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inducible nitric-oxide synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NO Synthase (50) PGE synthase (1) Angiotensin Receptor (1) Antibiotic (3) Apoptosis (9) Autophagy (2) Bacterial (3) COX (3) Endogenous Metabolite (6) ERK (1) Estrogen Receptor/ERR (1) Fungal (1) Guanylate Cyclase (1) HMG-CoA Reductase (HMGCR) (2) HSV (1) IKK (1) Interleukin Related (3) Keap1-Nrf2 (1) Lipoxygenase (1) NF-κB (7) NOD-like Receptor (NLR) (1) Phosphatase (1) PKC (1) TNF Receptor (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (13) Endocrinology (4) Infection (6) Inflammation/Immunology (42) Metabolic Disease (6) Neurological Disease (18)
Oligonucleotides:	Solubilizing Agents (1)

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Targets Recommended: NO Synthase PGE synthase Thymidylate Synthase ATP Synthase Acetolactate Synthase (ALS) Glucosylceramide Synthase (GCS) Fatty Acid Synthase (FASN) Cyclic GMP-AMP Synthase Salt-inducible Kinase (SIK) Itk GSK-3 HIF/HIF Prolyl-Hydroxylase AIM2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107584

BYK 191023 dihydrochloride 1 Publications Verification	Others	Metabolic Disease
BYK 191023 is a highly selective inducible nitric-oxide synthase (iNOS) inhibitor. BYK 191023 interacts with the catalytic center of the enzyme. BYK 191023 can be used to study the in vivo and in vitro effects mediated by iNOS .

HY-110275

RA839	Keap1-Nrf2	Others
RA839 is a noncovalent small molecule binder to Keap1 with a K_d of ∼6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2 .

HY-127029A

Umbelliprenin	NO Synthase Lipoxygenase	Neurological Disease Inflammation/Immunology Cancer
Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as **inducible nitric oxide synthase (NO synthase)** .

HY-101175

3-Bromo-7-nitroindazole	NO Synthase	Neurological Disease
3-Bromo-7-nitroindazole is a more potent and selective inhibitor of *neuronal nitric oxide* synthase (nNOS)** than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain .

HY-18731

1400W Dihydrochloride Maximum Cited Publications 15 Publications Verification	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-122060

BYK 191023	NO Synthase	Metabolic Disease
BYK 191023 is a selective and L-arginine competitive **inducible nitric-oxide synthase inhibitor with an IC₅₀** value of 86 nM, 17 µM, 162 µM for inducible (iNOS), neuronal (nNOS), and endothelial (eNOS) NO synthases respectively .

HY-U00432B

S-MTC acetate S-Methyl-L-thiocitrulline acetate	Others	Inflammation/Immunology
S-MTC acetate (S-Methyl-L-thiocitrulline acetate) acts as a powerful inhibitor of inducible nitric oxide synthase, favoring the inhibition of constitutive (neuronal) nitric oxide synthase over inducible (endothelial) nitric oxide synthase.

HY-18730

1400W W1400	NO Synthase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a K_d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .

HY-164361

2′-Hydroxy-2,3-dimethoxychalcone	NO Synthase	Inflammation/Immunology
α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells .

HY-115744

Mercaptoethylguanidine (MEG) (dihydrobromide)	NO Synthase	Inflammation/Immunology
Mercaptoethylguanidine (MEG) dihydrobromide is selective inhibitor of the inducible **nitric oxide synthase and peroxynitrite** scavenger. Mercaptoethylguanidine (MEG) dihydrobromide has the potential for inflammatory bowel diseases research.

HY-W408607

N-Benzylacetamidine hydrobromide	NO Synthase	Inflammation/Immunology
N-Benzylacetamidine (hydrobromide) is a acetamidine compound. N-Benzylacetamidine (hydrobromide) is a selective inducible nitric oxide synthase (iNOS) inhibitor with an IC₅₀ of 0.20 μM .

HY-133098

Juncutol	NO Synthase	Inflammation/Immunology
Juncutol is a potent inducible nitric oxide synthase (iNOS) inhibitor. Juncutol decreases the LPS (HY-D1056)-stimulated iNOS protein expression .

HY-117786

Go 7874	PKC	Neurological Disease
Go 7874 is a protein kinase C (PKC) inhibitor. Go 7874 mediated neuroprotection against LPS/IFNg-induced neuronal cell death in an immune-mediated neurotoxicity model, not through PKC activity. In contrast, the neuroprotective mechanism of Go 7874 involves inhibition of inducible nitric oxide synthase (iNOS) gene expression, followed by reduced nitric oxide (NO) production .

HY-N6770

Curvularin (S)-Curvularin	NO Synthase	Infection Inflammation/Immunology
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC₅₀ of 9.5 µM .

HY-N1382

Asperuloside 2 Publications Verification	NO Synthase	Metabolic Disease Inflammation/Immunology
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .

HY-79457

S-Methylisothiourea sulfate 1 Publications Verification	NO Synthase HSV	Infection Inflammation/Immunology
S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock .

HY-N0455

L-Arginine 5+ Cited Publications	NO Synthase Endogenous Metabolite	Cardiovascular Disease Cancer
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455A

L-Arginine hydrochloride 5+ Cited Publications (S)-(+)-Arginine hydrochloride	NO Synthase Endogenous Metabolite	Cancer
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0268

Irisflorentin 1 Publications Verification	NO Synthase	Inflammation/Immunology
Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

HY-114798

Rabelomycin	Antibiotic Bacterial NO Synthase	Infection Neurological Disease
Rabelomycin is antibiotic, which exhibits antimicrobial activity against gram positive bacteria. Rabelomycin exhibits inhibitory activity against inducible nitric oxide synthase (iNOS) with an IC₅₀ of 63.9 μM .

HY-12124

BBS-4	NO Synthase	Cardiovascular Disease
BBS-4 is a potent and selective inducible nitric oxide synthase (NOS2) dimerization inhibitor, with an IC₅₀ of 0.49 nM. BBS-4 can protect mice from the cardiovascular dysfunction of sepsis .

HY-136341

7,8-Dihydroneopterin	Apoptosis NO Synthase Endogenous Metabolite	Neurological Disease Inflammation/Immunology
7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases .

HY-161255

3,4-DAA	NO Synthase	Inflammation/Immunology
3,4-DAA is an orally active Anthranilic acid derivative with potent immunosuppressive activities. 3, 4-DAA can alleviate the severity of colitis through inhibiting Th1 cells response, promoting Th2 cytokines expression and inducing CD4 ⁺CD25 ⁺ T cells expression . 3,4-DAA suppressed expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release from EOC20 cells induced by IFN-γ and Lipopolysaccharide .

HY-N6893

Ergolide 2 Publications Verification	NF-κB	Inflammation/Immunology
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .

HY-12122A

AR-C102222 hydrochloride	NO Synthase	Neurological Disease Inflammation/Immunology
AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC₅₀ of 37 nM . AR-C102222 hydrochloride has antinociception and anti-inflammatory activities .

HY-N8444

Triptoquinone A	Interleukin Related	Cardiovascular Disease
Triptoquinone A, an interleukin 1 inhibitor, inhibits endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced vascular relaxation .

HY-N11085

Isophysalin A	NO Synthase IKK	Inflammation/Immunology
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity .

HY-W022047

nNOS-IN-1	NO Synthase	Cardiovascular Disease Neurological Disease
nNOS-IN-1(Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC₅₀s of 2.5, 5.7 and 13 μM, respectively .

HY-145846

iNOs-IN-1 1 Publications Verification	NO Synthase Interleukin Related	Inflammation/Immunology
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .

HY-135224

1,4-PBIT dihydrobromide 1,4-PB-ITU dihydrobromide	NO Synthase	Cancer
1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with K_i values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively .

HY-100986

L-NIO dihydrochloride 1 Publications Verification	NO Synthase	Cardiovascular Disease
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with K_is of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats .

HY-100986B

L-NIO	NO Synthase	Cardiovascular Disease
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with K_is of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO induces a consistentfocal ischemic infarctin rats .

HY-N1382R

Asperuloside (Standard)	NO Synthase	Metabolic Disease Inflammation/Immunology
Asperuloside (Standard) is the analytical standard of Asperuloside. This product is intended for research and analytical applications. Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .

HY-N0455R

L-Arginine (Standard)	NO Synthase Endogenous Metabolite	Cardiovascular Disease Cancer
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455AR

L-Arginine (hydrochloride) (Standard)	NO Synthase Endogenous Metabolite	Cancer
L-Arginine (hydrochloride) (Standard) is the analytical standard of L-Arginine (hydrochloride). This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-B1041

Aminoguanidine hydrochloride 4 Publications Verification Pimagedine hydrochloride; GER-11; Aminoguanidinium chloride	NO Synthase Apoptosis	Endocrinology
Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and **nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis** induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research .

HY-B1041A

Aminoguanidine Pimagedine; GER-11(free base) ; Aminoguanidinium	NO Synthase Apoptosis	Endocrinology
Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and **nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis** induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research .

HY-124996

(Rac)-ZLc-002	NO Synthase	Neurological Disease Inflammation/Immunology Cancer
(Rac)-ZLc-002, an inhibitor of nNOS interaction with nitric oxide synthase 1 adaptor protein (NOS1AP), suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with Paclitaxel (HY-B0015) to reduce tumor cell viability .

HY-122063

FR260330	NO Synthase	Inflammation/Immunology
FR260330 is a selective, orally active inhibitor for inducible nitric oxide synthase (iNOS) through suppression of iNOS dimerization. FR260330 inhibits the NO accumulation in rat splenocytes and human DLD-110 cells, with IC₅₀ of 27 and 10 nM. FR260330 ameliorates the Lipopolysaccharides (HY-D1056)-induced inflammatory diseases in rats model .

HY-146309

iNOS-IN-2	NO Synthase	Inflammation/Immunology
iNOS-IN-2 (Compound 53) is a potent down-regulator of inducible nitric oxide synthase (iNOS) protein. iNOS-IN-2 effectively inhibits the NO production (IC₅₀=6.4 μM). iNOS-IN-2 has a potential therapeutic effect on chronic inflammation .

HY-150055

iNOs-IN-3	NO Synthase	Inflammation/Immunology
iNOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC₅₀=3.342 µM). iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research .

HY-N0268R

Irisflorentin (Standard)	NO Synthase	Inflammation/Immunology
Irisflorentin (Standard) is the analytical standard of Irisflorentin. This product is intended for research and analytical applications. Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .

HY-N6966

Ethyl Caffeate 1 Publications Verification	NF-κB NO Synthase COX PGE synthase	Inflammation/Immunology Cancer
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin .

HY-161513

iNOS/COX-2-IN-1	COX NO Synthase	Inflammation/Immunology
iNOS/COX-2-IN-1 (Compound 12e) is an inhibitor of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). iNOS/COX-2-IN-1 inhibits the NF-κB and MAPKs signaling pathways and thus exerts anti-inflammatory effects .

HY-156241

Meliadubin B	NO Synthase Fungal	Infection Inflammation/Immunology
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC₅₀ of 5.54 μM). Meliadubin B inhibits **inducible nitric oxide synthase*. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae* with IC₅₀ of 182.50 μM.

HY-N12224

1-Heptadecanoyl-rac-glycerol MG(17:0/0:0/0:0); 1-Heptadecanoin	NO Synthase	Inflammation/Immunology
1-Heptadecanoyl-rac-glycerol (1-Heptadecanoin) is a glyceride compound with anti-inflammatory activity. 1-Heptadecanoyl-rac-glycerol inhibits the occurrence of inflammation by suppressing the expression of **inducible nitric oxide synthase (iNOS**) related to inflammation. 1-Heptadecanoyl-rac-glycerol can be used for research on diseases related to inflammation .

HY-115889

L-NAPNA	NO Synthase	Neurological Disease
L-NAPNA is a nitric oxide synthase (NOS) inhibitor with an IC₅₀ of 1.4 μM. L-NAPNA exhibits analgesic effects by inhibiting formalin-induced paw licking behavior in mice (ED₅₀ of 57.2 mg/kg) and suppressing acetic acid-induced abdominal writhing in mice (ED₅₀ of 25 mg/kg). L-NAPNA can be used in research related to central nervous system diseases .

HY-118160

PPM-18 NSC 73233	NO Synthase	Inflammation/Immunology Cancer
PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter . PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways .

HY-N7012

7,3',4'-Tri-O-methylluteolin 5-Hydroxy-3',4',7-trimethoxyflavone	TNF Receptor Interleukin Related COX	Inflammation/Immunology
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2 .

HY-118700

2-Iminobiotin Guanidinobiotin	NO Synthase	Neurological Disease
2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible **nitric oxide synthases inhibitor with K_is of 21.8 and 37.5μM for murine iNOS and rat n-cNOS*, respectively . 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced* cell damage .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80725

	iNOS Antibody NOS2; NOS2A; nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; inducible NO synthase; inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	iNOS Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 131 kDa, targeting to iNOS. It can be used for ICC/IF,WB,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

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HY-N0455

L-Arginine 5+ Cited Publications		Solubilizing Agents
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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inducible nitric-oxide synthase

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