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hydrolysis activity

" in MedChemExpress (MCE) Product Catalog:

91

Inhibitors & Agonists

5

Fluorescent Dye

5

Biochemical Assay Reagents

16

Peptides

12

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150504

    Others Inflammation/Immunology
    ERAP2-IN-1 (compound 61) is an uncompetitive ERAP2 inhibitor. ERAP2-IN-1 specifically inhibits the ERAP2 peptide hydrolysis activity, inhibiting Arg-AMC hydrolysis with an IC50 of 27 μM and model peptide hydrolysis with an IC50 of 44 μM .
    ERAP2-IN-1
  • HY-126488

    Endogenous Metabolite Metabolic Disease
    H-Ser-His-OH is a short peptide with hydrolysis cleavage activity, an endogenous metabolite .
    H-Ser-His-OH
  • HY-77195

    Polo-like Kinase (PLK) Cancer
    Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.
    Poloxime
  • HY-108666
    ATPγS tetralithium salt
    1 Publications Verification

    Adenosine-5'-O-3-thiotriphosphate (tetralithium salt); Adenosine 5'-[γ-thio]triphosphate tetralithium salt

    Eukaryotic Initiation Factor (eIF) Inflammation/Immunology
    ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A .
    ATPγS tetralithium salt
  • HY-N6667

    Others Others
    Glucovanillin extracted from Vanilla planifolia Andrews and simultaneously transformed to vanillin by a combination of enzyme activities involving cell wall degradation and glucovanillin hydrolysis.
    Glucovanillin
  • HY-N6821

    Others Cancer
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid is a glucoside derivative of ascorbic acid, shows anti-cancer activity after enzymatic hydrolysis to ascorbic acid .
    2-O-α-D-Glucopyranosyl-L-ascorbic Acid
  • HY-P3948

    Fluorescent Dye Others
    Fluorescent Substrate for Pro-Specific Proteases is a fluorescent substrate of pro-specific proteases. Fluorescent Substrate for Pro-Specific Proteases can be used to detect the hydrolysis rate and activity of target enzyme .
    Fluorescent Substrate for Pro-Specific Proteases
  • HY-P10615

    Fluorescent Dye Transthyretin (TTR) Others
    Abz-YGGRASDQ-EDDnp is a fluorescent substrate of transthyretin (TTR) protein and is used to detect the hydrolytic activity of TTR protein .
    Abz-YGGRASDQ-EDDnp
  • HY-19602

    Others Cancer
    Cedefingol is an antitumor compound with α-glucosidase inhibitory activity. Cedefingol was identified together with other compounds in fermented dark tea samples. The biotransformation of cedefingol is related to enzymatic hydrolysis, hydrolysis and biosynthesis. Cedefingol exhibited different bioactivities in samples with different fermentation times. The antioxidant properties of cedefingol showed certain activity in the DPPH model .
    Cedefingol
  • HY-E70409

    Endogenous Metabolite Metabolic Disease
    Diacetinase, Bacillus subtilis is a member of the esterase family and is responsible for catalyzing the hydrolysis of diacetin. This enzyme is used in the measurement of lipase activity .
    Diacetinase, bacillus subtilis
  • HY-106975

    Neprilysin Cardiovascular Disease
    SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity .
    SCH-42354
  • HY-128476

    Others Others
    Sodium Tartrate is a pH-Regulating agent with antioxidant activity. Sodium Tartrate is particularly effective retarding hydrolysis while heating at high temperatures, resulting in increase of acid values (AVs) of vegetable oils .
    Sodium Tartrate
  • HY-139041

    Others Others
    Palmitoylcholine chloride reduces membrane stress and reduces enzyme activity by Ca(2+)-dependent phosphatidylinositol phosphodiesterase (EC 3.1.4.10) hydrolysis of phosphatidylinositol monolayers .
    Palmitoylcholine chloride
  • HY-134019

    Others Others
    Arachidonoyl p-nitroaniline is a substrate for the hydrolysis of p-nitroaniline by FAAH in Dictyostelium discoideum with long-chain unsaturated fatty acids. Arachidonoyl p-nitroaniline can be used in enzyme kinetic studies. Examples include determining the hydrolysis rate of Arachidonoyl p-nitroaniline and analyzing the fatty acid amide hydrolase activity of recombinant His-FAAH purified from Dictyostelium to characterize the binding and catalytic specificity of mammalian FAAH enzymes .
    Arachidonoyl p-nitroaniline
  • HY-N6731

    Others Infection
    Hydrolyzed Fumonisin B2 (HFB2) is a hydrolysis product of fumonisins (HF), which retains biological activity. Hydrolyzed Fumonisin B2 (HFB2) exhibits phytotoxicity .
    Hydrolyzed Fumonisin B2
  • HY-137252

    Ivermectin Impurity G

    Parasite Infection
    22,23-Dihydroavermectin B1a aglycon is an acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin. It can inhibit nematode larval development, but does not cause paralytic activity.
    22,23-Dihydroavermectin B1a aglycon
  • HY-160519

    Bacterial Antibiotic Infection
    Targocil-II (Compound 2) is an ABC transporter inhibitor with a IC50 value of 137 nM. Targocil-II prevents ATP hydrolysis by binding to allosteric sites of the TM domain. Targocil-II has (antibacterial) activity .
    Targocil-II
  • HY-120166
    DiFMUP
    1 Publications Verification

    6,8-Difluoro-4-methylumbelliferyl phosphate

    Phosphatase Others
    DiFMUP is a fluorogenic substrate, and has been widely used for the continuous detection of phosphatase activities. DiFMUP is hydrolysis by a phosphatase results in the release of Xuorescent DIFMU, which can be easily followed in continuous mode by a Xuorescence reader .
    DiFMUP
  • HY-116571

    Antibiotic Bacterial Infection
    RU44790 is a monocyclic beta-lactam antibiotic that exerts potent activity against gram-negative bacteria and is highly resistant to hydrolysis by various beta-lactamases. RU44790 can be utilized in anti-bacteria research .
    RU44790
  • HY-129217

    Glucosidase Others
    Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .
    Naringinase
  • HY-121694

    Others Infection
    CENTA is a colorimetric cephalosporin substrate for β-lactamases. Upon hydrolysis by β-lacatamases, CENTA turns from light yellow to chrome yellow, which can be quantified by colorimetric detection at 405 nm as a measure of β-lactamase activity.
    CENTA
  • HY-N13110

    Others Others
    23-Aldehyde-16-O-angeloybarringtogenol C (compound 7) is a tea seed saponin, an acid hydrolysis product obtained by oxidative alkaline degradation. Tea seed saponins have potential quinine oxidoreductase inducing activity .
    23-Aldehyde-16-O-angeloybarringtogenol C
  • HY-116895

    Androgen Receptor MAGL Metabolic Disease
    JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively .
    JJH260
  • HY-160973

    ELFP

    Biochemical Assay Reagents Others
    ELF97 phosphate (ELFP) is a phosphatase substrate, which can produced a fluorescent, water-insoluble product ELF97 alcohol after hydrolysis by phosphatases. ELF97 phosphate can be utilized to study and quantify the activity of extracellular phosphatases of algae in natural water .
    ELF97 phosphate
  • HY-100045

    4-Nitrophenylphosphorylcholine; 4-Nitrophenylphosphorylcholine; O-(4-Nitrophenylphosphoryl)choline

    Endogenous Metabolite Metabolic Disease
    p-Nitrophenyl phosphorylcholine (4-Nitrophenylphosphorylcholine) is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. Hydrolysis of p-nitrophenylphosphorylcholine by PLC results in the liberation of p-nitrophenol, which can be measured at 405 nm at pH 7.2-7.5.
    p-Nitrophenyl phosphorylcholine
  • HY-111396

    Bacterial Infection
    PC58538 is a cell division inhibitor, targeting to FtsZ. PC58538 shows moderate antibacterial activity, and inhibits cell division in vegetative cells of wild-type B. subtilis. PC58538 is also known to modulate the rate of GTP hydrolysis .
    PC58538
  • HY-P4465

    Fluorescent Dye Others
    Gly-Arg-pNA is a fluorogenic substrate for the measurement of protease activity. Gly-Arg-pNA undergoes hydrolysis and releases the fluorescent product p-nitroaniline. p-nitroaniline is in a fluorescent state under ultraviolet light irradiation and can emit a fluorescent signal .
    Gly-Arg-pNA
  • HY-125143

    MAGL Metabolic Disease
    ABC34 is an inactive control compound of JJH260. ABC34 does not inhibit the fluorophosphonate reactivity or fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1. ABC34 can inhibit both ABHD6 and PPT122 .
    ABC34
  • HY-B0593
    Ceftazidime
    Maximum Cited Publications
    21 Publications Verification

    GR20263

    Beta-lactamase Bacterial Antibiotic Infection Cancer
    Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
    Ceftazidime
  • HY-P4417

    Fluorescent Dye Others
    Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Ac-IEPD-AMC
  • HY-124324

    p-Nitopheyl β-D-cellotioside

    Fluorescent Dye Others
    4-Nitrophenyl β-D-cellotrioside (p-Nitopheyl β-D-cellotioside) is a chromogenic substrate for endoglucanases and cellulose biohydrolases. As a fluorescent dye, nitrophenyl β-D-Cellotrioside can be hydrolyzed by enzymes to release 4-nitrophenol, producing a yellow color. The activity of the enzyme can be quantitatively analyzed by monitoring the change in absorbance at 405 nm .
    4-Nitrophenyl β-D-cellotrioside
  • HY-N2512
    1-Monomyristin
    1 Publications Verification

    FAAH Bacterial Fungal Endogenous Metabolite Autophagy Infection
    1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans .
    1-Monomyristin
  • HY-B0593A
    Ceftazidime pentahydrate
    Maximum Cited Publications
    21 Publications Verification

    GR20263 pentahydrate

    Beta-lactamase Bacterial Antibiotic Infection Cancer
    Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
    Ceftazidime pentahydrate
  • HY-D1652

    Caspase Others
    Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity .
    Ac-LEHD-AMC
  • HY-P4406

    Fluorescent Dye Others
    Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
    Abz-AGLA-Nba
  • HY-157808

    Bacterial Infection
    Antibacterial agent 185 (compound IP-01) is a potent antibacterial agent. Antibacterial agent 185 inhibits filamentous temperature-sensitive mutant Z (FtsZ) polymerization and bundling by increasing GTP hydrolysis. Antibacterial agent 185 inhibits Streptococcus pneumoniae and shows narrow-spectrum activity .
    Antibacterial agent 185
  • HY-116022

    p-Nitrophenyl phosphate

    Biochemical Assay Reagents Others
    4-Nitrophenyl phosphate (p-Nitrophenyl phosphate) is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases.4-Nitrophenyl phosphate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .
    4-Nitrophenyl phosphate
  • HY-N8326

    Others Others
    Maltononaose is a linear oligosaccharide consisting of 9 glucose units linked by alpha-1, 4-glucoside bonds. Maltononaose is used as a substrate to study the subsites affinity of glucoamylase. Maltononaose can be used to determine the activity of amylase and to optimize the process of starch hydrolysis .
    Maltononaose
  • HY-W104635

    6-Bromo-2-naphthyl-beta-D-galactopyranoside

    Biochemical Assay Reagents Others
    6-Bromo-2-naphthyl-β-D-galactopyranoside is a chromogenic substrate commonly used to measure β-galactosidase enzyme activity in food, enzyme substrates, and culture media. Upon hydrolysis by β-galactosidase, it generates a yellow precipitate indicating the enzyme's presence.
    6-Bromo-2-naphthyl-β-D-galactopyranoside
  • HY-142688

    Carboxylesterase Wnt Cancer
    Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease .
    Carboxylesterase-IN-2
  • HY-142689

    Carboxylesterase Wnt Cancer
    Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease .
    Carboxylesterase-IN-3
  • HY-P4417A

    Fluorescent Dye Others
    Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
    Ac-IEPD-AMC TFA
  • HY-P4323

    Fluorescent Dye Others
    Boc-Gln-Arg-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Boc-Gln-Arg-Arg-AMC
  • HY-P4408

    Fluorescent Dye Others
    Ac-Arg-Gly-Lys-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Arg-Gly-Lys-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Ac-Arg-Gly-Lys-AMC
  • HY-P4323A

    Fluorescent Dye Others
    Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Boc-Gln-Arg-Arg-AMC acetate
  • HY-116022A

    p-Nitrophenyl phosphate disodium hexahydrate

    Biochemical Assay Reagents Others
    4-Nitrophenyl phosphate (p-nitrophenyl phosphate) disodium hexahydrate is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. 4-Nitrophenyl phosphate disodium hexahydrate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .
    4-Nitrophenyl phosphate disodium hexahydrate
  • HY-B1064A

    Clindamycin 2-phosphate hydrochloride; U-28508 hydrochloride

    Bacterial Antibiotic Parasite Infection Cancer
    Clindamycin phosphate (Clindamycin 2-phosphate) hydrochloride is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate hydrochloride is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate hydrochloride can be used for researching acne and bacterial vaginosis .
    Clindamycin phosphate hydrochloride
  • HY-P2840

    Endogenous Metabolite Metabolic Disease
    Dextranase, Trichoderma reesei, glucan hydrolase, is often used in biochemical research. Dextranase can catalyze the hydrolysis of α-(1,6)-glucosidic bonds in dextran, and has a wide range of applications, such as food processing, sugar modification, agent preparation, and medicine for enhancing the activity of endocarditis antibiotics wait .
    Dextranase, Trichoderma reesei
  • HY-P4400

    Fluorescent Dye Others
    Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals .
    Z-VDVAD-AFC
  • HY-P4416

    Fluorescent Dye Others
    Ac-Gly-Ala-Lys(Ac)-AMC is a fluorogenic substrate for the determination of protease activity. Ac-Gly-Ala-Lys(Ac)-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Ac-Gly-Ala-Lys(Ac)-AMC

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