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Results for "

inducible nitric-oxide synthase

" in MedChemExpress (MCE) Product Catalog:

80

Inhibitors & Agonists

5

Biochemical Assay Reagents

33

Natural
Products

2

Isotope-Labeled Compounds

2

Antibodies

1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107584

    NO Synthase Metabolic Disease
    BYK 191023 is a highly selective inducible nitric-oxide synthase (iNOS) inhibitor. BYK 191023 interacts with the catalytic center of the enzyme. BYK 191023 can be used to study the in vivo and in vitro effects mediated by iNOS .
    BYK 191023 dihydrochloride
  • HY-127029A

    NO Synthase Lipoxygenase Neurological Disease Inflammation/Immunology Cancer
    Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase) .
    Umbelliprenin
  • HY-101175

    NO Synthase Neurological Disease
    3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain .
    3-Bromo-7-nitroindazole
  • HY-18731
    1400W Dihydrochloride
    Maximum Cited Publications
    20 Publications Verification

    NO Synthase Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .
    1400W Dihydrochloride
  • HY-122060

    NO Synthase Metabolic Disease
    BYK 191023 is a selective and L-arginine competitive inducible nitric-oxide synthase inhibitor with an IC50 value of 86 nM, 17 µM, 162 µM for inducible (iNOS), neuronal (nNOS), and endothelial (eNOS) NO synthases respectively .
    BYK 191023
  • HY-U00432B

    S-Methyl-L-thiocitrulline acetate

    NO Synthase Endogenous Metabolite Inflammation/Immunology
    S-MTC acetate (S-Methyl-L-thiocitrulline acetate) acts as a powerful inhibitor of inducible nitric oxide synthase, favoring the inhibition of constitutive (neuronal) nitric oxide synthase over inducible (endothelial) nitric oxide synthase.
    S-MTC acetate
  • HY-18730

    W1400

    NO Synthase Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .
    1400W
  • HY-164361

    NO Synthase Inflammation/Immunology
    α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells .
    2′-Hydroxy-2,3-dimethoxychalcone
  • HY-N3602A

    Rengyolone

    TNF Receptor NF-κB NO Synthase Inflammation/Immunology
    rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS (HY-D1056), thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production .
    rel-Cleroindicin F
  • HY-W408607

    NO Synthase Inflammation/Immunology
    N-Benzylacetamidine (hydrobromide) is a acetamidine compound. N-Benzylacetamidine (hydrobromide) is a selective inducible nitric oxide synthase (iNOS) inhibitor with an IC50 of 0.20 μM .
    N-Benzylacetamidine hydrobromide
  • HY-115744

    NO Synthase Inflammation/Immunology
    Mercaptoethylguanidine (MEG) dihydrobromide is selective inhibitor of the inducible nitric oxide synthase and peroxynitrite scavenger. Mercaptoethylguanidine (MEG) dihydrobromide has the potential for inflammatory bowel diseases research.
    Mercaptoethylguanidine (MEG) (dihydrobromide)
  • HY-34748

    Ethylideneacetone; (3Z)-pent-3-en-2-one

    Biochemical Assay Reagents Endogenous Metabolite Inflammation/Immunology
    3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) .
    3-Penten-2-one
  • HY-133098

    NO Synthase Inflammation/Immunology
    Juncutol is a potent inducible nitric oxide synthase (iNOS) inhibitor. Juncutol decreases the LPS (HY-D1056)-stimulated iNOS protein expression .
    Juncutol
  • HY-117786

    PKC Neurological Disease
    Go 7874 is a protein kinase C (PKC) inhibitor. Go 7874 mediated neuroprotection against LPS/IFNg-induced neuronal cell death in an immune-mediated neurotoxicity model, not through PKC activity. In contrast, the neuroprotective mechanism of Go 7874 involves inhibition of inducible nitric oxide synthase (iNOS) gene expression, followed by reduced nitric oxide (NO) production .
    Go 7874
  • HY-110275

    Keap1-Nrf2 NO Synthase Infection Inflammation/Immunology
    RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (Kd is approximately 6 μM). RA839 prevents inducible nitric oxide synthase expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects .
    RA839
  • HY-N6770

    (S)-Curvularin

    NO Synthase Infection Inflammation/Immunology
    Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM .
    Curvularin
  • HY-79457
    S-Methylisothiourea sulfate
    1 Publications Verification

    NO Synthase HSV Infection Inflammation/Immunology
    S-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of inducible nitric oxide synthase (iNOS). S-Methylisothiourea sulfate exerts beneficial effects in rodent models of septic shock .
    S-Methylisothiourea sulfate
  • HY-N1382
    Asperuloside
    2 Publications Verification

    NO Synthase Metabolic Disease Inflammation/Immunology
    Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .
    Asperuloside
  • HY-N0455A
    L-Arginine hydrochloride
    10+ Cited Publications

    (S)-(+)-Arginine hydrochloride

    NO Synthase Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology
    L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .
    L-Arginine hydrochloride
  • HY-N0455
    L-Arginine
    10+ Cited Publications

    NO Synthase Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology
    L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .
    L-Arginine
  • HY-114798

    Antibiotic Bacterial NO Synthase Infection Neurological Disease
    Rabelomycin is antibiotic, which exhibits antimicrobial activity against gram positive bacteria. Rabelomycin exhibits inhibitory activity against inducible nitric oxide synthase (iNOS) with an IC50 of 63.9 μM .
    Rabelomycin
  • HY-N0268
    Irisflorentin
    1 Publications Verification

    NO Synthase Inflammation/Immunology
    Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .
    Irisflorentin
  • HY-12124

    NO Synthase Cardiovascular Disease
    BBS-4 is a potent and selective inducible nitric oxide synthase (NOS2) dimerization inhibitor, with an IC50 of 0.49 nM. BBS-4 can protect mice from the cardiovascular dysfunction of sepsis .
    BBS-4
  • HY-136341

    Apoptosis NO Synthase Endogenous Metabolite Neurological Disease Inflammation/Immunology
    7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases .
    7,8-Dihydroneopterin
  • HY-161255

    NO Synthase Inflammation/Immunology
    3,4-DAA is an orally active Anthranilic acid derivative with potent immunosuppressive activities. 3, 4-DAA can alleviate the severity of colitis through inhibiting Th1 cells response, promoting Th2 cytokines expression and inducing CD4 +CD25 + T cells expression . 3,4-DAA suppressed expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release from EOC20 cells induced by IFN-γ and Lipopolysaccharide .
    3,4-DAA
  • HY-N6893
    Ergolide
    2 Publications Verification

    NF-κB Inflammation/Immunology
    Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .
    Ergolide
  • HY-12122A

    NO Synthase Neurological Disease Inflammation/Immunology
    AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC50 of 37 nM . AR-C102222 hydrochloride has antinociception and anti-inflammatory activities .
    AR-C102222 hydrochloride
  • HY-N8444

    Interleukin Related Cardiovascular Disease
    Triptoquinone A, an interleukin 1 inhibitor, inhibits endomycin (LPS) or interleukin (IL-1β)-promoted induction of nitric oxide synthase (NOS) in vascular smooth muscle, thereby inhibiting Arg-induced vascular relaxation .
    Triptoquinone A
  • HY-W022047

    NO Synthase Cardiovascular Disease Neurological Disease
    nNOS-IN-1(Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC50s of 2.5, 5.7 and 13 μM, respectively .
    nNOS-IN-1
  • HY-N11085

    NO Synthase IKK Inflammation/Immunology
    Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity .
    Isophysalin A
  • HY-145846
    iNOs-IN-1
    1 Publications Verification

    NO Synthase Interleukin Related Inflammation/Immunology
    iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .
    iNOs-IN-1
  • HY-135224

    1,4-PB-ITU dihydrobromide

    NO Synthase Cancer
    1,4-PBIT (1,4-PB-ITU) dihydrobromide (compound 46) is a potent nitric oxide synthases (NOS) inhibitor, with Ki values of 7.6 nM, 360 nM, and 16 nM for the inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) isozymes, respectively .
    1,4-PBIT dihydrobromide
  • HY-100986
    L-NIO dihydrochloride
    1 Publications Verification

    NO Synthase Cardiovascular Disease
    L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats .
    L-NIO dihydrochloride
  • HY-100986B

    NO Synthase Cardiovascular Disease
    L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO induces a consistentfocal ischemic infarctin rats .
    L-NIO
  • HY-N1382R

    Reference Standards NO Synthase Metabolic Disease Inflammation/Immunology
    Asperuloside (Standard) is the analytical standard of Asperuloside. This product is intended for research and analytical applications. Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .
    Asperuloside (Standard)
  • HY-N0455R

    Reference Standards NO Synthase Endogenous Metabolite Cardiovascular Disease Cancer
    L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .
    L-Arginine (Standard)
  • HY-N0455AR

    (S)-(+)-Arginine hydrochloride (Standard)

    Reference Standards NO Synthase Endogenous Metabolite Cancer
    L-Arginine (hydrochloride) (Standard) is the analytical standard of L-Arginine (hydrochloride). This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .
    L-Arginine hydrochloride (Standard)
  • HY-B1041
    Aminoguanidine hydrochloride
    5 Publications Verification

    Pimagedine hydrochloride; GER-11; Aminoguanidinium chloride

    NO Synthase Apoptosis Endocrinology
    Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research .
    Aminoguanidine hydrochloride
  • HY-B1041A

    Pimagedine; GER-11(free base) ; Aminoguanidinium

    NO Synthase Apoptosis Endocrinology
    Aminoguanidine (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine has antioxidant properties. Aminoguanidine can be used in diabetic nephropathy research .
    Aminoguanidine
  • HY-124996

    NO Synthase Neurological Disease Inflammation/Immunology Cancer
    (Rac)-ZLc-002, an inhibitor of nNOS interaction with nitric oxide synthase 1 adaptor protein (NOS1AP), suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with Paclitaxel (HY-B0015) to reduce tumor cell viability .
    (Rac)-ZLc-002
  • HY-122063

    NO Synthase Inflammation/Immunology
    FR260330 is a selective, orally active inhibitor for inducible nitric oxide synthase (iNOS) through suppression of iNOS dimerization. FR260330 inhibits the NO accumulation in rat splenocytes and human DLD-110 cells, with IC50 of 27 and 10 nM. FR260330 ameliorates the Lipopolysaccharides (HY-D1056)-induced inflammatory diseases in rats model .
    FR260330
  • HY-150055

    NO Synthase Inflammation/Immunology
    iNOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 µM). iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research .
    iNOs-IN-3
  • HY-146309

    NO Synthase Inflammation/Immunology
    iNOS-IN-2 (Compound 53) is a potent down-regulator of inducible nitric oxide synthase (iNOS) protein. iNOS-IN-2 effectively inhibits the NO production (IC50=6.4 μM). iNOS-IN-2 has a potential therapeutic effect on chronic inflammation .
    iNOS-IN-2
  • HY-N0268R

    Reference Standards NO Synthase Inflammation/Immunology
    Irisflorentin (Standard) is the analytical standard of Irisflorentin. This product is intended for research and analytical applications. Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .
    Irisflorentin (Standard)
  • HY-161513

    COX NO Synthase Inflammation/Immunology
    iNOS/COX-2-IN-1 (Compound 12e) is an inhibitor of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). iNOS/COX-2-IN-1 inhibits the NF-κB and MAPKs signaling pathways and thus exerts anti-inflammatory effects .
    iNOS/COX-2-IN-1
  • HY-N6966
    Ethyl Caffeate
    1 Publications Verification

    NF-κB NO Synthase COX PGE synthase Inflammation/Immunology Cancer
    Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin .
    Ethyl Caffeate
  • HY-N2406
    Dihydrocaffeic acid
    2 Publications Verification

    3,4-Dihydroxy-benzenepropanoic acid

    p38 MAPK Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Inflammation/Immunology
    Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .
    Dihydrocaffeic acid
  • HY-156241

    NO Synthase Fungal Infection Inflammation/Immunology
    Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC50 of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC50 of 182.50 μM.
    Meliadubin B
  • HY-B0503

    Thiouracil

    NO Synthase Endocrinology Cancer
    2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments .
    2-Thiouracil
  • HY-N12224

    MG(17:0/0:0/0:0); 1-Heptadecanoin

    NO Synthase Inflammation/Immunology
    1-Heptadecanoyl-rac-glycerol (1-Heptadecanoin) is a glyceride compound with anti-inflammatory activity. 1-Heptadecanoyl-rac-glycerol inhibits the occurrence of inflammation by suppressing the expression of inducible nitric oxide synthase (iNOS) related to inflammation. 1-Heptadecanoyl-rac-glycerol can be used for research on diseases related to inflammation .
    1-Heptadecanoyl-rac-glycerol

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