of Heracleum rapula Franch .
|
-
- HY-W087433
-
-
- HY-D1085
-
|
|
Fluorescent Dye
|
Others
|
|
AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .
|
-
- HY-N2898
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Artanin is a coumarin, has biological activities related to Alzheimer’s disease. Artanin exerts function including AChE inhibitory and AChE- and self-induced amyloid beta (Aβ) aggregation inhibitory activities, with IC50s of 51 μM, 98 μM, and 124 μM, respectively .
|
-
- HY-N0053R
-
|
|
Apoptosis
HIV
Influenza Virus
|
Cancer
|
|
Psoralen (Standard) is the analytical standard of Psoralen. This product is intended for research and analytical applications. Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al .
|
-
- HY-N0518
-
|
|
PAI-1
|
Cardiovascular Disease
|
|
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM .
|
-
- HY-D0025
-
|
|
Fluorescent Dye
|
Others
|
|
7-Amino-4-methylcoumarin-3-acetic acid is a fluorescent protein labelling agent. 7-Amino-4-methylcoumarin-3-acetic acid emits in the blue region (440-460 nm) on activation with UV light (350 nm) .
|
-
- HY-146305
-
-
- HY-137877
-
|
4-Methylumbelliferyl acetate
|
Glutathione S-transferase
|
Others
|
|
7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition .
|
-
- HY-163005
-
|
|
Glucosidase
|
Metabolic Disease
|
|
α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor (IC50: 4.32 μM) with acute hypoglycemic activity. α-Glucosidase-IN-43 exhibits safety and in vivo efficacy, is nontoxic to normal mouse fibroblasts, and is able to rescue streptozotocin (HY-13753)-induced diabetic rats. α-Glucosidase-IN-43 can be used to study postprandial hyperglycemia in diabetic patients .
|
-
- HY-158235
-
|
|
Tyrosinase
|
Others
|
|
Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC50: 0.88 μM) that statically quenches TYR. Tyrosinase-IN-27 increases the hydrophobicity of the enzyme microenvironment by binding to TYR, reducing the content of α-helices in the enzyme and changing its secondary structure. Tyrosinase-IN-27 can be used in the food industry to effectively inhibit the browning of lotus root slices .
|
-
- HY-163892
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
POLRMT-IN-1 (compound S7) is a POLRMT inhibitor. POLRMT-IN-1 can be used in cancer-related research .
|
-
- HY-N4286
-
|
|
Apoptosis
|
Cancer
|
|
4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation .
|
-
- HY-76547
-
|
4-Methylbenzoic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
p-Toluic acid (4-Methylbenzoic acid), coumarin, is a substituted benzoic acid. p-Toluic acidis synthetic p-aminomethylbenzoic acid (PAMBA), intermediates such as p-toluonitrile. p-Toluic acidMay have potential reproductive toxicity, press 1g/kgRepeated administration of doses can produce a variety of adverse effects on the epididymis .
|
-
- HY-D0128
-
|
7-Methoxy-4-methylcoumarin
|
Bacterial
|
Infection
|
|
4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label, has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 values of 11.76 μg/ml and 13.47 μg/ml .
|
-
- HY-127170
-
|
|
Lipoxygenase
|
Others
|
|
3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage .
|
-
- HY-N6856
-
|
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
|
-
- HY-N0188
-
Esculin
4 Publications Verification
|
p38 MAPK
|
Inflammation/Immunology
Cancer
|
|
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .
|
-
- HY-150695
-
|
|
Carbonic Anhydrase
Apoptosis
|
Cancer
|
|
hCAIX/XII-IN-5 (Coumarin 9a) a carbonic anhydrase (CA) inhibitor, and exhibits excellent hCA IX/XII selectivity (Ki=93.9 and 85.7 nM, respectively) over hCA I and hCA II. hCAIX/XII-IN-5 shows anti-proliferative activities to cancer cells. hCAIX/XII-IN-5 can delay cell cycle and induce apoptosis .
|
-
- HY-135560
-
|
Nicotellin
|
Cytochrome P450
|
Neurological Disease
|
|
Nicotelline (Nicotellin) is a nicotine-related alkaloid, as well as a weak inhibitor of human cDNA-expressed cytochrome P-450 2A6 (CYP2A6). CYP2A6 mediates coumarin 7-hydroxylation, while Nicotelline fails to exhibit inhibition at 300 μM. Nicotelline can be used as a tracer and biomarker of particulate matter (PM) derived from tobacco smoke .
|
-
- HY-N0774
-
|
|
ERK
COX
MMP
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
|
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .
|
-
- HY-N4102R
-
|
|
Fungal
Bacterial
|
Infection
|
|
5,7-Dihydroxy-4-methylcoumarin (Standard) is the analytical standard of 5,7-Dihydroxy-4-methylcoumarin. This product is intended for research and analytical applications. 5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities .
|
-
- HY-147948
-
|
|
DNA/RNA Synthesis
Bacterial
|
Infection
|
|
DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively .
|
-
- HY-D0035
-
|
|
Fluorescent Dye
|
Others
|
|
MPAC-Br is a highly sensitive fluorescent derivatization reagent for carboxylic acids in HPLC .
|
-
- HY-D0067
-
7ACC1
Maximum Cited Publications
9 Publications Verification
DEAC; Coumarin D 1421; D 1421
|
Monocarboxylate Transporter
|
Cancer
|
|
7ACC1 (DEAC; Coumarin D 1421; D 1421) is a monocarboxylate transporter 1 (MCT-1)/MCT-4 specifc blocker. 7ACC1 attenuates renal cancer cell proliferation, migration, invasion and down-regulates the levels of MCT1/MCT4 expression and extracellular lactate. 7ACC1 is promising for research of cancers .
|
-
- HY-N7085
-
|
5,7-Dimethoxycoumarin; Limettin
|
JNK
p38 MAPK
ERK
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .
|
-
- HY-W027544S
-
|
7-Methoxy-d3-2-oxo-2H-1-benzopyran-4-acetic acid; 7-Methoxy-d3-2H-chromen-2-one-4-acetic acid
|
Isotope-Labeled Compounds
|
Others
|
|
(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].
|
-
- HY-149958
-
|
|
Parasite
|
Infection
|
|
Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
|
-
- HY-163457
-
|
|
Aminoacyl-tRNA Synthetase
Parasite
|
Infection
|
|
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .
|
-
- HY-135646
-
|
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities .
|
-
- HY-76779
-
|
|
Others
|
Cancer
|
|
4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .
|
-
- HY-N0188R
-
|
|
p38 MAPK
|
Inflammation/Immunology
Cancer
|
|
Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .
|
-
- HY-149414
-
|
|
Microtubule/Tubulin
Apoptosis
ERK
TGF-beta/Smad
|
Cancer
|
|
MY-673 is a colchicine binding site inhibitor (CBSI), that inhibits tubulin polymerization. MY-673 inhibits the ERK signaling pathway, which in turn affects SMAD4 protein expression levels in the TGF-β/SMAD pathway. MY-673 inhibited cell proliferation, migration and induced apoptosis in vivo and in vitro .
|
-
- HY-N12062
-
|
|
Others
|
Others
|
|
Lucenin 1 is a flavonoid isolated from the aerial parts of Erucaria microcarpa Boiss .
|
-
- HY-157992
-
-
- HY-N0709S1
-
|
|
Bacterial
Fungal
Isotope-Labeled Compounds
|
Cancer
|
|
Coumarin-d6 is deuterated labeled trans-2-Undecenal (HY-W127505). Trans-2-UndecenalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2-UndecenalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.
|
-
- HY-N0774R
-
|
|
ERK
COX
MMP
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
|
Isofraxidin (Standard) is the analytical standard of Isofraxidin. This product is intended for research and analytical applications. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .
|
-
- HY-N7085R
-
|
|
ERK
JNK
p38 MAPK
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Citropten (Standard) is the analytical standard of Citropten. This product is intended for research and analytical applications. Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .
|
-
- HY-120957
-
|
AMC-AA; 7-Amino-4-methyl coumarin-arachidonamide
|
Endogenous Metabolite
|
Metabolic Disease
|
|
AMC arachidonoyl amide (AMC-AA) is one of several fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity.1 FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate anandamide.2 Exposure of AMC-AA to FAAH activity results in the release of the fluorescent aminomethyl coumarin that absorbs at 360 nm and emits at 465 nm. This allows the fast and convenient measurement of FAAH activity using a simple cuvette or microplate fluorometer.
|
-
- HY-N4288
-
|
|
Glutathione Peroxidase
Cathepsin
Phosphatase
|
Inflammation/Immunology
Cancer
|
|
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases .
|
-
- HY-123357
-
|
|
Apoptosis
|
Neurological Disease
|
|
IMM-H004, a coumarin derivative, possesses neuroprotective and potent free radical scavenging abilities. IMM-H004 significantly inhibits amyloid-β (Aβ)-induced cytotoxicity and apoptosis, offering potential value for research into neurodegenerative diseases such as Alzheimer's disease. Additionally, IMM-H004 is also capable of effectively blocking the calcium mobilization and chemotaxis induced by CKLF1-C27 (HY-P3418), thereby alleviating asthmatic pathological changes in the lung tissue of CKLF1 transgenic mice .
|
-
- HY-D0002
-
|
Coumarin 120 hydrogensulfate; AMC hydrogensulfate
|
Fluorescent Dye
|
Others
|
|
7-Amino-4-methylcoumarin hydrogensulfate (Coumarin 120 hydrogensulfate; AMC hydrogensulfate) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
-
- HY-158402
-
|
|
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
|
Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .
|
-
- HY-145708
-
-
- HY-147750
-
|
|
Phosphodiesterase (PDE)
|
Neurological Disease
Cancer
|
|
TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM .
|
-
- HY-N0281
-
|
7,8-Dihydroxycoumarin
|
EGFR
PKA
PKC
Autophagy
Apoptosis
AMPK
Akt
mTOR
Reactive Oxygen Species
Caspase
Bcl-2 Family
PARP
Parasite
|
Inflammation/Immunology
Cancer
|
|
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
|
-
- HY-W027544S1
-
|
5-(Dimethyl-d6-amino)-N-(prop-2-ynyl)naphthalene-1-sulfonamide
|
Isotope-Labeled Compounds
|
Others
|
|
(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-N0281R
-
|
|
EGFR
PKA
PKC
Autophagy
Apoptosis
AMPK
Akt
mTOR
Reactive Oxygen Species
Caspase
Bcl-2 Family
PARP
Parasite
|
Inflammation/Immunology
Cancer
|
|
Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
|
-
- HY-119539
-
|
|
Phosphatase
|
Endocrinology
Cancer
|
|
Limocitrin is a natural product that can be isolated from the buds of P. acerifolia and P. orientalis. Limocitrin suppresses estradiol-dependent proliferation of MCF7 cells weakly but estradiol-induced AlkP (alkaline phosphatase) expression only marginally .
|
-
-
-
HY-L0107V
-
|
|
13,236 compounds
|
|
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Nowadays, new drugs based on Natural products are successfully applied to treat tumors, viral and bacterial diseases, and nervous disorders.
In response to the current drug discovery demand, we created this natural product-like compound library with 13,236 in-stock synthetic compounds similar to natural ones. The library was designed by 2D fingerprint similarity filtering, chemical descriptor-based and natural-likeness scoring selection. These compounds are useful tools for high throughput screening (HTS) and high content screening (HCS) programs.
|
| Cat. No. |
Product Name |
Type |
-
- HY-D0078
-
|
|
Fluorescent Dyes/Probes
|
|
DCIA is a fluorescent dye. DCIA contains a coumarin fluorophore and conjugates specifically with free cysteines in the protein .
|
-
- HY-101887
-
|
|
Fluorescent Dyes/Probes
|
|
Calcein Blue, a membrane-impermeant fluorescent dye, is a coumarin derivative that contains an iminodiacetic acid structure. Calcein Blue is also a metallofluorochromic indicator .
|
-
- HY-W027544
-
|
|
Fluorescent Dyes/Probes
|
|
MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
|
-
- HY-121930
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin 6H, a Coumarin (Coumarin (HY-N0709)) derivative, is a laser dye. The fluorescence emission of Coumarin 6H can be enhanced by hydrogen bonding interactions .
|
-
- HY-D0027
-
|
Coumarin 120; AMC
|
Fluorescent Dyes/Probes
|
|
7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.
|
-
- HY-W324391
-
|
Coumarin 478
|
Dyes
|
|
Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56) .
|
-
- HY-D2099
-
|
|
Dyes
|
|
Coumarin-PEG2-SCO, a Coumarin (HY-N0709) deravitive, is a fluorescent dye, and can be used for labeling of small molecules and biomolecules .
|
-
- HY-D0066
-
|
DCCH
|
Dyes
|
|
7-Diethylaminocoumarin-3-carbohydrazide is a coumarin. 7-Diethylaminocoumarin-3-carbohydrazide can be used to detect sugar chains and quantify biological carbonyl compounds .
|
-
- HY-D0092
-
|
|
Fluorescent Dyes/Probes
|
|
7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6 .
|
-
- HY-D2157
-
|
Coumarin 343-aminohexanoic acid-NHS ester
|
Fluorescent Dyes/Probes
|
|
Coumarin 343 X NHS ester is a homologue of Coumarin 343 (HY-W267364). Coumarin 343 is a hydrophilic fluorescent probe for use in microfluids.
|
-
- HY-125750
-
|
|
Protein Labeling
|
|
Coumarin 7 is a coumarin laser dye in plants in the form of glycosides .
|
-
- HY-D0027R
-
|
|
Fluorescent Dyes/Probes
|
|
7-Amino-4-methylcoumarin (Standard) is the analytical standard of 7-Amino-4-methylcoumarin. This product is intended for research and analytical applications. 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively. [4]
|
-
- HY-156302
-
|
|
Dyes
|
|
Coumarin-PEG2-endoBCN is a fluorescent dye containing a coumarin fluorophore and can be used as a click chemistry reagent .
|
-
- HY-156304
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D0981
-
|
Coumarin 151; AFC
|
Fluorescent Dyes/Probes
|
|
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a fluorescent marker for the sensitive detection of proteinases. The excitation and emission wavelengths are 400 and 490 nm, respectively.
|
-
- HY-156303
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-PEG2-TCO is a dye derivative of Coumarin (HY-N0709) containing 2 PEG units. Coumarin-PEG2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-156306
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-PEG3-TCO is a dye derivative of Coumarin (HY-N0709) containing 3 PEG units. Coumarin-PEG3-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-156309
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-PEG8-tetrazine is a dye derivative of Coumarin (HY-N0709) containing 8 PEG units. Coumarin-PEG8-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-156305
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-C2-exoBCN is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-exoBCN contains the lyophilic bidentate macrocyclic ligand exo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to generate stable triazoles under catalyst-free conditions.
|
-
- HY-W027857
-
|
|
Dyes
|
|
Coumarin 314 is a dye which has an intense absorption in the visible and additionally presents a large solvent dependence .
|
-
- HY-W267393
-
|
|
Dyes
|
|
4,6-Dimethyl-7-ethylaminocoumarin is a laser dye for pulse and continuous operation .
|
-
- HY-124197
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin hydrazine is a fluorescent chemical probe (λex=420–450/λem=468nm) to label cellular protein- and lipid-bound carbonyls .
|
-
- HY-162075
-
|
|
Fluorescent Dyes/Probes
|
|
RF16 is a fluorescent macromolecular material. RF16 precisely retains in cells to track IRE1-Halo protein with the HaloTag ligand .
|
-
- HY-137845
-
|
|
Fluorescent Dyes/Probes
|
|
4-Methylumbelliferyl β-D-galactopyranoside is a fluorescent substrate for β-galactosidase which, when cleaved, produces a water-soluble blue fluorescent coumarin fluorophore that can be detected using a fluoroenzymeter or fluorometer .
|
-
- HY-D2266
-
|
|
Fluorescent Dyes/Probes
|
|
FluoBar1 is an imaging fluorescence probe modified by a barbiturate ligand with fluorescent coumarin. FluoBar1 can monitor L-type voltage-gated calcium channels (LTCC) in living cells in real time for the study of neurological diseases .
|
-
- HY-N7131
-
Coumarin 6
Maximum Cited Publications
7 Publications Verification
|
Fluorescent Dyes/Probes
|
|
Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems (λexc=450 nm, λem=505 nm) .
|
-
- HY-D1085
-
|
|
Fluorescent Dyes/Probes
|
|
AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .
|
-
- HY-D0025
-
|
|
Fluorescent Dyes/Probes
|
|
7-Amino-4-methylcoumarin-3-acetic acid is a fluorescent protein labelling agent. 7-Amino-4-methylcoumarin-3-acetic acid emits in the blue region (440-460 nm) on activation with UV light (350 nm) .
|
-
- HY-D0035
-
|
|
Fluorescent Dyes/Probes
|
|
MPAC-Br is a highly sensitive fluorescent derivatization reagent for carboxylic acids in HPLC .
|
-
- HY-D0002
-
|
Coumarin 120 hydrogensulfate; AMC hydrogensulfate
|
Dyes
|
|
7-Amino-4-methylcoumarin hydrogensulfate (Coumarin 120 hydrogensulfate; AMC hydrogensulfate) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
|
| Cat. No. |
Product Name |
Type |
-
- HY-D0046
-
|
2-Oxo-2H-chromene-6-sulfonyl chloride
|
Biochemical Assay Reagents
|
|
Coumarin-6-sulfonyl chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N0341R
-
-
- HY-N0564
-
-
- HY-N9359
-
-
- HY-N3230
-
-
- HY-N2733
-
-
- HY-N0825R
-
-
- HY-N0564R
-
-
- HY-N10603
-
-
- HY-N12070
-
-
- HY-N1065
-
-
- HY-N8850
-
-
- HY-N0709
-
-
- HY-N11434
-
-
- HY-113791
-
-
- HY-N6063
-
-
- HY-N9364
-
-
- HY-121430
-
-
- HY-N11904
-
-
- HY-N1254
-
-
- HY-N10819
-
-
- HY-N3233
-
-
- HY-N1366
-
-
- HY-N10783
-
-
- HY-N10785
-
-
- HY-N12582
-
-
- HY-116931
-
-
- HY-N4178
-
-
- HY-N10811
-
-
- HY-138545
-
-
- HY-133182
-
-
- HY-N9063
-
-
- HY-N3860
-
-
- HY-N3884
-
-
- HY-N3466
-
-
- HY-N3232
-
-
- HY-N1321
-
-
- HY-N9126
-
-
- HY-A0145
-
-
- HY-N4052
-
-
- HY-N4052A
-
-
- HY-N10609
-
-
- HY-N8591
-
-
- HY-N8832
-
-
- HY-N1348
-
-
- HY-N1146
-
-
- HY-137015
-
-
- HY-N1058
-
-
- HY-N8941
-
-
- HY-N3468
-
-
- HY-N4280
-
-
- HY-N2859
-
-
- HY-N1233
-
-
- HY-N3300A
-
-
- HY-N2669
-
-
- HY-N7839
-
-
- HY-N3319
-
-
- HY-N7816
-
-
- HY-N0080
-
-
- HY-N3280
-
-
- HY-N2176
-
-
- HY-N4207
-
-
- HY-N7804
-
-
- HY-N2690
-
-
- HY-N0573
-
-
- HY-N2263
-
-
- HY-N4283
-
-
- HY-N2623
-
-
- HY-N2356
-
-
- HY-N4050
-
-
- HY-N7732
-
-
- HY-N7759
-
-
- HY-N2488
-
-
- HY-N12068
-
-
- HY-N6063R
-
-
- HY-N2748
-
-
- HY-N8576
-
-
- HY-N0362
-
-
- HY-Y1298
-
-
- HY-N9538
-
-
- HY-N12968
-
-
- HY-W401797
-
-
- HY-N8782
-
-
- HY-N10167
-
-
- HY-N2157
-
-
- HY-N2750
-
-
- HY-N4116
-
-
- HY-N4236
-
-
- HY-129605
-
-
- HY-N4283A
-
-
- HY-N9896
-
-
- HY-N8851
-
-
- HY-N4235
-
-
- HY-N2558
-
-
- HY-N10015
-
-
- HY-138145
-
-
- HY-N3468R
-
-
- HY-N9265
-
-
- HY-N6656
-
-
- HY-N3907
-
-
- HY-N4022
-
-
- HY-N8982
-
-
- HY-N7650
-
-
- HY-N4207R
-
-
- HY-N9288
-
-
- HY-N0053
-
-
- HY-N8431
-
-
- HY-N0573R
-
-
- HY-138548
-
-
- HY-N4102
-
-
- HY-N2746
-
-
- HY-N12933
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- HY-N2176R
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- HY-N8626
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- HY-N4113
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- HY-N0362R
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- HY-N3231
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- HY-128105
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- HY-N8618
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Structural Classification
Monophenols
Source classification
Sapindaceae
Phenols
Acer saccharum Marshall
Plants
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Others
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Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .
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- HY-141442
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- HY-N7131
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- HY-Y1298R
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- HY-N12875
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- HY-N4051
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- HY-N2898
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- HY-N0053R
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- HY-N0518
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- HY-N4286
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- HY-76547
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- HY-127170
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- HY-N6856
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- HY-N0188
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- HY-N0774
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- HY-N4102R
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- HY-N7085
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- HY-135646
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- HY-N0188R
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Structural Classification
Monophenols
other families
Source classification
Coumarins
Phenols
Phenylpropanoids
Plants
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p38 MAPK
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Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .
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- HY-N12062
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- HY-N0774R
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- HY-N7085R
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Structural Classification
Natural Products
Rutaceae
Plants
Citrus medica Linn. var. sarcodactylis (Noot.) Swingle
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ERK
JNK
p38 MAPK
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Citropten (Standard) is the analytical standard of Citropten. This product is intended for research and analytical applications. Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis .
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- HY-N4288
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- HY-N0281
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7,8-Dihydroxycoumarin
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Structural Classification
Daphne
Classification of Application Fields
Thymelaeaceae
Source classification
Coumarins
Phenols
Polyphenols
Phenylpropanoids
Plants
Disease Research Fields
Cancer
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EGFR
PKA
PKC
Autophagy
Apoptosis
AMPK
Akt
mTOR
Reactive Oxygen Species
Caspase
Bcl-2 Family
PARP
Parasite
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Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
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- HY-N0281R
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Structural Classification
Daphne
Thymelaeaceae
Source classification
Coumarins
Phenols
Polyphenols
Phenylpropanoids
Plants
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EGFR
PKA
PKC
Autophagy
Apoptosis
AMPK
Akt
mTOR
Reactive Oxygen Species
Caspase
Bcl-2 Family
PARP
Parasite
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Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
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- HY-119539
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-N0709S
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Coumarin-d4 is the deuterium labeled Coumarin. Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities.
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- HY-W015551S
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trans-2-Decenal-d2 is deuterated labeled Coumarin (HY-N0709). Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity .
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- HY-120201S
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7-Hydroxy Coumarin-d5 β-D-glucuronide (sodium) is the deuterium labeled 7-Hydroxy Coumarin β-D-glucuronide sodium[1].
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- HY-131126S
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Metolcarb-d3 is the deuterium labeled Herniarin. Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.
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- HY-N0573S
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Umbelliferone-d5 is the deuterium labeled Umbelliferone. Umbelliferone (7-Hydroxycoumarin), a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.
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- HY-W027544S
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(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].
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- HY-N0709S1
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Coumarin-d6 is deuterated labeled trans-2-Undecenal (HY-W127505). Trans-2-UndecenalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2-UndecenalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.
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- HY-W027544S1
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(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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| Cat. No. |
Product Name |
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Classification |
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- HY-156302
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- HY-156304
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TCO
Labeling and Fluorescence Imaging
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Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
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- HY-156303
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TCO
Labeling and Fluorescence Imaging
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Coumarin-PEG2-TCO is a dye derivative of Coumarin (HY-N0709) containing 2 PEG units. Coumarin-PEG2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
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- HY-156306
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Labeling and Fluorescence Imaging
TCO
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Coumarin-PEG3-TCO is a dye derivative of Coumarin (HY-N0709) containing 3 PEG units. Coumarin-PEG3-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
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- HY-156309
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Labeling and Fluorescence Imaging
Tetrazine
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Coumarin-PEG8-tetrazine is a dye derivative of Coumarin (HY-N0709) containing 8 PEG units. Coumarin-PEG8-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-156305
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BCN
Labeling and Fluorescence Imaging
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Coumarin-C2-exoBCN is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-exoBCN contains the lyophilic bidentate macrocyclic ligand exo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to generate stable triazoles under catalyst-free conditions.
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- HY-W027544S1
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5-(Dimethyl-d6-amino)-N-(prop-2-ynyl)naphthalene-1-sulfonamide
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Alkynes
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(7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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